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Reference on EC 1.3.1.21 - 7-dehydrocholesterol reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Srikantaiah, M.V.; Assef, S.; Morin, R.J.
Effects of Tween 80 on liver microsomal 7-dehydrocholesterol reductase
Biochem. Biophys. Res. Commun.
81
1087-1090
1978
Rattus norvegicus
Manually annotated by BRENDA team
Bjrkhem, I.; Holmberg, I.
Mechanism of enzymatic reduction of steroid double bonds
Eur. J. Biochem.
33
364-367
1973
Rattus norvegicus
Manually annotated by BRENDA team
Banik, N.L.; Davison, A.N.
Exchange of sterols between myelin and other membranes of developing rat brain
Biochem. J.
122
751-758
1971
Rattus norvegicus
Manually annotated by BRENDA team
Kandutsch, A.A.
Enzymatic reduction of the DELTA7 bond of 7-dehydrocholesterol
J. Biol. Chem.
237
358-362
1962
Mus musculus
Manually annotated by BRENDA team
Dempsey, M.E.; Seaton, J.D.; Schroepfer, G.J.; Trockman, R.W.
The intermediary role of DELTA5,7-cholestadien-3beta-ol in cholesterol biosynthesis
J. Biol. Chem.
239
1381-1387
1964
Rattus norvegicus
Manually annotated by BRENDA team
Niemiro, R.; Fumagalli, R.
Studies on the inhibitory mechanism of some hypocholesterolemic agents on 7-dehydrocholesterol DELTA-7-bond reductase activity
Biochim. Biophys. Acta
98
624-631
1965
Rattus norvegicus
Manually annotated by BRENDA team
Dempsey, M.E.
Pathways of enzymic synthesis and conversion to cholesterol of DELTA-5,7,24-cholestatrien-3beta-ol and other naturally occurring sterols
J. Biol. Chem.
240
4176-4188
1965
Rattus norvegicus
Manually annotated by BRENDA team
Trzaskos, J.M.; Gaylor, J.L.
Cytosolic modulators of activities of microsomal enzymes of cholesterol biosynthesis. Purification and characterization of a non-specific lipid-transfer protein
Biochim. Biophys. Acta
751
52-65
1983
Rattus norvegicus
Manually annotated by BRENDA team
Wilton, D.C.; Munday, K.A.; Skinner, S.J.M.; Akhtar, M.
The biological conversion of 7-dehydrocholesterol into cholesterol and comments on the reduction of double bonds
Biochem. J.
106
803
1968
Rattus norvegicus
Manually annotated by BRENDA team
Lecain, E.; Chenivesse, X.; Spagnoli, R.; Pompon, D.
Cloning by metabolic interference in yeast and enzymic characterization of Arabidopsis thaliana sterol DELTA7-reductase
J. Biol. Chem.
271
10866-10873
1996
Arabidopsis thaliana (Q9LDU6)
Manually annotated by BRENDA team
Lee, J.N.; Paik, Y.K.
Cholesterol biosynthesis from lanosterol: development of a novel assay method, characterization, and solubilization of rat hepatic microsomal sterol DELTA7-reductase
J. Biochem. Mol. Biol.
30
370-377
1997
Rattus norvegicus
-
Manually annotated by BRENDA team
Rahier, A.; Taton, M.
Sterol biosynthesis: Strong inhibition of maize DELTA5,7-sterol DELTA7-reductase by novel 6-aza-B-homosteroids and other analogs of a presumptive carbocationic intermediate of the reduction reaction
Biochemistry
35
7069-7076
1996
Zea mays
Manually annotated by BRENDA team
Waterham, H.R.; Wanders, R.J.A.
Biochemical and genetic aspects of 7-dehydrocholesterol reductase and Smith-Lemli-Opitz syndrome
Biochim. Biophys. Acta
1529
340-356
2000
Arabidopsis thaliana, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Honda, A.; Salen, G.; Nguyen, L.B.; Tint, G.S.; Batta, A.K.; Shefer, S.
Down-regulation of cholesterol biosynthesis in sitosterolemia: diminished activities of acetoacetyl-CoA thiolase, 3-hydroxy-3-methylglutaryl-CoA synthase, reductase, squalene synthase, and 7-dehydrocholesterol DELTA7-reductase in liver and mononuclear leukocytes
J. Lipid Res.
39
44-50
1998
Homo sapiens
Manually annotated by BRENDA team
Shefer, S.; Salen, G.; Honda, A.; Batta, A.K.; Nguyen, L.B.; Tint, G.S.; Ioannou, Y.A.; Desnick, R.
Regulation of rat hepatic 3beta-hydroxysterol DELTA7-reductase: substrate specificity, competitive and non-competitive inhibition, and phosphorylation/dephosphorylation
J. Lipid Res.
39
2471-2476
1998
Rattus norvegicus
Manually annotated by BRENDA team
Honda, A.; Salen, G.; Shefer, S.; Batta, A.K.; Honda, M.; Xu, G.; Tint, G.S.; Matsuzaki, Y.; Shoda, J.; Tanaka, N.
Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7.alpha-hydroxylase and 27-hydroxylase activities in rat liver
J. Lipid Res.
40
1520-1528
1999
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Jira, P.E.; Waterham, H.R.; Wanders, R.J.; Smeitink, J.A.; Sengers, R.C.; Wevers, R.A.
Smith-Lemli-Opitz syndrome and the DHCR7 gene
Ann. Hum. Genet.
67
269-280
2003
Homo sapiens
Manually annotated by BRENDA team
Shim, Y.H.; Bae, S.H.; Kim, J.H.; Kim, K.R.; Kim, C.J.; Paik, Y.K.
A novel mutation of the human 7-dehydrocholesterol reductase gene reduces enzyme activity in patients with holoprosencephaly
Biochem. Biophys. Res. Commun.
315
219-223
2004
Homo sapiens (Q9UBM7), Homo sapiens
Manually annotated by BRENDA team
Lee, J.N.; Bae, S.H.; Paik, Y.K.
Structure and alternative splicing of the rat 7-dehydrocholesterol reductase gene
Biochim. Biophys. Acta
1576
148-156
2002
Mus musculus (O88455), Mus musculus, Rattus norvegicus (Q9E2H5), Rattus norvegicus (Q9Z2Z8), Homo sapiens (Q9UBM7), Homo sapiens
Manually annotated by BRENDA team
Anbalagan, M.; Yashwanth, R.; Jagannadha Rao, A.
DD-RT-PCR identifies 7-dehydrocholesterol reductase as a key marker of early Leydig cell steroidogenesis
Mol. Cell. Endocrinol.
219
37-45
2004
Rattus norvegicus
Manually annotated by BRENDA team
Ginat, S.; Battaile, K.P.; Battaile, B.C.; Maslen, C.; Gibson, K.M.; Steiner, R.D.
Lowered DHCR7 activity measured by ergosterol conversion in multiple cell types in Smith-Lemli-Opitz syndrome
Mol. Genet. Metab.
83
175-183
2004
Homo sapiens
Manually annotated by BRENDA team
Correa-Cerro, L.S.; Porter, F.D.
3beta-hydroxysterol DELTA7-reductase and the Smith-Lemli-Opitz syndrome
Mol. Genet. Metab.
84
112-126
2005
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Lin, X.; Chen, Z.; Yue, P.; Averna, M.; Ostlund, R.E.; Watson, M.A.; Schonfeldt, G.
A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidation
Am. J. Physiol. Gastrointest. Liver Physiol.
290
1170-1176
2006
Mus musculus
-
Manually annotated by BRENDA team
Lee, E.Y.; Shim, Y.H.; Chitwood, D.J.; Hwang, S.B.; Lee, J.; Paik, Y.K.
Cholesterol-producing transgenic Caenorhabditis elegans lives longer due to newly acquired enhanced stress resistance
Biochem. Biophys. Res. Commun.
328
929-936
2005
Homo sapiens
Manually annotated by BRENDA team
Anstey, A.V.; Azurdia, R.M.; Rhodes, L.E.; Pearse, A.D.; Bowden, P.E.
Photosensitive Smith-Lemli-Opitz syndrome is not caused by a single gene mutation: analysis of the gene encoding 7-dehydrocholesterol reductase in five U.K. families
Br. J. Dermatol.
153
774-779
2005
Homo sapiens
Manually annotated by BRENDA team
Tadjuidje, E.; Hollemann, T.
Cholesterol homeostasis in development: The role of Xenopus 7-dehydrocholesterol reductase (Xdhcr7) in neural development
Dev. Dyn.
235
2095-2110
2006
Mus musculus, Xenopus laevis
Manually annotated by BRENDA team
Koide, T.; Hayata, T.; Cho, K.W.Y.
Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase
Development
133
2395-2405
2006
Homo sapiens, Xenopus laevis
Manually annotated by BRENDA team
Romano, F.; fiore, B.; Pezzino, F.M.; Longombardo, M.T.; Cefalu, A.B.; Noto, D.; Puglisi, A.; Brogna, A.; Mattina, T.; Averna, M.; Travali, S.
A novel mutation of the DHCR7 gene in a Sicilian compound heterozygote with Smith-Lemli-Optiz syndrome
Mol. Diagn.
