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Disease on EC 1.5.3.13 - N1-acetylpolyamine oxidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Threatened
Serum polyamine-oxidase activity in spontaneous abortion.
Adenocarcinoma
A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model.
Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.
The growth of MAT-LyLu rat prostatic adenocarcinoma can be prevented in vivo by polyamine deprivation.
Arthritis, Rheumatoid
Polyamine oxidase activity in rheumatoid arthritis synovial fluid.
Brain Edema
Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion.
Brain Injuries
Contribution of polyamine oxidase to brain injury after trauma.
Brain Injuries, Traumatic
Contribution of polyamine oxidase to brain injury after trauma.
Elevated N1-acetylspermidine levels in gerbil and rat brains after CNS injury.
Brain Ischemia
Elevated N1-acetylspermidine levels in gerbil and rat brains after CNS injury.
Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal.
[Changes and significance of PAO activities and polyamine levels at different time of reperfusion after transient focal cerebral ischemia in rats]
Breast Neoplasms
Estrogens and polyamines in breast cancer: their profiles and values in disease staging.
Inducible expression of maize polyamine oxidase in the nucleus of MCF-7 human breast cancer cells confers sensitivity to etoposide.
Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.
Carcinoma
Cytotoxic effects of the polyamine oxidase inactivator MDL 72527 to two human colon carcinoma cell lines SW480 and SW620.
Endogenous and exogenous polyamines in support of tumor growth.
Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells.
Inhibition of polyamine oxidase improves the antitumoral effect of ornithine decarboxylase inhibitors.
Inhibition of polyamine oxidase prevented cyclin-dependent kinase inhibitor-induced apoptosis in HCT 116 colon carcinoma cells.
Polyamine oxidase activity in a human colonic carcinoma cell line.
The gastrointestinal tract as polyamine source for tumor growth.
[Effect of serum polyamine oxidase on normal and tumor cells]
Carcinoma, Hepatocellular
Expression of spermidine/spermine N1-acetyltransferase in growing Yoshida AH-130 hepatoma cells.
[Effect of serum polyamine oxidase on normal and tumor cells]
Carcinoma, Lewis Lung
Endogenous and exogenous polyamines in support of tumor growth.
Inhibition of polyamine oxidase improves the antitumoral effect of ornithine decarboxylase inhibitors.
The gastrointestinal tract as polyamine source for tumor growth.
Cataract
Polyamine Oxidase Is Involved in Spermidine Reduction of Transglutaminase Type 2-Catalyzed ?H-Crystallins Polymerization in Calcium-Induced Experimental Cataract.
Cervical Intraepithelial Neoplasia
Cervical intraepithelial neoplasia is associated with increased polyamine oxidase and diamine oxidase concentrations in cervical mucus.
Colonic Neoplasms
Inhibition of polyamine oxidase enhances the cytotoxicity of polyamine oxidase substrates. A model study with N(1)-(n-octanesulfonyl)spermine and human colon cancer cells.
Colorectal Neoplasms
Polyamine oxidase activity and polyamine levels in human colorectal cancer and in normal surrounding mucosa.
Diabetes Mellitus, Type 1
Does polyamine oxidase activity influence the oxidative metabolism of children who suffer of diabetes mellitus?
Dwarfism
Role of polyamines in plant vascular development.
Epilepsy
A barley polyamine oxidase isoform with distinct structural features and subcellular localization.
Glioblastoma
Inhibition of the growth of U-251 human glioblastoma in nude mice by polyamine deprivation.
Hyperbilirubinemia, Neonatal
Polyamine oxidase activity in peripheral blood of newborn infants with neonatal hyperbilirubinemia: is bilirubin an antioxidant?
Infarction, Middle Cerebral Artery
Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion.
Infections
Free polyamine and polyamine regulation during pre?penetration and penetration resistance events in oat against crown rust (Puccinia coronata f. sp. avenae)
Polyamines as a common source of hydrogen peroxide in host- and nonhost hypersensitive response during pathogen infection.
Intestinal Volvulus
The polyamine metabolism of filarial worms as chemotherapeutic target.
Kidney Failure, Chronic
Polyamines in renal failure.
[Physiological functions of polyamines and regulation of polyamine content in cells]
Leukemia
Participation of T-lymphocytes in the curative effect of a novel synthetic polyamine analogue, N,N'-bis[3-(ethylamino)propyl]-1,7-heptanediamine, against L1210 leukemia in vivo.
Separation of two isozymes of polyamine oxidase from murine L1210 leukemia cells.
The gastrointestinal tract as polyamine source for tumor growth.
Lung Neoplasms
Highly expressed N1-acetylpolyamine oxidase detoxifies polyamine analogue N1-cyclopropylmethyl-N11-ethylnorspermine in human lung cancer cell line A549.
Malaria
Bis(benzyl)polyamine analogs as novel substrates for polyamine oxidase.
Polyamine oxidase in human retroplacental serum inhibits the growth of Plasmodium falciparum.
Melanoma
Polyamine oxidase activity and concentration of polyamines in tissues and serum of hamsters with transplantational pigmented melanoma IC-Sofia.
Melanoma, Experimental
Polyamine transporter recognization and antitumor effects of anthracenymethyl homospermidine.
Neoplasms
Alterations in polyamine catabolic enzymes in human breast cancer tissue.
Cervical intraepithelial neoplasia is associated with increased polyamine oxidase and diamine oxidase concentrations in cervical mucus.
Cytotoxicity of the polyamine oxidase inactivator MDL 72527 to cancer cells: comparison with a saturated structural analogue.
Effect of polyamine analogues and inhibition of polyamine oxidase on spermidine/spermine N1-acetyltransferase activity and cell proliferation.
Effect of polyamine deprivation on the survival of intracranial glioblastoma bearing rats.
Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.
Inhibition of polyamine oxidase activity affects tumor development during the maize-Ustilago maydis interaction.
Inhibition of polyamine oxidase enhances the cytotoxicity of polyamine oxidase substrates. A model study with N(1)-(n-octanesulfonyl)spermine and human colon cancer cells.
Inhibition of the growth of U-251 human glioblastoma in nude mice by polyamine deprivation.
Microarray analysis uncovers retinoid targets in human bronchial epithelial cells.
Polyamine catabolism in rodent and human cells in culture.
Polyamine deprivation, malnutrition and tumor growth.
Polyamine metabolism in maize tumors induced by Ustilago maydis.
Polyamine oxidase activity and growth in human cancer cells.
Polyamine oxidase activity in serum of cancer patients and healthy subjects.
Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells.
Stimulation of clonal tumor cell growth in vitro by inhibiting the serum polyamine oxidase activity.
Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis.
The role of macrophage activation in chronic inflammation.
The role of polyamine catabolism in anti-tumour drug response.
[Effect of serum polyamine oxidase on normal and tumor cells]
Neurodegenerative Diseases
Targeting Polyamine Oxidase to Prevent Excitotoxicity-Induced Retinal Neurodegeneration.
Ovarian Neoplasms
Polyamine catabolism in platinum drug action: Interactions between oxaliplatin and the polyamine analogue N1,N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase.
Pancreatitis
Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase.
[Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism]
Parasitemia
Trypanosoma brucei: polyamine oxidase mediated trypanolytic activity in the serum of naturally resistant cattle.
Prostatic Neoplasms
A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model.
Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling.
Stroke
Acrolein, IL-6 and CRP as markers of silent brain infarction.
Polyamine oxidase and acrolein as novel biochemical markers for diagnosis of cerebral stroke.
[Physiological functions of polyamines and regulation of polyamine content in cells]
Ureteral Obstruction
Polyamine oxidase and diamine oxidase activities in acute ureteral obstruction.
Uterine Cervical Neoplasms
Altered urinary profiles of polyamines and endogenous steroids in patients with benign cervical disease and cervical cancer.
Cervical intraepithelial neoplasia is associated with increased polyamine oxidase and diamine oxidase concentrations in cervical mucus.
Vascular System Injuries
Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy.