Reference on EC 2.1.1.1 - nicotinamide N-methyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Cantoni, G.L.
Methylation of nicotinamide with a soluble enzyme system from rat liver
J. Biol. Chem.
189
203-217
1951
Rattus norvegicus
Alston, T.A.; Abeles, R.H.
Substrate specificity of nicotinamide methyltransferase isolated from porcine liver
Arch. Biochem. Biophys.
260
601-608
1988
Sus scrofa
Rini, J.; Szumlanski, C.; Guerciolini, R.; Weinshilboum, R.M.
Human liver nicotinamide N-methyltransferase: ion-pairing radiochemical assay, biochemical properties and individual variation
Clin. Chim. Acta
186
359-374
1990
Homo sapiens
Smith, M.L.; Burnett, D.; Bennett, P.; Waring, R.H.; Brown, H.M.; Williams, A.C.; Ramsden, D.B.
A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol
Biochim. Biophys. Acta
1442
238-244
1998
Homo sapiens
Aksoy, S.; Szumlanski, C.L.; Weinshilboum, R.M.
Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization
J. Biol. Chem.
269
14835-14840
1994
Homo sapiens
Yan, L.; Otterness, D.M.; Kozak, C.A.; Weinshilboum, R.M.
Mouse nicotinamide N-methyltransferase gene: molecular cloning, structural characterization, and chromosomal localization
DNA Cell Biol.
17
659-667
1998
Mus musculus
Fujimura, S.; Okamura, A.; Ohmura, Y.; Moriyama, Y.; Ohwada, H.; Horitsu, K.; Ohkubo, M.
Nicotinamide methyltransferase activity and cell-death in the liver of the mouse bearing Ehrlich ascites tumor
Adv. Exp. Med. Biol.
398
507-511
1996
Mus musculus, Rattus norvegicus
Scheller, T.; Orgacka, H.; Szumlanski, C.L.; Weinshilboum, R.M.
Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains
Pharmacogenetics
6
43-53
1996
Mus musculus, Mus musculus C57/BL6J
Aoyama, K.; Matsubara, K.; Kondo, M.; Murakawa, Y.; Suno, M.; Yamashita, K.; Yamaguchi, S.; Kobayashi, S.
Nicotinamide-N-methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinson's disease
Neurosci. Lett.
298
78-80
2001
Homo sapiens
Kassem, H.S.; Sangar, V.; Cowan, R.; Clarke, N.; Margison, G.P.
A potential role of heat shock proteins and nicotinamide N-methyl transferase in predicting response to radiation in bladder cancer
Int. J. Cancer
101
454-460
2002
Homo sapiens
Okamura, A.; Ohmura, Y.; Islam, M.M.; Tagawa, M.; Horitsu, K.; Moriyama, Y.; Fujimura, S.
Increased hepatic nicotinamide N-methyltransferase activity as a marker of cancer cachexia in mice bearing colon 26 adenocarcinoma
Jpn. J. Cancer Res.
89
649-656
1998
Mus musculus
Parsons, R.B.; Smith, M.L.; Williams, A.C.; Waring, R.H.; Ramsden, D.B.
Expression of nicotinamide N-methyltransferase (E.C. 2.1.1.1) in the Parkinsonian brain
J. Neuropathol. Exp. Neurol.
61
111-124
2002
Homo sapiens
Xu, J.; Moatamed, F.; Caldwell, J.S.; Walker, J.R.; Kraiem, Z.; Taki, K.; Brent, G.A.; Hershman, J.M.
Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells
J. Clin. Endocrinol. Metab.
88
4990-4996
2003
Homo sapiens
Parsons, R.B.; Smith, S.W.; Waring, R.H.; Williams, A.C.; Ramsden, D.B.
High expression of nicotinamide N-methyltransferase in patients with idiopathic Parkinson's disease
Neurosci. Lett.
342
13-16
2003
Homo sapiens
van Driel, L.M.; Smedts, H.P.; Helbing, W.A.; Isaacs, A.; Lindemans, J.; Uitterlinden, A.G.; van Duijn, C.M.; de Vries, J.H.; Steegers, E.A.; Steegers-Theunissen, R.P.
Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide
Eur. Heart J.
29
1424-1431
2008
Homo sapiens (P40261), Homo sapiens
Tomida, M.; Ohtake, H.; Yokota, T.; Kobayashi, Y.; Kurosumi, M.
Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells
J. Cancer Res. Clin. Oncol.
134
551-559
2008
Homo sapiens (P40261), Homo sapiens
Sartini, D.; Santarelli, A.; Rossi, V.; Goteri, G.; Rubini, C.; Ciavarella, D.; Lo Muzio, L.; Emanuelli, M.
Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma
Mol. Med.
13
415-421
2007
Homo sapiens (P40261)
Zhang, L.; Miyaki, K.; Araki, J.; Nakayama, T.; Muramatsu, M.
The relation between nicotinamide N-methyltransferase gene polymorphism and plasma homocysteine concentration in healthy Japanese men
Thromb. Res.
121
55-58
2007
Homo sapiens (P40261), Homo sapiens
Riederer, M.; Erwa, W.; Zimmermann, R.; Frank, S.; Zechner, R.
Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine
Atherosclerosis
204
412-417
2009
Homo sapiens, Mus musculus
Lu, W.; Zhu, H.; Wen, S.; Yang, W.; Shaw, G.M.; Lammer, E.J.; Finnell, R.H.
Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida
Birth Defects Res. Part A Clin. Mol. Teratol.
82
670-675
2008
Homo sapiens
Emanuelli, M.; Santarelli, A.; Sartini, D.; Ciavarella, D.; Rossi, V.; Pozzi, V.; Rubini, C.; Lo Muzio, L.
Nicotinamide N-methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma
Histol. Histopathol.
25
15-20
2010
Homo sapiens
Dostalek, M.; Hardy, K.D.; Milne, G.L.; Morrow, J.D.; Chen, C.; Gonzalez, F.J.; Gu, J.; Ding, X.; Johnson, D.A.; Johnson, J.A.; Martin, M.V.; Guengerich, F.P.
Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems
J. Biol. Chem.
283
17147-17157
2008
Mus musculus, Rattus norvegicus, Mus musculus C57BL/6
Tomida, M.; Mikami, I.; Takeuchi, S.; Nishimura, H.; Akiyama, H.
Serum levels of nicotinamide N-methyltransferase in patients with lung cancer
J. Cancer Res. Clin. Oncol.
135
1223-1229
2009
Homo sapiens
Wu, Y.; Siadaty, M.S.; Berens, M.E.; Hampton, G.M.; Theodorescu, D.
Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration
Oncogene
27
6679-6689
2008
Homo sapiens
Mateuszuk, L.; Khomich, T.I.; Slominska, E.; Gajda, M.; Wojcik, L.; Lomnicka, M.; Gwozdz, P.; Chlopicki, S.
Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis
Pharmacol. Rep.
61
76-85
2009
Mus musculus, Mus musculus C57/BL6J
Kim, H.C.; Mofarrahi, M.; Vassilakopoulos, T.; Maltais, F.; Sigala, I.; Debigare, R.; Bellenis, I.; Hussain, S.N.
Expression and functional significance of nicotinamide N-methyl transferase in skeletal muscles of patients with chronic obstructive pulmonary disease
Am. J. Respir. Crit. Care Med.
181
797-805
2010
Homo sapiens
Parsons, R.B.; Aravindan, S.; Kadampeswaran, A.; Evans, E.A.; Sandhu, K.K.; Levy, E.R.; Thomas, M.G.; Austen, B.M.; Ramsden, D.B.
The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors
Biochem. J.
436
145-155
2011
Homo sapiens
Peng, Y.; Sartini, D.; Pozzi, V.; Wilk, D.; Emanuelli, M.; Yee, V.C.
Structural basis of substrate recognition in human nicotinamide N-methyltransferase
Biochemistry
50
7800-7808
2011
Homo sapiens (P40261), Homo sapiens
Sartini, D.; Pozzi, V.; Renzi, E.; Morganti, S.; Rocchetti, R.; Rubini, C.; Santarelli, A.; Lo Muzio, L.; Emanuelli, M.
Analysis of tissue and salivary nicotinamide N-methyltransferase in oral squamous cell carcinoma: basis for the development of a noninvasive diagnostic test for early-stage disease
Biol. Chem.
393
505-511
2012
Homo sapiens
Tang, S.W.; Yang, T.C.; Lin, W.C.; Chang, W.H.; Wang, C.C.; Lai, M.K.; Lin, J.Y.
Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells
Carcinogenesis
32
138-145
2011
Homo sapiens
Xie, X.; Yu, H.; Wang, Y.; Zhou, Y.; Li, G.; Ruan, Z.; Li, F.; Wang, X.; Liu, H.; Zhang, J.
Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells
Arch. Biochem. Biophys.
564
52-66
2014
Homo sapiens
Liu, K.Y.; Mistry, R.J.; Aguirre, C.A.; Fasouli, E.S.; Thomas, M.G.; Klamt, F.; Ramsden, D.B.; Parsons, R.B.
Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3
Biochem. Biophys. Res. Commun.
467
491-496
2015
Homo sapiens
Sartini, D.; Seta, R.; Pozzi, V.; Morganti, S.; Rubini, C.; Zizzi, A.; Tomasetti, M.; Santarelli, L.; Emanuelli, M.
Role of nicotinamide N-methyltransferase in non-small cell lung cancer: in vitro effect of shRNA-mediated gene silencing on tumourigenicity
Biol. Chem.
396
225-234
2015
Homo sapiens
Bi, H.C.; Pan, Y.Z.; Qiu, J.X.; Krausz, K.W.; Li, F.; Johnson, C.H.; Jiang, C.T.; Gonzalez, F.J.; Yu, A.M.
N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis
Carcinogenesis
35
2264-2272
2014
Homo sapiens
Sartini, D.; Morganti, S.; Guidi, E.; Rubini, C.; Zizzi, A.; Giuliante, R.; Pozzi, V.; Emanuelli, M.
Nicotinamide N-methyltransferase in non-small cell lung cancer: promising results for targeted anti-cancer therapy
Cell Biochem. Biophys.
67
865-873
2013
Homo sapiens
Thomas, M.G.; Saldanha, M.; Mistry, R.J.; Dexter, D.T.; Ramsden, D.B.; Parsons, R.B.
Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling
Cell Death Dis.
4
e669
2013
Homo sapiens
Yu, T.; Wang, Y.T.; Chen, P.; Li, Y.H.; Chen, Y.X.; Zeng, H.; Yu, A.M.; Huang, M.; Bi, H.C.
Effects of nicotinamide N-methyltransferase on PANC-1 cells proliferation, metastatic potential and survival under metabolic stress
Cell. Physiol. Biochem.
35
710-721
2015
Homo sapiens
Mori, Y.; Sugawara, A.; Tsuji, M.; Kakamu, T.; Tsuboi, S.; Kanda, H.; Hayakawa, T.; Fukushima, T.
Toxic effects of nicotinamide methylation on mouse brain striatum neuronal cells and its relation to manganese
Environ. Health Prev. Med.
17
371-376
2012
Mus musculus
Milani, Z.H.; Ramsden, D.B.; Parsons, R.B.
Neuroprotective effects of nicotinamide N-methyltransferase and its metabolite 1-methylnicotinamide
J. Biochem. Mol. Toxicol.
27
451-456
2013
Homo sapiens
Patel, M.; Vasaya, M.M.; Asker, D.; Parsons, R.B.
HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples: evidence for substrate inhibition kinetics
J. Chromatogr. B
921-922
87-95
2013
Oryctolagus cuniculus, Homo sapiens, Mus musculus
Hong, S.; Moreno-Navarrete, J.M.; Wei, X.; Kikukawa, Y.; Tzameli, I.; Prasad, D.; Lee, Y.; Asara, J.M.; Fernandez-Real, J.M.; Maratos-Flier, E.; Pissios, P.
Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization
Nat. Med.
21
887-894
2015
Mus musculus, Mus musculus C57Bl6/J
Win, K.T.; Lee, S.W.; Huang, H.Y.; Lin, L.C.; Lin, C.Y.; Hsing, C.H.; Chen, L.T.; Li, C.F.
Nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma
Tumour Biol.
34
3923-3931
2013
Homo sapiens
Swaminathan, S.; Birudukota, S.; Thakur, M.K.; Parveen, R.; Kandan, S.; Juluri, S.; Shaik, S.; Anand, N.N.; Burri, R.R.; Kristam, R.; Hallur, M.S.; Rajagopal, S.; Schreuder, H.; Langer, T.; Rudolph, C.; Ruf, S.; Dhakshinamoorthy, S.; Gosu, R.; Kannt, A.
Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide
Biochem. Biophys. Res. Commun.
491
416-422
2017
Macaca mulatta (F7ERX8), Mus musculus (O55239), Mus musculus
Thomas, M.G.; Sartini, D.; Emanuelli, M.; van Haren, M.J.; Martin, N.I.; Mountford, D.M.; Barlow, D.J.; Klamt, F.; Ramsden, D.B.; Reza, M.; Parsons, R.B.
Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous beta-carboline norharman evidence for a novel detoxification pathway
Biochem. J.
473
3253-3267
2016
Homo sapiens (P40261)
Loring, H.S.; Thompson, P.R.
Kinetic mechanism of nicotinamide N-methyltransferase
Biochemistry
57
5524-5532
2018
Homo sapiens (P40261), Homo sapiens
Hong, S.; Zhai, B.; Pissios, P.
Nicotinamide N-methyltransferase interacts with enzymes of the methionine cycle and regulates methyl donor metabolism
Biochemistry
57
5775-5779
2018
Mus musculus (O55239), Mus musculus
Ruf, S.; Hallur, M.S.; Anchan, N.K.; Swamy, I.N.; Murugesan, K.R.; Sarkar, S.; Narasimhulu, L.K.; Putta, V.P.R.K.; Shaik, S.; Chandrasekar, D.V.; Mane, V.S.; Kadnur, S.V.; Suresh, J.; Bhamidipati, R.K.; Singh, M.; Burri, R.R.; Kristam, R.; Schreuder, H.; Czech, J.; Rudolph, C.; Marker, A.; Langer, T.; Mullangi,
Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase
Bioorg. Med. Chem. Lett.
28
922-925
2018
Homo sapiens (P40261)
Li, Q.; He, M.D.; Mao, L.; Wang, X.; Jiang, Y.L.; Li, M.; Lu, Y.H.; Yu, Z.P.; Zhou, Z.
Nicotinamide N-methyltransferase suppression participates in nickel-induced histone H3 lysine9 dimethylation in BEAS-2B cells
Cell. Physiol. Biochem.
41
2016-2026
2017
Homo sapiens (P40261), Homo sapiens
Kannt, A.; Pfenninger, A.; Teichert, L.; Toenjes, A.; Dietrich, A.; Schoen, M.R.; Kloeting, N.; Blueher, M.
Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance
Diabetologia
58
799-808
2015
Homo sapiens (P40261)
van Haren, M.J.; Thomas, M.G.; Sartini, D.; Barlow, D.J.; Ramsden, D.B.; Emanuelli, M.; Klamt, F.; Martin, N.I.; Parsons, R.B.
The kinetic analysis of the N-methylation of 4-phenylpyridine by nicotinamide N-methyltransferase Evidence for a novel mechanism of substrate inhibition
Int. J. Biochem. Cell Biol.
98
127-136
2018
Homo sapiens (P40261), Homo sapiens
Neelakantan, H.; Wang, H.Y.; Vance, V.; Hommel, J.D.; McHardy, S.F.; Watowich, S.J.
Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase
J. Med. Chem.
60
5015-5028
2017
Homo sapiens (P40261)
Babault, N.; Allali-Hassani, A.; Li, F.; Fan, J.; Yue, A.; Ju, K.; Liu, F.; Vedadi, M.; Liu, J.; Jin, J.
Discovery of bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT)
J. Med. Chem.
61
1541-1551
2018
Homo sapiens (P40261), Homo sapiens
Chen, D.; Li, L.; Diaz, K.; Iyamu, I.D.; Yadav, R.; Noinaj, N.; Huang, R.
Novel propargyl-linked bisubstrate analogues as tight-binding inhibitors for nicotinamide N-methyltransferase
J. Med. Chem.
62
10783-10797
2019
Homo sapiens (P40261)
Gao, Y.; van Haren, M.J.; Moret, E.E.; Rood, J.J.M.; Sartini, D.; Salvucci, A.; Emanuelli, M.; Craveur, P.; Babault, N.; Jin, J.; Martin, N.I.
Bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT) with enhanced activity
J. Med. Chem.
62
6597-6614
2019
Homo sapiens (P40261), Homo sapiens
Policarpo, R.L.; Decultot, L.; May, E.; Kuzmic, P.; Carlson, S.; Huang, D.; Chu, V.; Wright, B.A.; Dhakshinamoorthy, S.; Kannt, A.; Rani, S.; Dittakavi, S.; Panarese, J.D.; Gaudet, R.; Shair, M.D.
High-affinity alkynyl bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT)
J. Med. Chem.
62
9837-9873
2019
Homo sapiens (P40261)
You, Z.; Liu, Y.; Liu, X.
Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1
Oncol. Lett.
15
9195-9201
2018
Homo sapiens (P40261), Homo sapiens
Hah, Y.; Cho, H.; Jo, S.; Park, Y.; Yoon, T.; Heo, E.
Nicotinamide N-methyltransferase induces the proliferation and invasion of squamous cell carcinoma cells
Oncol. Rep.
42
1805-1814
2019
Homo sapiens (P40261)
Xie, X.; Liu, H.; Wang, Y.; Zhou, Y.; Yu, H.; Li, G.; Ruan, Z.; Li, F.; Wang, X.; Zhang, J.
Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway
Oncotarget
7
45837-45848
2016
Homo sapiens (P40261), Homo sapiens
van Haren, M.J.; Taig, R.; Kuppens, J.; Sastre Torano, J.; Moret, E.E.; Parsons, R.B.; Sartini, D.; Emanuelli, M.; Martin, N.I.
Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state
Org. Biomol. Chem.
15
6656-6667
2017
Homo sapiens (P40261)
Schmeisser, K.; Parker, J.
Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy
PLoS Genet.
14
e1007561
2018
Caenorhabditis elegans (P34254)
html completed