Information on EC 1.8.3.4 - methanethiol oxidase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.8.3.4
-
RECOMMENDED NAME
GeneOntology No.
methanethiol oxidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + H2O2
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
dimethyl sulfide degradation I
-
-
Sulfur metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
methanethiol:oxygen oxidoreductase
-
CAS REGISTRY NUMBER
COMMENTARY hide
112821-28-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain EG
-
-
Manually annotated by BRENDA team
strain EG
-
-
Manually annotated by BRENDA team
strain TK-m
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ethyl mercaptan + O2 + H2O
acetaldehyde + H2S + H2O2
show the reaction diagram
methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
show the reaction diagram
sulfide + O2
sulfur + H2O2
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(NH4)2SO4
-
-
cyanide
ethyl mercaptan
K2SO4
-
inhibition at concentration below 200 mM, original activity is recovered at 200 mM
methanethiol
methylamine
-
-
NaCl
-
inhibition at concentration below 200 mM, original activity is recovered at 200 mM
Sulfide
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.018
ethyl mercaptan
-
-
0.005 - 0.0313
methanethiol
0.06
Sulfide
-
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.04
cyanide
-
-
0.008 - 0.042
methanethiol
1.4
methylamine
-
-
0.09
Sulfide
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
29000
-
gel filtration
40000 - 50000
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 64500, SDS-PAGE
monomer
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50
-
10 min, stable
65
-
10 min, complete loss of activity
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, stable for months
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE