Reference on EC 1.4.1.3 - glutamate dehydrogenase [NAD(P)+]
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Smith, E.L.; Austen, B.M.; Blumenthal, K.M.; Nyc, J.F.
Glutamate dehydrogenase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
11
293-367
1975
Acholeplasma laidlawii, Bos taurus, Gallus gallus, Auxenochlorella pyrenoidosa, Homo sapiens, Lithobates catesbeianus, Rattus norvegicus, Squalus acanthias, Sus scrofa, Thunnus thynnus
-
Olson, J.A.; Anfinsen, C.B.
The crystallization and characterization of L-glutamate acid dehydrogenase
J. Biol. Chem.
197
67-79
1952
Bos taurus
Tsenova, E.N.
Isolation and properties of glutamate dehydrogenase from pea chloroplasts
Enzymologia
43
397-408
1972
Pisum sativum
Silverstein, E.
Equilibrium kinetic study of bovine liver glutamate dehydrogenase at high pH
Biochemistry
13
3750-3754
1974
Bos taurus
Di Prisco, G.; Garofano, F.
Purification and some properties of glutamate dehydrogenase from ox liver nuclei
Biochem. Biophys. Res. Commun.
58
683-689
1974
Bos taurus
Hornby, D.P.; Aitchison, M.J.; Engel, P.C.
The kinetic mechanism of ox liver glutamate dehydrogenase in the presence of the allosteric effector ADP. The oxidative deamination of L-glutamate
Biochem. J.
223
161-168
1984
Bos taurus
Tang, M.Q.; Ando, S.; Yamada, S.; Hayashi, S.
The trypsin-catalyzed activation of glutamate dehydrogenase purified from eel liver
J. Biochem.
111
655-661
1992
Anguilla anguilla
Beattie, R.E.; Graham, L.D.; Griffin, T.O.; Tipton, K.F.
Purification of NAD+-dependent dehydrogenases by affinity precipitation with adipo-N2,N2-dihydrazzidobis-(N6-carboxymethyl-NAD+) (bis-NAD+)
Biochem. Soc. Trans.
12
433
1984
Bos taurus
-
Arnold, H.; Maier, K.P.
Glutamate dehydrogenase from rat liver
Biochim. Biophys. Acta
251
133-140
1971
Rattus norvegicus
Piszkiewicz, D.; Smith, E.L.
Bovine liver glutamate dehydrogenase. Equilibria and kinetics of inactivation by pyridoxal
Biochemistry
10
4538-4544
1971
Bos taurus
Nemat-Gorgani, M.; Dodd, G.
The interaction of phospholipid membranes and detergents with glutamate dehydrogenase
Eur. J. Biochem.
74
129-137
1977
Bos taurus
-
Di Prisco, G.
Effect of pH and ionic strength on the catalytic and allosteric properties of native and chemically modified ox liver mitochondrial glutamate dehydrogenase
Arch. Biochem. Biophys.
171
604-612
1975
Bos taurus
Ehmke, A.; Hartmann, T.
Properties of glutamate dehydrogenase from Lemna minor
Phytochemistry
15
1611-1617
1976
Lemna minor
-
Langridge, W.H.R.; Komuniecki, P.; DeToma, F.J.
Isolation and regulatory properties of two glutamate dehydrogenases from the cellular slime mold Dictyostelium discoideum
Arch. Biochem. Biophys.
178
581-587
1977
Dictyostelium discoideum
Veronese, F.M.; Bevilacqua, R.; Boccu, E.; Brown, D.M.
Purification, characteristics and sequence of a peptide containing an essential lysine residue
Biochim. Biophys. Acta
445
1-13
1976
Thunnus thynnus
Mc Kenzie, E.A.; Copeland, L.; Lees, E.M.
Glutamate dehydrogenase activity in developing soybean seed: kinetic properties of three forms of the enzyme
Arch. Biochem. Biophys.
212
298-305
1981
Glycine max
Mc Kenzie, E.A.; Lees, E.M.
Glutamate dehydrogenase activity in developing soybean seed: isolation and characterization of three forms of the enzyme
Arch. Biochem. Biophys.
212
290-297
1981
Glycine max
Engelhardt, H.; Klemme, J.H.
Characterization of an allosteric, nucleotide-unspecific glutamate dehydrogenase from Rhodopseudomonas sphaeroides
FEMS Microbiol. Lett.
3
287-290
1978
Cereibacter sphaeroides
-
Kimura, K.; Miyakawa, A.; Imai, T.; Sasakawa, T.
Glutamate dehydrogenase from Bacillus subtilis PCI 219. I. Purification and properties
J. Biochem.
81
467-476
1977
Bacillus subtilis, Bacillus subtilis PCI 219
Electricwala, A.H.; Dickinson, F.M.
Kinetic studies of dogfish liver glutamate dehydrogenase
Biochem. J.
177
449-459
1979
dogfish
Rife, J.E.; Cleland, W.W.
Kinetic mechanism of glutamate dehydrogenase
Biochemistry
19
2321-2328
1980
Bos taurus
Graham, L.D.; Griffin, T.O.; Beatty, R.E.; McCarthy, A.D.; Tipton, K.F.
Purification of liver glutamate dehydrogenase by affinity precipitation and studies on its denaturation
Biochim. Biophys. Acta
828
266-269
1985
Bos taurus, Rattus norvegicus
McCarthy, A.D.; Tipton, K.F.
Ox glutamate dehydrogenase. Comparison of the kinetic properties of native and proteolysed preparations
Biochem. J.
230
95-99
1985
Bos taurus
Maulik, P.; Ghosh, S.
NADPH/NADH-dependent cold-labile glutamate dehydrogenase in Azospirillum brasilense. Purification and properties
Eur. J. Biochem.
155
595-602
1986
Azospirillum brasilense
Kim, H.; Haley, B.E.
Synthesis and properties of 2-azido-NAD+. A study of interaction with glutamate dehydrogenase
J. Biol. Chem.
265
3636-3641
1990
Bos taurus
Ottolina, G.; Carrea, G.; Riva, S.
Coenzymatic properties of low molecular-weight and macromolecular N6-derivatives of NAD+ and NADP+ with dehydrogenases of interest for organic synthesis
Enzyme Microb. Technol.
12
596-602
1990
Bos taurus
Yamamoto, I.; Abe, A.; Ishimoto, M.
Properties of glutamate dehydrogenase purified from Bacteroides fragilis
J. Biochem.
101
1391-1397
1987
Bacteroides fragilis
Yamamoto, I.; Saito, H.; Ishimoto, M.
Comparison of properties of glutamate dehydrogenases in members of the Bacteroides fragilis group
J. Gen. Appl. Microbiol.
33
429-436
1987
Parabacteroides distasonis, Bacteroides fragilis, Bacteroides ovatus, Phocaeicola vulgatus
-
Saito, H.; Yamamoto, I.; Ishimoto, M.
Reversible inactivation of glutamate dehydrogenase in Bacteroides fragilis: purification and characterization of high activity- and low activity-enzymes
J. Gen. Appl. Microbiol.
34
377-385
1988
Bacteroides fragilis
-
Schinkinger, M.F.; Redl, B.; Stffler, G.
Purification and properties of an extreme thermostable glutamate dehydrogenase from the archaebacterium Sulfolobus solfataricus
Biochim. Biophys. Acta
1073
142-148
1991
Saccharolobus solfataricus
Moyano, E.; Cardenas, J.; Munoz-Blanco, J.
Purification and properties of three NAD(P)+ isozymes of L-glutamate dehydrogenase of Chlamydomonas reinhardtii
Biochim. Biophys. Acta
1119
63-68
1992
Chlamydomonas reinhardtii
Robb, F.T.; Park, J.B.; Adams, M.W.W.
Characterization of an extremely thermostable glutamate dehydrogenase: a key enzyme in the primary metabolism of the hyperthermophilic archaebacterium, Pyrococcus furiosus
Biochim. Biophys. Acta
1120
267-272
1992
Pyrococcus furiosus
Lee, A.R.; Balinsky, J.B.
A kinetic study of glutamate dehydrogenase from xenopus laevis
Int. J. Biochem.
5
795-805
1974
Xenopus laevis
-
Teller, J.K.
Purification and some properties of glutamate dehydrogenase from the mealworm fat body
Insect Biochem.
18
101-106
1988
Tenebrio molitor
-
Rajas, F.; Rousset, B.
A membrane-bound form of glutamate dehydrogenase possesses an ATP-dependent high-affinity microtubule-binding activity
Biochem. J.
295
447-455
1993
Bos taurus, Rattus norvegicus, Sus scrofa
-
DiRuggiero, J.; Robb, F.T.; Jagus, R.; Klump, H.H.; Borges, K.M.; Kessel, M.; Mai, X.; Adams, M.W.W.
Characterization, cloning, and in vitro expression of the extremely thermostable glutamate dehydrogenase from the hyperthermophilic archaeon, ES4
J. Biol. Chem.
268
17767-17774
1993
Pyrococcus sp.
