Disease on EC 2.1.1.17 - phosphatidylethanolamine N-methyltransferase
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Alzheimer Disease
A metabolic link between S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in Alzheimer's disease.
Alzheimer Disease
Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease.
Alzheimer Disease
PEMT G523A (V175M) Is Associated with Sporadic Alzheimer's Disease in a Chinese Population.
Asthma
A pilot study to evaluate self initiated computer patient education in children with acute asthma in pediatric emergency department.
Asthma
Prospective tracking of a pediatric emergency department e-kiosk to deliver asthma education.
Asthma
[Membrane phosphatidylethanolamine methylase in blood leukocytes and alveolar macrophages of asthmatic patients]
Atherosclerosis
Hepatic Expression of PEMT, but Not Dietary Choline Supplementation, Reverses the Protection against Atherosclerosis in Pemt-/-/Ldlr-/- Mice.
Atherosclerosis
Impaired Phosphatidylcholine Biosynthesis Reduces Atherosclerosis and Prevents Lipotoxic Cardiac Dysfunction in ApoE-/- Mice.
Atherosclerosis
Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice.
Atherosclerosis
Phospholipid methylation in mammals: from biochemistry to physiological function.
Breast Neoplasms
Dietary choline and betaine intake, choline-metabolising genetic polymorphisms and breast cancer risk: a case-control study in China.
Breast Neoplasms
Epigenetic repression of phosphatidylethanolamine, N-methyltransferase (PEMT) in BRCA1-mutated breast cancer.
Carcinoma
Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer.
Carcinoma, Hepatocellular
A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling.
Carcinoma, Hepatocellular
An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins.
Carcinoma, Hepatocellular
Diminished expression of phosphatidylethanolamine N-methyltransferase 2 during hepatocarcinogenesis.
Carcinoma, Hepatocellular
Expression of phosphatidylethanolamine N-methyltransferase in human hepatocellular carcinomas.
Carcinoma, Hepatocellular
Expression of phosphatidylethanolamine N-methyltransferase in Yoshida ascites hepatoma cells and the livers of host rats.
Carcinoma, Hepatocellular
Expression of phosphatidylethanolamine N-methyltransferase-2 in McArdle-RH7777 hepatoma cells inhibits the CDP-choline pathway for phosphatidylcholine biosynthesis via decreased gene expression of CTP:phosphocholine cytidylyltransferase.
Carcinoma, Hepatocellular
Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2.
Carcinoma, Hepatocellular
Inactivation of PEMT2 in hepatocytes initiated by DENA in fasted/refed rats.
Carcinoma, Hepatocellular
Inactivation of phosphatidylethanolamine N-methyltransferase-2 in aflatoxin-induced liver cancer and partial reversion of the neoplastic phenotype by PEMT transfection of hepatoma cells.
Carcinoma, Hepatocellular
Induction of hepatocyte proliferation after partial hepatectomy is accompanied by a markedly reduced expression of phosphatidylethanolamine N-methyltransferase-2.
Carcinoma, Hepatocellular
Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress.
Carcinoma, Hepatocellular
Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase.
Carcinoma, Hepatocellular
Over-expression of pemt2 into rat hepatoma cells contributes to the mitochondrial apoptotic pathway.
Carcinoma, Hepatocellular
The Concentration of Phosphatidylethanolamine in Mitochondria Can Modulate ATP Production and Glucose Metabolism in Mice.
Carcinoma, Hepatocellular
[Comparison of the expression and activity of phosphatidylethanolamine N-methyltransferase 2 between primary cultured hepatocytes and hepatoma cells in rats]
Cholestasis, Intrahepatic
The role of phosphatidylethanolamine methyltransferase in a mouse model of intrahepatic cholestasis.
Choline Deficiency
Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota.
Choline Deficiency
Common genetic polymorphisms affect the human requirement for the nutrient choline.
Choline Deficiency
Effect of choline deficiency on the enzymes that synthesize phosphatidylcholine and phosphatidylethanolamine in rat liver.
Choline Deficiency
No up-regulation of the phosphatidylethanolamine N-methyltransferase pathway and choline production by sex hormones in cats.
Choline Deficiency
Resolution of severe hepatosteatosis in a cystic fibrosis patient with multifactorial choline deficiency: A case report.
Choline Deficiency
Sexually dimorphic activation of liver and brain phosphatidylethanolamine N-methyltransferase by dietary choline deficiency.
Colonic Neoplasms
Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer.
cystathionine beta-synthase deficiency
Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria.
Cystic Fibrosis
Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota.
Cystic Fibrosis
Lymphocyte and granulocyte phosphatidylethanolamine N-methyltransferase: properties and activity in cystic fibrosis.
Diabetes Mellitus
Higher homocysteine and lower betaine increases the risk of microangiopathy in patients with diabetes mellitus carrying the GG genotype of PEMT G774C.
Diabetes Mellitus, Type 1
Pemt deficiency ameliorates endoplasmic reticulum stress in diabetic nephropathy.
Diabetes Mellitus, Type 2
Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action.
Diabetic Nephropathies
Pemt deficiency ameliorates endoplasmic reticulum stress in diabetic nephropathy.
Dyspnea
Diagnostic accuracy of physician-staffed emergency medical teams: a retrospective observational cohort study of prehospital versus hospital diagnosis in a 10-year interval.
Endometriosis
Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility.
Fatty Liver
Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice.
Fatty Liver
Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis.
Fatty Liver
Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress.
Fatty Liver
Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet.
Fatty Liver
Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice.
Fatty Liver
Phospholipid methylation in mammals: from biochemistry to physiological function.
Fatty Liver
Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-(PEMT) deficient mice.
Fatty Liver
Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD).
Fatty Liver
Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans.
Fatty Liver
Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression.
Fatty Liver
Vagus nerve contributes to the development of steatohepatitis and obesity in phosphatidylethanolamine N-methyltransferase deficient mice.
Fatty Liver
Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice.
Fatty Liver
Whole-Exome Sequencing Identifies a Variant in Phosphatidylethanolamine N-Methyltransferase Gene to be Associated With Lean-Nonalcoholic Fatty Liver Disease.
Fetal Death
Importance of polymorphic variants of phosphatidylethanolamine N-methyltransferase (PEMT) gene in the etiology of intrauterine fetal death in the Polish population.
Gallstones
Hyperhomocysteinemia from trimethylation of hepatic phosphatidylethanolamine during cholesterol cholelithogenesis in inbred mice.
glycine n-methyltransferase deficiency
Methyl balance and transmethylation fluxes in humans.
guanidinoacetate n-methyltransferase deficiency
Methyl balance and transmethylation fluxes in humans.
Homocystinuria
Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria.
Hyperthyroidism
The effect of hyper and hypothyroidism, hypophysectomy and adrenalectomy on phosphatidylethanolamine methyltransferase, phosphatidyldimethyl-ethanolamine methyltransferase and choline phosphotransferase of rat liver microsomes.
Hypothyroidism
The effect of hyper and hypothyroidism, hypophysectomy and adrenalectomy on phosphatidylethanolamine methyltransferase, phosphatidyldimethyl-ethanolamine methyltransferase and choline phosphotransferase of rat liver microsomes.
Infertility
Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility.
Insulin Resistance
Distinct infrastructure of lipid networks in visceral and subcutaneous adipose tissues in overweight humans.
Insulin Resistance
Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q.
Insulin Resistance
GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women.
Insulin Resistance
Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance.
Insulin Resistance
Implication of phosphatidylethanolamine N-methyltransferase in adipocyte differentiation.
Insulin Resistance
Lack of phosphatidylethanolamine N-methyltransferase in mice does not promote fatty acid oxidation in skeletal muscle.
Insulin Resistance
Phospholipid methylation in mammals: from biochemistry to physiological function.
Insulin Resistance
Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-(PEMT) deficient mice.
Insulin Resistance
The Concentration of Phosphatidylethanolamine in Mitochondria Can Modulate ATP Production and Glucose Metabolism in Mice.
Kidney Diseases
New Insights Into the Role and Mechanism of Partial Epithelial-Mesenchymal Transition in Kidney Fibrosis.
Lipidoses
No up-regulation of the phosphatidylethanolamine N-methyltransferase pathway and choline production by sex hormones in cats.
Liver Diseases
Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction.
Liver Diseases
Phosphatidylethanolamine N-methyltransferase gene rs7946 polymorphism plays a role in risk of nonalcoholic fatty liver disease: evidence from meta-analysis.
Liver Diseases
Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-(PEMT) deficient mice.
Liver Diseases
Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD).
Liver Diseases
Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans.
Liver Diseases
Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo.
Liver Diseases
Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice.
Liver Diseases
Whole-Exome Sequencing Identifies a Variant in Phosphatidylethanolamine N-Methyltransferase Gene to be Associated With Lean-Nonalcoholic Fatty Liver Disease.
Liver Diseases, Alcoholic
Hepatic, metabolic, and nutritional disorders of alcoholism: from pathogenesis to therapy.
Liver Failure
Dimethylethanolamine does not prevent liver failure in phosphatidylethanolamine N-methyltransferase-deficient mice fed a choline-deficient diet.
Liver Failure
Physiological consequences of disruption of mammalian phospholipid biosynthetic genes.
Liver Neoplasms
Inactivation of phosphatidylethanolamine N-methyltransferase-2 in aflatoxin-induced liver cancer and partial reversion of the neoplastic phenotype by PEMT transfection of hepatoma cells.
Lung Neoplasms
Increased phosphatidylethanolamine N-methyltransferase gene expression in non-small-cell lung cancer tissue predicts shorter patient survival.
Melanoma
Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells.
Neoplasm Metastasis
Interplay between tumor microenvironment and partial EMT as the driver of tumor progression.
Neoplasms
Expression of phosphatidylethanolamine N-methyltransferase in human hepatocellular carcinomas.
Neoplasms
GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women.
Neoplasms
Inactivation of phosphatidylethanolamine N-methyltransferase-2 in aflatoxin-induced liver cancer and partial reversion of the neoplastic phenotype by PEMT transfection of hepatoma cells.
Neoplasms
Increased phosphatidylethanolamine N-methyltransferase gene expression in non-small-cell lung cancer tissue predicts shorter patient survival.
Neoplasms
Interplay between tumor microenvironment and partial EMT as the driver of tumor progression.
Neoplasms
LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk.
Neoplasms
Precursor B lymphoblastic leukemia 32 months after local therapy for a primary extramedullary myeloid cell tumor.
Neoplasms
Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer.
Neoplasms
Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells.
Neoplasms
Weighted gene correlation network analysis identifies the critical long non-coding RNAs participate in the progression of osteosarcoma.
Non-alcoholic Fatty Liver Disease
Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance.
Non-alcoholic Fatty Liver Disease
NAFLD Susceptibility Genes and their Association with Type 2 Diabetes and Obesity in a New Mexico Population.
Non-alcoholic Fatty Liver Disease
Phosphatidylethanolamine N-methyltransferase gene rs7946 polymorphism plays a role in risk of nonalcoholic fatty liver disease: evidence from meta-analysis.
Non-alcoholic Fatty Liver Disease
Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-(PEMT) deficient mice.
Non-alcoholic Fatty Liver Disease
Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD).
Non-alcoholic Fatty Liver Disease
Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans.
Non-alcoholic Fatty Liver Disease
Relationship Between Nonalcoholic Fatty Liver Disease Susceptibility Genes and Coronary Artery Disease.
Non-alcoholic Fatty Liver Disease
Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice.
Non-alcoholic Fatty Liver Disease
Whole-Exome Sequencing Identifies a Variant in Phosphatidylethanolamine N-Methyltransferase Gene to be Associated With Lean-Nonalcoholic Fatty Liver Disease.
Obesity
Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action.
Obesity
Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice.
Obesity
Gene-by-environment interactions of the CLOCK, PEMT, and GHRELIN loci with average sleep duration in relation to obesity traits using a cohort of 643 New Zealand European children.
Obesity
Implication of phosphatidylethanolamine N-methyltransferase in adipocyte differentiation.
Obesity
Insufficient glucose supply is linked to hypothermia upon cold exposure in high-fat diet-fed mice lacking PEMT.
Obesity
Lack of phosphatidylethanolamine N-methyltransferase in mice does not promote fatty acid oxidation in skeletal muscle.
Obesity
Phospholipid biosynthesis genes and susceptibility to obesity: analysis of expression and polymorphisms.
Obesity
Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-(PEMT) deficient mice.
Obesity
Single Nucleotide Polymorphisms in PEMT and MTHFR Genes are Associated with Omega 3 and 6 Fatty Acid Levels in the Red Blood Cells of Children with Obesity.
Obesity
The Concentration of Phosphatidylethanolamine in Mitochondria Can Modulate ATP Production and Glucose Metabolism in Mice.
Obesity
Vagus nerve contributes to the development of steatohepatitis and obesity in phosphatidylethanolamine N-methyltransferase deficient mice.
Osteosarcoma
Weighted gene correlation network analysis identifies the critical long non-coding RNAs participate in the progression of osteosarcoma.
Overnutrition
Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance.
phosphatidylethanolamine n-methyltransferase deficiency
Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice.
phosphatidylethanolamine n-methyltransferase deficiency
Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q.
phosphatidylethanolamine n-methyltransferase deficiency
Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance.
phosphatidylethanolamine n-methyltransferase deficiency
Impaired Phosphatidylcholine Biosynthesis Reduces Atherosclerosis and Prevents Lipotoxic Cardiac Dysfunction in ApoE-/- Mice.
phosphatidylethanolamine n-methyltransferase deficiency
Implication of phosphatidylethanolamine N-methyltransferase in adipocyte differentiation.
phosphatidylethanolamine n-methyltransferase deficiency
Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress.
phosphatidylethanolamine n-methyltransferase deficiency
Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice.
phosphatidylethanolamine n-methyltransferase deficiency
Lack of phosphatidylethanolamine N-methyltransferase in mice does not promote fatty acid oxidation in skeletal muscle.
phosphatidylethanolamine n-methyltransferase deficiency
Pemt deficiency ameliorates endoplasmic reticulum stress in diabetic nephropathy.
phosphatidylethanolamine n-methyltransferase deficiency
The Concentration of Phosphatidylethanolamine in Mitochondria Can Modulate ATP Production and Glucose Metabolism in Mice.
phosphatidylethanolamine n-methyltransferase deficiency
The role of phosphatidylethanolamine methyltransferase in a mouse model of intrahepatic cholestasis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Precursor B lymphoblastic leukemia 32 months after local therapy for a primary extramedullary myeloid cell tumor.
Premature Birth
Dietary Choline Intake during Pregnancy and PEMT rs7946 Polymorphism on Risk of Preterm Birth: A Case-Control Study.
Sarcoidosis
Phosphatidylethanolamine methyltransferase and cAMP, cGMP phosphodiesterases in lymphocytes and monocytes in sarcoidosis.
Spinal Dysraphism
Phosphatidylethanolamine N-methyltransferase (PEMT) gene polymorphisms and risk of spina bifida.
Stroke, Lacunar
Alternative Splicing of Putative Stroke/Vascular Risk Factor Genes Expressed in Blood Following Ischemic Stroke Is Sexually Dimorphic and Cause-Specific.
Urinary Bladder Neoplasms
LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk.
Virus Diseases
Effect of Friend virus infection on the biosynthetic enzymes of phosphatidylcholine biosynthesis in spleen microsomes.
Vitamin B 6 Deficiency
Effect of pyridoxine deficiency on phospholipid methylation in rat liver microsomes.
Whooping Cough
Light activation of phosphatidylethanolamine N-methyltransferase in rod outer segments and its modulation by association states of transducin.
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