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Disease on EC 1.8.5.1 - glutathione dehydrogenase (ascorbate)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acatalasia
Glutathione oxidation in response to intracellular H2O2: Key but overlapping roles for dehydroascorbate reductases.
Acidosis
Acidosis-induced metallothionein (MT) mRNA expression in neonatal rat primary astrocyte cultures.
Dimethyl sulfoxide, but not acidosis-induced metallothionein mRNA expression in neonatal rat primary astrocyte cultures is inhibited by the bioflavonoid, quercetin.
Adenocarcinoma
Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo.
Alzheimer Disease
Influence of Transgenic Metallothionein-1 on Gliosis, CA1 Neuronal Loss, and Brain Metal Levels of the Tg2576 Mouse Model of Alzheimer's Disease.
Overexpression of Metallothionein-1 Modulates the Phenotype of the Tg2576 Mouse Model of Alzheimer's Disease.
Structure, function and disease relevance of Omega-class glutathione transferases.
Amyotrophic Lateral Sclerosis
Structure, function and disease relevance of Omega-class glutathione transferases.
Arthritis
Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A
Arthritis, Rheumatoid
Metallothionein-1 suppresses rheumatoid arthritis pathogenesis by shifting the Th17/Treg balance.
Asthma
GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1?-induced eosinophilic airway inflammation.
Sanfu herbal patch applied at acupoints in patients with bronchial asthma: study protocol for a randomized controlled trial.
Bone Resorption
Systemic over-secretion of growth hormone in transgenic mice results in a specific pattern of skeletal modeling and adaptation.
Brain Diseases
Metallothioneins are multipurpose neuroprotectants during brain pathology.
Brain Injuries
Differential regulation of metallothionein-I and metallothionein-II mRNA expression in the rat brain following traumatic brain injury.
Metallothionein (MT) -I and MT-II Expression Are Induced and Cause Zinc Sequestration in the Liver after Brain Injury.
Brain Injuries, Traumatic
Differential regulation of metallothionein-I and metallothionein-II mRNA expression in the rat brain following traumatic brain injury.
The comparison of mouse full metallothionein-1 versus alpha and beta domains and metallothionein-1-to-3 mutation following traumatic brain injury reveals different biological motifs.
Brain Ischemia
Evidence for a protective role of metallothionein-1 in focal cerebral ischemia.
Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion.
Neuroprotective effect of erythropoietin, and role of metallothionein-1 and -2, in permanent focal cerebral ischemia.
Breast Neoplasms
A case-control study of Metallothionein-1 expression in breast cancer and breast fibroadenoma.
A Role for Glutathione Transferase Omega 1 (GSTO1-1) in the Glutathionylation Cycle.
Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs.
Genome-wide DNA methylation analysis reveals estrogen-mediated epigenetic repression of metallothionein-1 gene cluster in breast cancer.
S-(4-Nitrophenacyl)glutathione is a specific substrate for glutathione transferase omega 1-1.
Structure, function and disease relevance of Omega-class glutathione transferases.
Thioltransferase overexpression increases resistance of MCF-7 cells to adriamycin.
Carcinogenesis
Increased susceptibility of estrogen-induced bladder outlet obstruction in a novel mouse model.
Metallothionein deficiency promotes mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene.
Carcinoma
Expression of metallothionein in lung carcinoma: correlation with histological type and grade.
Metallothionein-1 Genotypes in the Risk of Oral Squamous Cell Carcinoma.
Peculiarities of antioxidant system and iron metabolism in organism during development of tumor resistance to cisplatin.
The upregulation of metallothionein-1 expression in areca quid chewing-associated oral squamous cell carcinomas.
Upregulated glutathione transferase omega-1 correlates with progression of urinary bladder carcinoma.
Carcinoma, Hepatocellular
Amplification of the metallothionein-1 and metallothionein-2 genes in copper-resistant hepatoma cells.
Effects of Metallothionein-1 Genetic Polymorphism and Cigarette Smoking on the Development of Hepatocellular Carcinoma.
Expression of metallothionein-1 and metallothionein-2 as a prognostic marker in hepatocellular carcinoma.
Metallothionein mRNA stability in chicken and mouse cells.
Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib.
Prognostic Significance of 14-3-3?, Aldo-keto Reductase Family 1 B10 and Metallothionein-1 in Hepatocellular Carcinoma.
ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma.
[Glutathione: dehydroascorbate-oxidoreductase activity in rat tissues]
Carcinoma, Transitional Cell
Upregulated glutathione transferase omega-1 correlates with progression of urinary bladder carcinoma.
catalase deficiency
Glutathione oxidation in response to intracellular H2O2: Key but overlapping roles for dehydroascorbate reductases.
Cataract
Structure, function and disease relevance of Omega-class glutathione transferases.
Cerebral Infarction
Role of Metallothionein-1 and Metallothionein-2 in the Neuroprotective Mechanism of Sevoflurane Preconditioning in Mice.
Chagas Disease
Metallothionein-1 and nitric oxide expression are inversely correlated in a murine model of Chagas disease.
Colitis
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.
Colonic Neoplasms
Glutathione transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation.
Colorectal Neoplasms
Glutathione transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation.
Cystic Fibrosis
Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
Dehydration
Antioxidant response of wheat roots to drought acclimation.
Ascorbic acid mitigation of water stress-inhibition of root growth in association with oxidative defense in tall fescue (Festuca arundinacea Schreb.).
Cytological and physiological changes in orthodox maize embryos during cryopreservation.
Cytological and physiological changes in recalcitrant Chinese fan palm (Livistona chinensis) embryos during cryopreservation.
Dioscorin, the major tuber storage protein of yam (Dioscorea batatas decne) with carbonic anhydrase and trypsin inhibitor activities.
Drought-responsive mechanisms in rice genotypes with contrasting drought tolerance during reproductive stage.
Effect of short-term water deficit stress on antioxidative systems in cucumber seedling roots.
Effect of water stress on antioxidant systems and oxidative parameters in fruits of tomato (Solanum lycopersicon L, cv. Micro-tom).
Jasmonic acid regulates ascorbate and glutathione metabolism in Agropyron cristatum leaves under water stress
Nitric Oxide Signal, Nitrogen Metabolism, and Water Balance Affected by ?-Aminobutyric Acid (GABA) in Relation to Enhanced Tolerance to Water Stress in Creeping Bentgrass.
Possible Involvement of Reactive Oxygen Species Scavenging Enzymes in Desiccation Sensitivity of Antiaris toxicaria Seeds and Axes.
Pretreatment with NaCl Promotes the Seed Germination of White Clover by Affecting Endogenous Phytohormones, Metabolic Regulation, and Dehydrin-Encoded Genes Expression under Water Stress.
Dengue
Potent virucidal activity against Flaviviridae of a group IIA phospholipase A2 isolated from the venom of Bothrops asper.
Dental Caries
Status of dental caries and treatment needs in tribal children of Mandu (Central India).
Dermatitis, Atopic
Commentary on Nagaraja, Kanwar, Dhar, and Singh: frequency and significance of minor clinical features in various age-related subgroups of atopic dermatitis in children.
Diabetes Mellitus
Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications.
Diabetes Mellitus, Type 2
Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications.
Encephalitis
Specificity and divergence in the neurobiologic effects of different metallothioneins after brain injury.
Eosinophilia
GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1?-induced eosinophilic airway inflammation.
Esophageal Neoplasms
[Expression of metallothionein-3 in esophageal cancer and its correlations to expression of metallothionein-1 and -2.]
Fibroadenoma
A case-control study of Metallothionein-1 expression in breast cancer and breast fibroadenoma.
Fluorosis, Dental
Dental fluorosis and associated risk factors in early adolescents in India.
Gastrointestinal Stromal Tumors
Expression of Metallothionein and Ki-67 Antigen in GISTs of Different Grade of Malignancy.
Glioblastoma
Glioblastoma CUSA Fluid Protein Profiling: A Comparative Investigation of the Core and Peripheral Tumor Zones.
Glioma
Regulated expression of the diphtheria toxin A gene in human glioma cells using prokaryotic transcriptional control elements.
Glucose Intolerance
135-Day Interventions of Yam Dioscorin and the Dipeptide Asn-Trp (NW) To Reduce Weight Gains and Improve Impaired Glucose Tolerances in High-Fat Diet-Induced C57BL/6 Mice.
Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats.
glutathione dehydrogenase (ascorbate) deficiency
Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs.
GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1?-induced eosinophilic airway inflammation.
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.
Novel folding and stability defects cause a deficiency of human glutathione transferase omega 1.
Hyperalgesia
Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A
Hypersensitivity
Overexpression of metallothionein-II sensitizes rodent cells to apoptosis induced by DNA cross-linking agent through inhibition of NF-kappa B activation.
Hypertension
Both dioscorin, the tuber storage protein of yam (Dioscorea alata cv. Tainong No. 1), and its peptic hydrolysates exhibited angiotensin converting enzyme inhibitory activities.
Infarction, Middle Cerebral Artery
Assessment of the Therapeutic Potential of Metallothionein-II Application in Focal Cerebral Ischemia In Vitro and In Vivo.
Infections
Ascorbate, glutathione and related enzymes in chloroplasts of tomato leaves infected by Botrytis cinerea.
Identification of proteins induced or upregulated by Fusarium head blight infection in the spikes of hexaploid wheat (Triticum aestivum).
Interferon-alpha-induced changes in metallothionein expression in liver biopsies from patients with chronic hepatitis C.
The effect of Botrytis cinerea infection on the antioxidant profile of mitochondria from tomato leaves.
Up-regulation of the ascorbate-dependent antioxidative system in barley leaves during powdery mildew infection.
Inflammatory Bowel Diseases
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.
Influenza, Human
Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms.
Insulin Resistance
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.
Ischemic Stroke
Assessment of the Therapeutic Potential of Metallothionein-II Application in Focal Cerebral Ischemia In Vitro and In Vivo.
Leprosy, Paucibacillary
Thalidomide does not modify the ability of cells in leprosy patients to incorporate [3H]-thymidine when incubated with M. leprae antigens.
Leukemia
Association of glutathione S-transferase ? 1-1 polymorphisms (A140D and E208K) with the expression of interleukin-8 (IL-8), transforming growth factor beta (TGF-?), and apoptotic protease-activating factor 1 (Apaf-1) in humans chronically exposed to arsenic in drinking water.
Metallothionein-1 isoforms and vimentin are direct PU.1 downstream target genes in leukemia cells.
Liver Neoplasms
MDM2-TP53 Crossregulation: An Underestimated Target to Promote Loss of TP53 Function and Cell Survival.
Lordosis
The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat.
Lung Diseases
Association of glutathione S-transferase ? 1-1 polymorphisms (A140D and E208K) with the expression of interleukin-8 (IL-8), transforming growth factor beta (TGF-?), and apoptotic protease-activating factor 1 (Apaf-1) in humans chronically exposed to arsenic in drinking water.
Lung Injury
Molecular signatures of trauma-hemorrhagic shock-induced lung injury: hemorrhage- and injury-associated genes.
Lung Neoplasms
Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure.
Lymphoma
Different types of hypersensitive sites in the mouse metallothionein gene region.
Lymphoma, Non-Hodgkin
Long-term cadmium exposure enhances metallothionein-1 induction after subsequent exposure to high concentrations of cadmium in P1798 mouse lymphosarcoma cells.
Medulloblastoma
MDM2-TP53 Crossregulation: An Underestimated Target to Promote Loss of TP53 Function and Cell Survival.
Melanoma
Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor.
Melanoma associated with the use of melanotan-II.
Metabolic Syndrome
Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats.
Motor Neuron Disease
Effect of Neuroprotective Drugs on Gene Expression in G93A/SOD1 Mice.
Multiple Sclerosis
Mouse metallothionein-1 and metallothionein-2 are not biologically interchangeable in an animal model of multiple sclerosis, EAE.
Neoplasms
Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R.
Covalent sequestration of melphalan by metallothionein and selective alkylation of cysteines.
Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs.
Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor.
Differential Expression of Inflammatory Cytokines and Stress Genes in Male and Female Mice in Response to a Lipopolysaccharide Challenge.
Ectopic expression of rhombotin-2 causes selective expansion of CD4-CD8- lymphocytes in the thymus and T-cell tumors in transgenic mice.
Effects of environmental lead contamination on cattle in a lead/zinc mining area: Changes in cattle immune systems on exposure to lead in vivo and in vitro.
Enhancement of immunogenicity of tumor cells by cotransfection with genes encoding antisense insulin-like growth factor-1 and B7.1 molecules.
Expression of Metallothionein and Ki-67 Antigen in GISTs of Different Grade of Malignancy.
Expression of metallothionein in lung carcinoma: correlation with histological type and grade.
Glioblastoma CUSA Fluid Protein Profiling: A Comparative Investigation of the Core and Peripheral Tumor Zones.
GSTO1*CC Genotype (rs4925) Predicts Shorter Survival in Clear Cell Renal Cell Carcinoma Male Patients.
Immunohistochemically detectable metallothionein expression in malignant pleural mesotheliomas is strongly associated with early failure to platin-based chemotherapy.
Isolation and characterization of complementary DNA clones corresponding to genes induced in mouse epidermis in vivo by tumor promoters.
MDM2-TP53 Crossregulation: An Underestimated Target to Promote Loss of TP53 Function and Cell Survival.
Metallothionein-1 and -2 expression in cadmium- or arsenic-derived human malignant urothelial cells and tumor heterotransplants and as a prognostic indicator in human bladder cancer.
Metallothioneins, longevity and cancer: Comment on "Deficiency of metallothionein-1 and -2 genes shortens the lifespan of the 129/Sv mouse strain".
Peculiarities of antioxidant system and iron metabolism in organism during development of tumor resistance to cisplatin.
Polymorphism of glutathione transferase Omega 1 in a population exposed to a high environmental arsenic burden.
Polyomavirus large T-antigen expression in heart of transgenic mice causes cardiomyopathy.
Prognostic Significance of 14-3-3?, Aldo-keto Reductase Family 1 B10 and Metallothionein-1 in Hepatocellular Carcinoma.
Regulation of metallothionein gene expression.
Structure-Based Design of N-(5-Phenylthiazol-2-yl)acrylamides as Novel and Potent Glutathione S-Transferase Omega 1 Inhibitors.
Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat.
Upregulated glutathione transferase omega-1 correlates with progression of urinary bladder carcinoma.
Nervous System Diseases
Photoreceptor Survival Is Regulated by GSTO1-1 in the Degenerating Retina.
Neuralgia
Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain.
Neuroblastoma
Ascorbic acid recycling in N-myc amplified human neuroblastoma cells.
Neurodegenerative Diseases
The role of metallothionein II in neuronal differentiation and survival.
Neuroinflammatory Diseases
Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain.
Expression of metallothionein-I, -II, and -III in Alzheimer disease and animal models of neuroinflammation.
Obesity
Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats.
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.
Obesity and hyperleptinemia in metallothionein (-I and -II) null mice.
The effect of the melanocortin agonist, MT-II, on the defended level of body adiposity.
Osteoarthritis
Metallothionein-1 is associated with osteoarthritis disease activity and suppresses proinflammatory cytokines production in synovial cells.
Ototoxicity
Co-treatment with melanotan-II, a potent melanocortin, does not protect against cisplatin ototoxicity.
Paralysis
Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis.
Parkinson Disease
Structure, function and disease relevance of Omega-class glutathione transferases.
Pulmonary Disease, Chronic Obstructive
Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients.
Structure, function and disease relevance of Omega-class glutathione transferases.
Retinal Degeneration
Photoreceptor Survival Is Regulated by GSTO1-1 in the Degenerating Retina.
Shock, Septic
Structure, function and disease relevance of Omega-class glutathione transferases.
Squamous Cell Carcinoma of Head and Neck
Metallothionein-1 Genotypes in the Risk of Oral Squamous Cell Carcinoma.
The upregulation of metallothionein-1 expression in areca quid chewing-associated oral squamous cell carcinomas.
Starvation
Potassium starvation induces oxidative stress inSolanum lycopersicumL. roots.
Stomach Neoplasms
Inducible Expression of bcl-2 Antisense RNA Promotes Apoptosis of Human Gastric Cancer Cell Line.
Stroke
Assessment of the Therapeutic Potential of Metallothionein-II Application in Focal Cerebral Ischemia In Vitro and In Vivo.
Sunburn
Photoprotection mechanism in the 'Fuji' apple peel at different levels of photooxidative sunburn.
Photoprotection mechanism in the ‘Fuji’ apple peel at different levels of photooxidative sunburn
Testicular Neoplasms
Decreased Fas antigen receptor expression in testicular tumor cell lines derived from polyomavirus large T-antigen transgenic mice.
The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue.
Tics
Metallothionein gene expression in testicular interstitial cells and liver of rats treated with cadmium.
Tuberculosis
Caught between two proteins: a mycobacterial inhibitor challenges the mold.
Urinary Bladder Neoplasms
Metallothionein-1 and -2 expression in cadmium- or arsenic-derived human malignant urothelial cells and tumor heterotransplants and as a prognostic indicator in human bladder cancer.
Vaccinia
A glutaredoxin, encoded by the G4L gene of vaccinia virus, is essential for virion morphogenesis.
Glutaredoxin homolog encoded by vaccinia virus is a virion-associated enzyme with thioltransferase and dehydroascorbate reductase activities.
Virus Diseases
Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms.
Wilms Tumor
Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells.