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Disease on EC 1.6.5.2 - NAD(P)H dehydrogenase (quinone)

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DISEASE
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Aberrant Crypt Foci
Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats.
Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats.
Acute Lung Injury
ASSOCIATION OF HUMAN NAD(P)H:QUINONE OXIDOREDUCTASE 1 (NQO1) POLYMORPHISM WITH DEVELOPMENT OF ACUTE LUNG INJURY.
Adenocarcinoma
609 C --> T polymorphism in NAD(P)H:quinone oxidoreductase gene in patients with prostatic adenocarcinoma or benign prostatic hyperplasia.
Association between NAD(P)H: quinone oxidoreductase 1 (NQ01) inactivating C609T polymorphism and adenocarcinoma of the upper gastrointestinal tract.
C609T polymorphism of the NAD(P)H:quinone oxidoreductase I gene does not significantly affect susceptibility for esophageal adenocarcinoma.
Chemopreventive effect of protein extract of Asterina pectinifera in HT-29 human colon adenocarcinoma cells.
Cytoenzymology of benign and malignant tumours of the corpus uteri. I. Respiratory enzymes.
Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples.
DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas.
Enzymorphology of adenocarcinoma of the endometrium; beta-glucuronidase, acid phosphatase, reduced diphosphopyridine nucleotide (DPNH) diaphorase, and alpha-naphthyl esterase.
Evidence of differential cisplatin-DNA adduct formation, removal and tolerance of DNA damage in three human lung carcinoma cell lines.
Hypoxia-selective antitumor agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
Identification of a methylcholanthrene-induced aldehyde dehydrogenase in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance.
Increased levels of NAD(P)H: quinone oxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A Potential biomarker of early damage in the pancreas.
Increased levels of NAD(P)H: quinone oxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A potential biomarker of early damage in the pancreas.
NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by ?-lapachone.
Pharmacological determinants of the antitumour activity of mitomycin C.
The NAD(P)H:quinone oxidoreductase I C609T polymorphism modifies the risk of Barrett esophagus and esophageal adenocarcinoma.
The NQO1 bioactivatable drug, ?-Lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.
Adenoma
A Diagnostic Method for Gastric Cancer Using Two-Photon Microscopy With Enzyme-Selective Fluorescent Probes: A Pilot Study.
Contribution of NAD(P)H Quinone Oxidoreductase 1 (NQO1) Pro187Ser Polymorphism and Risks of Colorectal Adenoma and Cancer for Caucasians: A Meta-analysis.
miRNA-7a-2-3p Inhibits Neuronal Apoptosis in Oxygen-Glucose Deprivation (OGD) Model.
Adenoma, Pleomorphic
Over-expression of glutathione S-transferases, DT-diaphorase and an apparently tumour-specific cytosolic class-3 aldehyde dehydrogenase by Warthin tumours and mucoepidermoid carcinomas of the human parotid gland.
Alzheimer Disease
Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease.
Association of NAD(P)H:Quinone Oxidoreductase 1 Polymorphism and Alzheimer's Disease in Chinese.
Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: normal anatomy and alterations in Alzheimer's disease.
E3 Ligase STUB1/CHIP Regulates NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Accumulation in Aged Brain, a Process Impaired in Certain Alzheimer Disease Patients.
Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease.
Regional NAD(P)H:quinone oxidoreductase activity in Alzheimer's disease.
[Association between NAD(P)H: quinone oxidoreductase and apolipoprotein E gene polymorphisms in Alzheimer's disease]
Anemia, Hemolytic
Comparative effects of mono-, di-, tri-, and tetrasulfides derived from plants of the Allium family: redox cycling in vitro and hemolytic activity and Phase 2 enzyme induction in vivo.
Effects of butylated hydroxyanisole and dicoumarol on the toxicity of menadione to rats.
Effects of modulation of tissue activities of DT-diaphorase on the toxicity of 2,3-dimethyl-1,4-naphthoquinone to rats.
NAD(P)H: quinone oxidoreductase 1 expression in kidney podocytes.
Anemia, Iron-Deficiency
Methaemoglobin diaphorase of human erythrocytes in iron-deficiency anaemia.
Ascorbic Acid Deficiency
NAD(P)H: quinone oxidoreductase 1 deficiency conjoint with marginal vitamin C deficiency causes cigarette smoke induced myelodysplastic syndromes.
Asthma
NAD(P)H: Quinone oxidoreductase 1, glutathione S-transferase M1, environmental tobacco smoke exposure, and childhood asthma.
Opposing effects of nasal epithelial NAD(P)H dehydrogenase quinine 1 and heme oxygenase 1 expression on upper and lower airway symptoms in adolescents with asthma.
PM2.5 aggravates NQO1-induced mucus hyper-secretion through release of neutrophil extracellular traps in an asthma model.
[The NADPH-diaphorase activity of the bronchial epithelium in chronic lung diseases]
Avitaminosis
Activity of xenobiotic-metabolizing enzymes in the liver of rats with multi-vitamin deficiency.
Barrett Esophagus
The NAD(P)H:quinone oxidoreductase I C609T polymorphism modifies the risk of Barrett esophagus and esophageal adenocarcinoma.
Brain Contusion
[Histochemical determination of date of cortical contusion - studies of changes in NADP diaphorase, glycero-3-PH-dehydrogenase, glucose-6-PH-DH and naphtylacetate-esterase]
Brain Injuries
Role of Nrf2 in Protection against Traumatic Brain Injury in Mice.
Brain Ischemia
The antioxidant enzyme quinone reductase is up-regulated in vivo following cerebral ischemia.
Breast Neoplasms
DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma.
Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.
Dietary menhaden oil enhances mitomycin C antitumor activity toward human mammary carcinoma MX-1.
Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.
DT-diaphorase and cytochrome B5 reductase in human lung and breast tumours.
Estrogen receptor regulation of quinone reductase in breast cancer: implications for estrogen-induced breast tumor growth and therapeutic uses of tamoxifen.
Estrogen receptors: selective ligands, partners, and distinctive pharmacology.
gamma-Tocotrienol controls proliferation, modulates expression of cell cycle regulatory proteins and up-regulates quinone reductase NQO2 in MCF-7 breast cancer cells.
Histopathological effect of radiofrequency ablation therapy for primary breast cancer, with special reference to changes in cancer cells and stromal structure and a comparison with enzyme histochemistry.
Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin.
Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer.
Low expression of NQO1 predicts pathological complete response to neoadjuvant chemotherapy in breast cancer patients treated with TAC regimen.
Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology.
NAD(P)H:quinone oxidoreductase 1 determines radiosensitivity of triple negative breast cancer cells and is controlled by long non-coding RNA NEAT1.
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.
NAD(P)H:quinone oxidoreductase 1 Pro187Ser polymorphism and expression do not cosegregate with clinico-pathological characteristics of human mammary tumors.
Overexpression of NAD(P)H:quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones.
Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance.
Significance of genetic variation at the glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase 1 detoxification genes in breast cancer development.
The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites.
Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts.
Bronchitis
[The NADPH-diaphorase activity of the bronchial epithelium in chronic lung diseases]
Bronchopulmonary Dysplasia
Association of C609T-Inborn Polymorphism of NAD(P)H: Quinone Oxidoreductase 1 with the Risk of Bronchopulmonary Dysplasia in Preterm Neonates.
Burkitt Lymphoma
NAD(P)H:quinone oxidoreductase (NQO1) loss of function in Burkitt's lymphoma cell lines.
Carcinogenesis
609 C --> T polymorphism in NAD(P)H:quinone oxidoreductase gene in patients with prostatic adenocarcinoma or benign prostatic hyperplasia.
A novel geranylated derivative, ethyl 3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate, synthesized from ferulic acid suppresses carcinogenesis and inducible nitric oxide synthase in rat tongue.
A relationship found between intra-oral sites of 4NQO reductase activity and chemical carcinogenesis.
Ascorbic acid differentially modulates the induction of heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase Ya by As(3+), Cd(2+) and Cr(6+).
Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues.
Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.
Cellular kinetics of induction by oltipraz and its keto derivative of detoxication enzymes in human colon adenocarcinoma cells.
Chemoprevention by Hippophae rhamnoides: effects on tumorigenesis, phase II and antioxidant enzymes, and IRF-1 transcription factor.
Chemoprevention by inducers of carcinogen detoxication enzymes.
Chemoprevention of colon carcinogenesis by organosulfur compounds.
Chemopreventive effect of bovine lactoferrin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats.
Chemopreventive effect of dietary flavonoid morin on chemically induced rat tongue carcinogenesis.
Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats.
Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors.
Deficiency of NRH:quinone oxidoreductase 2 differentially regulates TNF signaling in keratinocytes: up-regulation of apoptosis correlates with down-regulation of cell survival kinases.
Dietary glucosinolates as blocking agents against carcinogenesis: glucosinolate breakdown products assessed by induction of quinone reductase activity in murine hepa1c1c7 cells.
DNA methylation of a non-CpG island promoter represses NQO1 expression in rat arsenic-transformed lung epithelial cells.
DT-diaphorase: possible roles in cancer chemotherapy and carcinogenesis.
Effect of alpha-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats.
Effect of chronic ingestion of a fermented dairy product containing Lactobacillus acidophilus and Bifidobacterium bifidum on metabolic activities of the colonic flora in humans.
Effects of psoralen from Psoralea corylifolia on quinone reductase, ornithine decarboxylase, and JB6 cells transformation promotion.
Elevation of quinone reductase activity by anticarcinogenic antioxidants.
Enhanced quinone reductase (QR) activity correlates with promotion potential of diethyl maleate (DEM) in rat forestomach and glandular stomach carcinogenesis initiated with N-methyl-N'-nitrosoguanidine (MNNG).
Evidence that ferric nitrilotriacetate mediates oxidative stress by down-regulating DT-diaphorase activity: implications for carcinogenesis.
Improving the NQO1-Inducing Activities of Phenolic Acids from Radix Salvia miltiorrhiza: a Methylation Strategy.
Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.
Induction of NAD(P)H:quinone reductase by probucol: a possible mechanism for protection against chemical carcinogenesis and toxicity.
Induction of quinone reductase by tamoxifen or DPN protects against mammary tumorigenesis.
Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer.
Inhibition of urinary bladder carcinogenesis by broccoli sprouts.
Long term effects of benzo(a)pyrene on the activity of NAD(P)H:quinone reductase in the forestomach and glandular stomach of ICR/Ha mice.
Modifications of 3'-methyl-4-dimethylaminoazobenzene carcinogenesis of rat liver and carcinogen metabolism by portacaval anastomosis.
Modulation of Estrogen Chemical Carcinogenesis by Botanical Supplements used for Postmenopausal Women's Health.
Mouse strain variations in the magnitude of induction of liver DT-diaphorase and hereditary transmission of the trait.
NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin.
NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis.
New hits as phase II enzymes inducers from a focused library with heteroatom-heteroatom and Michael-acceptor motives.
Nrf2-Keap1 Signaling as a Potential Target for Chemoprevention of Inflammation-Associated Carcinogenesis.
Nuclear factor E2-related factor 2-mediated induction of NAD(P)H:quinone oxidoreductase 1 by 3,5-dimethoxy-trans-stilbene.
Null association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer in north Indian population and meta-analysis.
Phenolics from Barleria cristata var. Alba as carcinogenesis blockers against menadione cytotoxicity through induction and protection of quinone reductase.
Protective roles of quinone reductase and tamoxifen against estrogen-induced mammary tumorigenesis.
Rat strain variations in liver cytosolic DT-diaphorase activity and possible significance of the trait in carcinogenesis by azo dyes.
Significant association of PKM2 and NQO1 proteins with poor prognosis in breast cancer.
Some acute effects of monochromatic ultraviolet B irradiation on mouse epidermis measured by the tetrazolium-reduction test and determination of DT-diaphorase activity, with reference to carcinogenesis.
The levels of quinone reductases, superoxide dismutase and glutathione-related enzymatic activities in diethylstilbestrol-induced carcinogenesis in the kidney of male Syrian golden hamsters.
The pitfall of detoxifying enzymes.
Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity.
Transfection of COS-1 cells with DT-diaphorase cDNA: role of a base change at position 609.
[Azoreductase in neoplastic liver tissue. II. Variations during oncogenesis and the effect of treatment with flavin.]
Carcinoma
Aberrant expression of nitric oxide synthase in human polyps, neoplastic colonic mucosa and surrounding peritumoral normal mucosa.
Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma.
Activity and immunohistochemistry of DT-diaphorase in hamster and human kidney tumours.
Arsenic methylation capability, heme oxygenase-1 and NADPH quinone oxidoreductase-1 genetic polymorphisms and the stage and grade of urothelial carcinomas.
Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population.
Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci.
Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis.
Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase.
Biochemical and quantitative histochemical study of reduced pyridine nucleotide dehydrogenation by human colonic carcinomas.
Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in Walker cells.
Calcium and calcium sensing receptor modulates the expression of thymidylate synthase, NAD(P)H:quinone oxidoreductase 1 and survivin in human colon carcinoma cells: Promotion of cytotoxic response to mitomycin C and fluorouracil.
Catechol estrogen metabolites and conjugates in different regions of the prostate of Noble rats treated with 4-hydroxyestradiol: implications for estrogen-induced initiation of prostate cancer.
Cigarette smoking is a determinant of DT-diaphorase gene expression in human non-small cell lung carcinoma.
Dietary menhaden oil enhances mitomycin C antitumor activity toward human mammary carcinoma MX-1.
Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.
DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas.
DT-diaphorase as a critical determinant of sensitivity to mitomycin C in human colon and gastric carcinoma cell lines.
DT-diaphorase: possible roles in cancer chemotherapy and carcinogenesis.
Effects of hypoxia on detoxicating enzyme activity and expression in HT29 colon adenocarcinoma cells.
Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cł.
Evidence of differential cisplatin-DNA adduct formation, removal and tolerance of DNA damage in three human lung carcinoma cell lines.
Expression of NAD(P)H:quinone oxidoreductase and glutathione S-transferases alpha and pi in human renal cell carcinoma and in kidney cancer-derived cell lines.
Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro.
Immunological quantitation of DT-diaphorase in carcinoma cell lines and clinical colon cancers: advanced tumors express greater levels of DT-diaphorase.
Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9.
Loss of heterozygosity at the NAD(P)H: quinone oxidoreductase locus associated with increased resistance against mitomycin C in a human bladder carcinoma cell line.
Mapping of DNA alkylation sites induced by aziridinylbenzoquinones in human cells by ligation-mediated polymerase chain reaction.
Mesoporous Silica Nanoparticle-Based Combination of NQO1 Inhibitor and 5-Fluorouracil for Potent Antitumor Effect Against Head and Neck Squamous Cell Carcinoma (HNSCC).
Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells.
Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.
Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C.
NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.
Nonenzymatic reductive activation of 7-N-((2-([2-(gamma-L-glutamylamino)ethyl]dithio)ethyl))mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor cells.
Potential mechanism of phytochemical-induced apoptosis in human prostate adenocarcinoma cells: Therapeutic synergy in genistein and beta-lapachone combination treatment.
Preliminary crystallographic data for NAD(P)H quinone reductase isolated from the Walker 256 rat carcinoma cell line.
Role of a DT-diaphorase mutation in the response of anal canal carcinoma to radiation, 5-fluorouracil, and mitomycin C.
Role of NAD(P)H:quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin.
Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones.
Talarolutins A-D: Meroterpenoids from an endophytic fungal isolate of Talaromyces minioluteus.
The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)
The NAD(P)H:quinone oxidoreductase locus in human colon carcinoma HCT 116 cells resistant to mitomycin C.
The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.
The role of NAD(P)H:quinone oxidoreductase in quinone-mediated p21 induction in human colon carcinoma cells.
[Histoenzymatic studies of cervical carcinoma. II. Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, TPN diaphorase and DPN diaphorase]
[The NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and susceptibility to esophageal cancer]
Carcinoma, Basal Cell
Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci.
Carcinoma, Hepatocellular
1,2-Dithiol-3-thione analogs: effects on NAD(P)H:quinone reductase and glutathione levels in murine hepatoma cells.
2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a novel NQO1 inducing agent from Echinops grijsii Hance.
7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes.
?-Carboline Derivatives and Diphenols from Soy Sauce Are in Vitro Quinone Reductase (QR) Inducers.
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.
A tissue homogenate method to prepare gram-scale allium thiosulfinates and their disulfide conjugates with cysteine and glutathione.
Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.
Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase II enzyme, quinone reductase.
Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.
An histochemical investigation of diaphorase and succine dehydrogenase in induced and transplanted hepatomas.
Anti-carcinogenic activity of 6-methylsulfinylhexyl isothiocyanate-, an active anti-proliferative principal of wasabi (Eutrema wasabi Maxim.).
Antimutagenicity and DT-diaphorase inducing activity of Gynostemma pentaphyllum Makino extract.
Antioxidant and Quinone Reductase Activity of Soyasaponins in Hepa1c1c7 Mouse Hepatocarcinoma Cells.
Antioxidant functions of selected allium thiosulfinates and S-alk(en)yl-L-cysteine sulfoxides.
Aqueous extract from Spanish black radish (Raphanus sativus L. Var. niger) induces detoxification enzymes in the HepG2 human hepatoma cell line.
Beta-ionone-inhibited proliferation of breast cancer cells by inhibited COX-2 activity.
Bi-functional induction of the quinone reductase and cytochrome P450 1A1 by youngiasides via Nrf2-ARE and AhR-XRE pathways.
Bioactive Constituents of Indigofera spicata.
Camel milk modulates the expression of aryl hydrocarbon receptor-regulated genes, Cyp1a1, Nqo1, and Gsta1, in murine hepatoma Hepa 1c1c7 cells.
Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes.
Cancer chemopreventive activity of sulforamate derivatives.
Characterization of flavonoids as monofunctional or bifunctional inducers of quinone reductase in murine hepatoma cell lines.
Chemical and molecular regulation of enzymes that detoxify carcinogens.
Chemical structures critical for the induction of FMN-dependent NADH-quinone reductase in Escherichia coli.
Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE).
Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers.
Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes.
Compounds obtained from sida acuta with the potential to induce quinone reductase and to inhibit 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions in a mouse mammary organ culture model.
Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase.
Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.
Cysteine and glutathione mixed-disulfide conjugates of thiosulfinates: chemical synthesis and biological activities.
Cytosolic activation of aromatic and heterocyclic amines. Inhibition by dicoumarol and enhancement in viral hepatitis B.
Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes.
Differences in induction by xenobiotics in murine tissues and the Hepa1c1c7 cell line of mRNAs encoding glutathione transferase, quinone reductase, and CYP1A P450s.
Differential effects of mercury, lead and copper on the constitutive and inducible expression of aryl hydrocarbon receptor (AHR)-regulated genes in cultured hepatoma Hepa 1c1c7 cells.
Differential effects of vegetable-derived indoles on the induction of quinone reductase in hepatoma cells.
Effects of the administration of anticoagulants on the activity of the enzyme-reduced NAD(P)H dehydrogenase in rat livers, hepatomas and precarcinomatous rat liver lesions.
Epigenetic silencing of NAD(P)H:quinone oxidoreductase 1 by hepatitis B virus X protein increases mitochondrial injury and cellular susceptibility to oxidative stress in hepatoma cells.
Esculetin-induced protection of human hepatoma HepG2 cells against hydrogen peroxide is associated with the Nrf2-dependent induction of the NAD(P)H: Quinone oxidoreductase 1 gene.
Establishment by adriamycin exposure of multidrug-resistant rat ascites hepatoma AH130 cells showing low DT-diaphorase activity and high cross resistance to mitomycins.
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.
Functional detection of chemopreventive glucosinolates in Arabidopsis thaliana.
Genotoxicity, cytotoxicity and chemical profile from Inga laurina (Fabaceae).
Human NAD(P)H:quinone oxidoreductase induction in human hepatoma cells after exposure to industrial acrylates, phenolics, and metals.
Hypermethylation of NAD(P)H: quinone oxidoreductase 1 (NQO1) gene in human hepatocellular carcinoma.
Identification of Chemopreventive Components from Halophytes Belonging to Aizoaceae and Cactaceae Through LC/MS-Bioassay Guided Approach.
In vitro induction of the anticarcinogenic marker enzyme, quinone reductase, in human hepatoma cells by food extracts.
Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.
Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: a model system for the study of anticarcinogens.
Induction of phase II enzyme activity by various selenium compounds.
Induction of phase II enzyme, quinone reductase, in murine hepatoma cells in vitro by grape extracts and selected phytochemicals
Induction of quinone reductase activity by stilbene analogs in mouse Hepa 1c1c7 cells.
Induction of quinone reductase by a methanol extract of Scutellaria baicalensis and its flavonoids in murine Hepa 1c1c7 cells.
Induction of quinone reductase by allylisothiocyanate (AITC) and the N-acetylcysteine conjugate of AITC in Hepa1c1c7 mouse hepatoma cells.
Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells.
Induction of quinone reductase by withanolides isolated from Physalis philadelphica (tomatillos).
Induction of quinone reductase by withanolides.
Induction of the anti-carcinogenic enzyme quinone reductase by food extracts using murine hepatoma cells.
Induction of the anticarcinogenic marker enzyme, quinone reductase, in murine hepatoma cells in vitro by flavonoids.
Influence of DT diaphorase on quinone-mediated genotoxicity in human and fish cell lines.
Isolation and absolute stereochemistry of coussaric acid, a new bioactive triterpenoid from the stems of Coussarea brevicaulis.
Isolation and identification of phase II enzyme inductors obtained from black Shawaya sorghum [Sorghum bicolor (L.) Moench] bran
Isolation and identification of phase II enzyme-inducing agents from nonpolar extracts of green onion (Allium spp.).
Isolation and identification of potential cancer chemopreventive agents from methanolic extracts of green onion (Allium cepa).
Isolation of quinone reductase (QR) inducing agents from ginger rhizome and their in vitro anti-inflammatory activity
Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells.
Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes.
Mechanism-based in vitro screening of potential cancer chemopreventive agents.
Mechanisms of induction of enzymes that protect against chemical carcinogenesis.
Mercurials and dimercaptans: synergism in the induction of chemoprotective enzymes.
Modulation of aryl hydrocarbon receptor-regulated gene expression by arsenite, cadmium, and chromium.
Modulation of NAD(P)H:quinone oxidoreductase by vanadium in human hepatoma HepG2 cells.
NAD(P)H : Quinone Oxidoreductase 1 Inducer Activity of Some Saudi Arabian Medicinal Plants.
NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.
New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes.
New lanostanoids from Ganoderma lucidum that induce NAD(P)H:quinone oxidoreductase in cultured hepalcic7 murine hepatoma cells.
No association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and risk of hepatocellular carcinoma development in Turkish subjects.
Nonenzymatic reductive activation of 7-N-((2-([2-(gamma-L-glutamylamino)ethyl]dithio)ethyl))mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor cells.
Novel iodinated quinazolinones bearing sulfonamide as new scaffold targeting radiation induced oxidative stress.
Nrf2-mediated induction of phase 2 detoxifying enzymes by glyceollins derived from soybean exposed to Aspergillus sojae.
On the mechanisms of induction of cancer-protective enzymes: a unifying proposal.
Oral administration of trans-resveratrol to guinea pigs increases cardiac DT-diaphorase and catalase activities, and protects isolated atria from menadione toxicity.
Overexpression of NAD(P)H: Quinone Oxidoreductase 1 Inhibits Hepatocellular Carcinoma Cell Proliferation and Induced Apoptosis by Activating AMPK/PGC-1? Pathway.
Phase II enzyme induction and anti?inflammatory effects of crude extracts and secondary fractions obtained from bran from five black glutinous rice cultivars
Phase II enzyme-inducing and antioxidant activities of beetroot (Beta vulgaris L.) extracts from phenotypes of different pigmentation.
Phase II-Inducing, Polyphenols Content and Antioxidant Capacity of Corn (Zea mays L.) from Phenotypes of White, Blue, Red and Purple Colors Processed into Masa and Tortillas.
Phenolic compounds obtained from stems of Couepia ulei with the potential to induce quinone reductase.
Phloretamide, an apple phenolic compound, activates the Nrf2/ARE pathway in human hepatocytes.
Pinostrobin from honey and Thai ginger (Boesenbergia pandurata): a potent flavonoid inducer of mammalian phase 2 chemoprotective and antioxidant enzymes.
Polyozellin isolated from Polyozellus multiplex induces phase 2 enzymes in mouse hepatoma cells and differentiation in human myeloid leukaemic cell lines.
Potential cancer chemopreventive constituents of the leaves of Macaranga triloba.
Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean).
Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells.
Rapid detection of inducers of enzymes that protect against carcinogens.
Rat liver NAD(P)H: Quinone reductase. Regulation of quinone reductase gene expression by planar aromatic compounds and determination of the exon structure of the quinone reductase structural gene.
Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.
Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver.
Role of Catechin Quinones in the Induction of EpRE-Mediated Gene Expression.
Role of catechin quinones in the induction of EpRE-mediated gene expression.
Role of cytochrome P1-450 in the induction of NAD(P)H:quinone reductase in a murine hepatoma cell line and its mutants.
Screening for Phase II Enzyme-inducing and Antioxidant Activities of Common Vegetables
Selective increase of the potential anticarcinogen 4-methylsulphinylbutyl glucosinolate in broccoli.
Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers.
Sorghum 3-Deoxyanthocyanins Possess Strong Phase II Enzyme Inducer Activity and Cancer Cell Growth Inhibition Properties.
Svalbamides A and B, Pyrrolidinone-Bearing Lipodipeptides from Arctic Paenibacillus sp.
The activity of the D-T diaphorase in experimental hepatomas.
The anticancer enzyme DT diaphorase is induced selectively in liver during ascites hepatoma growth.
The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT).
The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)
The electrophile counterattack response: protection against neoplasia and toxicity.
The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations.
The rat quinone reductase antioxidant response element. Identification of the nucleotide sequence required for basal and inducible activity and detection of antioxidant response element-binding proteins in hepatoma and non-hepatoma cell lines.
The synergistic effect of cell wall extracted from probiotic biomass containing Lactobacillus acidophilus CL1285, L. casei LBC80R, and L. rhamnosus CLR2 on the anticancer activity of cranberry juice-HPLC fractions.
Transcriptional modulation of the NAD(P)H:quinone oxidoreductase 1 by mercury in human hepatoma HepG2 cells.
Tyrphostin [correction of Tryphostin] AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements.
[6]-Dehydroshogaol, a minor component in ginger rhizome, exhibits quinone reductase inducing and anti-inflammatory activities that rival those of curcumin
[Approaches to a selective chemotherapy of hepatocellular carcinoma (author's transl)]
[Relationship between hepatocellular carcinoma and the interaction between NQO1 polymorphisms and environmental factors].
Carcinoma, Mucoepidermoid
Over-expression of glutathione S-transferases, DT-diaphorase and an apparently tumour-specific cytosolic class-3 aldehyde dehydrogenase by Warthin tumours and mucoepidermoid carcinomas of the human parotid gland.
Carcinoma, Non-Small-Cell Lung
A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.
Activity profile of the novel aziridinylbenzoquinones MeDZQ and RH1 in human tumour xenografts.
Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy.
Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.
Cigarette smoking is a determinant of DT-diaphorase gene expression in human non-small cell lung carcinoma.
Discovery of Non-Quinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small Cell Lung Cancer.
Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cł.
Enhanced glycometabolism as a mechanism of NQO1 potentiated growth of NSCLC revealed by metabolomic profiling.
Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1.
The importance of DT-diaphorase and hypoxia in the cytotoxicity of RH1 in human breast and non-small cell lung cancer cell lines.
The Role of NQO1 Polymorphisms in the Susceptibility and Chemotherapy Response of Chinese NSCLC Patients.
Carcinoma, Renal Cell
Expression of NAD(P)H:quinone oxidoreductase and glutathione S-transferases alpha and pi in human renal cell carcinoma and in kidney cancer-derived cell lines.
Carcinoma, Small Cell
Evidence of differential cisplatin-DNA adduct formation, removal and tolerance of DNA damage in three human lung carcinoma cell lines.
Carcinoma, Squamous Cell
Mesoporous Silica Nanoparticle-Based Combination of NQO1 Inhibitor and 5-Fluorouracil for Potent Antitumor Effect Against Head and Neck Squamous Cell Carcinoma (HNSCC).
Cardiotoxicity
Lipid peroxidation and antioxidant defense mechanisms in rat renal tissue after daunorubicin administration.
The decrease of NAD(P)H:quinone oxidoreductase 1 activity and increase of ROS production by NADPH oxidases are early biomarkers in doxorubicin cardiotoxicity.
Cardiovascular Diseases
NAD(P)H:Quinone Oxidoreductase 1 and its Potential Protective Role in Cardiovascular Diseases and Related Conditions.
Chemical and Drug Induced Liver Injury
Genetic polymorphisms of manganese superoxide dismutase, NAD(P)H:quinone oxidoreductase, glutathione S-transferase M1 and T1, and the susceptibility to drug-induced liver injury.
Cholangiocarcinoma
Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells.
Downregulation of NAD(P)H:quinone oxidoreductase 1 inhibits proliferation, cell cycle and migration of cholangiocarcinoma cells.
Inflammatory cytokines suppress NAD(P)H:quinone oxidoreductase-1 and induce oxidative stress in cholangiocarcinoma cells.
Suppression of NAD(P)H-quinone oxidoreductase 1 enhanced the susceptibility of cholangiocarcinoma cells to chemotherapeutic agents.
Cholestasis
Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis.
Colitis
Host nuclear factor erythroid 2-related factor-2 defense system determines the outcome of dextran sulfate sodium-induced colitis in mice.
Identification of a new azoreductase driven prodrug from bardoxolone methyl and 5-aminosalicylate for the treatment of colitis in mice.
Nrf2 is not required for epithelial prohibitin-dependent attenuation of experimental colitis.
Colitis, Ulcerative
Identification of a new azoreductase driven prodrug from bardoxolone methyl and 5-aminosalicylate for the treatment of colitis in mice.
In-Situ Imaging of Azoreductase Activity in the Acute and Chronic Ulcerative Colitis Mice by a Near-Infrared Fluorescent Probe.
Involvement of NAD(P)H:Quinone Oxidoreductase 1 and Superoxide Dismutase Polymorphisms in Ulcerative Colitis.
Ulcerative colitis-induced hepatic damage in mice: studies on inflammation, fibrosis, oxidative DNA damage and GST-P expression.
Colonic Neoplasms
A NAD(P)H:quinone oxidoreductase 1 polymorphism is a risk factor for human colon cancer.
Aberrant expression of nitric oxide synthase in human polyps, neoplastic colonic mucosa and surrounding peritumoral normal mucosa.
Benzo(a)pyrene activates extracellular signal-related and p38 mitogen-activated protein kinases in HT29 colon adenocarcinoma cells: involvement in NAD(P)H:quinone reductase activity and cell proliferation.
Chemopreventive effects of polysaccharides extract from Asterina pectinifera on HT-29 human colon adenocarcinoma cells.
Development of novel quinone phosphorodiamidate prodrugs targeted to DT-diaphorase.
Effect of dietary fiber on colonic bacterial enzymes and bile acids in relation to colon cancer.
Enzymatic and pH modulation of mitomycin C-induced DNA damage in mitomycin C-resistant HCT 116 human colon cancer cells.
Genetic polymorphism 609C>T in NAD(P)H:quinone oxidoreductase 1 enhances the risk of proximal colon cancer.
Immunological quantitation of DT-diaphorase in carcinoma cell lines and clinical colon cancers: advanced tumors express greater levels of DT-diaphorase.
Induction of NAD(P)H:quinone reductase by vitamins A, E and C in Colo205 colon cancer cells.
Influence of diet and age on fecal bacterial enzymes.
Interaction of heat and hypoxia in modulating transcription of DT diaphorase in human colon adenocarcinoma cells.
NAD(P)H:quinone oxidoreductase expression and mitomycin C resistance developed by human colon cancer HCT 116 cells.
NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling.
NQO1 C609T polymorphism correlated to colon cancer risk in farmers from western region of Inner Mongolia.
Quinone-induced apoptosis in human colon adenocarcinoma cells via DT-diaphorase mediated bioactivation.
Regulatory network of mitomycin C action in human colon cancer cells.
Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones.
Role of the AP-1 element and redox factor-1 (Ref-1) in mediating transcriptional induction of DT-diaphorase gene expression by oltipraz: a target for chemoprevention.
Serotonin glucuronidation by Ah receptor- and oxidative stress-inducible human UDP-glucuronosyltransferase (UGT) 1A6 in Caco-2 cells.
Sorghum 3-Deoxyanthocyanins Possess Strong Phase II Enzyme Inducer Activity and Cancer Cell Growth Inhibition Properties.
The importance of DT-diaphorase in mitomycin C resistance in human colon cancer cell lines.
Colorectal Neoplasms
A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.
Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population.
Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis.
Correlative polymorphism of NAD(P)H: quinone oxidoreductase (NQO1) with telomere shortening in colorectal cancer.
Design, Synthesis, Characterization, and Crystal Structure Studies of Nrf2 Modulators for Inhibiting Cancer Cell Growth In Vitro and In Vivo.
Geldanamycin-induced cytotoxicity in human colon-cancer cell lines: evidence against the involvement of c-Src or DT-diaphorase.
Glutathione S-transferases--biomarkers of cancer risk and chemopreventive response.
NAD(P)H quinone oxidoreductase 1 codon 609 polymorphism and its association to colorectal cancer.
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese.
NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and colorectal cancer predisposition in the ethnic Kashmiri population.
NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis.
Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer.
The Analysis of NADPH Quinone Reductase 1 (NQO1) Polymorphism in Polish Patients with Colorectal Cancer.
The influence of fruit and vegetable consumption and genetic variation on NAD(P)H:quinone oxidoreductase (NQO1) phenotype in an endoscopy-based population.
Contracture
The inhibitory effect of papaverine on respiration-dependent contracture of guinea pig taenia coli in high-K medium. III. The differential effect of papaverine and rotenone on DT diaphorase.
Crohn Disease
Bacterial enzymes used for colon-specific drug delivery are decreased in active Crohn's disease.
Cystitis, Interstitial
NAD(P)H:quinone oxidoreductase 1 protects bladder epithelium against painful bladder syndrome in mice.
Dehydration
Identification of a functional respiratory complex in chloroplasts through analysis of tobacco mutants containing disrupted plastid ndh genes.
Diabetes Mellitus
Genetic polymorphisms of GSTT1, GSTM1, and NQO1 genes and diabetes mellitus risk in Chinese population.
Diabetes Mellitus, Type 1
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
Diabetes Mellitus, Type 2
Genetic polymorphisms of GSTT1, GSTM1, and NQO1 genes and diabetes mellitus risk in Chinese population.
Diabetic Nephropathies
Genetic association of NAD(P)H quinone oxidoreductase (NQO1*2) polymorphism with NQO1 levels and risk of diabetic nephropathy.
The potential roles of NAD(P)H:quinone oxidoreductase 1 in the development of diabetic nephropathy and actin polymerization.
dihydrolipoyl dehydrogenase deficiency
Congenital methaemoglobinaemia due to NADH methaemoglobin reductase deficiency: successful treatment with oral riboflavin.
Down Syndrome
DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.
Endometrial Neoplasms
A small compound spindlactone A sensitizes human endometrial cancer cells to TRAIL-induced apoptosis via the inhibition of NAD(P)H dehydrogenase quinone 1.
Erratum: A small compound spindlactone A sensitizes human endometrial cancer cells to TRAIL-induced apoptosis via the inhibition of NAD(P)H dehydrogenase quinone 1 [Corrigendum].
Enzootic Bovine Leukosis
Nitrobenzimidazoles as substrates for DT-diaphorase and redox cycling compounds: their enzymatic reactions and cytotoxicity.
Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs.
The toxicity of aromatic nitrocompounds to bovine leukemia virus-transformed fibroblasts: the role of single-electron reduction.
Esophageal Neoplasms
Correlation between NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and increased risk of esophageal cancer: evidence from a meta-analysis.
[Polymorphism of NAD(P)H dehydrogenase (quinone) 1 (NQO1) C 609 T and risk of esophageal neoplasm]
[The NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and susceptibility to esophageal cancer]
Esophageal Squamous Cell Carcinoma
Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population.
[The NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and susceptibility to esophageal cancer]
Fetal Resorption
Developmental role of nuclear factor E2-related factor 2 in mitigating methamphetamine fetal toxicity and postnatal neurodevelopmental deficits.
Glioblastoma
2-Methoxy-6-acetyl-7-methyljuglone (MAM) induced programmed necrosis in glioblastoma by targeting NAD(P)H: Quinone oxidoreductase 1 (NQO1).
Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells.
Glioma
Synergistic cytotoxicity induced by ?-solanine and ?-chaconine.
Heart Diseases
Diaphorase deficiency methaemoglobinaemia mimicking cardiac disease in pregnancy.
Down-Regulation of Porcine Heart Diaphorase Reactivity by Trimanganese Hexakis(3,5-Diisopropylsalicylate), Mn(3)(3,5-DIPS)6, and Down-Regulation of Nitric Oxide Synthase Reactivity by Mn(3)(3,5-DIPS)(6) and Cu(II)(2)(3,5-DIPS)(4).
Heart Failure
Altered number of diaphorase (NOS) positive neurons in the hypothalamus of rats with heart failure.
Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer.
Hematologic Neoplasms
Irradiation-induced p53 expression is attenuated in cells with NQO1 C465T polymorphism.
Hemolytic-Uremic Syndrome
NAD(P)H: quinone oxidoreductase 1 expression in kidney podocytes.
Hepatitis A
Elevations of hepatic quinone reductase, glutathione, and alpha- and mu-class glutathione S-transferase isoforms in mice with chronic hepatitis: a compensatory response to injury.
Hepatitis B
Epigenetic silencing of NAD(P)H:quinone oxidoreductase 1 by hepatitis B virus X protein increases mitochondrial injury and cellular susceptibility to oxidative stress in hepatoma cells.
Hepatitis C
[The enzyme activity of neutrophils of blood in patients with chronic viral hepatitis C depending on gender characteristics].
Hepatitis, Chronic
Elevations of hepatic quinone reductase, glutathione, and alpha- and mu-class glutathione S-transferase isoforms in mice with chronic hepatitis: a compensatory response to injury.
Hepatoblastoma
Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.
Huntington Disease
The effect of nitric oxide synthase inhibition on quinolinic acid toxicity in the rat striatum.
Hyperalgesia
The Inhibitory Effects of Slow-Releasing Hydrogen Sulfide Donors in the Mechanical Allodynia, Grip Strength Deficits, and Depressive-Like Behaviors Associated with Chronic Osteoarthritis Pain.
Treatment with 5-fluoro-2-oxindole Increases the Antinociceptive Effects of Morphine and Inhibits Neuropathic Pain.
Hyperglycemia
Nrf2 Suppression Delays Diabetic Wound Healing Through Sustained Oxidative Stress and Inflammation.
Hyperparathyroidism, Primary
Nitric Oxide Synthase in Human Parathyroid Glands and Parathyroid Adenomas.
Hypersensitivity
Patch testing with the textile dyes Disperse Orange 1 and Disperse Yellow 3 and some of their potential metabolites, and simultaneous reactions to para-amino compounds.
Quinone reductase inhibitors block SAPK/JNK and NFkappaB pathways and potentiate apoptosis.
Hypertension
Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity.
Enhanced activation of NAD(P)H: quinone oxidoreductase 1 attenuates spontaneous hypertension by improvement of endothelial nitric oxide synthase coupling via tumor suppressor kinase liver kinase B1/adenosine 5'-monophosphate-activated protein kinase-mediated guanosine 5'-triphosphate cyclohydrolase 1 preservation.
Hypoprothrombinemias
Effect of N-methyltetrazolethiol on liver microsomal vitamin K reductase.
In vivo effects of beta-lactam antibiotics and heterocyclic thiol compounds on vitamin K-dependent carboxylation activity and blood coagulation factors in vitamin K-deficient rats.
Hypotension, Orthostatic
Involvement of the ventrolateral medulla in parkinsonism with autonomic failure.
Infections
Bovine Herpesvirus 1 Productive Infection Led to Inactivation of Nrf2 Signaling through Diverse Approaches.
Combined therapy with chemotherapeutic agents and herpes simplex virus type 1 ICP34.5 mutant (HSV-1716) in human non-small cell lung cancer.
Differential regulation of wheat quinone reductases in response to powdery mildew infection.
Dying for Good: Virus-Bacterium Biofilm Co-evolution Enhances Environmental Fitness.
Inhibition of NFE2L2-Antioxidant Response Element Pathway by Mitochondrial Reactive Oxygen Species Contributes to Development of Cardiomyopathy and Left Ventricular Dysfunction in Chagas Disease.
Inflammatory Bowel Diseases
Investigation into drug release from colon-specific azoreductase-activated steroid prodrugs using in-vitro models.
Role of tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease prodrug balsalazide.
Influenza, Human
Organic synthesis and anti-influenza A virus activity of cyclobakuchiols A, B, C, and D.
Insulin Resistance
The expression of NAD(P)H:quinone oxidoreductase 1 is high in human adipose tissue, reduced by weight loss, and correlates with adiposity, insulin sensitivity, and markers of liver dysfunction.
Intellectual Disability
Mental retardation in methemoglobinemia due to diaphorase deficiency.
Intestinal Diseases
In-Situ Imaging of Azoreductase Activity in the Acute and Chronic Ulcerative Colitis Mice by a Near-Infrared Fluorescent Probe.
Ischemic Stroke
Association of cytochrome P4502E1 and NAD(P)H:quinone oxidoreductase 1 genetic polymorphisms with susceptibility to large artery atherosclerotic ischemic stroke: a case-control study in the Turkish population.
Kidney Calculi
Predisposition towards urolithiasis associated with the NQO1 null-allele.
Kidney Diseases
Systematic review of the nuclear factor erythroid 2-related factor 2 (NRF2) system in human chronic kidney disease: alterations, interventions, and relation to morbidity.
Kidney Neoplasms
Dicoumarol sensitizes renal cell carcinoma Caki cells to TRAIL-induced apoptosis through down-regulation of Bcl-2, Mcl-1 and c-FLIP in a NQO1-independent manner.
Leiomyoma
Cytoenzymology of benign and malignant tumours of the corpus uteri. I. Respiratory enzymes.
Leprosy
Carbohydrate metabolism of the murine leprosy bacillus. I. Studies on the respiratory enzyme system, especially the diaphorase and malic dehydrogenase activities.
Leukemia
A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators.
Associations of NQO1 C609T and NQO1 C465T polymorphisms with acute leukemia risk: a PRISMA-compliant meta-analysis.
Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway.
Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by alpha-lipoic acid in human leukemia HL-60 cells.
Detoxification ability and toxicity of quinones in mouse and human tumor cell lines used for anticancer drug screening.
Evaluation of selected lichens from iceland for cancer chemopreventive and cytotoxic activity.
Hydroquinone resistance in a murine myeloblastic leukemia cell line. Involvement of quinone reductase and glutathione-dependent detoxification in nonclassical multidrug resistance.
Hypothesis: phenol and hydroquinone derived mainly from diet and gastrointestinal flora activity are causal factors in leukemia.
Irradiation-induced p53 expression is attenuated in cells with NQO1 C465T polymorphism.
Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults.
Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children.
Molecular biomarkers for the study of childhood leukemia.
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese.
NAD(P)H:quinone oxidoreductase 1 null genotype is not associated with pediatric de novo acute leukemia.
NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis.
The association of a distinctive allele of NAD(P)H:quinone oxidoreductase with pediatric acute lymphoblastic leukemias with MLL fusion genes in Japan.
Leukemia, Erythroblastic, Acute
Alterations in electrophoretic mobility, diaphorase activity, and terminal differentiation induced in murine erythroleukemia lines by differentiating agents.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese.
Leukemia, Myeloid
Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia.
Leukemia, Myeloid, Acute
Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia.
Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy.
The frequencies of NAD(P)H quinone oxidoreductase (NQO1) variant allele in Israeli ethnic groups and the relationship of NQO1*2 to adult acute myeloid leukemia in Israeli patients.
Liver Cirrhosis, Biliary
Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury.
Liver Diseases
Nuclear factor erythroid 2-like 2 (Nrf2) expression in end-stage liver disease.
The expression of NAD(P)H:quinone oxidoreductase 1 is high in human adipose tissue, reduced by weight loss, and correlates with adiposity, insulin sensitivity, and markers of liver dysfunction.
Liver Neoplasms
Biochemical and histochemical properties of hepatic tumors of rainbow trout, Oncorhynchus mykiss.
Effects of the administration of anticoagulants on the activity of the enzyme-reduced NAD(P)H dehydrogenase in rat livers, hepatomas and precarcinomatous rat liver lesions.
Enzyme-activated nanoconjugates for tunable release of doxorubicin in hepatic cancer cells.
NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.
NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma.
Liver Neoplasms, Experimental
Experimental hepatomas: dehydrogenation of reduced pyridine nucleotides by the D-T diaphorase.
The activity of the D-T diaphorase in experimental hepatomas.
Lung Injury
Genetic ablation of Nrf2 enhances susceptibility to acute lung injury after traumatic brain injury in mice.
NAD(P)H:quinone oxidoreductase 1 protects lungs from oxidant-induced emphysema in mice.
Quercetin attenuates the hyperoxic lung injury in neonatal mice: Implications for Bronchopulmonary dysplasia (BPD).
Lung Neoplasms
A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.
Activity profile of the novel aziridinylbenzoquinones MeDZQ and RH1 in human tumour xenografts.
Analysis of NQO1, GSTP1, and MnSOD genetic polymorphisms on lung cancer risk in Taiwan.
Arsenite pretreatment enhances the cytotoxicity of mitomycin C in human cancer cell lines via increased NAD(P)H quinone oxidoreductase 1 expression.
Association of the NAD(P)H:quinone oxidoreductase (NQO1) 609C->T polymorphism with lung cancer risk among male smokers.
Association of the NAD(P)H:quinone oxidoreductase 609C-->T polymorphism with a decreased lung cancer risk.
Aziridinyl quinone antitumor agents based on indoles and cyclopent[b]indoles: structure-activity relationships for cytotoxicity and antitumor activity.
Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy.
Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.
Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility.
Discovery of Non-Quinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small Cell Lung Cancer.
Effects of 6-arylamino-5,8-quinolinediones and 6-chloro-7-arylamino-5,8-isoquinolinediones on NAD(P)H: quinone oxidoreductase (NQO1) activity and their cytotoxic potential.
Enhanced glycometabolism as a mechanism of NQO1 potentiated growth of NSCLC revealed by metabolomic profiling.
Evaluation of the risk of lung cancer associated with NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism in male current cigarette smokers from the Eastern India.
Evidence of differential cisplatin-DNA adduct formation, removal and tolerance of DNA damage in three human lung carcinoma cell lines.
Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer.
Genetic polymorphisms of NAD(P)H quinone oxidoreductase, CYP1A1 and microsomal epoxide hydrolase and lung cancer risk in Nanjing, China.
Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking.
Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1.
Lack of association between NADPH quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and lung cancer: a case-control study and a meta-analysis.
Lung cancer in Mexican-Americans and African-Americans is associated with the wild-type genotype of the NAD(P)H: quinone oxidoreductase polymorphism.
Modulation of Nad(P)H:quinone oxidoreductase (NQO1) activity mediated by 5-arylamino-2-methyl-4,7-dioxobenzothiazoles and their cytotoxic potential.
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and lung cancer risk: a meta-analysis.
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese.
NAD(P)H: quinone oxidoreductase polymorphism and lung cancer in Taiwan.
NAD(P)H:quinone oxidoreductase 1 Pro187Ser polymorphism and the risk of lung cancer: A meta-analysis.
NAD(P)H:quinone oxidoreductase-1 overexpression predicts poor prognosis in small cell lung cancer.
NQO1, MPO, and the risk of lung cancer: a HuGE review.
Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in Benzo(a)pyrene induced experimental lung carcinogenesis.
Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer.
Polymorphisms in the NAD(P)H: quinone oxidoreductase gene and small cell lung cancer risk in a UK population.
Protective role of mangiferin against Benzo(a)pyrene induced lung carcinogenesis in experimental animals.
Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines.
Sulindac compounds facilitate the cytotoxicity of ?-lapachone by up-regulation of NAD(P)H quinone oxidoreductase in human lung cancer cells.
The importance of DT-diaphorase and hypoxia in the cytotoxicity of RH1 in human breast and non-small cell lung cancer cell lines.
The NAD(P)H:quinone oxidoreductase 1 gene polymorphism and lung cancer: differential susceptibility based on smoking behavior.
The Role of NQO1 Polymorphisms in the Susceptibility and Chemotherapy Response of Chinese NSCLC Patients.
Lymphoma
Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas.
Induction of DT-diaphorase by 1,2-dithiole-3-thione and increase of antitumour activity of bioreductive agents.
Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents.
Induction of DT-diaphorase in cancer chemoprevention and chemotherapy.
Lymphoma, Non-Hodgkin
Role of the naphthoquinone moiety in the biological activities of sakyomicin A.
Malaria
Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria.
Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2).
Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages.
Manganese Poisoning
Dihydronicotinamide-adenine dinucleotide (NADH2) diaphorase, thiamine pyrophosphatase and acid phosphatase in the spinal cords of rabbits with chronic manganese poisoning.
Melanoma
17-Aminogeldanamycin selectively diminishes IRE1?-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAFV600E inhibitors in melanoma cells of different genetic subtypes.
A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent.
Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1.
Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines.
Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity.
Carnosic acid, an inducer of NAD(P)H quinone oxidoreductase 1, enhances the cytotoxicity of ?-lapachone in melanoma cell lines.
Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase.
Immunohistochemical localization of NAD(P)H:quinone oxidoreductase in conjunctival melanomas and primary acquired melanosis.
NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.
Reactive oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-kappaB in malignant melanoma cells.
Study of DT-diaphorase in pigment-producing cells.
The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
The expression of NAD(P)H:quinone oxidoreductase 1 is increased along with NF-kappaB p105/p50 in human cutaneous melanomas.
The NAD(P)H:Quinone Oxidoreductase 1 induces cell cycle progression and proliferation of melanoma cells.
Melanosis
Immunohistochemical localization of NAD(P)H:quinone oxidoreductase in conjunctival melanomas and primary acquired melanosis.
Memory Disorders
?-Lapachone attenuates cognitive impairment and neuroinflammation in beta-amyloid induced mouse model of Alzheimer's disease.
Transthyretin: a key gene involved in the maintenance of memory capacities during aging.
Metabolic Diseases
Biomarkers of Broccoli Consumption: Implications for Glutathione Metabolism and Liver Health.
Methemoglobinemia
Biochemical and functional properties of methemoglobin diaphorase in congenital methemoglobinemia.
Congenital methemoglobinemia due to diaphorase deficiency.
HEREDITARY DIAPHORASE DEFICIENCY AND METHEMOGLOBINEMIA.
Hereditary methemoglobinemia due to diaphorase deficiency in a Finnish child.
HEREDITARY METHEMOGLOBINEMIA DUE TO DIAPHORASE DEFICIENCY IN NAVAJO INDIANS.
Hereditary methemoglobinemia due to diaphorase deficiency. Report of a case of heterozygote presenting with cyanosis after birth.
Leukocyte diaphorase deficiency in congenital methemoglobinemia: a valuable prognostic indicator.
Mental retardation in methemoglobinemia due to diaphorase deficiency.
Studies on the congenital methemoglobinemia in Okinawa Island. II. Diaphorase activity.
The enzymic defect of hereditary methemoglobinemia: diaphorase.
The relation of diaphorase of human erythrocytes to inheritance of methemoglobinemia.
The structure of the S127P mutant of cytochrome b5 reductase that causes methemoglobinemia shows the AMP moiety of the flavin occupying the substrate binding site.
[A family with congenital methemoglobinemia due to diaphorase deficiency]
[Congenital methemoglobinemia caused by diaphorase deficency. (Study of 3 members of one family)]
[CONGENITAL METHEMOGLOBINEMIA OF THE RECESSIVE TYPE DUE TO DIAPHORASE DEFICIT WITH OLIGOPHRENIA.]
[Familial methemoglobinemia due to diaphorase deficiency: a 3d Swiss line]
Mitochondrial Myopathies
Changes in motor innervation and histochemical pattern of muscle fibers in some congenital myopathies.
Multiple Myeloma
Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma.
Multiple Sclerosis
NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions.
The C609T inborn polymorphism in NAD(P)H:quinone oxidoreductase 1 is associated with susceptibility to multiple sclerosis and affects the risk of development of the primary progressive form of the disease.
Multiple System Atrophy
Involvement of the ventrolateral medulla in parkinsonism with autonomic failure.
Muscular Diseases
Absence of nitric oxide synthase I despite the presence of the dystrophin complex in human striated muscle.
Myelodysplastic Syndromes
NAD(P)H: quinone oxidoreductase 1 deficiency conjoint with marginal vitamin C deficiency causes cigarette smoke induced myelodysplastic syndromes.
Myopathy, Central Core
Changes in motor innervation and histochemical pattern of muscle fibers in some congenital myopathies.
nad(p)h dehydrogenase (quinone) deficiency
Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase.
Congenital methemoglobinemia due to diaphorase deficiency.
Diaphorase deficiency methaemoglobinaemia mimicking cardiac disease in pregnancy.
HEREDITARY DIAPHORASE DEFICIENCY AND METHEMOGLOBINEMIA.
Hereditary methemoglobinemia due to diaphorase deficiency in a Finnish child.
HEREDITARY METHEMOGLOBINEMIA DUE TO DIAPHORASE DEFICIENCY IN NAVAJO INDIANS.
Hereditary methemoglobinemia due to diaphorase deficiency. Report of a case of heterozygote presenting with cyanosis after birth.
Hereditary methemoglobinemic cyanosis due to diaphorase deficiency in three successive generations.
Leukocyte diaphorase deficiency in congenital methemoglobinemia: a valuable prognostic indicator.
Mental retardation in methemoglobinemia due to diaphorase deficiency.
NAD(P)H: quinone oxidoreductase 1 deficiency conjoint with marginal vitamin C deficiency causes cigarette smoke induced myelodysplastic syndromes.
NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin.
NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis.
[A family with congenital methemoglobinemia due to diaphorase deficiency]
[Familial methemoglobinemia due to diaphorase deficiency: a 3d Swiss line]
nadh:ubiquinone reductase (h+-translocating) deficiency
The effects of idebenone on mitochondrial bioenergetics.
Neoplasm Metastasis
NQO1 as a Marker of Chemosensitivity and Prognosis for Colorectal Liver Metastasis.
Neoplasms
5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo.
609 C --> T polymorphism in NAD(P)H:quinone oxidoreductase gene in patients with prostatic adenocarcinoma or benign prostatic hyperplasia.
A comprehensive study of the active site residues of DT-diaphorase: rational design of benzimidazolediones as DT-diaphorase substrates.
A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy.
A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer.
A fluorescent turn-on probe for visualizing lysosomes in hypoxic tumor cells.
A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators.
A Model for NAD(P)H:Quinoneoxidoreductase 1 (NQO1) Targeted Individualized Cancer Chemotherapy.
A Near-Infrared, Wavelength-Shiftable, Turn-on Fluorescent Probe for the Detection and Imaging of Cancer Tumor Cells.
A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.
A Novel Class of CC-1065 and Duocarmycin Analogues Subject to Mitomycin-Related Reductive Activation.
A pH-Responsive Charge-Reversal Drug Delivery System with Tumor-Specific Drug Release and ROS Generation for Cancer Therapy.
A physiological threshold for protection against menadione toxicity by human NAD(P)H:quinone oxidoreductase (NQO1) in Chinese hamster ovary (CHO) cells.
A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent.
A self-immolative and DT-diaphorase-activatable prodrug for drug-release tracking and therapy.
A sequential enzyme-activated and light-triggered pro-prodrug nanosystem for cancer detection and therapy.
A Tumor-Specific Cascade Amplification Drug Release Nanoparticle for Overcoming Multidrug Resistance in Cancers.
Absolute configuration of novel bioactive flavonoids from Tephrosia purpurea.
Absolute quantification of NAD(P)H:quinone oxidoreductase 1 in human tumor cell lines and tissues by liquid chromatography-mass spectrometry/mass spectrometry using both isotopic and non-isotopic internal standards.
Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma.
Activation of the Nrf2/ARE signaling pathway by probucol contributes to inhibiting inflammation and neuronal apoptosis after spinal cord injury.
Activity and immunohistochemistry of DT-diaphorase in hamster and human kidney tumours.
Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.
Administration of the optimized ?-Lapachone-poloxamer-cyclodextrin ternary system induces apoptosis, DNA damage and reduces tumor growth in a human breast adenocarcinoma xenograft mouse model.
ALDH2 polymorphisms and bone mineral density in an elderly Japanese population.
Alternative splicing and differential expression of DT-diaphorase transcripts in human colon tumors and in peripheral mononuclear cells in response to mitomycin C treatment.
An efficient two-photon fluorescent probe for human NAD(P)H:quinone oxidoreductase (hNQO1) detection and imaging in tumor cells.
An improved cell-permeable fluorogenic substrate as the basis for a highly sensitive test for NAD(P)H quinone oxidoreductase 1 (NQO1) in living cells.
An NAD(P)H:quinone oxidoreductase 1 (NQO1) enzyme responsive nanocarrier based on mesoporous silica nanoparticles for tumor targeted drug delivery in vitro and in vivo.
An NAD(P)H:Quinone Oxidoreductase 1 Responsive and Self-Immolative Prodrug of 5-Fluorouracil for Safe and Effective Cancer Therapy.
An NIR-Fluorophore-Based Theranostic for Selective Initiation of Tumor Pyroptosis-Induced Immunotherapy.
An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis.
An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.
Anion-specific interaction with human NQO1 inhibits flavin binding.
Anti-inflammatory and Quinone Reductase-Inducing Compounds from Beilschmiedia mannii.
Antiangiogenic, bioreductive and gene therapy approaches to the treatment of hypoxic tumours.
Antioxidant response element-mediated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induction of human NAD(P)H:quinone oxidoreductase 1 gene expression.
Arsenite and cadmium, but not chromium, induce NAD(P)H:quinone oxidoreductase 1 through transcriptional mechanisms, in spite of post-transcriptional modifications.
Arsenite pretreatment enhances the cytotoxicity of mitomycin C in human cancer cell lines via increased NAD(P)H quinone oxidoreductase 1 expression.
Assessment of various formulation approaches for the application of beta-lapachone in prostate cancer therapy.
Association Between Polymorphisms in the Genes for Tumor Suppressor Protein p53 and its Regulator NAD(P)H: Quinone Oxidoreductase 1 (NQO1) and Schizophrenia in a Syrian Study Cohort.
Association of NQO1 and TNF polymorphisms with Parkinson's disease: A meta-analysis of 15 genetic association studies.
Associations between disease risk and eight polymorphisms adopted for genotype announcements at Nagoya University Hospital.
Aziridinyl quinone antitumor agents based on indoles and cyclopent[b]indoles: structure-activity relationships for cytotoxicity and antitumor activity.
Beccaridiol, an unusual 28-nortriterpenoid from the leaves of Diplectria beccariana.
Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.
Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.
Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.
Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum.
Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents.
Biochemical and histochemical properties of hepatic tumors of rainbow trout, Oncorhynchus mykiss.
Black tea polyphenols modulate xenobiotic-metabolizing enzymes, oxidative stress and adduct formation in a rat hepatocarcinogenesis model.
Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair.
Cancer Cell Sensitivity to Redox-Cycling Quinones is Influenced by NAD(P)H: Quinone Oxidoreductase 1 Polymorphism.
Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice.
Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes.
Cancer chemopreventive diterpenes from Salvia corrugata.
Cancer-Specific hNQO1-Responsive Biocompatible Naphthalimides Providing a Rapid Fluorescent Turn-On with an Enhanced Enzyme Affinity.
Carbazole-, Aspidofractinine-, and Aspidocarpamine-Type Alkaloids from Pleiocarpa pycnantha.
Carnosic acid, an inducer of NAD(P)H quinone oxidoreductase 1, enhances the cytotoxicity of ?-lapachone in melanoma cell lines.
Catechol estrogen metabolites and conjugates in different regions of the prostate of Noble rats treated with 4-hydroxyestradiol: implications for estrogen-induced initiation of prostate cancer.
Cellular approaches to bioreductive drug mechanisms.
Cellular kinetics of induction by oltipraz and its keto derivative of detoxication enzymes in human colon adenocarcinoma cells.
Cellular levels of class 1 and class 3 aldehyde dehydrogenases and certain other drug-metabolizing enzymes in human breast malignancies.
Chemical profile of mango (Mangifera indica L.) using electrospray ionisation mass spectrometry (ESI-MS).
Chemiluminescent Probe for the In?Vitro and In?Vivo Imaging of Cancers Over-Expressing NQO1.
Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE).
Chemoprevention of colon carcinogenesis by organosulfur compounds.
Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats.
Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers.
Cigarette smoking is a determinant of DT-diaphorase gene expression in human non-small cell lung carcinoma.
Clinical significance of a NAD(P)H: quinone oxidoreductase 1 polymorphism in patients with disseminated peritoneal cancer receiving intraperitoneal hyperthermic chemotherapy with mitomycin C.
Combination of Double-Mediator System with Large-Scale Integration-Based Amperometric Devices for Detecting NAD(P)H:quinone Oxidoreductase 1 Activity of Cancer Cell Aggregates.
Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.
Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase.
Contribution of NAD(P)H Quinone Oxidoreductase 1 (NQO1) Pro187Ser Polymorphism and Risks of Colorectal Adenoma and Cancer for Caucasians: A Meta-analysis.
Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors.
Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.
Covalent-Assembly Based Fluorescent Probes for Detection of hNQO1 and Imaging in Living Cells.
Current issues in the enzymology of mitomycin C metabolic activation.
Cutaneous NAD(P)H: quinone reductase: a xenobiotica-metabolizing enzyme with potential cancer and oxidation stress-protecting properties.
Cysteine and glutathione mixed-disulfide conjugates of thiosulfinates: chemical synthesis and biological activities.
Cytoenzymology of benign and malignant tumours of the corpus uteri. I. Respiratory enzymes.
Cytosolic NQO1 Enzyme-Activated Near-Infrared Fluorescence Imaging and Photodynamic Therapy with Polymeric Vesicles.
Cytotoxicity of RH1: NAD(P)H:quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction.
Cytotoxicity of the bioreductive agent RH1 and its lack of interaction with radiation.
Deficiency of NRH:quinone oxidoreductase 2 differentially regulates TNF signaling in keratinocytes: up-regulation of apoptosis correlates with down-regulation of cell survival kinases.
Dehydrogenation of reduced pyridine nucleotides by Leydig cell tumors of the rat testis.
Design and synthesis of NQO1 responsive fluorescence probe and its application in bio-imaging for cancer diagnosis.
Design of cancer-specific antitumor agents based on aziridinylcyclopent[b]indoloquinones.
Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.
Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer.
Detecting Attomolar DNA-Damaging Anticancer Drug Activity in Cell Lysates with Electrochemical DNA Devices.
Detection of (NAD(P)H:Quinone oxidoreductase-1, EC 1.6.99.2) 609C-->T and 465C-->T polymorphisms in formalin-fixed, paraffin-embedded human tumour tissue using PCR-RFLP.
Detoxifying enzymes in human ovarian tissues: comparison of normal and tumor tissues and effects of chemotherapy.
Development and validation of a spectrophotometric assay for measuring the activity of NADH: cytochrome b5 reductase in human tumour cells.
Development of a lyophilised RH1 formulation: a novel DT diaphorase activated alkylating agent.
Development of a second-generation radiofrequency ablation using sintered MgFe(2)O(4) needles and alternating magnetic field for human cancer therapy.
Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels.
Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells.
Dicoumarol impairs mitochondrial electron transport and pyrimidine biosynthesis in human myeloid leukemia HL-60 cells.
Dietary menhaden oil enhances mitomycin C antitumor activity toward human mammary carcinoma MX-1.
Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors.
Discovery of Natural Products Targeting NQO1 via an Approach Combining Network-Based Inference and Identification of Privileged Substructures.
Distinct responses of compartmentalized glutathione redox potentials to pharmacologic quinones targeting NQO1.
Distribution of DT-diaphorase and reduced nicotinamide adenine dinucleotide phosphate: cytochrome p450 oxidoreductase in bladder tissues and tumors.
DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas.
DT-diaphorase activity in NSCLC and SCLC cell lines: a role for fos/jun regulation.
DT-diaphorase and cancer chemotherapy.
DT-diaphorase as a critical determinant of sensitivity to mitomycin C in human colon and gastric carcinoma cell lines.
DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90.
DT-diaphorase in morbidly obese patients.
DT-diaphorase triggered theranostic nanoparticles induce the self-burst of reactive oxygen species for tumor diagnosis and treatment.
DT-diaphorase: possible roles in cancer chemotherapy and carcinogenesis.
Effect of ?-Eudesmol on NQO1 suppression-enhanced sensitivity of cholangiocarcinoma cells to chemotherapeutic agents.
Effect of anthocyanin fractions from selected cultivars of Georgia-grown blueberries on apoptosis and phase II enzymes.
Effects of 6-arylamino-5,8-quinolinediones and 6-chloro-7-arylamino-5,8-isoquinolinediones on NAD(P)H: quinone oxidoreductase (NQO1) activity and their cytotoxic potential.
Effects of different processing methods on induction of quinone reductase by dietary broccoli in rats.
Effects of psoralen from Psoralea corylifolia on quinone reductase, ornithine decarboxylase, and JB6 cells transformation promotion.
eIF2 kinases mediate ?-lapachone toxicity in yeast and human cancer cells.
Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cł.
Endophytic fungi associated with Taxus fuana (West Himalayan Yew) of Pakistan: potential bio-resources for cancer chemopreventive agents.
Engineering an NIR rhodol derivative with spirocyclic ring-opening activation for high-contrast photoacoustic imaging.
Enhanced activation of NAD(P)H: quinone oxidoreductase 1 attenuates spontaneous hypertension by improvement of endothelial nitric oxide synthase coupling via tumor suppressor kinase liver kinase B1/adenosine 5'-monophosphate-activated protein kinase-mediated guanosine 5'-triphosphate cyclohydrolase 1 preservation.
Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase.
Enhancement of the antineoplastic effect of mitomycin C by dietary fat.
Enzymatic and pH modulation of mitomycin C-induced DNA damage in mitomycin C-resistant HCT 116 human colon cancer cells.
Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase.
Enzyme-Triggered Disassembly of Polymeric Micelles by Controlled Depolymerization via Cascade Cyclization for Anticancer Drug Delivery.
Enzymology of mitomycin C metabolic activation in tumour tissue. Characterization of a novel mitochondrial reductase.
Enzymology of mitomycin C metabolic activation in tumour tissue: implications for enzyme-directed bioreductive drug development.
Enzymology of the reduction of the potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR 4233 (WIN 59075) by NAD(P)H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells.
Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.
EO9: relationship between DT-diaphorase levels and response in vitro and in vivo.
Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo.
Evaluation of selected lichens from iceland for cancer chemopreventive and cytotoxic activity.
Evaluation of urinary N-acetyl cysteinyl allyl isothiocyanate as a biomarker for intake and bioactivity of Brussels sprouts.
Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro.
Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia.
Factors influencing the induction of DT-diaphorase activity by 1,2-dithiole-3-thione in human tumor cell lines.
FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1.
Following anticancer drug activity in cell lysates with DNA devices.
Free radical generation by redox cycling of estrogens.
Gamma-tocopherol supplementation ameliorated hyper-inflammatory response during the early cutaneous wound healing in alloxan-induced diabetic mice.
Gene targeting of DT-diaphorase in mouse embryonic stem cells: establishment of null mutant and its mitomycin C-resistance.
Genetic ablation of Nrf2 enhances susceptibility to acute lung injury after traumatic brain injury in mice.
Genetic polymorphism and cancer risk.
Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer.
Genotoxicity, cytotoxicity and chemical profile from Inga laurina (Fabaceae).
Genotype announcement in a genetic polymorphism study for health checkup examinees at Nagoya University Hospital.
Genotyping of NAD(P)H:quinone oxidoreductase (NQO1) in a panel of human tumor xenografts: relationship between genotype status, NQO1 activity and the response of xenografts to Mitomycin C chemotherapy in vivo(1).
Heat-induced up-regulation of NAD(P)H:quinone oxidoreductase potentiates anticancer effects of beta-lapachone.
Hedera nepalensis K. Koch: A Novel Source of Natural Cancer Chemopreventive and Anticancerous Compounds.
High levels of expression of the NAD(P)H:quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin.
Histochemistry of therapeutically relevant enzymes in human tumours transplanted into severe combined immunodeficient (SCID) mice: nitric oxide synthase-associated diaphorase, beta-D-glucuronidase and non-specific alkaline phosphatase.
Human DT-diaphorase, a potential cancer protecting enzyme. Its purification from abdominal adipose tissue.
Human NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan.
Human NAD(P)H:quinone oxidoreductase type I (hNQO1) activation of quinone propionic acid trigger groups.
Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells.
Identification of dialkyl diacetylene diols with potent cancer chemopreventive activity.
Identification of jun-B as third member in human antioxidant response element-nuclear proteins complex.
Identification of novel NAD(P)H dehydrogenase [quinone] 1 antagonist using computational approaches.
Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy.
Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors.
Immunohistochemical localization of NAD(P)H:quinone oxidoreductase in conjunctival melanomas and primary acquired melanosis.
Immunohistochemical localization of NQO1 in epithelial dysplasia and neoplasia and in donor eyes.
Immunological quantitation of DT-diaphorase in carcinoma cell lines and clinical colon cancers: advanced tumors express greater levels of DT-diaphorase.
Impact of tumor blood flow modulation on tumor sensitivity to the bioreductive drug banoxantrone.
In vitro and in vivo regulation of antioxidant response element-dependent gene expression by estrogens.
In vitro anticancer activity of fruit extracts from Vaccinium species.
In vivo relevance of two critical levels for NAD(P)H:quinone oxidoreductase (NQO1)-mediated cellular protection against electrophile toxicity found in vitro.
Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies.
Increased levels of NAD(P)H: quinone oxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A Potential biomarker of early damage in the pancreas.
Increased levels of NAD(P)H: quinone oxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A potential biomarker of early damage in the pancreas.
Increased tumor necrosis factor-alpha sensitivity of MCF-7 cells transfected with NAD(P)H:quinone reductase.
Indolequinone antitumour agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase.
INDQ/NO, a bioreductively activated nitric oxide prodrug.
Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents.
Induction of DT-diaphorase by doxorubicin and combination therapy with mitomycin C in vitro.
Induction of DT-diaphorase in cancer chemoprevention and chemotherapy.
Induction of NAD (P)H: Quinone reductase 1 (QR1) and antioxidant activities in vitro of 'Toranja Burarama' (Citrus maxima [Burm.] Merr.).
Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer.
Induction of quinone reductase activity by stilbene analogs in mouse Hepa 1c1c7 cells.
Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells.
Induction of quinone reductase by withanolides isolated from Physalis philadelphica (tomatillos).
Induction of rat pancreatic glutathione S-transferase and quinone reductase activities by a mixture of glucosinolate breakdown derivatives found in Brussels sprouts.
Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: A mechanism of cancer chemoprotection.
Inflammatory cytokines suppress NAD(P)H:quinone oxidoreductase-1 and induce oxidative stress in cholangiocarcinoma cells.
Inhibition of estrogen-induced kidney carcinogenesis in Syrian hamsters by modulators of estrogen metabolism.
Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.
Inhibition of p300/CBP-Associated Factor Attenuates Renal Tubulointerstitial Fibrosis through Modulation of NF-kB and Nrf2.
Integrated block copolymer prodrug nanoparticles for combination of tumor oxidative stress amplification and ROS-responsive drug release.
Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems.
Investigation of an NQO1 polymorphism as a possible risk and prognostic factor for chronic lymphocytic leukemia.
Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species.
Isolation and identification of phase II enzyme-inducing agents from nonpolar extracts of green onion (Allium spp.).
Isolation and identification of potential cancer chemopreventive agents from methanolic extracts of green onion (Allium cepa).
Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells.
Lack of NQO1 induction in human tumor cells is not due to changes in the promoter region of the gene.
Light-Enhanced Hypoxia-Response of Conjugated Polymer Nanocarrier for Successive Synergistic Photodynamic and Chemo-Therapy.
Low expression of NQO1 predicts pathological complete response to neoadjuvant chemotherapy in breast cancer patients treated with TAC regimen.
Lupeol, a triterpene, prevents free radical mediated macromolecular damage and alleviates benzoyl peroxide induced biochemical alterations in murine skin.
MAK-4 and -5 supplemented diet inhibits liver carcinogenesis in mice.
Measuring NQO1 Bioactivation Using [2H7]Glucose.
Mechanism of inhibition of estrogen-induced renal carcinogenesis in male Syrian hamsters by vitamin C.
Mesoporous nanocarriers with a stimulus-responsive cyclodextrin gatekeeper for targeting tumor hypoxia.
Minor withanolides from Physalis philadelphica: structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation as artifacts.
miRNA-7a-2-3p Inhibits Neuronal Apoptosis in Oxygen-Glucose Deprivation (OGD) Model.
Mitochondria-targeted aggregation induced emission theranostics: crucial importance of in situ activation.
Mitomycin C is not metabolized by but is an inhibitor of human kidney NAD(P)H: (quinone-acceptor)oxidoreductase.
Modulation of Nad(P)H:quinone oxidoreductase (NQO1) activity mediated by 5-arylamino-2-methyl-4,7-dioxobenzothiazoles and their cytotoxic potential.
Modulation of xenobiotic-metabolizing enzymes by ethanolic neem leaf extract during hamster buccal pouch carcinogenesis.
Molecular basis of the catalytic differences among DT-diaphorase of human, rat, and mouse.
Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2.
Molecular targeting of mitomycin C chemotherapy.
Multifunctional Programmable DNA Nanotrain for Activatable Hypoxia Imaging and Mitochondrion-Targeted Enhanced Photodynamic Therapy.
NAD(P)H quinone oxidoreductase 1 (NQO1) genetic C609T polymorphism is associated with the risk of digestive tract cancer: a meta-analysis based on 21 case-control studies.
NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b).
NAD(P)H Quinone Oxidoreductase-1 in Organ and Tumor Tissues: Distinct Activity Levels Observed with a Benzo-rosol-Based Dual-Excitation and Dual-Emission Probe.
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T gene polymorphism association with digestive tract cancer: a meta-analysis.
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese.
NAD(P)H: quinone oxidoreductase 1 and NRH:quinone oxidoreductase 2 polymorphisms in papillary thyroid microcarcinoma: correlation with phenotype.
NAD(P)H:Quinone Oxidoreductase 1 (NQO1) as a Therapeutic and Diagnostic Target in Cancer.
NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis.
NAD(P)H:quinone oxidoreductase 1 Pro187Ser polymorphism and expression do not cosegregate with clinico-pathological characteristics of human mammary tumors.
NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by ?-lapachone.
Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway.
Natural inhibitors of carcinogenesis.
Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues.
Neoflavonoids and Tetrahydroquinolones as Possible Cancer Chemopreventive Agents.
New lanostanoids from Ganoderma lucidum that induce NAD(P)H:quinone oxidoreductase in cultured hepalcic7 murine hepatoma cells.
Nitroimidazole adducts as markers for tissue hypoxia: mechanistic studies in aerobic normal tissues and tumour cells.
No association of NAD(P)H quinone oxidoreductase 1 expression with p53 expression or tumour outcome in patients with superficial and minimally invasive urothelial bladder cancers.
Nonenzymatic reductive activation of 7-N-((2-([2-(gamma-L-glutamylamino)ethyl]dithio)ethyl))mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor cells.
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
Novel anti-tumour activity of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4- benzoquinone (CV-6504) against established murine adenocarcinomas (MAC).
Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation.
Novel tumor-ablation device for liver tumors utilizing heat energy generated under an alternating magnetic field.
NQO1 expression in pancreatic cancer and its potential use as a biomarker.
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance.
NQO1-activated phenothiazinium redox cyclers for the targeted bioreductive induction of cancer cell apoptosis.
Nrf2: control of sensitivity to carcinogens.
NRH:quinone oxidoreductase 2 and NAD(P)H:quinone oxidoreductase 1 protect tumor suppressor p53 against 20s proteasomal degradation leading to stabilization and activation of p53.
Nuclear factor E2-related factor 2 knockdown enhances glucose uptake and alters glucose metabolism in AML12 hepatocytes.
Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC ?/?II by Gymnasterkoreayne B.
Over-expression of DT-diaphorase in transfected NIH 3T3 cells does not lead to increased anticancer quinone drug sensitivity: a questionable role for the enzyme as a target for bioreductively activated anticancer drugs.
Over-expression of glutathione S-transferases, DT-diaphorase and an apparently tumour-specific cytosolic class-3 aldehyde dehydrogenase by Warthin tumours and mucoepidermoid carcinomas of the human parotid gland.
Overexpression of NAD(P)H: Quinone Oxidoreductase 1 Inhibits Hepatocellular Carcinoma Cell Proliferation and Induced Apoptosis by Activating AMPK/PGC-1? Pathway.
Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen.
Pertussis toxin-induced alterations of murine hepatic drug metabolism following administration of diphtheria and tetanus toxoids and pertussis vaccine adsorbed.
pH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin.
Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species.
Pharmacological inhibitors of NAD(P)H quinone oxidoreductase, NQO1: structure/activity relationships and functional activity in tumour cells.
Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice.
Phase 1 study of ARQ 761, a ?-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis.
Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1.
Phase I study of napabucasin in combination with FOLFIRI?+?bevacizumab in Japanese patients with metastatic colorectal cancer.
Possible role of DT-diaphorase in the bioactivation of antitumor quinones.
Potential chemopreventive activity of a new macrolide antibiotic from a marine-derived Micromonospora sp.
Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.
Potentiation of CB 1954 cytotoxicity by reduced pyridine nucleotides in human tumour cells by stimulation of DT diaphorase activity.
Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours.
Predicting tumor responses to mitomycin C on the basis of DT-diaphorase activity or drug metabolism by tumor homogenates: implications for enzyme-directed bioreductive drug development.
Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches.
Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction.
Quinone reductase activity in the first trimester placenta: effect of cigarette smoking and polycyclic aromatic hydrocarbons.
Quinone reductase induction as a biomarker for cancer chemoprevention.
Radiofrequency ablation as local therapy for early breast carcinomas.
Rapid isolation and purification of 1-cyano-2-hydroxy-3-butene (crambene) from Crambe abyssinica seed meal using immiscible solvent extraction and high-performance liquid chromatography.
Reactive oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-kappaB in malignant melanoma cells.
Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites.
Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.
Relationship between the antioxidant enzyme DT-diaphorase and tumor response to mitomycin C treatment.
Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines.
Relevance of DT-diaphorase activity to mitomycin C (MMC) efficacy on human cancer cells: differences in in vitro and in vivo systems.
Retraction: NRH:Quinone Oxidoreductase 2 and NAD(P)H:Quinone Oxidoreductase 1 Protect Tumor Suppressor p53 against 20S Proteasomal Degradation Leading to Stabilization and Activation of p53.
Role of NAD(P)H:quinone oxidoreductase 1 on tumor necrosis factor-alpha-induced migration of human vascular smooth muscle cells.
Role of NAD(P)H:quinone oxidoreductase polymorphism at codon 187 in susceptibility to lung, laryngeal and oral/pharyngeal cancers.
Role of Nrf2 in Protection against Traumatic Brain Injury in Mice.
Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs.
Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.
Shedding light by cancer redox-human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye.
Signal transduction pathways leading to cell cycle arrest and apoptosis induction in cancer cells by Allium vegetable-derived organosulfur compounds: a review.
Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones.
Structure-activity study with bioreductive benzoquinone alkylating agents: effects on DT-diaphorase-mediated DNA crosslink and strand break formation in relation to mechanisms of cytotoxicity.
Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells.
Sulindac compounds facilitate the cytotoxicity of ?-lapachone by up-regulation of NAD(P)H quinone oxidoreductase in human lung cancer cells.
Suppression of NAD(P)H-quinone oxidoreductase 1 enhanced the susceptibility of cholangiocarcinoma cells to chemotherapeutic agents.
Surfactant protein D protects against acute hyperoxic lung injury.
Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1).
Systemic delivery and preclinical evaluation of Au nanoparticle containing beta-lapachone for radiosensitization.
Tailoring targeted therapy to individual patients: lessons to be learnt from the development of mitomycin C.
Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer.
Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin.
The Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt) is required for tumor initiation by benzo(a)pyrene.
The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
The enzymology of doxorubicin quinone reduction in tumour tissue.
The human dioxin-inducible NAD(P)H: quinone oxidoreductase cDNA-encoded protein expressed in COS-1 cells is identical to diaphorase 4.
The Inhibition Kinetics and Potential Anti-Migration Activity of NQO1 Inhibitory Coumarins on Cholangiocarcinoma Cells.
The NQO1 bioactivatable drug, ?-Lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.
The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis.
The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233).
The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.
The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.
The role of rhynchophylline in alleviating early brain injury following subarachnoid hemorrhage in rats.
The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction.
Transcription Factor Nrf2 Plays a Pivotal Role in Protection Against Traumatic Brain Injury-Induced Acute Intestinal Mucosal Injury in Mice.
Transcriptional modulation of the NAD(P)H:quinone oxidoreductase 1 by mercury in human hepatoma HepG2 cells.
Tumor-Selective, Futile Redox Cycle-Induced Bystander Effects Elicited by NQO1 Bioactivatable Radiosensitizing Drugs in Triple-Negative Breast Cancers.
Tumor-Specific Expansion of Oxidative Stress by Glutathione Depletion and Use of a Fenton Nanoagent for Enhanced Chemodynamic Therapy.
Ultrasound-guided laser-induced thermal therapy for small palpable invasive breast carcinomas: a feasibility study.
Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells.
Use of quinones in brain-tumor therapy: preliminary results of preclinical laboratory investigations.
Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer.
Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.
Xenobiotic metabolizing enzymes in genetically and chemically initiated mouse liver tumors.
Xenobiotic-metabolising enzymes in patients with adenocarcinoma of the breast: Correlation with clinical stage and menopausal status.
Xenobiotic-metabolizing enzymes in canine mammary tumours.
[Acquisition of resistance associated with impairment of metabolic activation of anticancer drugs]
[Approaches to a selective chemotherapy of hepatocellular carcinoma (author's transl)]
[Induction of NAD(P)H: quinone reductase by anticarcinogenic ingredients of tea]
[Mitomycin C and its bioreduction: relevance of NAD(P)H: quinone oxidoreductase activity to mitomycin C-induced DNA damage and cytotoxicity]
Neuralgia
Analgesic and Antidepressant Effects of Oltipraz on Neuropathic Pain in Mice by Modulating Microglial Activation.
Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain.
Treatment with 5-fluoro-2-oxindole Increases the Antinociceptive Effects of Morphine and Inhibits Neuropathic Pain.
Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated.
Neuroblastoma
A genomic screen for activators of the antioxidant response element.
Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1.
Potent induction of total cellular GSH and NQO1 as well as mitochondrial GSH by 3H-1,2-dithiole-3-thione in SH-SY5Y neuroblastoma cells and primary human neurons: protection against neurocytotoxicity elicited by dopamine, 6-hydroxydopamine, 4-hydroxy-2-nonenal, or hydrogen peroxide.
Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by alpha-lipoic acid in human neuroblastoma SH-SY5Y cells: protection against neurotoxicant-elicited cytotoxicity.
Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway.
Sulforaphane as an Inducer of Glutathione Prevents Oxidative Stress-induced Cell Death in a Dopaminergic-like Neuroblastoma Cell Line.
The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats.
The single subunit NADH dehydrogenase reduces generation of reactive oxygen species from complex I.
Neurodegenerative Diseases
Discovery of Natural Products Targeting NQO1 via an Approach Combining Network-Based Inference and Identification of Privileged Substructures.
Enhanced NAD(P)H:quinone reductase activity prevents glutamate toxicity produced by oxidative stress.
Neuroectodermal Tumors
[Histochemistry of the oxidation-reduction enzymes in the cells of neuroectodermal tumors]
Neuroinflammatory Diseases
?-Lapachone attenuates cognitive impairment and neuroinflammation in beta-amyloid induced mouse model of Alzheimer's disease.
Neutropenia
ABCB1 polymorphism as a predictive biomarker for amrubicin-induced neutropenia.
Nijmegen Breakage Syndrome
Polymorphisms in DNA repair and metabolic genes in bladder cancer.
Obesity
Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity.
NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes.
Odontogenic Cysts
Enzyme histochemical studies on the formation of hyalin bodies in the epithelium of odontogenic cysts.
Osteoarthritis
The Inhibitory Effects of Slow-Releasing Hydrogen Sulfide Donors in the Mechanical Allodynia, Grip Strength Deficits, and Depressive-Like Behaviors Associated with Chronic Osteoarthritis Pain.
Ovarian Neoplasms
Characteristics of ovarian cancer detection by a near-infrared fluorescent probe activated by human NAD(P)H: quinone oxidoreductase isozyme 1 (hNQO1).
Genetic variants in SOD2, MPO, and NQO1, and risk of ovarian cancer.
Increased DT-diaphorase expression and cross-resistance to mitomycin C in a series of cisplatin-resistant human ovarian cancer cell lines.
NAD(P)H:quinone oxidoreductase 1 and nrh:quinone oxidoreductase 2 activity and expression in bladder and ovarian cancer and lower NRH:quinone oxidoreductase 2 activity associated with an NQO2 exon 3 single-nucleotide polymorphism.
Rational design of pyrrolo.
Pancreatic Diseases
Genetic polymorphism of N-acetyltransferases, glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase in relation to malignant and benign pancreatic disease risk. The International Pancreatic Disease Study Group.
Pancreatic Neoplasms
5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo.
Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.
Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells.
DNA damage induced by KP372-1 hyperactivates PARP1 and enhances lethality of pancreatic cancer cells with PARP inhibition.
Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1.
Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of ?-lapachone for pancreatic cancer therapy.
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(Allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells.
Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.
Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancer.
Targeting NAD(P)H:Quinone oxidoreductase (NQO1) in pancreatic cancer.
Targeting NAD(P)H:Quinone Oxidoreductase (NQO1) in Pancreatic Cancer.
Pancreatitis
Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells.
Parasitemia
Antimalarial activity of nepodin isolated from Rumex crispus.
Parathyroid Neoplasms
Nitric Oxide Synthase in Human Parathyroid Glands and Parathyroid Adenomas.
Parkinson Disease
Effects of the DT-diaphorase inhibitor dicumarol on striatal monoamine levels in L-DOPA and L-deprenyl pre-treated rats.
On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: mitochondria damage, necrosis, and hydroxyl radical formation.
Overexpression of NQO1 protects human SK-N-MC neuroblastoma cells against dopamine-induced cell death.
Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson's disease. Possible neuroprotective role of DT-diaphorase.
[A study on the relationship between polymorphism of human NAD(P)H: quinone oxidoreductase and Parkinson's disease in Chinese]
[Polymorphism of MAO-B gene and NAD(P)H: quinone oxidoreductase gene in Parkinson's disease]
Peptic Ulcer
[Activity of gastric mucosal NO synthase in duodenal ulcer]
Pneumonia
Lack of Transcription Factor p53 Exacerbates Elastase-Induced Emphysema in Mice.
Pouchitis
Azoreductase and nitroreductase activity of bacteria in feces from patients with an ileal reservoir.
Pre-Eclampsia
L-arginine depletion in preeclampsia orients nitric oxide synthase toward oxidant species.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Excess transmission of the NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in families of children with acute lymphoblastic leukemia.
Genetic polymorphism of NAD(P)H:quinone oxidoreductase is associated with an increased risk of infant acute lymphoblastic leukemia without MLL gene rearrangements.
Increased Risk for Acute Lymphoblastic Leukemia in Children with Cytochrome P(450) A(1)(CYP1A1)- and NAD(P)H:Quinone Oxidoreductase 1 (NQO1)-Inherited Gene Variants.
Molecular biomarkers for the study of childhood leukemia.
NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis.
Prostatic Hyperplasia
609 C --> T polymorphism in NAD(P)H:quinone oxidoreductase gene in patients with prostatic adenocarcinoma or benign prostatic hyperplasia.
NAD(P)H-quinone oxidoreductase 1 silencing aggravates hormone-induced prostatic hyperplasia in mice.
Prostatic Neoplasms
?-Lapachone Induces NQO1- and Oxidative Stress-Dependent Hsp90 Cleavage and Inhibits Tumor Growth and Angiogenesis.
beta-Lapachone-induced apoptosis in human prostate cancer cells: involvement of NQO1/xip3.
Identification of potential prostate cancer preventive agents through induction of quinone reductase in vitro.
Intratumoral delivery of beta-lapachone via polymer implants for prostate cancer therapy.
Investigation of NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in prostate cancer.
NAD(P)H:Quinone Oxidoreductase 1 (NQO1) P187S Polymorphism and Prostate Cancer Risk in Caucasians.
Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation.
Pulmonary Disease, Chronic Obstructive
Functional characterisation of bone marrow-derived mesenchymal stromal cells from COPD patients.
Pyloric Stenosis, Hypertrophic
Nitric oxide synthase activity in infantile hypertrophic pyloric stenosis.
Rectal Neoplasms
Napabucasin (BBI 608), a potent chemoradiosensitizer in rectal cancer.
Sarcoma
Cytoenzymology of benign and malignant tumours of the corpus uteri. I. Respiratory enzymes.
Sarcoma, Synovial
NAD(P)H Quinone Oxidoreductase 1 (NQO1)-Bioactivated Pronqodine A Regulates Prostaglandin Release from Human Synovial Sarcoma Cells.
Seizures
Activation of Nrf2-ARE signal pathway in hippocampus of amygdala kindling rats.
Skin Neoplasms
Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to 20S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancer.
Stress-induced NQO1 controls stability of C/EBP? against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancer.
Small Cell Lung Carcinoma
NAD(P)H:quinone oxidoreductase-1 overexpression predicts poor prognosis in small cell lung cancer.
Polymorphisms in the NAD(P)H: quinone oxidoreductase gene and small cell lung cancer risk in a UK population.
Spinal Cord Injuries
Histochemical evidence of the increased expression of nicotinamide adenine dinucleotide phosphate-dependent diaphorase in neurons of the myenteric plexus after acute spinal cord injury in adult rats.
Squamous Cell Carcinoma of Head and Neck
Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy.
Starvation
Characterization and analysis of an NAD(P)H dehydrogenase transcriptional regulator critical for the survival of cyanobacteria facing inorganic carbon starvation and osmotic stress.
Stomach Neoplasms
A Diagnostic Method for Gastric Cancer Using Two-Photon Microscopy With Enzyme-Selective Fluorescent Probes: A Pilot Study.
Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase.
Meta-analysis demonstrates that the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene 609 C>T polymorphism is associated with increased gastric cancer risk in Asians.
Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation.
[Interaction between polymorphisms in NQO1(C609T) and XRCC1(G28152A) and their correlation with smoking on gastric cancer.]
Tardive Dyskinesia
No association between a functional NAD(P)H: quinone oxidoreductase gene polymorphism (Pro187Ser) and tardive dyskinesia.
Thrombocytopenia
NAD(P)H: quinone oxidoreductase 1 expression in kidney podocytes.
Thyroid Nodule
[Cyto-inactivation instantly induced by microwave ablation on thyroid nodules].
Triple Negative Breast Neoplasms
Following anticancer drug activity in cell lysates with DNA devices.
NAD(P)H:quinone oxidoreductase 1 determines radiosensitivity of triple negative breast cancer cells and is controlled by long non-coding RNA NEAT1.
Tuberculosis
Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level.
Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis.
Rv3303c of Mycobacterium tuberculosis protects tubercle bacilli against oxidative stress in vivo and contributes to virulence in mice.
Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria.
Urinary Bladder Diseases
Distribution of DT-diaphorase and reduced nicotinamide adenine dinucleotide phosphate: cytochrome p450 oxidoreductase in bladder tissues and tumors.
Urinary Bladder Neoplasms
A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9.
Association between NAD(P)H:quinone oxidoreductase 1 rs1800566 polymorphism and risk of bladder cancer.
Association of Bladder Cancer Risk with an NAD(P)H:Quinone Oxidoreductase Polymorphism in an Ethnic Kashmiri Population.
CYP2E1 and NQO1 genotypes and bladder cancer risk in a Lebanese population.
Distribution of DT-diaphorase and reduced nicotinamide adenine dinucleotide phosphate: cytochrome p450 oxidoreductase in bladder tissues and tumors.
Evaluation of isothiocyanates as potent inducers of carcinogen-detoxifying enzymes in the urinary bladder: critical nature of in vivo bioassay.
Expression of DT-diaphorase and cytochrome P450 reductase correlates with mitomycin C activity in human bladder tumors.
Genetic polymorphisms in NQO1 and SOD2: Interactions with smoking, schistosoma infection, and bladder cancer risk in Egypt.
Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy.
Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts.
Inhibition of urinary bladder carcinogenesis by aqueous extract of sclerotia of Polyporus umbellatus fries and polyporus polysaccharide.
Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina.
NAD(P)H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C.
No association of NAD(P)H quinone oxidoreductase 1 expression with p53 expression or tumour outcome in patients with superficial and minimally invasive urothelial bladder cancers.
Pesticide, Gene Polymorphisms and Bladder Cancer among Egyptian Agricultural Workers.
Polymorphisms in DNA repair and metabolic genes in bladder cancer.
The NQO1 rs1800566 Polymorphism and Risk of Bladder Cancer: Evidence from 6,169 Subjects.
Uterine Cervical Neoplasms
Association of the NAD(P)H: quinone oxidoreductase C609T polymorphism and the risk of cervical cancer in Japanese subjects.
NAD(P)H: quinone oxidoreductase 1 gene rs1800566 polymorphism increases the risk of cervical cancer in a Chinese Han sample: A STROBE-complaint case-control study.
Vascular System Injuries
Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation.
The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction.
Virus Diseases
[Diaphorase activity at the conjunctival level in an experimentally produced viral infection]
Vitamin A Deficiency
Effects of vitamin A deficiency on selected xenobiotic-metabolizing enzymes and defenses against oxidative stress in mouse liver.
Xeroderma Pigmentosum
Impact of Occupational Exposures and Genetic Polymorphisms on Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer.
Polymorphisms in DNA repair and metabolic genes in bladder cancer.