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Disease on EC 1.5.1.5 - methylenetetrahydrofolate dehydrogenase (NADP+)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Increased activity of renal glycine-cleavage-enzyme complex in metabolic acidosis.
Anemia, Megaloblastic
Precision Molecular Diagnosis Defines Specific Therapy in Combined Immunodeficiency with Megaloblastic Anemia Secondary to MTHFD1 Deficiency.
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Anencephaly
Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions.
Angina, Stable
Methylenetetrahydrofolate Dehydrogenase 1 Polymorphisms Modify the Associations of Plasma Glycine and Serine With Risk of Acute Myocardial Infarction in Patients With Stable Angina Pectoris in WENBIT (Western Norway B Vitamin Intervention Trial).
Atherosclerosis
[Features of allele polymorphism of genes involved in homocysteine and folate metabolism in patients with atherosclerosis of the lower extremity arteries]
Atypical Hemolytic Uremic Syndrome
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Breast Neoplasms
Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy.
Increased MTHFD2 expression is associated with poor prognosis in breast cancer.
Carcinogenesis
Methylenetetrahydrofolate Dehydrogenase 1 Silencing Expedites the Apoptosis of Non-Small Cell Lung Cancer Cells via Modulating DNA Methylation.
Carcinoma
High Expression of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Esophageal Squamous Cell Carcinoma and its Clinical Prognostic Significance.
Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) is Underexpressed in Clear Cell Renal Cell Carcinoma Tissue and Transfection and Overexpression in Caki-1 Cells Inhibits Cell Proliferation and Increases Apoptosis.
MTHFD2 Overexpression Predicts Poor Prognosis in Renal Cell Carcinoma and is Associated with Cell Proliferation and Vimentin-Modulated Migration and Invasion.
The Prognostic Significance of Immune-Related Metabolic Enzyme MTHFD2 in Head and Neck Squamous Cell Carcinoma.
Carcinoma, Endometrioid
Origin of clear cell carcinoma: nature or nurture?
Carcinoma, Hepatocellular
Methylenetetrahydrofolate dehydrogenase 2 overexpression is associated with tumor aggressiveness and poor prognosis in hepatocellular carcinoma.
[The preliminary study on the function of methylenetetrahydrofolate dehydrogenase 2 in hepatocellular carcinoma].
Carcinoma, Non-Small-Cell Lung
Methylenetetrahydrofolate Dehydrogenase 1 Silencing Expedites the Apoptosis of Non-Small Cell Lung Cancer Cells via Modulating DNA Methylation.
Carcinoma, Renal Cell
Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) is Underexpressed in Clear Cell Renal Cell Carcinoma Tissue and Transfection and Overexpression in Caki-1 Cells Inhibits Cell Proliferation and Increases Apoptosis.
MTHFD2 Overexpression Predicts Poor Prognosis in Renal Cell Carcinoma and is Associated with Cell Proliferation and Vimentin-Modulated Migration and Invasion.
Carcinoma, Squamous Cell
The Prognostic Significance of Immune-Related Metabolic Enzyme MTHFD2 in Head and Neck Squamous Cell Carcinoma.
Colorectal Neoplasms
The importance of mitochondrial folate enzymes in human colorectal cancer.
Congenital Abnormalities
Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects.
Down Syndrome
Combined folate gene MTHFD and TC polymorphisms as maternal risk factors for Down syndrome in China.
Methylenetetrahydrofolate dehydrogenase (MTHFD) enzyme polymorphism as a maternal risk factor for trisomy 21: a clinical study.
Esophageal Squamous Cell Carcinoma
High Expression of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Esophageal Squamous Cell Carcinoma and its Clinical Prognostic Significance.
Glioma
Expression and Prognostic Value Identification of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Brain Low-Grade Glioma.
Heart Defects, Congenital
Relationship between polymorphism of methylenetetrahydrofolate dehydrogenase and congenital heart defect.
Heart Diseases
MTHFR c.1793G>A polymorphism is associated with congenital cardiac disease in a Chinese population.
Hernia, Umbilical
Folate-related genes and omphalocele.
Hypertension
Investigation of homocysteine-pathway-related variants in essential hypertension.
Significant Association of Methylenetetrahydrofolate dehydrogenase 1 Promoter Hypomethylation with Stroke in a Chinese Population with Primary Hypertension.
Laryngeal Neoplasms
Polymorphic variants of folate metabolism genes and the risk of laryngeal cancer.
Leukemia, Myeloid, Acute
miR-92a Inhibits Proliferation and Induces Apoptosis by Regulating Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) Expression in Acute Myeloid Leukemia.
Lung Neoplasms
Methylenetetrahydrofolate Dehydrogenase 1 Silencing Expedites the Apoptosis of Non-Small Cell Lung Cancer Cells via Modulating DNA Methylation.
Modulating redox homeostasis and cellular reprogramming through inhibited methylenetetrahydrofolate dehydrogenase 2 enzymatic activities in lung cancer.
Prognostic significance of folate metabolism polymorphisms for lung cancer.
Meningomyelocele
Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions.
Myocardial Infarction
Methylenetetrahydrofolate Dehydrogenase 1 Polymorphisms Modify the Associations of Plasma Glycine and Serine With Risk of Acute Myocardial Infarction in Patients With Stable Angina Pectoris in WENBIT (Western Norway B Vitamin Intervention Trial).
Neoplasms
Association of methylenetetrahydrofolate dehydrogenase 1 polymorphisms with cancer: a meta-analysis.
Detection and characterisation of novel alternative splicing variants of the mitochondrial folate enzyme MTHFD2.
Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2.
Folate enzymes in Ehrlich ascites carcinoma-bearing mice.
Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy.
High Expression of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Esophageal Squamous Cell Carcinoma and its Clinical Prognostic Significance.
KRAS mutation status is associated with enhanced dependency on folate metabolism pathways in Non Small Cell Lung Cancer cells.
Methylenetetrahydrofolate dehydrogenase 2 overexpression is associated with tumor aggressiveness and poor prognosis in hepatocellular carcinoma.
Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development.
Modulating redox homeostasis and cellular reprogramming through inhibited methylenetetrahydrofolate dehydrogenase 2 enzymatic activities in lung cancer.
MTHFD2 promotes tumorigenesis and metastasis in lung adenocarcinoma by regulating AKT/GSK-3?/?-catenin signalling.
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.
NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview.
NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells. Purification and properties.
p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage.
Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.
The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.
The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation.
Neural Tube Defects
Association between MTHFD1 G1958A polymorphism and neural tube defects susceptibility: a meta-analysis.
Deletion of the neural tube defect-associated gene
MTHFD1 polymorphism as maternal risk for neural tube defects: a meta-analysis.
Paternal transmission of MTHFD1 G1958A variant predisposes to neural tube defects in the offspring.
Polymorphisms in MTHFD1 Gene and Susceptibility to Neural Tube Defects: A Case-Control Study in a Chinese Han Population with Relatively Low Folate Levels.
Ovarian Neoplasms
Lack of association between MTHFD1 G401A polymorphism and ovarian cancer susceptibility.
Pregnancy Complications
Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells.
Prostatic Neoplasms
Lack of association between methylenetetrahydrofolate dehydrogenase 1 G1958A polymorphism and prostate cancer risk: a meta-analysis.
Severe Combined Immunodeficiency
Precision Molecular Diagnosis Defines Specific Therapy in Combined Immunodeficiency with Megaloblastic Anemia Secondary to MTHFD1 Deficiency.
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Small Cell Lung Carcinoma
Prognostic significance of folate metabolism polymorphisms for lung cancer.
Spinal Dysraphism
The methylenetetrahydrofolate dehydrogenase (MTHFD1) 1958G>A variant is not associated with spina bifida risk in the Dutch population.
Squamous Cell Carcinoma of Head and Neck
The Prognostic Significance of Immune-Related Metabolic Enzyme MTHFD2 in Head and Neck Squamous Cell Carcinoma.
Stroke
A comprehensive association analysis between homocysteine metabolic pathway gene methylation and ischemic stroke in a Chinese hypertensive population.
Significant Association of Methylenetetrahydrofolate dehydrogenase 1 Promoter Hypomethylation with Stroke in a Chinese Population with Primary Hypertension.
Urinary Bladder Neoplasms
Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer.