Reference on EC 2.1.1.142 - cycloartenol 24-C-methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mangla, A.T.; Nes, W.D.
Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition
Bioorg. Med. Chem.
8
925-936
2000
Prototheca wickerhamii
Schaeffer, A.; Bronner, R.; Benveniste, P.; Schaller, H.
The ratio of campesterol to sitosterol that modulates growth in Arabidopsis is controlled by sterol methyltransferase 2;1
Plant J.
25
605-615
2001
Arabidopsis thaliana
Nes, W.D.; Janssen, G.G.; Bergenstrahle, A.
Structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase
J. Biol. Chem.
266
15202-15212
1991
Helianthus annuus
Rahier, A.; Genot, J.C.; Schuber, F.; Benveniste, P.; Narula, A.S.
Inhibition of S-adenosyl-L-methionine sterol-C-24-methyltransferase by analogues of a carbocationic ion high-energy intermediate. Structure activity relationships for C-25 heteroatoms (N, As, S) substituted triterpenoid derivatives
J. Biol. Chem.
259
15215-15223
1984
Zea mays
Diener, A.C.; Li, H.; Zhou, W.X.; Whoriskey, W.J.; Nes, W.D.; Fink, G.R.
Sterol methyltransferase 1 controls the level of cholesterol in plants
Plant Cell
12
853-870
2000
Arabidopsis thaliana (Q9LM02)
Shi, J.; Gonzales, R.A.; Bhattacharyya, M.K.
Identification and characterization of an S-adenosyl-L-methionine:DELTA24-sterol-C-methyltransferase cDNA from soybean
J. Biol. Chem.
271
9384-9389
1996
Glycine max, Glycine max (Q43445)
Holmberg, N.; Harker, M.; Wallace, A.D.; Clayton, J.C.; Gibbard, C.L.; Safford, R.
Co-expression of N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase and C24-sterol methyltransferase type 1 in transgenic tobacco enhances carbon flux towards end-product sterols
Plant J.
36
12-20
2003
Nicotiana tabacum
Zhou, W.; Nes, W.D.
Sterol methyltransferase2: purification, properties, and inhibition
Arch. Biochem. Biophys.
420
18-34
2003
Arabidopsis thaliana
Nes, W.D.; Song, Z.; Dennis, A.L.; Zhou, W.; Nam, J.; Miller, M.B.
Biosynthesis of phytosterols. Kinetic mechanism for the enzymatic C-methylation of sterols
J. Biol. Chem.
278
34505-34516
2003
Glycine max
Zhou, W.; Song, Z.; Kanagasabai, R.; Liu, J.; Jayasimha, P.; Sinha, A.; Veeramachanemi, P.; Miller, M.B.; Nes, W.D.
Mechanism-based enzyme inactivators of phytosterol biosynthesis
Molecules
9
185-203
2004
Glycine max
Zhou, W.; Song, Z.; Liu, J.; Miller, M.B.; Nes, W.D.
24-Thiacycloartanol, a potent mechanism-based inactivator of plant sterol methyltransferase
Tetrahedron Lett.
45
875-878
2004
Glycine max
-
Nes, W.D.; Sinha, A.; Jayasimha, P.; Zhou, W.; Song, Z.; Dennis, A.L.
Probing the sterol binding site of soybean sterol methyltransferase by site-directed mutagenesis: functional analysis of conserved aromatic amino acids in Region 1
Arch. Biochem. Biophys.
448
23-30
2006
Glycine max
Song, Z.; Nes, W.D.
Inactivation of soybean sterol 24-C-methyltransferase by elongated sterol side chains at C26
Bioorg. Med. Chem. Lett.
17
5902-5906
2007
Glycine max
Wang, J.; Liu, J.; Song, Z.; Nes, W.D.
Sterol C24-methyltransferase: Mechanistic studies of the C-methylation reaction with 24-fluorocycloartenol
Bioorg. Med. Chem. Lett.
18
232-235
2008
Glycine max
Luo, M.; Tan, K.; Xiao, Z.; Hu, M.; Liao, P.; Chen, K.
Cloning and expression of two sterol C-24 methyltransferase genes from upland cotton (Gossypium hirsuturm L.)
J. Genet. Genomics
35
357-363
2008
Gossypium hirsutum
Wang, J.; Nes, W.D.
Cyclobranol: a substrate for C25-methyl sterol side chains and potent mechanism-based inactivator of plant sterol methyltransferase
Bioorg. Med. Chem. Lett.
18
3878-3881
2008
Glycine max
Neelakandan, A.K.; Song, Z.; Wang, J.; Richards, M.H.; Wu, X.; Valliyodan, B.; Nguyen, H.T.; Nes, W.D.
Cloning, functional expression and phylogenetic analysis of plant sterol 24C-methyltransferases involved in sitosterol biosynthesis
Phytochemistry
70
1982-1998
2009
Glycine max, Glycine max (D2D5G4), Glycine max (Q43445)
Pereira, M.; Song, Z.; Santos-Silva, L.K.; Richards, M.H.; Nguyen, T.T.; Liu, J.; de Almeida Soares, C.M.; da Silva Cruz, A.H.; Ganapathy, K.; Nes, W.D.
Cloning, mechanistic and functional analysis of a fungal sterol C24-methyltransferase implicated in brassicasterol biosynthesis
Biochim. Biophys. Acta
1801
1163-1174
2010
Paracoccidioides brasiliensis, Paracoccidioides brasiliensis Pb0, ATCC MYA-826
Neelakandan, A.K.; Nguyen, H.T.; Kumar, R.; Tran, L.S.; Guttikonda, S.K.; Quach, T.N.; Aldrich, D.L.; Nes, W.D.; Nguyen, H.T.
Molecular characterization and functional analysis of Glycine max sterol methyl transferase 2 genes involved in plant membrane sterol biosynthesis
Plant Mol. Biol.
74
503-518
2010
Arabidopsis thaliana, Glycine max
Carland, F.; Fujioka, S.; Nelson, T.
The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products
Plant Physiol.
153
741-756
2010
Arabidopsis thaliana
Patkar, P.; Haubrich, B.A.; Qi, M.; Nguyen, T.T.; Thomas, C.D.; Nes, W.D.
C-24-methylation of 26-fluorocycloartenols by recombinant sterol C-24-methyltransferase from soybean: evidence for channel switching and its phylogenetic implications
Biochem. J.
456
253-262
2013
Glycine max
Neelakandan, A.; Chamala, S.; Valliyodan, B.; Nes, W.; Nguyen, H.
Metabolic engineering of soybean affords improved phytosterol seed traits
Plant Biotechnol. J.
10
12-19
2012
Glycine max (Q43445)
Kaneshiro, E.; Johnston, L.; Nkinin, S.; Romero, B.; Giner, J.
Sterols of Saccharomyces cerevisiae erg6 knockout mutant expressing the Pneumocystis carinii S-adenosylmethionine sterol C-24 methyltransferase (SAM SMT)
J. Eukaryot. Microbiol.
62
298-306
2015
Pneumocystis carinii (Q96WX4), Pneumocystis carinii, Pneumocystis carinii B80 (Q96WX4)
Guan, H.; Zhao, Y.; Su, P.; Tong, Y.; Liu, Y.; Hu, T.; Zhang, Y.; Zhang, X.; Li, J.; Wu, X.; Huang, L.; Gao, W.
Molecular cloning and functional identification of sterol C24-methyltransferase gene from Tripterygium wilfordii
Acta Pharm. Sin. B
7
603-609
2017
Tripterygium wilfordii (A0A2U7MCR4), Tripterygium wilfordii
Guan, H.Y.; Su, P.; Zhao, Y.J.; Zhang, X.N.; Dai, Z.B.; Guo, J.; Tong, Y.R.; Liu, Y.J.; Hu, T.Y.; Yin, Y.; Gao, L.H.; Gao, W.; Huang, L.Q.
Cloning and functional analysis of two sterol-C24-methyltransferase 1 (SMT1) genes from Paris polyphylla
J. Asian Nat. Prod. Res.
20
595-604
2018
Paris polyphylla (A0A2R2UK37)
Haubrich, B.; Collins, E.; Howard, A.; Wang, Q.; Snell, W.; Miller, M.; Thomas, C.; Pleasant, S.; Nes, W.
Characterization, mutagenesis and mechanistic analysis of an ancient algal sterol C24-methyltransferase Implications for understanding sterol evolution in the green lineage
Phytochemistry
113
64-72
2015
Chlamydomonas reinhardtii (A8IJ34), Chlamydomonas reinhardtii
Zhou, W.; Debnath, A.; Jennings, G.; Hahn, H.; Vanderloop, B.; Chaudhuri, M.; Nes, W.; Podust, L.
Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri
PLoS Pathog.
14
e1007245
2018
Naegleria fowleri
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