Information on EC 2.1.1.211 - tRNASer (uridine44-2'-O)-methyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Saccharomyces cerevisiae

EC NUMBER
COMMENTARY hide
2.1.1.211
-
RECOMMENDED NAME
GeneOntology No.
tRNASer (uridine44-2'-O)-methyltransferase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + uridine44 in tRNASer = S-adenosyl-L-homocysteine + 2'-O-methyluridine44 in tRNASer
show the reaction diagram
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
tRNA methylation (yeast)
-
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:tRNASer (uridine44-2'-O)-methyltransferase
The 2'-O-methylation of uridine44 contributes to stability of tRNASer(CGA).
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
trm44-DELTA strain lacks 2'-O-methyltransferase activity and has undetectable levels of Um44 in its tRNASer. Although trm44-DELTA mutants have no detectable growth defect, TRM44 is required for survival at 33°C in a tan1-DELTA mutant strain, which lacks ac4C12 in tRNASer and tRNALeu
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + uridine44 in tRNASer
S-adenosyl-L-homocysteine + 2'-O-methyluridine44 in tRNASer
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + uridine44 in tRNASer
S-adenosyl-L-homocysteine + 2'-O-methyluridine44 in tRNASer
show the reaction diagram
Q02648
2'-O-methylation of uridine44 contributes to stability of tRNASer(CGA)
-
-
?
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli