Information on EC 2.1.1.109 - demethylsterigmatocystin 6-O-methyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.1.1.109
-
RECOMMENDED NAME
GeneOntology No.
demethylsterigmatocystin 6-O-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 6-demethylsterigmatocystin = S-adenosyl-L-homocysteine + sterigmatocystin
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
aflatoxins B2 and G2 biosynthesis
-
-
sterigmatocystin biosynthesis
-
-
Aflatoxin biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase
Dihydrodemethylsterigmatocystin can also act as acceptor. Involved in the biosynthesis of aflatoxins in fungi.
CAS REGISTRY NUMBER
COMMENTARY hide
123516-47-2
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 6-demethylsterigmatocystin
S-adenosyl-L-homocysteine + sterigmatocystin
show the reaction diagram
S-adenosyl-L-methionine + dihydrodemethylsterigmatocystin
S-adenosyl-L-homocysteine + dihydrosterigmatocystin
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 6-demethylsterigmatocystin
S-adenosyl-L-homocysteine + sterigmatocystin
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6-demethylsterigmatocystin
-
at higher concentrations
dihydrodemethylsterigmatocystin
-
at higher concentrations
N-ethylmaleimide
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00094
6-demethylsterigmatocystin
-
-
0.0025
dihydrodemethylsterigmatocystin
-
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.108
6-demethylsterigmatocystin
-
-
0.171
dihydrodemethylsterigmatocystin
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.043
-
with dihydrodemethylsterigmatocystin
0.061
-
with 6-demethylsterigmatocystin
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
15000
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
phenyl-Sepharose, Sephacryl S-300, Matrex gel Green A
-
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE