Information on EC 2.1.1.120 - 12-hydroxydihydrochelirubine 12-O-methyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)

The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.1.1.120
-
RECOMMENDED NAME
GeneOntology No.
12-hydroxydihydrochelirubine 12-O-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine = S-adenosyl-L-homocysteine + dihydromacarpine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
sanguinarine and macarpine biosynthesis
-
-
Isoquinoline alkaloid biosynthesis
-
-
Metabolic pathways
-
-
Biosynthesis of secondary metabolites
-
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase
This reaction is part of the pathway for synthesis of benzophenanthridine alkaloid macarpine in plants.
CAS REGISTRY NUMBER
COMMENTARY hide
158736-40-4
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Thalictrum bulgaricum
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine
?
show the reaction diagram
Thalictrum bulgaricum
-
involved in biosynthesis of macarpine, the most highly oxidized benzophenanthridine alkaloid, not significantly affected by elicitation
-
-
-
S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine
S-adenosyl-L-homocysteine + dihydromacarpine
show the reaction diagram
Thalictrum bulgaricum
-
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine
?
show the reaction diagram
Thalictrum bulgaricum
-
involved in biosynthesis of macarpine, the most highly oxidized benzophenanthridine alkaloid, not significantly affected by elicitation
-
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
Thalictrum bulgaricum
-
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
Thalictrum bulgaricum
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Thalictrum bulgaricum
-
-
Manually annotated by BRENDA team
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
-
Thalictrum bulgaricum
-