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Disease on EC 1.4.3.21 - primary-amine oxidase

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DISEASE
TITLE OF PUBLICATION
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Acute Kidney Injury
Association of endothelial and glycocalyx injury biomarkers with fluid administration, development of acute kidney injury, and 90-day mortality: data from the FINNAKI observational study.
Vascular adhesion protein-1 enhances neutrophil infiltration by generation of hydrogen peroxide in renal ischemia/reperfusion injury.
Vascular Adhesion Protein-1 Is Associated With Acute Kidney Injury in High-Risk Patients After Cardiac Surgery.
Acute Lung Injury
Ischemia-reperfusion injury is attenuated in VAP-1-deficient mice and by VAP-1 inhibitors.
Adenocarcinoma
PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG.
Albuminuria
Efficacy of a novel inhibitor of vascular adhesion protein-1 in reducing albuminuria in patients with diabetic kidney disease (ALBUM): a randomised, placebo-controlled, phase 2 trial.
Mechanism-based modeling of the effect of a novel inhibitor of vascular adhesion protein-1 on albuminuria and renal function markers in patients with diabetic kidney disease.
Population pharmacokinetics and pharmacodynamics of a novel vascular adhesion protein-1 inhibitor using a multiple-target mediated drug disposition model.
Alzheimer Disease
A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE.
An update on amine oxidase inhibitors: Multifaceted drugs.
Comparison of phenelzine and geometric isomers of its active metabolite, ?-phenylethylidenehydrazine, on rat brain levels of amino acids, biogenic amine neurotransmitters and methylamine.
Immunohistochemical study of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 in the hippocampal vasculature: Pathological synergy of Alzheimer's disease and diabetes mellitus.
Novel Hydrazine Molecules as Tools To Understand the Flexibility of Vascular Adhesion Protein-1 Ligand-Binding Site: Toward More Selective Inhibitors.
SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer's Disease.
Synthetic polyamines as potential amine oxidase inhibitors: a preliminary study.
Aortic Diseases
In search of a new therapeutic target for the treatment of genetically triggered thoracic aortic aneurysms and cardiovascular conditions: insights from human and animal lathyrism.
Aortic Valve Stenosis
Assessment of the Relationship Between Serum Vascular Adhesion Protein-1 (VAP-1) and Severity of Calcific Aortic Valve Stenosis.
Arthritis
In vivo detection of vascular adhesion protein-1 in experimental inflammation.
Lymphocyte binding to vascular endothelium in inflamed skin revisited: a central role for vascular adhesion protein-1 (VAP-1).
The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function.
Arthritis, Rheumatoid
68Ga-DOTA-Siglec-9--a new imaging tool to detect synovitis.
Astrocytoma
Overexpression of vascular adhesion protein-1 is associated with poor prognosis of astrocytomas.
Atherosclerosis
Age-, sex- and glucose-dependent correlation of plasma soluble vascular adhesion protein-1 concentration with cardiovascular risk factors and subclinical atherosclerosis.
Assessment of the Relationship Between Serum Vascular Adhesion Protein-1 (VAP-1) and Severity of Calcific Aortic Valve Stenosis.
Change of serum vascular adhesion protein-1 after glucose loading correlates to carotid intima-medial thickness in non-diabetic subjects.
Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques.
Serum vascular adhesion protein-1 level is higher in smokers than non-smokers.
Soluble vascular adhesion protein-1 correlates with cardiovascular risk factors and early atherosclerotic manifestations.
Vascular Adhesion Protein-1 (VAP-1)/Semicarbazide-Sensitive Amine Oxidase (SSAO): A Potential Therapeutic Target for Atherosclerotic Cardiovascular Diseases.
Vascular adhesion protein-1 in hemodialysis and hemodiafiltration patients: effect of single hemodialysis session on its level in regard to type of anticoagulant.
Brain Edema
Vascular adhesion protein-1 inhibition provides antiinflammatory protection after an intracerebral hemorrhagic stroke in mice.
Brain Injuries
Vascular adhesion protein-1 in human ischaemic stroke.
Vascular adhesion protein-1 inhibition provides antiinflammatory protection after an intracerebral hemorrhagic stroke in mice.
Brain Injuries, Traumatic
Soluble vascular adhesion protein-1: decreased activity in the plasma of trauma victims and predictive marker for severity of traumatic brain injury.
Brain Ischemia
Involvement of SSAO/VAP-1 in oxygen-glucose deprivation-mediated damage using the endothelial hSSAO/VAP-1-expressing cells as experimental model of cerebral ischemia.
Simvastatin blocks soluble SSAO/VAP-1 release in experimental models of cerebral ischemia: Possible benefits for stroke-induced inflammation control.
Brain Neoplasms
Lysyl oxidase genetic variants and the prognosis of glioma.
Overexpression of vascular adhesion protein-1 is associated with poor prognosis of astrocytomas.
Breast Neoplasms
3D hydrogel breast cancer models for studying the effects of hypoxia on epithelial to mesenchymal transition.
Vascular adhesion protein-1 as indicator of breast cancer tumor aggressiveness and invasiveness.
Carcinoma, Ductal
Vascular adhesion protein-1 as indicator of breast cancer tumor aggressiveness and invasiveness.
Carcinoma, Hepatocellular
Circulating vascular adhesion protein-1(VAP-1): a possible biomarker for liver fibrosis associated with chronic hepatitis B and C.
Common Lymphatic Endothelial and Vascular Endothelial Receptor-1 Mediates the Transmigration of Regulatory T Cells across Human Hepatic Sinusoidal Endothelium.
Diamine oxidase activity in regenerating rat liver and in 4-dimethylaminoazobenzene-induced and Yoshida AH 130 hepatomas.
SSAO inhibitors suppress hepatocellular tumor growth in mice.
Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma.
Vascular adhesion protein-1 and intercellular adhesion molecule-1 mediate T-cell binding to human hepatocellular carcinoma.
Cardiomegaly
Polyamine levels and diamine oxidase activity in hypertrophic heart of spontaneously hypertensive rats and of rats treated with isoproterenol.
Cardiovascular Diseases
Age-, sex- and glucose-dependent correlation of plasma soluble vascular adhesion protein-1 concentration with cardiovascular risk factors and subclinical atherosclerosis.
An update on amine oxidase inhibitors: Multifaceted drugs.
Angiotensin-converting enzyme insertion/deletion (rs106180) and angiotensin type 1 receptor A1166 C (rs106165) genotypes and psoriasis: Correlation with cellular immunity, lipid profile, and oxidative stress markers.
Lymphocyte trafficking mediated by vascular adhesion protein-1: implications for immune targeting and cardiovascular disease.
Serum Vascular Adhesion Protein-1 Predicts End-Stage Renal Disease in Patients with Type 2 Diabetes.
Vascular Adhesion Protein-1 (VAP-1)/Semicarbazide-Sensitive Amine Oxidase (SSAO): A Potential Therapeutic Target for Atherosclerotic Cardiovascular Diseases.
Cerebral Infarction
Plasma benzylamine oxidase activity in cerebrovascular disease.
Cerebrovascular Disorders
A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE.
Plasma benzylamine oxidase activity in cerebrovascular disease.
SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer's Disease.
Cholangitis, Sclerosing
Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner.
Choroidal Neovascularization
Blockade of vascular adhesion protein-1 attenuates choroidal neovascularization.
Vascular adhesion protein-1 blockade suppresses choroidal neovascularization.
Colitis
Anti-inflammatory effects of inhibiting the amine oxidase activity of semicarbazide-sensitive amine oxidase.
Colonic Neoplasms
Inhibition of vascular adhesion protein-1 enhances the anti-tumor effects of immune checkpoint inhibitors.
Sensitization of human colon adenocarcinoma cells (LoVo) to reactive oxygen species by a lysosomotropic compound.
Colorectal Neoplasms
Circulating form of human vascular adhesion protein-1 (VAP-1): decreased serum levels in progression of colorectal cancer and predictive marker of lymphatic and hepatic metastasis.
Evaluation of serum and tissue levels of VAP-1 in colorectal cancer.
Serum vascular adhesion protein-1 predicts all-cause mortality and cancer-related mortality in subjects with colorectal cancer.
Compartment Syndromes
Alterations in plasma amine oxidase activities in a compartment syndrome model.
Conjunctivitis
Exploration of vascular adhesion protein-1 expression in patients with conjunctivitis associated systemic lupus erythematosus using 2D-DIGE.
Corneal Neovascularization
Preliminary studies of the effects of vascular adhesion protein-1 inhibitors on experimental corneal neovascularization.
Coronary Disease
Insulin-regulated increase of soluble vascular adhesion protein-1 in diabetes.
Cytomegalovirus Infections
Induction of vascular adhesion protein-1 during liver allograft rejection and concomitant cytomegalovirus infection in rats.
Dental Calculus
Primary structures for a mammalian cellular and serum copper amine oxidase.
Dermatitis
In vivo detection of vascular adhesion protein-1 in experimental inflammation.
Dermatitis, Allergic Contact
Safety of blocking vascular adhesion protein-1 in patients with contact dermatitis.
Dermatitis, Atopic
Expression of vascular adhesion protein-1 in atopic eczema.
Dermatitis, Contact
Safety of blocking vascular adhesion protein-1 in patients with contact dermatitis.
Diabetes Complications
Serum Vascular Adhesion Protein-1 Predicts End-Stage Renal Disease in Patients with Type 2 Diabetes.
Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema.
Diabetes Mellitus
Assessment of the Relationship Between Serum Vascular Adhesion Protein-1 (VAP-1) and Severity of Calcific Aortic Valve Stenosis.
Circulating renalase, catecholamines, and vascular adhesion protein 1 in hypertensive patients.
Comparison of phenelzine and geometric isomers of its active metabolite, ?-phenylethylidenehydrazine, on rat brain levels of amino acids, biogenic amine neurotransmitters and methylamine.
Immunohistochemical study of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 in the hippocampal vasculature: Pathological synergy of Alzheimer's disease and diabetes mellitus.
Physiological and pathological influences on sheep blood plasma amine oxidase: effect of pregnancy and experimental alloxan-induced diabetes mellitus.
Serum vascular adhesion protein-1 is higher in subjects with early stages of chronic kidney disease.
Structure-activity relationships of SSAO/VAP-1 arylalkylamine-based substrates.
Vascular adhesion protein-1 in hemodialysis and hemodiafiltration patients: effect of single hemodialysis session on its level in regard to type of anticoagulant.
Diabetes Mellitus, Type 2
Assessment of the Relationship Between Serum Vascular Adhesion Protein-1 (VAP-1) and Severity of Calcific Aortic Valve Stenosis.
Efficacy of a novel inhibitor of vascular adhesion protein-1 in reducing albuminuria in patients with diabetic kidney disease (ALBUM): a randomised, placebo-controlled, phase 2 trial.
Mechanism-based modeling of the effect of a novel inhibitor of vascular adhesion protein-1 on albuminuria and renal function markers in patients with diabetic kidney disease.
Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia.
Serum vascular adhesion protein-1 predicts 10-year cardiovascular and cancer mortality in individuals with type 2 diabetes.
Serum Vascular Adhesion Protein-1 Predicts End-Stage Renal Disease in Patients with Type 2 Diabetes.
Diabetes, Gestational
Assessment of relationship between serum vascular adhesion protein-1 (VAP-1) and gestational diabetes mellitus.
Diabetic Angiopathies
Insulin-regulated increase of soluble vascular adhesion protein-1 in diabetes.
Diabetic Nephropathies
Efficacy of a novel inhibitor of vascular adhesion protein-1 in reducing albuminuria in patients with diabetic kidney disease (ALBUM): a randomised, placebo-controlled, phase 2 trial.
Mechanism-based modeling of the effect of a novel inhibitor of vascular adhesion protein-1 on albuminuria and renal function markers in patients with diabetic kidney disease.
Population pharmacokinetics and pharmacodynamics of a novel vascular adhesion protein-1 inhibitor using a multiple-target mediated drug disposition model.
Synthesis and pharmacological evaluation of glycine amide derivatives as novel vascular adhesion protein-1 inhibitors without CYP3A4 and CYP2C19 inhibition.
Synthesis and structure activity relationships of carbamimidoylcarbamate derivatives as novel vascular adhesion protein-1 inhibitors.
Diabetic Retinopathy
Association of HMGB1 with oxidative stress markers and regulators in PDR.
Proteolytic cleavage of vascular adhesion protein-1 induced by vascular endothelial growth factor in retinal capillary endothelial cells.
Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy.
Soluble Vascular Adhesion Protein-1 Mediates Spermine Oxidation as Semicarbazide-Sensitive Amine Oxidase: Possible Role in Proliferative Diabetic Retinopathy.
Vascular adhesion protein 1 in the eye.
Drug-Related Side Effects and Adverse Reactions
Human Copper-Containing Amine Oxidases in Drug Design and Development.
Encephalitis
Inhibition of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 reduces lipopolysaccharide-induced neuroinflammation.
Encephalomyelitis
Vascular adhesion protein-1 is actively involved in the development of inflammatory lesions in rat models of multiple sclerosis.
Encephalomyelitis, Autoimmune, Experimental
Vascular adhesion protein-1 is actively involved in the development of inflammatory lesions in rat models of multiple sclerosis.
Epiretinal Membrane
Association of HMGB1 with oxidative stress markers and regulators in PDR.
Erythema
[Concentration of sVAP in serum of patients with different forms of Lyme borreliosis]
[Serum concentration of selected adhesive molecules in early localised and late disseminated Lyme borreliosis]
Gastritis
Selective up-regulation of endothelial E-selectin in response to H. pylori-induced gastritis.
Glioma
Increased Vascular Adhesion Protein 1 (VAP-1) Levels are Associated with Alternative M2 Macrophage Activation and Poor Prognosis for Human Gliomas.
Lysyl oxidase genetic variants and the prognosis of glioma.
Graft vs Host Disease
Inhibition of Vascular Adhesion Protein-1 for Treatment of Graft-Versus-Host Disease in Mice.
Granuloma
Immunolocalization of Vascular Adhesion Protein-1 in Human Conjunctival Tumors.
Vascular adhesion protein 1 in the eye.
Heart Failure
Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications.
Hemorrhagic Stroke
Vascular adhesion protein-1 inhibition provides antiinflammatory protection after an intracerebral hemorrhagic stroke in mice.
Hepatitis B
Circulating vascular adhesion protein-1(VAP-1): a possible biomarker for liver fibrosis associated with chronic hepatitis B and C.
Hepatitis C, Chronic
Increased Circulating VAP-1 Levels Are Associated with Liver Fibrosis in Chronic Hepatitis C Infection.
Hepatitis, Chronic
Circulating vascular adhesion protein-1(VAP-1): a possible biomarker for liver fibrosis associated with chronic hepatitis B and C.
Hyperglycemia
Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia.
Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively.
Serum vascular adhesion protein-1 predicts 10-year cardiovascular and cancer mortality in individuals with type 2 diabetes.
VAP-1 in peritoneally dialyzed patients.
Hypersensitivity
Histaminase PEGylation: preparation and characterization of a new bioconjugate for therapeutic application.
Hypertension
Circulating renalase, catecholamines, and vascular adhesion protein 1 in hypertensive patients.
Genome-wide scan for circulating vascular adhesion protein-1 levels: MACROD2 as a potential transcriptional regulator of adipogenesis.
Serum Vascular Adhesion Protein-1 Predicts End-Stage Renal Disease in Patients with Type 2 Diabetes.
Infarction, Middle Cerebral Artery
Post-ischemic vascular adhesion protein-1 inhibition provides neuroprotection in a rat temporary middle cerebral artery occlusion model.
Infections
Circulating vascular adhesion protein-1(VAP-1): a possible biomarker for liver fibrosis associated with chronic hepatitis B and C.
DNA microarray-based gene expression profiles of cytomegalovirus infection and acute rejection in liver transplants.
Increased Circulating VAP-1 Levels Are Associated with Liver Fibrosis in Chronic Hepatitis C Infection.
Induction of vascular adhesion protein-1 during liver allograft rejection and concomitant cytomegalovirus infection in rats.
VAP-1-Deficient Mice Display Defects in Mucosal Immunity and Antimicrobial Responses: Implications for Antiadhesive Applications.
Infertility
[Studies on diamine oxidase (DAO) activity in seminal plasma]
Inflammatory Bowel Diseases
Circulating soluble vascular adhesion protein 1 in patients with inflammatory bowel disease.
Induction and function of vascular adhesion protein-1 at sites of inflammation.
Insulin Resistance
Association of sVAP-1, sRAGE, and CML with lactation-induced insulin sensitivity in young non-diabetic healthy women.
Change in vascular adhesion protein-1 and metabolic phenotypes after vertical banded gastroplasty for morbid obesity.
Genome-wide scan for circulating vascular adhesion protein-1 levels: MACROD2 as a potential transcriptional regulator of adipogenesis.
SSAO substrates exhibiting insulin-like effects in adipocytes as a promising treatment option for metabolic disorders.
Ischemic Stroke
Involvement of SSAO/VAP-1 in oxygen-glucose deprivation-mediated damage using the endothelial hSSAO/VAP-1-expressing cells as experimental model of cerebral ischemia.
Vascular adhesion protein-1 in human ischaemic stroke.
Kidney Diseases
Serum vascular adhesion protein-1 is higher in subjects with early stages of chronic kidney disease.
Kidney Failure, Chronic
Assessment of the Relationship Between Serum Vascular Adhesion Protein-1 (VAP-1) and Severity of Calcific Aortic Valve Stenosis.
Serum Vascular Adhesion Protein-1 Predicts End-Stage Renal Disease in Patients with Type 2 Diabetes.
Leiomyoma
Human vascular adhesion protein-1 in smooth muscle cells.
Leiomyosarcoma
Human vascular adhesion protein-1 in smooth muscle cells.
Leukostasis
Localization of vascular adhesion protein-1 (VAP-1) in the human eye.
Lichen Planus
Lymphocyte binding to vascular endothelium in inflamed skin revisited: a central role for vascular adhesion protein-1 (VAP-1).
Liver Cirrhosis
Increased Circulating VAP-1 Levels Are Associated with Liver Fibrosis in Chronic Hepatitis C Infection.
Liver Cirrhosis, Biliary
Vascular adhesion protein 1 mediates binding of T cells to human hepatic endothelium.
Liver Diseases
Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion.
Circulating form of human vascular adhesion protein-1 (VAP-1): increased serum levels in inflammatory liver diseases.
Circulating soluble vascular adhesion protein 1 accounts for the increased serum monoamine oxidase activity in chronic liver disease.
Circulating vascular adhesion protein-1(VAP-1): a possible biomarker for liver fibrosis associated with chronic hepatitis B and C.
Hepatic consequences of vascular adhesion protein-1 expression.
Investigating the safety and activity of the use of BTT1023 (Timolumab), in the treatment of patients with primary sclerosing cholangitis (BUTEO): A single-arm, two-stage, open-label, multi-centre, phase II clinical trial protocol.
Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications.
Vascular adhesion protein-1 as a potential therapeutic target in liver disease.
Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis.
[Vascular adhesion protein-1: an unusual adhesion molecule]
Liver Neoplasms
Human vascular adhesion prote?n-1 (VAP-1): serum levels for hepatocellular carcinoma in non-alcoholic and alcoholic fatty liver disease.
Lung Diseases, Interstitial
Increased circulating soluble vascular adhesion protein-1 levels in systemic sclerosis: association with lower frequency and severity of interstitial lung disease.
Lupus Erythematosus, Systemic
Exploration of vascular adhesion protein-1 expression in patients with conjunctivitis associated systemic lupus erythematosus using 2D-DIGE.
Lyme Disease
Expression of adhesion molecules in synovia of patients with treatment-resistant lyme arthritis.
[Serum concentration of selected adhesive molecules in early localised and late disseminated Lyme borreliosis]
Lymphoma
Small-molecule inhibitors of vascular adhesion protein-1 reduce the accumulation of myeloid cells into tumors and attenuate tumor growth in mice.
Vascular adhesion protein 1 in the eye.
Lymphoma, B-Cell
Immunolocalization of Vascular Adhesion Protein-1 in Human Conjunctival Tumors.
Lymphoma, B-Cell, Marginal Zone
Immunolocalization of Vascular Adhesion Protein-1 in Human Conjunctival Tumors.
Macular Degeneration
VAP-1-Mediated M2 Macrophage Infiltration Underlies IL-1?- but Not VEGF-A-Induced Lymph- and Angiogenesis.
Vascular adhesion protein 1 in the eye.
Macular Edema
Novel 1H-imidazol-2-amine derivatives as potent and orally active vascular adhesion protein-1 (VAP-1) inhibitors for diabetic macular edema treatment.
Population pharmacokinetics and pharmacodynamics of a novel vascular adhesion protein-1 inhibitor using a multiple-target mediated drug disposition model.
Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema.
Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema: Part 2.
Melanoma
Anti-tumoral effect of native and immobilized bovine serum amine oxidase in a mouse melanoma model.
Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound.
Loss of vascular adhesion protein-1 expression in intratumoral microvessels of human skin melanoma.
Mechanism of cell death induced by spermine and amine oxidase in mouse melanoma cells.
Small-molecule inhibitors of vascular adhesion protein-1 reduce the accumulation of myeloid cells into tumors and attenuate tumor growth in mice.
The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: a new therapeutic approach.
Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527.
Melanoma, Experimental
Small-molecule inhibitors of vascular adhesion protein-1 reduce the accumulation of myeloid cells into tumors and attenuate tumor growth in mice.
Mesenteric Ischemia
Comparison of the diagnostic values of vascular adhesion protein-1 and intestinal fatty acid-binding protein in the diagnosis of acute mesenteric ischemia.
Metabolic Diseases
Increased primary amine oxidase expression and activity in white adipose tissue of obese and diabetic db-/- mice.
Multiple Sclerosis
Are Plasma Levels of Vascular Adhesion Protein-1 Associated Both with Cerebral Microbleeds in Multiple Sclerosis and Intracerebral Haemorrhages in Stroke?
Elevated serum soluble vascular adhesion protein-1 (VAP-1) in patients with active relapsing remitting multiple sclerosis.
Vascular adhesion protein-1 is actively involved in the development of inflammatory lesions in rat models of multiple sclerosis.
Multiple Sclerosis, Relapsing-Remitting
Elevated serum soluble vascular adhesion protein-1 (VAP-1) in patients with active relapsing remitting multiple sclerosis.
Myocardial Infarction
Angiotensin-converting enzyme insertion/deletion (rs106180) and angiotensin type 1 receptor A1166 C (rs106165) genotypes and psoriasis: Correlation with cellular immunity, lipid profile, and oxidative stress markers.
Myocardial Ischemia
Vascular adhesion protein-1, intercellular adhesion molecule-1 and P-selectin mediate leukocyte binding to ischemic heart in humans.
Neoplasm Metastasis
Circulating form of human vascular adhesion protein-1 (VAP-1): decreased serum levels in progression of colorectal cancer and predictive marker of lymphatic and hepatic metastasis.
