Information on EC 1.3.1.13 - prephenate dehydrogenase (NADP+)

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
1.3.1.13
-
RECOMMENDED NAME
GeneOntology No.
prephenate dehydrogenase (NADP+)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
oxidative decarboxylation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Phenylalanine, tyrosine and tryptophan biosynthesis
-
-
Metabolic pathways
-
-
Biosynthesis of secondary metabolites
-
-
Biosynthesis of antibiotics
-
-
SYSTEMATIC NAME
IUBMB Comments
prephenate:NADP+ oxidoreductase (decarboxylating)
-
CAS REGISTRY NUMBER
COMMENTARY hide
37251-11-9
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
ATCC 14987; ATCC 23055
-
-
Manually annotated by BRENDA team
ATCC 15309
-
-
Manually annotated by BRENDA team
strain C1W
-
-
Manually annotated by BRENDA team
strain C1W
-
-
Manually annotated by BRENDA team
strain ATCC 27893, 27898, 29151 and 29413
-
-
Manually annotated by BRENDA team
strain ATCC 29538
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Lyngbya sp.
strain ATCC 29119, 29121 and 29126
-
-
Manually annotated by BRENDA team
no activity in Anabaena sp.
strains ATCC 27892, 27899, 29211 and 29414
-
-
Manually annotated by BRENDA team
no activity in Beta vulgaris subsp. vulgaris
red beet, Beta vulgaris ssp. var. conditiva, Beta vulgaris ssp. vulgaris var. rubra
-
-
Manually annotated by BRENDA team
no activity in Calothrix sp.
strain ATCC 27901, 27905, 29112, 29156, 29158and 29171
-
-
Manually annotated by BRENDA team
no activity in Nostoc sp.
strain ATCC 29411 and 29132
-
-
Manually annotated by BRENDA team
no activity in Oryza sativa
rice
-
-
Manually annotated by BRENDA team
no activity in Pisum sativum
pea
-
-
Manually annotated by BRENDA team
no activity in Scytonema sp.
strain 29171
-
-
Manually annotated by BRENDA team
no activity in Scytonema sp. 29171
strain 29171
-
-
Manually annotated by BRENDA team
no activity in Synechocystis sp.
strain ATCC 29108
-
-
Manually annotated by BRENDA team
no activity in Triticum aestivum
wheat
-
-
Manually annotated by BRENDA team
strain ATCC 29105 and 29133
-
-
Manually annotated by BRENDA team
scarlet runner bean, L.
-
-
Manually annotated by BRENDA team
wax bean, L. var.Bountiful
-
-
Manually annotated by BRENDA team
Pseudomonas alkanolytica
-
-
-
Manually annotated by BRENDA team
strain ATCC 29404, Agmenellum quadruplicatum BG1, strain 27144, 27146 and 27192
-
-
Manually annotated by BRENDA team
strain ATCC 29109,27178 and 29235
-
-
Manually annotated by BRENDA team
broad bean, L. var. Windsor
-
-
Manually annotated by BRENDA team
mung bean, [L.] Wilczek, originally classified as Phaseolus aureus [L.] Roxb.
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
prephenate + NADP+
4-hydroxyphenylpyruvate + CO2 + NADPH
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
prephenate + NADP+
4-hydroxyphenylpyruvate + CO2 + NADPH
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-chloromercuriphenylsulfonic acid
-
-
L-tyrosine
N-ethylmaleimide
-
-
p-hydroxymercurybenzoic acid
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.005 - 0.079
NADP+
0.033 - 0.18
prephenate
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.009
L-tyrosine
-
competitive inhibition with respect to substrate and noncompetitively with respect to cofactor
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4 - 10.8
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
52000
-
gel filtration
210000
-
gel filtration
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 8
-
maximum stability in this range at 22°C
390556
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
55
-
up to 10 min inactivates the enzyme
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partially
-
strain 23055, partially
-