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Disease on EC 1.8.1.4 - dihydrolipoyl dehydrogenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) deficiency
Immunoextraction of lipoamide dehydrogenase from cultured skin fibroblasts in patients with combined alpha-ketoacid dehydrogenase deficiency.
Acidosis
Deficiency of dihydrolipoamide dehydrogenase due to two mutant alleles (E340K and G101del). Analysis of a family and prenatal testing.
Acidosis, Lactic
A defect in branched-chain amino acid metabolism in a patient with congenital lactic acidosis due to dihydrolipoyl dehydrogenase deficiency.
Congenital lactic acidosis, alpha-ketoglutaric aciduria and variant form of maple syrup urine disease due to a single enzyme defect: dihydrolipoyl dehydrogenase deficiency.
Deficiency of dihydrolipoyl dehydrogenase (a component of the pyruvate and alpha-ketoglutarate dehydrogenase complexes): a cause of congenital chronic lactic acidosis in infancy.
Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brain.
Leigh disease with deficiency of lipoamide dehydrogenase: treatment failure with dichloroacetate.
Lipoamide dehydrogenase deficiency with primary lactic acidosis: favorable response to treatment with oral lipoic acid.
Novel mutations in a boy with dihydrolipoamide dehydrogenase deficiency.
Pyruvate dehydrogenase subcomplex with lipoamide dehydrogenase deficiency in a patient with lactic acidosis and branched chain ketoaciduria.
Alzheimer Disease
A metabolic signature for long life in the Caenorhabditis elegans Mit mutants.
An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain.
Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish population.
Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease.
Dihydrolipoamide dehydrogenase suppression induces human tau phosphorylation by increasing whole body glucose levels in a C. elegans model of Alzheimer's Disease.
Suppression of a core metabolic enzyme dihydrolipoamide dehydrogenase (dld) protects against amyloid beta toxicity in C. elegans model of Alzheimer's disease.
Testing for linkage and association across the dihydrolipoyl dehydrogenase gene region with Alzheimer's disease in three sample populations.
Angiomyolipoma
Nicotinamide adenine dinucleotide staining immediately following radio frequency ablation of renal tumors-is a positive stain synonymous with ablative failure?
Aphasia
The evolution and pathology of frontotemporal dementia.
Aphasia, Primary Progressive
Clinical, neuroimaging, and pathologic features of progressive nonfluent aphasia.
Histopathological changes underlying frontotemporal lobar degeneration with clinicopathological correlation.
Ataxia
An investigation of pyruvate metabolism in patients with cerebellar and spinocerebellar degeneration.
Clinical correlations of partial deficiency of lipoamide dehydrogenase.
Evidence for a primary defect of lipoamide dehydrogenase in Friedreich's ataxia.
Leigh syndrome due to compound heterozygosity of dihydrolipoamide dehydrogenase gene mutations. Description of the first E3 splice site mutation.
Lipoamide dehydrogenase: rapid heat inactivation in platelets of patients with recessively inherited ataxia.
Preclinical diagnosis and carrier detection in ataxia associated with abnormalities of lipoamide dehydrogenase.
Pyruvate dehydrogenase, lipoamide dehydrogenase and citrate synthase activity in fibroblasts from patients with Friedreich's and Charlevoix-Saguenay ataxia.
Ataxia Telangiectasia
MicroRNA-361-5p slows down gliomas development through regulating UBR5 to elevate ATMIN protein expression.
Atherosclerosis
Inherited depression of arterial lipoamide dehydrogenase activity associated with susceptibility to atherosclerosis in pigeons.
Autoimmune Pancreatitis
Helicobacter pylori and pancreatic diseases.
Brain Diseases
Leigh syndrome in a girl with a novel DLD mutation causing E3 deficiency.
Brain Infarction
Mitochondrial Dihydrolipoamide Dehydrogenase is Upregulated in Response to Intermittent Hypoxic Preconditioning.
Brain Injuries
Mitochondrial Dihydrolipoamide Dehydrogenase is Upregulated in Response to Intermittent Hypoxic Preconditioning.
Breast Neoplasms
Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation.
Use of cytokeratin 8 immunohistochemistry for assessing cell death after radiofrequency ablation of breast cancers.
Carcinoma
Nicotinamide adenine dinucleotide staining immediately following radio frequency ablation of renal tumors-is a positive stain synonymous with ablative failure?
Carcinoma, Adenoid Cystic
[Multiple trichoepitheliomas, cylindromas and milia. An entity]
Carcinoma, Non-Small-Cell Lung
UBR5 inhibits the radiosensitivity of non-small cell lung cancer cells via the activation of the PI3K/AKT pathway.
Carcinoma, Renal Cell
Interaction of alpha-lipoic acid enantiomers and homologues with the enzyme components of the mammalian pyruvate dehydrogenase complex.
Nicotinamide adenine dinucleotide staining immediately following radio frequency ablation of renal tumors-is a positive stain synonymous with ablative failure?
Chagas Disease
Cloning, sequencing and functional expression of dihydrolipoamide dehydrogenase from the human pathogen Trypanosoma cruzi.
Inactivation of Trypanosoma cruzi dihydrolipoamide dehydrogenase by leukocyte myeloperoxidase systems: role of hypochloride and nitrite related radicals.
Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase.
Purification and characterization of lipoamide dehydrogenase from Trypanosoma cruzi.
Colitis
The E3 ubiquitin ligase UBR5 interacts with TTC7A and may be associated with very early onset inflammatory bowel disease.
Cryptorchidism
The effect of cryptorchidism on the quantitative histology, histochemistry and hydrolytic enzyme activity of the rat testis.
Dementia
Dementia lacking distinctive histologic features: a common non-Alzheimer degenerative dementia.
Hippocampal sclerosis and ubiquitin-positive inclusions in dementia lacking distinctive histopathology.
Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study.
Diabetes Mellitus, Type 2
Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress.
dihydrolipoyl dehydrogenase deficiency
A decrease in glycine cleavage activity in the liver of a patient with dihydrolipoyl dehydrogenase deficiency.
A defect in branched-chain amino acid metabolism in a patient with congenital lactic acidosis due to dihydrolipoyl dehydrogenase deficiency.
An Updated View on the Molecular Pathomechanisms of Human Dihydrolipoamide Dehydrogenase Deficiency in Light of Novel Crystallographic Evidence.
ATP synthesis in lipoamide dehydrogenase deficiency.
Biochemical and molecular diagnosis of lipoamide dehydrogenase deficiency in a North American Ashkenazi Jewish family.
Challenges in Diagnosing a Metabolic Disorder: Error of Pyruvate Metabolism or Drug Induced?
Chemical diagnosis of dihydrolipoyl dehydrogenase deficiency.
Coexisting hereditary methaemoglobinaemia and heterozygous beta-thalassaemia.
Congenital enzymopenic methaemoglobinaemia. Clinical and biochemical study of a family with three homozygotes.
Congenital lactic acidosis, alpha-ketoglutaric aciduria and variant form of maple syrup urine disease due to a single enzyme defect: dihydrolipoyl dehydrogenase deficiency.
Congenital lacticacidemia caused by lipoamide dehydrogenase deficiency with favorable outcome.
Congenital methaemoglobinaemia due to NADH methaemoglobin reductase deficiency: successful treatment with oral riboflavin.
Dihydrolipoamide dehydrogenase deficiency: A still overlooked cause of recurrent acute liver failure and Reye-like syndrome.
Dihydrolipoyl dehydrogenase deficiency: a therapeutic trial with branched-chain amino acid restriction.
Elevated plasma citrulline: look for dihydrolipoamide dehydrogenase deficiency.
HEPNet: A Knowledge Base Model of Human Energy Pool Network for Predicting the Energy Availability Status of an Individual.
Hereditary methemoglobinemia associated with NADH diaphorase deficiency.
Identification of two mutations in a compound heterozygous child with dihydrolipoamide dehydrogenase deficiency.
Lactic acidemia, neurologic deterioration and carbohydrate dependence in a girl with dihydrolipoyl dehydrogenase deficiency.
Leigh syndrome in a girl with a novel DLD mutation causing E3 deficiency.
Lipoamide dehydrogenase activity in lymphocytes.
Lipoamide dehydrogenase deficiency due to a novel mutation in the interface domain.
Lipoamide dehydrogenase deficiency in Ashkenazi Jews: an insertion mutation in the mitochondrial leader sequence.
Lipoamide dehydrogenase deficiency with primary lactic acidosis: favorable response to treatment with oral lipoic acid.
Lipoamide dehydrogenase deficiency.
Lipoamide dehydrogenase deficiency: a new cause for recurrent myoglobinuria.
Lipoamide dehydrogenase deficiency: a newly discovered cause of acute hepatitis in adults.
Liver disease in the Ashkenazi-Jewish lipoamide dehydrogenase deficiency.
Molecular basis of lipoamide dehydrogenase deficiency in Ashkenazi Jews.
Newborn screening for dihydrolipoamide dehydrogenase deficiency: Citrulline as a useful analyte.
Novel mutations in a boy with dihydrolipoamide dehydrogenase deficiency.
Novel mutations in dihydrolipoamide dehydrogenase deficiency in two cousins with borderline-normal PDH complex activity.
Pyruvate dehydrogenase subcomplex with lipoamide dehydrogenase deficiency in a patient with lactic acidosis and branched chain ketoaciduria.
Riboflavin responsive mitochondrial myopathy is a new phenotype of dihydrolipoamide dehydrogenase deficiency. The chaperon-like effect of vitamin B2.
Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency.
The expanding clinical spectrum of mitochondrial diseases.
Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
[Clinical and genetic analysis of a case of dihydrolipoamide dehydrogenase deficiency caused by novel variant of DLD gene].
[Familial NADH diaphorase deficiency]
[Heterogeneity of leucinosis. Correlations between clinical manifestations, protein tolerance and enzyme deficiency]
[Lipoamide dehydrogenase deficiency]
Endometrial Neoplasms
Proteomic identification of dihydrolipoamide dehydrogenase as a target of autoantibodies in patients with endometrial cancer.
Friedreich Ataxia
An investigation of pyruvate metabolism in patients with cerebellar and spinocerebellar degeneration.
Correlation between serum lipoamide dehydrogenase activity and phosphatidylcholine therapy in Friedreich's ataxia.
Evidence for a primary defect of lipoamide dehydrogenase in Friedreich's ataxia.
Friedreich ataxia. II. Normal kinetics of lipoamide dehydrogenase.
Immunoreactive levels of alpha-ketoglutarate dehydrogenase subunits in Friedreich's ataxia and spinocerebellar ataxia type 1.
Kinetic evidence for a structural abnormality of lipoamide dehydrogenase in two patients with Friedreich ataxia.
Lipoamide dehydrogenase in cultured human skin fibroblasts.
Lipoamide dehydrogenase in Friedreich's ataxia fibroblasts.
Lipoamide dehydrogenase: rapid heat inactivation in platelets of patients with recessively inherited ataxia.
Preclinical diagnosis and carrier detection in ataxia associated with abnormalities of lipoamide dehydrogenase.
Pyruvate dehydrogenase, lipoamide dehydrogenase and citrate synthase activity in fibroblasts from patients with Friedreich's and Charlevoix-Saguenay ataxia.
Serum and platelet lipoamide dehydrogenase in Friedreich's ataxia.
Frontotemporal Dementia
Histopathological changes underlying frontotemporal lobar degeneration with clinicopathological correlation.
Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia.
Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study.
Soluble amyloid beta-protein is increased in frontotemporal dementia with tau gene mutations.
The evolution and pathology of frontotemporal dementia.
Frontotemporal Lobar Degeneration
Dementia lacking distinctive histology (DLDH) revisited.
fumarate hydratase deficiency
The expanding clinical spectrum of mitochondrial diseases.
Genetic Diseases, Inborn
An Updated View on the Molecular Pathomechanisms of Human Dihydrolipoamide Dehydrogenase Deficiency in Light of Novel Crystallographic Evidence.
Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Glioblastoma
Biomarker discovery: a proteomic approach for brain cancer profiling.
Glioma
MicroRNA-361-5p slows down gliomas development through regulating UBR5 to elevate ATMIN protein expression.