Lysyl oxidase may play a critical role in hypoxia-induced NSCLC cells invasion and migration.
Overexpression of vascular adhesion protein-1 is associated with poor prognosis of astrocytomas.
Vascular adhesion protein-1 as indicator of breast cancer tumor aggressiveness and invasiveness.
VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice.
Neoplasms
Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships.
Barnidipine compared to lercanidipine in addition to losartan on endothelial damage and oxidative stress parameters in patients with hypertension and type 2 diabetes mellitus.
Bovine serum amine oxidase and spm potentiate docetaxel and interferon-alpha effects in inducing apoptosis on human cancer cells through the generation of oxidative stress.
Carotid imaging changes and serum IL-1?, sICAM-1, and sVAP-1 levels in benign paroxysmal positional vertigo.
Diamine oxidase (DAO) activity increase in sera of tumor patients: an unreliable marker.
Evaluation of serum and tissue levels of VAP-1 in colorectal cancer.
Histaminase (diamine oxidase) activity in human tumors: an expression of a mature genome.
Homing-associated molecules CD73 and VAP-1 as targets to prevent harmful inflammations and cancer spread.
Human Copper-Containing Amine Oxidases in Drug Design and Development.
Human vascular adhesion protein-1 in smooth muscle cells.
Hyaluronic Acid Nanohydrogels as a Useful Tool for BSAO Immobilization in the Treatment of Melanoma Cancer Cells.
Hyperthermia enhances cytotoxicity of amine oxidase and spermine on drug-resistant LoVo colon adenocarcinoma cells.
Identification, prioritization, and evaluation of glycoproteins for aggressive prostate cancer using quantitative glycoproteomics and antibody-based assays on tissue specimens.
Immunolocalization of Vascular Adhesion Protein-1 in Human Conjunctival Tumors.
Increased Vascular Adhesion Protein 1 (VAP-1) Levels are Associated with Alternative M2 Macrophage Activation and Poor Prognosis for Human Gliomas.
Inhibition of vascular adhesion protein-1 enhances the anti-tumor effects of immune checkpoint inhibitors.
Loss of vascular adhesion protein-1 expression in intratumoral microvessels of human skin melanoma.
Lysyl Oxidase Genetic Variants Affect Gene Expression in Cervical Cancer.
Lysyl oxidase may play a critical role in hypoxia-induced NSCLC cells invasion and migration.
Markers of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects.
Mechanism of cell death induced by spermine and amine oxidase in mouse melanoma cells.
Mitochondrial alterations induced by serum amine oxidase and spermine on human multidrug resistant tumor cells.
Nanoparticle strategies for cancer therapeutics: Nucleic acids, polyamines, bovine serum amine oxidase and iron oxide nanoparticles (Review).
Organ-selective regulation of vascular adhesion protein-1 expression in man.
Overexpression of vascular adhesion protein-1 is associated with poor prognosis of astrocytomas.
PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG.
Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase.
Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity.
Relationship between serum soluble vascular adhesion protein-1 level and gastric cancer prognosis.
Serum vascular adhesion protein-1 level is higher in smokers than non-smokers.
Serum vascular adhesion protein-1 level predicts risk of incident cancers in subjects with type II diabetes.
Serum vascular adhesion protein-1 predicts 10-year cardiovascular and cancer mortality in individuals with type 2 diabetes.
Serum vascular adhesion protein-1 predicts all-cause mortality and cancer-related mortality in subjects with colorectal cancer.
Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be utilized in PET-imaging of inflammation and cancer.
Small-molecule inhibitors of vascular adhesion protein-1 reduce the accumulation of myeloid cells into tumors and attenuate tumor growth in mice.
Somatic mutations of the lysyl oxidase gene on chromosome 5q23.1 in colorectal tumors.
SSAO inhibitors suppress hepatocellular tumor growth in mice.
Transfer of intestine-derived diamines into tumour cells during treatment of Ehrlich-ascites--carcinoma-bearing mice with polyamine anti-metabolites.
VAP-1-Mediated M2 Macrophage Infiltration Underlies IL-1?- but Not VEGF-A-Induced Lymph- and Angiogenesis.
Vascular adhesion protein 1 mediates binding of immunotherapeutic effector cells to tumor endothelium.
Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma.
Vascular adhesion protein-1 as indicator of breast cancer tumor aggressiveness and invasiveness.
Vascular adhesion protein-1 blockade suppresses choroidal neovascularization.
Vascular adhesion protein-1 enhances tumor growth by supporting recruitment of Gr-1+CD11b+ myeloid cells into tumors.
Vascular Adhesion Protein-1: A Cell Surface Amine Oxidase in Translation.
VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice.
[Vascular adhesion protein-1: an unusual adhesion molecule]
Nephrotic Syndrome
[Plasma benzylamine oxidase activity. IV. Children with the nephrotic syndrome]
Nervous System Diseases
A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE.
Neurodegenerative Diseases
Attenuation of the effects of oxidative stress by the MAO-inhibiting antidepressant and carbonyl scavenger phenelzine.
Theobromine and related methylxanthines as inhibitors of Primary Amine Oxidase.
Neuroinflammatory Diseases
Inhibition of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 reduces lipopolysaccharide-induced neuroinflammation.
VAP-1 blockade prevents subarachnoid hemorrhage-associated cerebrovascular dilating dysfunction via repression of a neutrophil recruitment-related mechanism.
Neurologic Manifestations
Pharmacologic blockade of vascular adhesion protein-1 lessens neurologic dysfunction in rats subjected to subarachnoid hemorrhage.
Non-alcoholic Fatty Liver Disease
Inhibition of vascular adhesion protein-1 modifies hepatic steatosis in vitro and in vivo.
Vascular adhesion protein 1 in nonalcoholic steatohepatitis: A novel biomarker?
Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis.
Obesity
Adipocytes release a soluble form of VAP-1/SSAO by a metalloprotease-dependent process and in a regulated manner.
Novel Hydrazine Molecules as Tools To Understand the Flexibility of Vascular Adhesion Protein-1 Ligand-Binding Site: Toward More Selective Inhibitors.
Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity.
Vascular adhesion protein-1 in hemodialysis and hemodiafiltration patients: effect of single hemodialysis session on its level in regard to type of anticoagulant.
Obesity, Abdominal
Association between metabolically healthy central obesity in women and levels of soluble receptor for advanced glycation end products, soluble vascular adhesion protein-1, and the activity of semicarbazide-sensitive amine oxidase.
Obesity, Morbid
Change in vascular adhesion protein-1 and metabolic phenotypes after vertical banded gastroplasty for morbid obesity.
Osteoarthritis, Knee
Vascular Adhesion Protein-1 (VAP-1) as Predictor of Radiographic Severity in Symptomatic Knee Osteoarthritis in the New York University Cohort.
Osteomyelitis
Synthesis, 68Ga labeling and preliminary evaluation of DOTA peptide binding vascular adhesion protein-1: a potential PET imaging agent for diagnosing osteomyelitis.
Parkinson Disease
Inhibitory effect of drugs used in the treatment of Parkinson's disease on plasma monoamine oxidase activity.
Relation of blood serotonin and benzylamine oxidase to clinical symptoms and prognosis in Parkinson's disease.
Pemphigoid, Bullous
Lymphocyte binding to vascular endothelium in inflamed skin revisited: a central role for vascular adhesion protein-1 (VAP-1).
Peritonitis
The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function.
Pneumonia
Expression of vascular adhesion protein-1 in normal and inflamed mice lungs and normal human lungs.
Feasibility of (68)Ga-labeled Siglec-9 peptide for the imaging of acute lung inflammation: a pilot study in a porcine model of acute respiratory distress syndrome.
Involvement of semicarbazide-sensitive amine oxidase-mediated deamination in lipopolysaccharide-induced pulmonary inflammation.
Strain-specific differences in perivascular inflammation in lungs in two murine models of allergic airway inflammation.
Pouchitis
Selective up-regulation of endothelial E-selectin in response to H. pylori-induced gastritis.
Pre-Eclampsia
Pre-eclampsia does not change the adhesion molecule status in the placental bed.
primary-amine oxidase deficiency
Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 deficiency reduces leukocyte infiltration into adipose tissue and favors fat deposition.
Prostatic Neoplasms
Identification, prioritization, and evaluation of glycoproteins for aggressive prostate cancer using quantitative glycoproteomics and antibody-based assays on tissue specimens.
Proteinuria
Serum Vascular Adhesion Protein-1 Predicts End-Stage Renal Disease in Patients with Type 2 Diabetes.
Psoriasis
Angiotensin II type 1 receptor A1166 C (rs5186) gene polymorphism increased risk and severity of psoriasis, contribution to oxidative stress, antioxidant statues, lipid peroxidation and correlation with vascular adhesion protein 1, preliminary report.
Lymphocyte binding to vascular endothelium in inflamed skin revisited: a central role for vascular adhesion protein-1 (VAP-1).
Methylentetrahydrofolatereductase (rs1801133) polymorphism and psoriasis: contribution to oxidative stress, lipid peroxidation and correlation with vascular adhesion protein 1, preliminary report.
Novel Hydrazine Molecules as Tools To Understand the Flexibility of Vascular Adhesion Protein-1 Ligand-Binding Site: Toward More Selective Inhibitors.
Novel inflammatory markers in psoriasis vulgaris: vaspin, vascular adhesion protein-1 (VAP-1), and YKL-40.
Serum lipid profile in psoriatic patients: correlation between vascular adhesion protein 1 and lipoprotein (a).
Vascular adhesion protein-1 (VAP-1) is overexpressed in psoriatic patients.
Pulmonary Disease, Chronic Obstructive
Correlation of serum vascular adhesion protein-1 with airflow limitation and quality of life in stable chronic obstructive pulmonary disease.
Pulmonary Fibrosis
Lysyl oxidase promotes epithelial-to-mesenchymal transition during paraquat-induced pulmonary fibrosis.
Renal Insufficiency, Chronic
Efficacy of a novel inhibitor of vascular adhesion protein-1 in reducing albuminuria in patients with diabetic kidney disease (ALBUM): a randomised, placebo-controlled, phase 2 trial.
Mechanism-based modeling of the effect of a novel inhibitor of vascular adhesion protein-1 on albuminuria and renal function markers in patients with diabetic kidney disease.
Serum vascular adhesion protein-1 is higher in subjects with early stages of chronic kidney disease.
Serum Vascular Adhesion Protein-1 Predicts End-Stage Renal Disease in Patients with Type 2 Diabetes.
VAP-1 in peritoneally dialyzed patients.
Vascular Adhesion Protein-1 Is Associated With Acute Kidney Injury in High-Risk Patients After Cardiac Surgery.
Reperfusion Injury
Ischemia-reperfusion injury is attenuated in VAP-1-deficient mice and by VAP-1 inhibitors.
Respiratory Distress Syndrome
Feasibility of (68)Ga-labeled Siglec-9 peptide for the imaging of acute lung inflammation: a pilot study in a porcine model of acute respiratory distress syndrome.
Rheumatic Diseases
68Ga-DOTA-Siglec-9--a new imaging tool to detect synovitis.
Scleroderma, Systemic
Increased circulating soluble vascular adhesion protein-1 levels in systemic sclerosis: association with lower frequency and severity of interstitial lung disease.
Sepsis
Association of endothelial and glycocalyx injury biomarkers with fluid administration, development of acute kidney injury, and 90-day mortality: data from the FINNAKI observational study.
Shock, Septic
Vascular adhesion protein-1 and syndecan-1 in septic shock.
Skin Diseases
Induction and function of vascular adhesion protein-1 at sites of inflammation.
[Activity of amine oxidases from blood plasma and thrombocytes in sensitization and allergy]
[Vascular adhesion protein-1: an unusual adhesion molecule]
Stomach Neoplasms
Evaluation of Serum Vascular Adhesion Protein-1 as a Potential Biomarker in Thyroid Cancer.
Relationship between serum soluble vascular adhesion protein-1 level and gastric cancer prognosis.
Serum soluble vascular adhesion protein-1 is a valuable prognostic marker in gastric cancer.
Stroke
Assessment of the Relationship Between Serum Vascular Adhesion Protein-1 (VAP-1) and Severity of Calcific Aortic Valve Stenosis.
Protective effect of the multitarget compound DPH-4 on human SSAO/VAP-1-expressing hCMEC/D3 cells under oxygen-glucose deprivation conditions: an in vitro experimental model of cerebral ischaemia.
SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer's Disease.
Vascular adhesion protein-1 in human ischaemic stroke.
[Serum benzylamine oxidase activity (BAO) in patients with sequelae of cerebrovascular accidents]
Subarachnoid Hemorrhage
Pharmacologic blockade of vascular adhesion protein-1 lessens neurologic dysfunction in rats subjected to subarachnoid hemorrhage.
VAP-1 blockade prevents subarachnoid hemorrhage-associated cerebrovascular dilating dysfunction via repression of a neutrophil recruitment-related mechanism.
Synovitis
68Ga-DOTA-Siglec-9--a new imaging tool to detect synovitis.
Thyroid Neoplasms
Evaluation of Serum Vascular Adhesion Protein-1 as a Potential Biomarker in Thyroid Cancer.
Thyroid Nodule
Evaluation of Serum Vascular Adhesion Protein-1 as a Potential Biomarker in Thyroid Cancer.
Tourette Syndrome
Enzyme activity in Tourette's syndrome.
Uveitis
Inhibition of vascular adhesion protein-1 suppresses endotoxin-induced uveitis.
Vascular adhesion protein 1 in the eye.
Vascular Diseases
Novel pyridazinone inhibitors for vascular adhesion protein-1 (VAP-1): old target-new inhibition mode.
Vascular cell lines expressing SSAO/VAP-1: a new experimental tool to study its involvement in vascular diseases.
Vasculitis
Anti endothelial cell autoantibodies selectively activate SAPK/JNK signalling in Wegener's granulomatosis.