Reference on EC 1.21.3.3 - reticuline oxidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bird, D.A.; Facchini, P.J.
Berberine bridge enzyme, a key branch-point enzyme in benzylisoquinoline alkaloid biosynthesis, contains a vacuolar sorting determinant
Planta
213
888-897
2001
Papaver somniferum
Hauschild, K.; Pauli, H.H.; Kutchan, T.M.
Isolation and analysis of a gene bbe1 encoding the berberine bridge enzyme from the California poppy Eschscholzia californica
Plant Mol. Biol.
36
473-478
1998
Eschscholzia californica
Facchini, P.J.; Penzes, C.; Johnson, A.G.; Bull, D.
Molecular characterization of berberine bridge enzyme genes from opium poppy
Plant Physiol.
112
1669-1677
1996
Papaver somniferum
Kutchan, T.M.; Dittrich, H.
Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated oxidase of benzophenanthridine alkaloid biosynthesis in plants
J. Biol. Chem.
270
24475-24481
1995
Eschscholzia californica
Kutchan, T.M.; Bock, A.; Dittrich, H.
Heterologous expression of the plant proteins strictosidine synthase and berberine bridge enzyme in insect cell culture
Phytochemistry
35
353-360
1994
Eschscholzia californica
Frenzel, T.; Beale, J.M.; Kobayashi, M.; Zenk, M.H.; Floss, H.G.
Stereochemistry of enzymatic formation of the berberine bridge in protoberine alkaloids
J. Am. Chem. Soc.
110
7878-7880
1988
Chelidonium majus
-
Steffens, P.; Nagakura, N.; Zenk, M.H.
Purification and characterization of the berberine bridge enzyme from Berberis beaniana cell cultures
Phytochemistry
24
2577-2583
1985
Berberis beaniana, Embryophyta
-
Steffens, P.; Nagakura, N.; Zenk, M.H.
The berberine bridge forming enzyme in tetrahydroprotoberberine synthesis
Tetrahedron Lett.
25
951-952
1984
Berberis beaniana
-
Weid, M.; Ziegler, J.; Kutchan, T.M.
The roles of latex and the vascular bundle in morphine biosynthesis in the opium poppy, Papaver somniferum
Proc. Natl. Acad. Sci. USA
101
13957-13962
2004
Eschscholzia californica, Papaver somniferum
Park, S.U.; Yu, M.; Facchini, P.J.
Modulation of berberine bridge enzyme levels in transgenic root cultures of California poppy alters the accumulation of benzophenanthridine alkaloids
Plant Mol. Biol.
51
153-164
2003
Eschscholzia californica, Papaver somniferum
Alcantara, J.; Bird, D.A.; Franceschi, V.R.; Facchini, P.J.
Sanguinarine biosynthesis is associated with the endoplasmic reticulum in cultured opium poppy cells after elicitor treatment
Plant Physiol.
138
173-183
2005
Papaver somniferum (P93479), Papaver somniferum
Samanani, N.; Alcantara, J.; Bourgault, R.; Zulak, K.G.; Facchini, P.J.
The role of phloem sieve elements and laticifers in the biosynthesis and accumulation of alkaloids in opium poppy
Plant J.
47
547-563
2006
Papaver somniferum
Winkler, A.; Hartner, F.; Kutchan, T.M.; Glieder, A.; Macheroux, P.
Biochemical evidence that berberine bridge enzyme belongs to a novel family of flavoproteins containing a bi-covalently attached FAD cofactor
J. Biol. Chem.
281
21276-21285
2006
Eschscholzia californica
Samanani, N.; Park, S.; Facchini, P.J.
Cell type-specific localization of transcripts encoding nine consecutive enzymes involved in protoberberine alkaloid biosynthesis
Plant Cell
17
915-926
2005
Thalictrum flavum subsp. glaucum
Winkler, A.; Kutchan, T.M.; Macheroux, P.
6-S-cysteinylation of bi-covalently attached FAD in berberine bridge enzyme tunes the redox potential for optimal activity
J. Biol. Chem.
282
24437-24443
2007
Eschscholzia californica
Fujii, N.; Inui, T.; Iwasa, K.; Morishige, T.; Sato, F.
Knockdown of berberine bridge enzyme by RNAi accumulates (S)-reticuline and activates a silent pathway in cultured California poppy cells
Transgenic Res.
16
363-375
2007
Eschscholzia californica
Winkler, A.; Motz, K.; Riedl, S.; Puhl, M.; Macheroux, P.; Gruber, K.
Structural and mechanistic studies reveal the functional role of bicovalent flavinylation in berberine bridge enzyme
J. Biol. Chem.
284
19993-20001
2009
Eschscholzia californica (P30986)
Winkler, A.; Lyskowski, A.; Riedl, S.; Puhl, M.; Kutchan, T.M.; Macheroux, P.; Gruber, K.
A concerted mechanism for berberine bridge enzyme
Nat. Chem. Biol.
4
739-741
2008
Eschscholzia californica
Winkler, A.; Puhl, M.; Weber, H.; Kutchan, T.M.; Gruber, K.; Macheroux, P.
Berberine bridge enzyme catalyzes the six electron oxidation of (S)-reticuline to dehydroscoulerine
Phytochemistry
70
1092-1097
2009
Eschscholzia californica (P30986)
Gonzalez-Candelas, L.; Alamar, S.; Sanchez-Torres, P.; Zacarias, L.; Marcos, J.F.
A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection
BMC Plant Biol.
10
194
2010
Citrus sinensis
Resch, V.; Schrittwieser, J.; Wallner, S.; MacHeroux, P.; Kroutil, W.
Biocatalytic oxidative C-C bond formation catalysed by the berberine bridge enzyme: Optimal reaction conditions
Adv. Synth. Catal.
353
2377-2383
2011
Eschscholzia californica (P30986)
-
Wallner, S.; Winkler, A.; Riedl, S.; Dully, C.; Horvath, S.; Gruber, K.; Macheroux, P.
Catalytic and structural role of a conserved active site histidine in berberine bridge enzyme
Biochemistry
51
6139-6147
2012
Eschscholzia californica (P30986)
Gaweska, H.M.; Roberts, K.M.; Fitzpatrick, P.F.
Isotope effects suggest a stepwise mechanism for berberine bridge enzyme
Biochemistry
51
7342-7347
2012
Eschscholzia californica
Resch, V.; Lechner, H.; Schrittwieser, J.H.; Wallner, S.; Gruber, K.; Macheroux, P.; Kroutil, W.
Inverting the regioselectivity of the berberine bridge enzyme by employing customized fluorine-containing substrates
Chemistry
18
13173-13179
2012
Eschscholzia californica (P30986)
Schrittwieser, J.H.; Resch, V.; Wallner, S.; Lienhart, W.D.; Sattler, J.H.; Resch, J.; Macheroux, P.; Kroutil, W.
Biocatalytic organic synthesis of optically pure (S)-scoulerine and berbine and benzylisoquinoline alkaloids
J. Org. Chem.
76
6703-6714
2011
Eschscholzia californica (P30986)
Galanie, S.; Smolke, C.
Optimization of yeast-based production of medicinal protoberberine alkaloids
Microb. Cell Fact.
14
144
2015
Papaver somniferum (P93479)
Gandomkar, S.; Fischereder, E.M.; Schrittwieser, J.H.; Wallner, S.; Habibi, Z.; Macheroux, P.; Kroutil, W.
Enantioselective oxidative aerobic dealkylation of N-ethyl benzylisoquinolines by employing the berberine bridge enzyme
Angew. Chem. Int. Ed. Engl.
54
15051-15054
2015
Eschscholzia californica
Daniel, B.; Konrad, B.; Toplak, M.; Lahham, M.; Messenlehner, J.; Winkler, A.; Macheroux, P.
The family of berberine bridge enzyme-like enzymes A treasure-trove of oxidative reactions
Arch. Biochem. Biophys.
632
88-103
2017
Eschscholzia californica (P30986), Eschscholzia californica
Daniel, B.; Pavkov-Keller, T.; Steiner, B.; Dordic, A.; Gutmann, A.; Nidetzky, B.; Sensen, C.W.; van der Graaff, E.; Wallner, S.; Gruber, K.; Macheroux, P.
Oxidation of monolignols by members of the berberine bridge enzyme family suggests a role in plant cell wall metabolism
J. Biol. Chem.
290
18770-18781
2015
Arabidopsis thaliana (O64743), Arabidopsis thaliana (Q93ZA3), Arabidopsis thaliana
Lewis, R.S.; Lopez, H.O.; Bowen, S.W.; Andres, K.R.; Steede, W.T.; Dewey, R.E.
Transgenic and mutation-based suppression of a berberine bridge enzyme-like (BBL) gene family reduces alkaloid content in field-grown tobacco
PLoS ONE
10
e0117273
2015
Nicotiana tabacum
Daniel, B.; Wallner, S.; Steiner, B.; Oberdorfer, G.; Kumar, P.; van der Graaff, E.; Roitsch, T.; Sensen, C.W.; Gruber, K.; Macheroux, P.
Structure of a berberine bridge enzyme-like enzyme with an active site specific to the plant family Brassicaceae
PLoS ONE
11
e0156892
2016
Arabidopsis thaliana (Q9FI21), Arabidopsis thaliana
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