Glucose Intolerance
Friedreich's ataxia 1979: an overview.
Head and Neck Neoplasms
Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer.
Hemorrhagic Fever, Crimean
Genetic characterization of Erve virus, a European Nairovirus distantly related to Crimean-Congo hemorrhagic fever virus.
Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein.
Hepatic Encephalopathy
The two catalytic components of the 2-oxoglutarate dehydrogenase complex in rat cerebral synaptic and nonsynaptic mitochondria: comparison of the response to in vitro treatment with ammonia, hyperammonemia, and hepatic encephalopathy.
Hepatitis
Lipoamide dehydrogenase deficiency: a newly discovered cause of acute hepatitis in adults.
Hepatitis B
Affibody-displaying bionanocapsules for specific drug delivery to HER2-expressing cancer cells.
Characterization of bio-nanocapsule as a transfer vector targeting human hepatocyte carcinoma by disulfide linkage modification.
Construction of arginine-rich peptide displaying bionanocapsules.
Hepatitis B Virus Core Promoter Double Mutations (A1762T, G1764A) Are Associated with Lower Levels of Serum Dihydrolipoyl Dehydrogenase.
In vivo uterine local gene delivery system using TAT-displaying bionanocapsules.
Myristoylated PreS1-domain of the hepatitis B virus L-protein mediates specific binding to differentiated hepatocytes.
Toleration of amino acid substitutions within hepatitis B virus envelope protein epitopes established by peptide replacement set analysis. II. Region S(122-136).
Hepatitis C
Proteinase 3 and dihydrolipoamide dehydrogenase (E3) are major autoantigens in hepatitis C virus (HCV) infection.
Hyperglycinemia, Nonketotic
Ketogenic diet in early myoclonic encephalopathy due to non ketotic hyperglycinemia.
Hypersensitivity
Disruption of ptLPD1 or ptLPD2, genes that encode isoforms of the plastidial lipoamide dehydrogenase, confers arsenate hypersensitivity in Arabidopsis.
Infections
Anaplasma phagocytophilum Dihydrolipoamide Dehydrogenase 1 Affects Host-Derived Immunopathology during Microbial Colonization.
Characterization of the dihydrolipoamide dehydrogenase from Streptococcus pneumoniae and its role in pneumococcal infection.
Energy Metabolism in the Placenta and the Role of Disturbances in the Development of Placental Insufficiency at an Exacerbation of Cytomegalovirus Infection.
Hepatitis B Virus Core Promoter Double Mutations (A1762T, G1764A) Are Associated with Lower Levels of Serum Dihydrolipoyl Dehydrogenase.
Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on RSV infection in human airway epithelium.
Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.
Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors.
Proteinase 3 and dihydrolipoamide dehydrogenase (E3) are major autoantigens in hepatitis C virus (HCV) infection.
Infertility
[Preliminary proteomics analysis of the total proteins of HL Type cytoplasmic male sterility rice anther]
Influenza, Human
Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription.
Intellectual Disability
Congenital enzymopenic methaemoglobinaemia. Clinical and biochemical study of a family with three homozygotes.
Leigh syndrome due to compound heterozygosity of dihydrolipoamide dehydrogenase gene mutations. Description of the first E3 splice site mutation.
Ischemic Stroke
Administration of 5-methoxyindole-2-carboxylic acid that potentially targets mitochondrial dihydrolipoamide dehydrogenase confers cerebral preconditioning against ischemic stroke injury.
Mitochondrial Dihydrolipoamide Dehydrogenase is Upregulated in Response to Intermittent Hypoxic Preconditioning.
Ketosis
Leigh syndrome in a girl with a novel DLD mutation causing E3 deficiency.
Pyruvate dehydrogenase subcomplex with lipoamide dehydrogenase deficiency in a patient with lactic acidosis and branched chain ketoaciduria.
Kidney Failure, Chronic
Light microscopic study of striated muscle in uremia.
Learning Disabilities
Leigh syndrome in a girl with a novel DLD mutation causing E3 deficiency.
Leigh Disease
Deficiency of pyruvate dehydrogenase complex (PDHC) in Leigh's disease fibroblasts: an abnormality in lipoamide dehydrogenase affecting PDHC activation.
Leigh disease with deficiency of lipoamide dehydrogenase: treatment failure with dichloroacetate.
Leigh syndrome due to compound heterozygosity of dihydrolipoamide dehydrogenase gene mutations. Description of the first E3 splice site mutation.
Leigh syndrome in a girl with a novel DLD mutation causing E3 deficiency.
Studies on pyruvate carboxylase, pyruvate decarboxylase and lipoamide dehydrogenase in subacute necrotizing encephalomyelopathy.
Liver Cirrhosis, Biliary
Autoantibody against dihydrolipoamide dehydrogenase, the E3 subunit of the 2-oxoacid dehydrogenase complexes: significance for primary biliary cirrhosis.
Hepatic portal infiltrates in mice immunized with syngeneic lymphoid cells: connotations for models of autoimmune liver disease.
Humoral and cellular immune responses to dihydrolipoamide dehydrogenase (E3): lack of specificity for primary biliary cirrhosis.
Liver Diseases
Hepatic portal infiltrates in mice immunized with syngeneic lymphoid cells: connotations for models of autoimmune liver disease.
Hepatitis B Virus Core Promoter Double Mutations (A1762T, G1764A) Are Associated with Lower Levels of Serum Dihydrolipoyl Dehydrogenase.
Liver disease in the Ashkenazi-Jewish lipoamide dehydrogenase deficiency.
Liver Failure
The two catalytic components of the 2-oxoglutarate dehydrogenase complex in rat cerebral synaptic and nonsynaptic mitochondria: comparison of the response to in vitro treatment with ammonia, hyperammonemia, and hepatic encephalopathy.
Liver Failure, Acute
Dihydrolipoamide dehydrogenase deficiency: A still overlooked cause of recurrent acute liver failure and Reye-like syndrome.
Liver Neoplasms, Experimental
Characteristics of mitochondria isolated by rate zonal centrifugation from normal liver and Novikoff hepatomas.
Lung Injury
Redox imbalance and mitochondrial abnormalities in the diabetic lung.
Lung Neoplasms
UBR5 inhibits the radiosensitivity of non-small cell lung cancer cells via the activation of the PI3K/AKT pathway.
Lymphocytic Choriomeningitis
Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain.
Maple Syrup Urine Disease
Congenital lactic acidosis, alpha-ketoglutaric aciduria and variant form of maple syrup urine disease due to a single enzyme defect: dihydrolipoyl dehydrogenase deficiency.
Newborn screening for dihydrolipoamide dehydrogenase deficiency: Citrulline as a useful analyte.
Pyruvate dehydrogenase subcomplex with lipoamide dehydrogenase deficiency in a patient with lactic acidosis and branched chain ketoaciduria.
Measles
Oligomerization of the Vesicular Stomatitis Virus Phosphoprotein Is Dispensable for mRNA Synthesis but Facilitates RNA Replication.
Melanoma
Downregulation of dihydrolipoyl dehydrogenase by UVA suppresses melanoma progression via triggering oxidative stress and altering energy metabolism.
Metabolic Diseases
Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brain.
Structural alterations induced by ten disease-causing mutations of human dihydrolipoamide dehydrogenase analyzed by hydrogen/deuterium-exchange mass spectrometry: Implications for the structural basis of E3 deficiency.
Metabolic Syndrome
E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity.
Methemoglobinemia
Hereditary methemoglobinemia associated with NADH diaphorase deficiency.
Microcephaly
Leigh syndrome due to compound heterozygosity of dihydrolipoamide dehydrogenase gene mutations. Description of the first E3 splice site mutation.
Mitochondrial Diseases
Successful TAT-mediated enzyme replacement therapy in a mouse model of mitochondrial E3 deficiency.
TAT-mediated Delivery of LAD Restores Pyruvate Dehydrogenase Complex Activity in the Mitochondria of Patients with LAD Deficiency.
TAT-mediated delivery of LAD restores pyruvate dehydrogenase complex activity in the mitochondria of patients with LAD deficiency.
Mitochondrial Myopathies
Riboflavin responsive mitochondrial myopathy is a new phenotype of dihydrolipoamide dehydrogenase deficiency. The chaperon-like effect of vitamin B2.
Motor Neuron Disease
Hippocampal sclerosis and ubiquitin-positive inclusions in dementia lacking distinctive histopathology.
Mucormycosis
Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors.
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brain.
Muscle Hypotonia
Leigh disease with deficiency of lipoamide dehydrogenase: treatment failure with dichloroacetate.
Muscle Spasticity
An investigation of pyruvate metabolism in patients with cerebellar and spinocerebellar degeneration.
Myocarditis
Analysis of mitochondrial antigens reveals inner membrane succinate dehydrogenase flavoprotein subunit as autoantigen to antibodies in anti-M7 sera.
Myoglobinuria
Lipoamide dehydrogenase deficiency: a new cause for recurrent myoglobinuria.
Lipoamide dehydrogenase deficiency: a newly discovered cause of acute hepatitis in adults.
Nairobi Sheep Disease
Genetic characterization of Erve virus, a European Nairovirus distantly related to Crimean-Congo hemorrhagic fever virus.
Neoplasms
Comprehensive Analysis of Somatic Mutations in Colorectal Cancer With Peritoneal Metastasis.
Dihydrolipoamide dehydrogenase moonlighting activity as a DNA chelating agent.
Feasibility of induction heating using a sintered MgFe2O4 needle for minimally invasive breast cancer therapy.
Feasibility study on radiofrequency ablation followed by partial mastectomy for stage I breast cancer patients.
Histopathological effect of radiofrequency ablation therapy for primary breast cancer, with special reference to changes in cancer cells and stromal structure and a comparison with enzyme histochemistry.
Identification of a recurrent transforming UBR5-ZNF423 fusion gene in EBV-associated nasopharyngeal carcinoma.
Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein.
Minimization of energy transduction confers resistance to phosphine in the rice weevil, Sitophilus oryzae.
Novel tumor-ablation device for liver tumors utilizing heat energy generated under an alternating magnetic field.
Overexpression of UBR5 promotes tumor growth in gallbladder cancer via PTEN/PI3K/Akt signal pathway.
Selective prostate cancer thermal ablation with laser activated gold nanoshells.
Targeting the Achilles' heel of cancer cells via integrin-mediated delivery of ROS-generating dihydrolipoamide dehydrogenase.
Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response.
The moonlighting activities of dihydrolipoamide dehydrogenase: Biotechnological and biomedical applications.
UBR5 inhibits the radiosensitivity of non-small cell lung cancer cells via the activation of the PI3K/AKT pathway.
UBR5 regulates proliferation and radiosensitivity in human laryngeal carcinoma via the p38/MAPK signaling pathway.
[Microwave coagulation at different temperatures for hepatocellular carcinoma management: efficacy evaluation by enzyme histochemical staining]
[Multiple trichoepitheliomas, cylindromas and milia. An entity]
Neuroblastoma
Electron spin resonance studies of the interaction of oxidoreductases with 2,6-dimethoxy-p-quinone and semiquinone.
Neurodegenerative Diseases
Notch-1 immunoexpression is increased in Alzheimer's and Pick's disease.
Obesity
Obesity-mediated regulation of cardiac protein acetylation: parallel analysis of total and acetylated proteins via TMT-tagged mass spectrometry.
Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle.
Ovarian Neoplasms
Identification of phosphorylation sites on the E3 ubiquitin ligase UBR5/EDD.
oxoglutarate dehydrogenase (succinyl-transferring) deficiency
A novel mutation in the dihydrolipoamide dehydrogenase E3 subunit gene (DLD) resulting in an atypical form of alpha-ketoglutarate dehydrogenase deficiency.
The expanding clinical spectrum of mitochondrial diseases.
Parkinson Disease
Role of lipoamide dehydrogenase and metallothionein on 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced neurotoxicity.
Pick Disease of the Brain
Dementia lacking distinctive histologic features: a common non-Alzheimer degenerative dementia.
[FTLD-U and Pick disease without Pick bodies--a clinical and pathological review]
Pneumococcal Infections
Characterization of the dihydrolipoamide dehydrogenase from Streptococcus pneumoniae and its role in pneumococcal infection.
Polycystic Kidney Diseases
Comprehensive Analysis of Somatic Mutations in Colorectal Cancer With Peritoneal Metastasis.
Polycystic Kidney, Autosomal Recessive
Comprehensive Analysis of Somatic Mutations in Colorectal Cancer With Peritoneal Metastasis.
Propionic Acidemia
Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brain.
Psoriasis
[Activity of NADH-2 oxidoreductase: a lipoamide dehydrogenase in red blooc cells of patients with psoriasis]
pyruvate dehydrogenase (acetyl-transferring) deficiency
Pyruvate dehydrogenase E3 binding protein (protein X) deficiency.
pyruvate dehydrogenase (nadp+) deficiency
The genetic heterogeneity of lactic acidosis: occurrence of recognizable inborn errors of metabolism in pediatric population with lactic acidosis.
Pyruvate Dehydrogenase Complex Deficiency Disease
Pyruvate dehydrogenase E3 binding protein (protein X) deficiency.
The genetic heterogeneity of lactic acidosis: occurrence of recognizable inborn errors of metabolism in pediatric population with lactic acidosis.
Rabies
Oligomerization of the Vesicular Stomatitis Virus Phosphoprotein Is Dispensable for mRNA Synthesis but Facilitates RNA Replication.
Respiratory Distress Syndrome
[Lung NADH diaphorase activity in rats with respiratory distress syndrome]
Reye Syndrome
Dihydrolipoamide dehydrogenase deficiency: A still overlooked cause of recurrent acute liver failure and Reye-like syndrome.
Riboflavin Deficiency
Radial diffusion assay of lipoamide dehydrogenase and its use to assess riboflavin deficiency.
Sepsis
Characterization of the dihydrolipoamide dehydrogenase from Streptococcus pneumoniae and its role in pneumococcal infection.
Sjogren's Syndrome
Identification of quantitative trait loci for murine autoimmune pancreatitis.
Spinocerebellar Degenerations
An investigation of pyruvate metabolism in patients with cerebellar and spinocerebellar degeneration.
Starvation
HEPNet: A Knowledge Base Model of Human Energy Pool Network for Predicting the Energy Availability Status of an Individual.
Stroke
Administration of 5-methoxyindole-2-carboxylic acid that potentially targets mitochondrial dihydrolipoamide dehydrogenase confers cerebral preconditioning against ischemic stroke injury.
Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress.
Mitochondrial Dihydrolipoamide Dehydrogenase is Upregulated in Response to Intermittent Hypoxic Preconditioning.
Tauopathies
Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia.
Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study.
Tuberculosis
Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level.
Characterization of a new member of the flavoprotein disulfide reductase family of enzymes from Mycobacterium tuberculosis.
Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis.
Dihydrolipoamide dehydrogenase-Lpd (Rv0462)-specific T cell recall responses are higher in healthy household contacts of TB: a novel immunodominant antigen from M. tuberculosis.
Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.
Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation.
Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes.
Mycobacterium tuberculosislpdC, Rv0462, induces dendritic cell maturation and Th1 polarization.
The lipoamide dehydrogenase from Mycobacterium tuberculosis permits the direct observation of flavin intermediates in catalysis.
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.
Uremia
HEPNet: A Knowledge Base Model of Human Energy Pool Network for Predicting the Energy Availability Status of an Individual.
Urinary Bladder Neoplasms
Histochemistry of NADH diaphorase and gamma-glutamyltranspeptidase in rat bladder tumors.
Varicose Veins
Muscle changes in patients with varicose veins.
Vesicular Stomatitis
Chemogenetic ON and OFF switches for RNA virus replication.
RNA- temperature-sensitive mutants of vesicular stomatitis virus: L-protein thermosensitivity accounts for transcriptase restriction of group I mutants.
Structure of a rabies virus polymerase complex from electron cryo-microscopy.
The Methyltransferase Region of Vesicular Stomatitis Virus L Polymerase Is a Target Site for Functional Intramolecular Insertion.