Information on EC 1.2.3.6 - pyruvate oxidase (CoA-acetylating)

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
1.2.3.6
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RECOMMENDED NAME
GeneOntology No.
pyruvate oxidase (CoA-acetylating)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
pyruvate + CoA + O2 = acetyl-CoA + CO2 + H2O2
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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-
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reduction
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Pyruvate metabolism
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SYSTEMATIC NAME
IUBMB Comments
pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)
A flavoprotein (FAD). May be identical with EC 1.2.7.1 pyruvate synthase.
CAS REGISTRY NUMBER
COMMENTARY hide
62213-57-4
may be identical with EC 1.2.7.1
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
no activity in Streptococcus pyogenes
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-
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Manually annotated by BRENDA team
strain PN-20; strain Rx1; strain TIGR4
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Manually annotated by BRENDA team
strain PN-20
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Manually annotated by BRENDA team
strain Rx1
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-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
pyruvate + CoA + O2
acetyl-CoA + CO2 + H2O2
show the reaction diagram
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-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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Ala282Thr mutation in strain D39 reduces SpxB activity, probably by reducing FAD binding
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate, hydroxyapatite, partially purified
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G389D
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spxB2 mutant, reduces H2O2 production to approximately that of a DELTAspxB null mutant. SpxB2 mutant shows an opaque colony phenotype and decreased production of H2O2
P449L
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spxB4 mutant, reduces H2O2 production to approximately that of a DELTAspxB null mutant. SpxB4 mutant shows an opaque colony phenotype and decreased production of H2O2
additional information
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information