Information on EC 1.21.99.1 - beta-cyclopiazonate dehydrogenase

Word Map on EC 1.21.99.1
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Penicillium cyclopium

EC NUMBER
COMMENTARY hide
1.21.99.1
-
RECOMMENDED NAME
GeneOntology No.
beta-cyclopiazonate dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
beta-cyclopiazonate + acceptor = alpha-cyclopiazonate + reduced acceptor
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
alpha-cyclopiazonate biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)
A flavoprotein (FAD). Cytochrome c and various dyes can act as acceptor. Cyclopiazonate is a microbial toxin.
CAS REGISTRY NUMBER
COMMENTARY hide
9059-00-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
beta-cyclopiazonate + acceptor
alpha-cyclopiazonate + reduced acceptor
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
beta-cyclopiazonate + acceptor
alpha-cyclopiazonate + reduced acceptor
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,6-dichlorophenolindophenol
-
competitive inhibition
alpha-cyclopiazonate
-
-
beta-Cyclopiazonate
-
-
diethyldicarbonate
-
-
Dihydro-beta-cyclopiazonate
-
-
L-tryptophan
-
-
Tryptophan tetramate
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00016
2,6-dichlorophenolindophenol
-
-
0.0021 - 0.014
beta-Cyclopiazonate
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8
-
beta-cyclopiazonate + 2,6-dichlorophenolindophenol
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50000
-
gel filtration, sedimentation velocity
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
55
-
unstable above
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
several months, 0-4°C, pH 6.6
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE