Information on EC 1.7.1.9 - nitroquinoline-N-oxide reductase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.7.1.9
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RECOMMENDED NAME
GeneOntology No.
nitroquinoline-N-oxide reductase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
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redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
37256-35-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.015
4-Nitroquinoline N-oxide
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-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.032
-
activity in cheek mucosa
0.07
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activity in corpus ventriculi and pyloric antrum
0.084
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activity in tongue mucosa
0.1
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activity in duodenum
0.12
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activity in esophagus
0.15
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activity in ileum and rectum
0.18
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activity in esophagus and caecum, cofactor NADH
0.25
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activity in forestomach and colon
0.3
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activity in cytosol from mucous membrane of esophagus
0.5
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activity in esophagus
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
200000
-
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partially
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