Shoemaker, M.T.; Haley, B.E.
Identification of a guanine binding domain peptide of the GTP binding site of glutamate dehydrogenase: Isolation with metal-chelate affinity chromatography
Biochemistry
32
1883-1890
1993
Bos taurus
Diruggiero, J.; Robb, F.T.
Expression and in vitro assembly of recombinant glutamate dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus
Appl. Environ. Microbiol.
61
159-164
1995
Pyrococcus furiosus
Heeschen, V.; Gerendas, J.; Richter, C.P.; Rudolph, H.
Glutamate dehydrogenase of Sphagnum
Phytochemistry
45
881-887
1997
Sphagnum fallax
-
Rahman, R.N.Z.A.; Fujiwara, S.; Takagi, M.; Imanaka, T.
Sequence analysis of glutamate dehydrogenase (GDH) from the hyperthermophilic archaeon Pyrococcus sp. KOD1 and comparison of the enzymic characteristics of native and recombinant GDHs
Mol. Gen. Genet.
257
338-347
1998
Pyrococcus
Choi, S.Y.; Hong, J.W.; Song, M.S.; Jeon, S.G.; Bahn, J.H.; Lee, B.R.; Ahn, J.Y.; Cho, S.W.
Different antigenic reactivities of bovine brain glutamate dehydrogenase isoproteins
J. Neurochem.
72
2162-2169
1999
Bos taurus
Lee, W.K.; Shin, S.; Cho, S.S.; Park, J.S.
Purification and characterization of glutamate dehydrogenase as another isoprotein binding to the membrane of rough endoplasmic reticulum
J. Cell. Biochem.
76
244-253
1999
Rattus norvegicus
Ahn, J.Y.; Lee, K.S.; Choi, S.Y.; Cho, S.W.
Regulatory properties of glutamate dehydrogenase from Sulfolobus solfataricus
Mol. Cells
10
25-31
2000
Saccharolobus solfataricus
Thatcher, B.J.; Storey, K.B.
Glutamate dehydrogenase from liver of euthermic and hibernating Richardson's ground squirrels: Evidence for two distinct enzyme forms
Biochem. Cell Biol.
79
11-19
2001
Bos taurus, Urocitellus richardsonii
Fang, J.; Hsu, B.Y.L.; MacMullen, C.M.; Poncz, M.; Smith, T.J.; Stanley, C.A.
Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
Biochem. J.
363
81-87
2002
Homo sapiens
Wang, S.; Feng, Y.; Zhang, Z.; Zheng, B.; Li, N.; Cao, S.; Matsui, I.; Kosugi, Y.
Heat effect on the structure and activity of the recombinant glutamate dehydrogenase from a hyperthermophilic archaeon
Arch. Biochem. Biophys.
411
56-62
2003
Pyrococcus horikoshii
Yoon, H.Y.; Lee, E.Y.; Cho, S.W.
Cassette mutagenesis and photoaffinity labeling of adenine binding domain of ADP regulatory site within human glutamate dehydrogenase
Biochemistry
41
6817-6823
2002
Homo sapiens
Yoon, H.Y.; Cho, E.H.; Yang, S.J.; Lee, H.J.; Huh, J.W.; Choi, M.M.; Cho, S.W.
Reactive amino acid residues involved in glutamate-binding of human glutamate dehydrogenase isozymes
Biochimie
86
261-267
2004
Homo sapiens
Yang, S.J.; Huh, J.W.; Lee, J.E.; Choi, S.Y.; Kim, T.U.; Cho, S.W.
Inactivation of human glutamate dehydrogenase by aluminum
Cell. Mol. Life Sci.
60
2538-2546
2003
Homo sapiens
Jang, S.H.; Kim, A.Y.; Bahn, J.H.; Eum, W.S.; Kim, D.W.; Park, J.; Lee, K.S.; Kang, T.C.; Won, M.H.; Kang, J.H.; Kwon, O.S.; Yoon, H.Y.; Lee, E.Y.; Cho, S.W.; Choi, S.Y.
Human glutamate dehydrogenase is immunologically distinct from other mammalian orthologues
Exp. Mol. Med.
35
249-256
2003
Homo sapiens
Lee, E.Y.; Huh, J.W.; Yang, S.J.; Choi, S.Y.; Cho, S.W.; Choi, H.J.
Histidine 454 plays an important role in polymerization of human glutamate dehydrogenase
FEBS Lett.
540
163-166
2003
Homo sapiens
Yang, S.J.; Huh, J.W.; Hong, H.N.; Kim, T.U.; Cho, S.W.
Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes
FEBS Lett.
562
59-64
2004
Homo sapiens
Bonete, M.J.; Perez-Pomares, F.; Diaz, S.; Ferrer, J.; Oren, A.
Occurrence of two different glutamate dehydrogenase activities in the halophilic bacterium Salinibacter ruber
FEMS Microbiol. Lett.
226
181-186
2003
Salinibacter ruber
Kim, D.W.; Eum, W.S.; Jang, S.H.; Yoon, C.S.; Kim, Y.H.; Choi, S.H.; Choi, H.S.; Kim, S.Y.; Kwon, H.Y.; Kang, J.H.; Kwon, O.s.; Cho, S.w.; Park, J.; Choi, S.Y.
Molecular gene cloning, expression, and characterization of bovine brain glutamate dehydrogenase
J. Biochem. Mol. Biol.
36
545-551
2003
Bos taurus
Zaganas, I.; Plaitakis, A.
Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme
J. Biol. Chem.
277
26422-26428
2002
Homo sapiens (P00367), Homo sapiens
Yoon, H.Y.; Cho, E.H.; Kwon, H.Y.; Choi, S.Y.; Cho, S.W.
Importance of glutamate 279 for the coenzyme binding of human glutamate dehydrogenase
J. Biol. Chem.
277
41448-41454
2002
Homo sapiens
Zaganas, I.; Spanaki, C.; Karpusas, M.; Plaitakis, A.
Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUD1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and L-leucine
J. Biol. Chem.
277
46552-46558
2002
Homo sapiens
Zhang, X.; Vincent, A.S.; Halliwell, B.; Wong, K.P.
A mechanism of sulfite neurotoxicity: direct inhibition of glutamate dehydrogenase
J. Biol. Chem.
279
43035-43045
2004
Rattus norvegicus
Smith, T.J.; Schmidt, T.; Fang, J.; Wu, J.; Siuzdak, G.; Stanley, C.A.
The structure of apo human glutamate dehydrogenase details subunit communication and allostery
J. Mol. Biol.
318
765-777
2002
Homo sapiens (P00367)
Plaitakis, A.; Spanaki, C.; Mastorodemos, V.; Zaganas, I.
Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme
Neurochem. Int.
43
401-410
2003
Homo sapiens (P00367), Homo sapiens (P49448)
Forde, J.; Oakey, L.; Jennings, L.; Mulcahy, P.
Fundamental differences in bioaffinity of amino acid dehydrogenases for N6- and S6-linked immobilized cofactors using kinetic-based enzyme-capture strategies
Anal. Biochem.
338
102-112
2005
Bos taurus
Choi, M.M.; Huh, J.W.; Yang, S.J.; Cho, E.H.; Choi, S.Y.; Cho, S.W.
Identification of ADP-ribosylation site in human glutamate dehydrogenase isozymes
FEBS Lett.
579
4125-4130
2005
Homo sapiens
Yang, S.J.; Cho, E.H.; Choi, M.M.; Lee, H.J.; Huh, J.W.; Choi, S.Y.; Cho, S.W.
Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes
Mol. Cell
19
97-103
2005
Homo sapiens
Consalvi, V.; Chiaraluce, R.; Politi, L.; Pasquo, A.; De Rosa, M.; Scandurra, R.
Glutamate dehydrogenase from the thermoacidophilic archaebacterium Sulfolobus solfataricus: studies on thermal and guanidine-dependent inactivation.
Biochim. Biophys. Acta
1202
207-215
1993
Saccharolobus solfataricus
Consalvi, V.; Chiaraluce, R.; Politi, L.; Gambacorta, A.; De Rosa, M.; Scandurra, R.
Glutamate dehydrogenase from the thermoacidophilic archaebacterium Sulfolobus solfataricus.
Eur. J. Biochem.
196
459-467
1991
Saccharolobus solfataricus
Kravos, M.; Malesic, I.
Kinetics and isoforms of serum glutamate dehydrogenase in alcoholics
Alcohol Alcohol.
43
281-286
2008
Homo sapiens
Bolivar, J.M.; Cava, F.; Mateo, C.; Rocha-Martin, J.; Guisan, J.M.; Berenguer, J.; Fernandez-Lafuente, R.
Immobilization-stabilization of a new recombinant glutamate dehydrogenase from Thermus thermophilus
Appl. Microbiol. Biotechnol.
80
49-58
2008
Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
Choi, M.M.; Hwang, E.Y.; Kim, E.A.; Huh, J.W.; Cho, S.W.
Identification of amino acid residues responsible for different GTP preferences of human glutamate dehydrogenase isozymes
Biochem. Biophys. Res. Commun.
368
742-747
2008
Homo sapiens
Hamelin, M.; Mary, J.; Vostry, M.; Friguet, B.; Bakala, H.
Glycation damage targets glutamate dehydrogenase in the rat liver mitochondrial matrix during aging
FEBS J.
274
5949-5961
2007
Rattus norvegicus (P10860)
Choi, M.M.; Kim, E.A.; Choi, S.Y.; Kim, T.U.; Cho, S.W.; Yang, S.J.
Inhibitory properties of nerve-specific human glutamate dehydrogenase isozyme by chloroquine
J. Biochem. Mol. Biol.
40
1077-1082
2007
Homo sapiens
Choi, M.M.; Kim, E.A.; Yang, S.J.; Choi, S.Y.; Cho, S.W.; Huh, J.W.
Amino acid changes within antenna helix are responsible for different regulatory preferences of human glutamate dehydrogenase isozymes
J. Biol. Chem.
282
19510-19517
2007
Homo sapiens
Kanavouras, K.; Mastorodemos, V.; Borompokas, N.; Spanaki, C.; Plaitakis, A.
Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase
J. Neurosci. Res.
85
1101-1109
2007
Homo sapiens
Carrigan, J.B.; Engel, P.C.
The structural basis of proteolytic activation of bovine glutamate dehydrogenase
Protein Sci.
17
1346-1353
2008
Bos taurus
Bahi-Buisson, N.; El Sabbagh, S.; Soufflet, C.; Escande, F.; Boddaert, N.; Valayannopoulos, V.; Bellane-Chantelot, C.; Lascelles, K.; Dulac, O.; Plouin, P.; de Lonlay, P.
Myoclonic absence epilepsy with photosensitivity and a gain of function mutation in glutamate dehydrogenase
Seizure
17
658-664
2008
Homo sapiens
Kravos, M.; Malesic, I.
Changes in leukocyte Glutamate Dehydrogenase activity in alcoholics upon break in alcohol consumption
Clin. Biochem.
43
272-277
2009
Homo sapiens
Islam, M.M.; Nautiyal, M.; Wynn, R.M.; Mobley, J.A.; Chuang, D.T.; Hutson, S.M.
The branched chain amino acid (BCAA) metabolon: Interaction of glutamate dehydrogenase with the mitochondrial branched chain aminotransferase (BCATm)
J. Biol. Chem.
285
265-276
2010
Rattus norvegicus (P10860)
Kanavouras, K.; Borompokas, N.; Latsoudis, H.; Stagourakis, A.; Zaganas, I.; Plaitakis, A.
Mutations in human GLUD2 glutamate dehydrogenase affecting basal activity and regulation
J. Neurochem.
109 Suppl 1
167-173
2009
Homo sapiens
Chik, K.K.; Chan, C.W.; Lam, C.W.; Ng, K.L.
Hyperinsulinism and hyperammonaemia syndrome due to a novel missense mutation in the allosteric domain of the glutamate dehydrogenase 1 gene
J. Paediatr. Child Health
44
517-519
2008
Homo sapiens
Zaganas, I.; Kanavouras, K.; Mastorodemos, V.; Latsoudis, H.; Spanaki, C.; Plaitakis, A.
The human GLUD2 glutamate dehydrogenase: localization and functional aspects
Neurochem. Int.
55
52-63
2009
Homo sapiens
Spanaki, C.; Zaganas, I.; Kleopa, K.A.; Plaitakis, A.
Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells
J. Biol. Chem.
285
16748-16756
2010
Homo sapiens (P49448), Homo sapiens
Bao, X.; Pal, R.; Hascup, K.N.; Wang, Y.; Wang, W.T.; Xu, W.; Hui, D.; Agbas, A.; Wang, X.; Michaelis, M.L.; Choi, I.Y.; Belousov, A.B.; Gerhardt, G.A.; Michaelis, E.K.
Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability
J. Neurosci.
29
13929-13944
2009
Mus musculus (P26443), Mus musculus, Mus musculus C57BL/6J x SJL (P26443)
Facchiano, A.M.; Ragone, R.; Consalvi, V.; Scandurra, R.; De Rosa, M.; Colonna, G.
Molecular properties of glutamate dehydrogenase from the extreme thermophilic archaebacterium Sulfolobus solfataricus
Biochim. Biophys. Acta
1251
170-176
1995
Saccharolobus solfataricus
Maras, B.; Consalvi, V.; Chiaraluce, R.; Politi, L.; De Rosa, M.; Bossa, F.; Scandurra, R.; Barra, D.
The protein sequence of glutamate dehydrogenase from Sulfolobus solfataricus, a thermoacidophilic archaebacterium. Is the presence of N-epsilon-methyllysine related to thermostability?
Eur. J. Biochem.
203
81-87
1992
Saccharolobus solfataricus (P80053), Saccharolobus solfataricus MT-4 / DSM 5833 (P80053)
Yip, K.S.; Baker, P.J.; Britton, K.L.; Engel, P.C.; Rice, D.W.; Sedelnikova, S.E.; Stillman, T.J.; Pasquo, A.; Chiaraluce, R.; Consalvi, V.; Scandurra, R.
Crystallization of the NAD(P)-dependent glutamate dehydrogenase from the hyperthermophile Pyrococcus furiosus
Acta Crystallogr. Sect. D
51
240-242
1995
Pyrococcus furiosus
Chiaraluce, R.; Schwerdtfeger, R.M.; Scandurra, R.; Antranikian, G.; Consalvi, V.
Acid-induced disassembly of glutamate dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus occurs below pH 2.0
Eur. J. Biochem.
247
224-230
1997
Pyrococcus furiosus (P80319)
Eggen, R.; Geerling, A.; Waldkotter, K.; Antranikian, G.; De Vos, M.
The glutamate dehydrogenase-encoding gene of the hyperthermophilic archaeon Pyrococcus furiosus: Sequence, transcription and analysis of the deduced amino acid sequence
Gene
132
143-158
1993
Pyrococcus woesei
Klump, H.; Di Ruggiero, J.; Kessel, M.; Park, J.B.; Adams, M.W.; Robb, F.T.
Glutamate dehydrogenase from the hyperthermophile Pyrococcus furiosus. Thermal denaturation and activation
J. Biol. Chem.
267
22681-22685
1992
Pyrococcus furiosus
Britton, K.L.; Yip, K.S.; Sedelnikova, S.E.; Stillman, T.J.; Adams, M.W.; Ma, K.; Maeder, D.L.; Robb, F.T.; Tolliday, N.; Vetriani, C.; Rice, D.W.; Baker, P.J.
Structure determination of the glutamate dehydrogenase from the hyperthermophile Thermococcus litoralis and its comparison with that from Pyrococcus furiosus
J. Mol. Biol.
293
1121-1132
1999
Thermococcus litoralis (Q56304)
Maras, B.; Valiante, S.; Chiaraluce, R.; Consalvi, V.; Politi, L.; de Rosa, M.; Bossa, F.; Scandurra, R.; Barra, D.
The amino acid sequence of glutamate dehydrogenase from Pyrococcus furiosus, a hyperthermophilic archaebacterium
J. Protein Chem.
13
253-259
1994
Pyrococcus furiosus (P80319)
Yip, K.S.; Stillman, T.J.; Britton, K.L.; Artymiuk, P.J.; Baker, P.J.; Sedelnikova, S.E.; Engel, P.C., Pasquo, A.; Chiaraluce, R.; Consalvi, V.; et al.
The structure of Pyrococcus furiosus glutamate dehydrogenase reveals a key role for ion-pair networks in maintaining enzyme stability at extreme temperatures
Structure
15
1147-1158
1995
Pyrococcus furiosus (P80319)
Abd Rahman, R.N.; Fujiwara, S.; Takagi, M.; Kanaya, S.; Imanaka, T.
Effect of heat treatment on proper oligomeric structure formation of thermostable glutamate dehydrogenase from a hyperthermophilic archaeon
Biochem. Biophys. Res. Commun.
241
646-652
1997
Thermococcus kodakarensis (O59650)
Amenabar, M.J.; Blamey, J.M.
Purification and characterization of a thermostable glutamate dehydrogenase from a thermophilic bacterium isolated from a sterilization drying oven
BMB Rep.
45
91-95
2012
uncultured bacterium
Umair, S.; Knight, J.S.; Patchett, M.L.; Bland, R.J.; Simpson, H.V.
Nucleotide allosteric regulation of the glutamate dehydrogenases of Teladorsagia circumcincta and Haemonchus contortus
Comp. Biochem. Physiol. B
161
255-260
2012
Haemonchus contortus, Teladorsagia circumcincta
Tomita, T.; Kuzuyama, T.; Nishiyama, M.
Structural basis for leucine-induced allosteric activation of glutamate dehydrogenase
J. Biol. Chem.
286
37406-37413
2011
Thermus thermophilus, Homo sapiens
Zaganas, I.; Pajecka, K.; Wendel Nielsen, C.; Schousboe, A.; Waagepetersen, H.S.; Plaitakis, A.
The effect of pH and ADP on ammonia affinity for human glutamate dehydrogenases
Metab. Brain Dis.
28
127-131
2013
Homo sapiens
Treberg, J.R.; Brosnan, M.E.; Brosnan, J.T.
The simultaneous determination of NAD(H) and NADP(H) utilization by glutamate dehydrogenase
Mol. Cell. Biochem.
344
253-259
2010
Bos taurus
Higuchi, S.; Nakasako, M.; Kudo, T.
Crystallization and preliminary x-ray diffraction studies of hyperthermostable glutamate dehydrogenase from Thermococcus profundus
Acta Crystallogr. Sect. D
55
1917-1919
1999
Thermococcus profundus (O74024)
Nakasako, M.; Fujisawa, T.; Adachi, S.; Kudo, T.; Higuchi, S.
Large-scale domain movements and hydration structure changes in the active-site cleft of unligated glutamate dehydrogenase from Thermococcus profundus studied by cryogenic X-ray crystal structure analysis and small-angle X-ray scattering
Biochemistry
40
3069-3079
2001
Thermococcus profundus (O74024)
Ando, T.; Sugawara, Y.; Nishio, R.; Murakami, M.; Isogai, E.; Yoneyama, H.
Cloning and characterization of the glutamate dehydrogenase gene in Streptococcus bovis
Anim. Sci. J.
88
1027-1033
2016
Streptococcus equinus (A0A1V1FMC4)
Vazquez-Martinez, O.; Mendez, I.; Turrubiate, I.; Valente-Godinez, H.; Perez-Mendoza, M.; Garcia-Tejada, P.; Diaz-Munoz, M.
Restricted feeding modulates the daily variations of liver glutamate dehydrogenase activity, expression, and histological location
Exp. Biol. Med. (Maywood)
242
945-952
2017
Rattus norvegicus (P10860)
Gomes, S.; Dolezalova, J.; Araujo, A.; Couto, C.; Montenegro, M.
Glutamate sol-gel amperometric biosensor based on co-immobilised NADP + and glutamate dehydrogenase
J. Anal. Chem.
68
794-800
2013
Bos taurus
-
Yokooji, Y.; Sato, T.; Fujiwara, S.; Imanaka, T.; Atomi, H.
Genetic examination of initial amino acid oxidation and glutamate catabolism in the hyperthermophilic archaeon Thermococcus kodakarensis
J. Bacteriol.
195
1940-1948
2013
Thermococcus kodakarensis (O59650)
Pajecka, K.; Nielsen, C.W.; Hauge, A.; Zaganas, I.; Bak, L.K.; Schousboe, A.; Plaitakis, A.; Waagepetersen, H.S.
Glutamate dehydrogenase isoforms with N-terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization
Neurochem. Res.
39
487-499
2014
Homo sapiens (P00367), Homo sapiens (P49448), Homo sapiens, Mus musculus (P26443), Mus musculus
Spanaki, C.; Kotzamani, D.; Plaitakis, A.
Widening spectrum of cellular and subcellular expression of human GLUD1 and GLUD2 glutamate dehydrogenases suggests novel functions
Neurochem. Res.
42
92-107
2017
Homo sapiens (P00367), Homo sapiens (P49448), Homo sapiens
Terce-Laforgue, T.; Bedu, M.; Dargel-Grafin, C.; Dubois, F.; Gibon, Y.; Restivo, F.M.; Hirel, B.
Resolving the role of plant glutamate dehydrogenase II. Physiological characterization of plants overexpressing the two enzyme subunits individually or simultaneously
Plant Cell Physiol.
54
1635-1647
2013
Nicotiana plumbaginifolia (O04937), Nicotiana plumbaginifolia (Q9LEC8)
Marchi, L.; Polverini, E.; Degola, F.; Baruffini, E.; Restivo, F.M.
Glutamate dehydrogenase isoenzyme 3 (GDH3) of Arabidopsis thaliana is less thermostable than GDH1 and GDH2 isoenzymes
Plant Physiol. Biochem.
83
225-231
2014
Arabidopsis thaliana (Q38946), Arabidopsis thaliana (Q43314), Arabidopsis thaliana (Q9S7A0)
Britton, K.; Baker, P.; Borges, K.; Engel, P.; Pasquo, A.; Rice, D.; Robb, F.; Scandurra, R.; Stillman, T.; Yip, K.
Insights into thermal stability from a comparison of the glutamate dehydrogenases from Pyrococcus furiosus and Thermococcus litoralis
Eur. J. Biochem.
229
688-695
1995
Pyrococcus furiosus (P80319), Thermococcus litoralis (Q56304), Thermococcus litoralis DSM 5473 (Q56304)
Lee, M.; Gonzlez, J.; Robb, F.
Extremely thermostable glutamate dehydrogenase (GDH) from the freshwater archaeon Thermococcus waiotapuensis Cloning and comparison with two marine hyperthermophilic GDHs
Extremophiles
6
151-159
2002
Pyrococcus furiosus (P80319), Thermococcus litoralis (Q56304), Thermococcus litoralis DSM 5473 (Q56304)
Adams, M.; Holden, J.; Menon, A.; Schut, G.; Grunden, A.; Hou, C.; Hutchins, A.; Jenney F.E., J.; Kim, C.; Ma, K.; Pan, G.; Roy, R.; Sapra, R.; Story, S.; Verhagen, M.
Key role for sulfur in peptide metabolism and in regulation of three hydrogenases in the hyperthermophilic archaeon Pyrococcus furiosus
J. Bacteriol.
183
716-724
2001
Pyrococcus furiosus (P80319)
Knapp, S.; De Vos, W.; Rice, D.; Ladenstein, R.
Crystal structure of glutamate dehydrogenase from the hyperthermophilic eubacterium Thermotoga maritima at 3.0 A resolution
J. Mol. Biol.
267
916-932
1997
Thermotoga maritima (P96110), Thermotoga maritima DSM 3109 (P96110)
Tomita, T.; Matsushita, H.; Yoshida, A.; Kosono, S.; Yoshida, M.; Kuzuyama, T.; Nishiyama, M.
Glutamate dehydrogenase from Thermus thermophilus is activated by AMP and leucine as a complex with catalytically inactive adenine phosphoribosyltransferase homolog
J. Bacteriol.
201
e00710-18
2019
Thermus thermophilus (Q93IM2), Thermus thermophilus
Suzuki, A.
Glutamate synthase and amino acid synthesis in higher plants
Adv. Bot. Res.
100
129
2021
Arabidopsis thaliana (Q43314 AND Q38946)
-
Plaitakis, A.; Kalef-Ezra, E.; Kotzamani, D.; Zaganas, I.; Spanaki, C.
The glutamate dehydrogenase pathway and its roles in cell and tissue biology in health and disease
Biology
6
11
2017
Homo sapiens (P00367), Homo sapiens (P49448), Homo sapiens
Kato, Y.; Kihara, H.; Fukui, K.; Kojima, M.
A ternary complex model of sirtuin4-NAD+-glutamate dehydrogenase
Comput. Biol. Chem.
74
94-104
2018
Homo sapiens (P00367)
Haghighi, O.; Davaeifar, S.; Zahiri, H.; Maleki, H.; Noghabi, K.
Homology modeling and molecular docking studies of glutamate dehydrogenase (GDH) from cyanobacterium Synechocystis sp. PCC 6803
Int. J. Pept. Res. Ther.
26
783-793
2020
Synechocystis sp. PCC 6803 (P73684)
-
Dimovasili, C.; Fadouloglou, V.E.; Kefala, A.; Providaki, M.; Kotsifaki, D.; Kanavouras, K.; Sarrou, I.; Plaitakis, A.; Zaganas, I.; Kokkinidis, M.
Crystal structure of glutamate dehydrogenase 2, a positively selected novel human enzyme involved in brain biology and cancer pathophysiology
J. Neurochem.
157
802-815
2021
Homo sapiens (P00367), Homo sapiens (P49448), Homo sapiens
Marchi, L.; Degola, F.; Baruffini, E.; Restivo, F.M.
How to easily detect plant NADH-glutamate dehydrogenase (GDH) activity? A simple and reliable in planta procedure suitable for tissues, extracts and heterologous microbial systems
Plant Sci.
304
110714
2021
Nicotiana plumbaginifolia (Q9LEC8)
Nassar, O.M.; Wong, K.Y.; Lynch, G.C.; Smith, T.J.; Pettitt, B.M.
Allosteric discrimination at the NADH/ADP regulatory site of glutamate dehydrogenase
Protein Sci.
28
2080-2088
2019
Bos taurus (P00366)
html completed