9
201-204
2005
Homo sapiens (Q9UBM7), Homo sapiens
Manually annotated by BRENDA team
Cardoso, M.L.; Balreia, A.; Martins, E.; Nunes, L.; Cabral, A.; Marques, M.; Reis Lima, M.; Marques, J.S.; Medeira, A.; Cordeiro, I.; Pedro, S.; Mota, M.C.; Dionisi-Vici, C.; Santorelli, F.M.; Jakobs, C.; Clayton, P.T.; Vilarinho, L.
Molecular studies in Portuguese patients with Smith-Lemli-Opitz syndrome an report of three new mutations in DHCR7
Mol. Genet. Metab.
85
228-235
2005
Homo sapiens
Manually annotated by BRENDA team
Zhang, S.; Sakuradani, E.; Shimizu, S.
Identification of a sterol DELTA7 reductase gene involved in desmosterol biosynthesis in Mortierella alpina 1S-4
Appl. Environ. Microbiol.
73
1736-1741
2007
Mortierella alpina (A4F244), Mortierella alpina 1S-4 (A4F244), Mortierella alpina 1S-4
Manually annotated by BRENDA team
Hagiwara, K.; Nakamura, Y.; Nishijima, M.; Yamakawa, Y.
Prevention of prion propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice
Biol. Pharm. Bull.
30
835-838
2007
Mus musculus
Manually annotated by BRENDA team
Marcos, J.; Shackleton, C.H.; Buddhikot, M.M.; Porter, F.D.; Watson, G.L.
Cholesterol biosynthesis from birth to adulthood in a mouse model for 7-dehydrosterol reductase deficiency (Smith-Lemli-Opitz syndrome)
Steroids
72
802-808
2007
Mus musculus
Manually annotated by BRENDA team
Serra, M.; Matabosch, X.; Ying, L.; Watson, G.; Shackleton, C.
Hair and skin sterols in normal mice and those with deficient dehydrosterol reductase (DHCR7), the enzyme associated with Smith-Lemli-Opitz syndrome
J. Steroid Biochem. Mol. Biol.
122
318-325
2010
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Jiang, X.S.; Backlund, P.S.; Wassif, C.A.; Yergey, A.L.; Porter, F.D.
Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency
Mol. Cell. Proteomics
9
1461-1475
2010
Mus musculus
Manually annotated by BRENDA team
Lauth, M.; Rohnalter, V.; Bergstroem, A.; Kooshesh, M.; Svenningsson, P.; Toftgard, R.
Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels
Mol. Pharmacol.
78
486-496
2010
Homo sapiens
Manually annotated by BRENDA team
Wollam, J.; Magomedova, L.; Magner, D.B.; Shen, Y.; Rottiers, V.; Motola, D.L.; Mangelsdorf, D.J.; Cummins, C.L.; Antebi, A.
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity
Aging Cell
10
879-884
2011
Caenorhabditis elegans (Q17938)
Manually annotated by BRENDA team
Yoshiyama-Yanagawa, T.; Enya, S.; Shimada-Niwa, Y.; Yaguchi, S.; Haramoto, Y.; Matsuya, T.; Shiomi, K.; Sasakura, Y.; Takahashi, S.; Asashima, M.; Kataoka, H.; Niwa, R.
The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme
J. Biol. Chem.
286
25756-25762
2011
Caenorhabditis elegans (Q17938), Bombyx mori (Q1JUZ2)
Manually annotated by BRENDA team
Horling, A.; Mueller, C.; Barthel, R.; Bracher, F.; Imming, P.
A new class of selective and potent 7-dehydrocholesterol reductase inhibitors
J. Med. Chem.
55
7614-7622
2012
Homo sapiens
Manually annotated by BRENDA team
Matabosch, X.; Ying, L.; Serra, M.; Wassif, C.A.; Porter, F.D.; Shackleton, C.; Watson, G.
Increasing cholesterol synthesis in 7-dehydrosterol reductase (DHCR7) deficient mouse models through gene transfer
J. Steroid Biochem. Mol. Biol.
122
303-309
2010
Mus musculus
Manually annotated by BRENDA team
Zou, L.; Li, L.; Porter, T.D.
7-Dehydrocholesterol reductase activity is independent of cytochrome P450 reductase
J. Steroid Biochem. Mol. Biol.
127
435-438
2011
Mus musculus
Manually annotated by BRENDA team
Najle, S.R.; Nusblat, A.D.; Nudel, C.B.; Uttaro, A.D.
The sterol-C7 desaturase from the ciliate Tetrahymena thermophila is a Rieske oxygenase, which is highly conserved in animals
Mol. Biol. Evol.
30
1630-1643
2013
Tetrahymena thermophila (I7ML19), Tetrahymena thermophila
Manually annotated by BRENDA team
Hall, P.; Michels, V.; Gavrilov, D.; Matern, D.; Oglesbee, D.; Raymond, K.; Rinaldo, P.; Tortorelli, S.
Aripiprazole and trazodone cause elevations of 7-dehydrocholesterol in the absence of Smith-Lemli-Opitz Syndrome
Mol. Genet. Metab.
110
176-178
2013
Homo sapiens
Manually annotated by BRENDA team
Prabhu, A.V.; Sharpe, L.J.; Brown, A.J.
The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis
Biochim. Biophys. Acta
1842
1431-1439
2014
Homo sapiens
Manually annotated by BRENDA team
Kim, H.Y.; Korade, Z.; Tallman, K.A.; Liu, W.; Weaver, C.D.; Mirnics, K.; Porter, N.A.
Inhibitors of 7-dehydrocholesterol reductase: screening of a collection of pharmacologically active compounds in Neuro2a cells
Chem. Res. Toxicol.
29
892-900
2016
Mus musculus
Manually annotated by BRENDA team
Liu, W.; Xu, L.; Lamberson, C.; Haas, D.; Korade, Z.; Porter, N.A.
A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome
J. Lipid Res.
55
329-337
2014
Mus musculus
Manually annotated by BRENDA team
Luu, W.; Hart-Smith, G.; Sharpe, L.J.; Brown, A.J.
The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally
J. Lipid Res.
56
888-897
2015
Homo sapiens
Manually annotated by BRENDA team
Zou, L.; Porter, T.D.
Rapid suppression of 7-dehydrocholesterol reductase activity in keratinocytes by vitamin D
J. Steroid Biochem. Mol. Biol.
148
64-71
2015
Homo sapiens
Manually annotated by BRENDA team
Prabhu, A.V.; Luu, W.; Sharpe, L.J.; Brown, A.J.
Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis
J. Steroid Biochem. Mol. Biol.
165
363-368
2017
Mesocricetus auratus
Manually annotated by BRENDA team
Boland, M.R.; Tatonetti, N.P.
Investigation of 7-dehydrocholesterol reductase pathway to elucidate off-target prenatal effects of pharmaceuticals: a systematic review
Pharmacogenomics J.
16
411-429
2016
Homo sapiens
Manually annotated by BRENDA team
Prabhu, A.V.; Luu, W.; Li, D.; Sharpe, L.J.; Brown, A.J.
DHCR7: A vital enzyme switch between cholesterol and vitamin D production
Prog. Lipid Res.
64
138-151
2016
Homo sapiens
Manually annotated by BRENDA team
Kohlhaas, J.; Jaeger, M.; Lust, L.; De La Torre, C.; Hecker, M.; Korff, T.
Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression
Exp. Cell Res.
399
112446
2021
Homo sapiens
Manually annotated by BRENDA team
Xiao, J.; Li, W.; Zheng, X.; Qi, L.; Wang, H.; Zhang, C.; Wan, X.; Zheng, Y.; Zhong, R.; Zhou, X.; Lu, Y.; Li, Z.; Qiu, Y.; Liu, C.; Zhang, F.; Zhang, Y.; Xu, X.; Yang, Z.; Chen, H.; Zhai, Q.; Wei, B.; Wang, H.
Targeting 7-dehydrocholesterol reductase integrates cholesterol metabolism and IRF3 activation to eliminate infection
Immunity
52
109-122.e6
2020
Homo sapiens (Q9UBM7)
Manually annotated by BRENDA team
Tuckey, R.; Tang, E.; Chen, Y.; Slominski, A.
Selective ability of rat 7-dehydrocholesterol reductase (DHCR7) to act on some 7-dehydrocholesterol metabolites but not on lumisterol metabolites
J. Steroid Biochem. Mol. Biol.
212
105929
2021
Rattus norvegicus (Q9Z2Z8)
Manually annotated by BRENDA team
Genaro-Mattos, T.C.; Allen, L.B.; Anderson, A.; Tallman, K.A.; Porter, N.A.; Korade, Z.; Mirnics, K.
Maternal aripiprazole exposure interacts with 7-dehydrocholesterol reductase mutations and alters embryonic neurodevelopment
Mol. Psychiatry
24
491-500
2019
Mus musculus (O88455), Mus musculus
Manually annotated by BRENDA team
Zhang, M.; Song, M.; Cheng, F.; Yang, Z.; Davoudi, M.; Chen, J.; Lou, Q.
Identification of a putative candidate gene encoding 7-dehydrocholesterol reductase involved in brassinosteroids biosynthesis for compact plant architecture in Cucumber (Cucumis sativus L.)
Theor. Appl. Genet.
134
2023-2034
2021
Cucumis sativus (A0A0A0KC98), Cucumis sativus
Manually annotated by BRENDA team