Information on EC 2.1.1.223 - tRNA1Val (adenine37-N6)-methyltransferase

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The expected taxonomic range for this enzyme is: Escherichia coli

EC NUMBER
COMMENTARY hide
2.1.1.223
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RECOMMENDED NAME
GeneOntology No.
tRNA1Val (adenine37-N6)-methyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + adenine37 in tRNA1Val = S-adenosyl-L-homocysteine + N6-methyladenine37 in tRNA1Val
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:tRNA1Val (adenine37-N6)-methyltransferase
The enzyme specifically methylates adenine37 in tRNA1Val (anticodon cmo5UAC).
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
inactivation of yfiC gene abolishes m6A formation in tRNA1(Val), while expression of the yfiC gene from a plasmid restores the modification
physiological function
the methylation of m6A in tRNA1(Val) by YfiC has little influence on the cell growth under standard conditions, the yfiC gene confers a growth advantage under conditions of osmotic and oxidative stress
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + adenine37 in tRNA1(Val)
S-adenosyl-L-homocysteine + N6-methyladenine37 in tRNA1(Val)
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + adenine37 in tRNA1(Val)
S-adenosyl-L-homocysteine + N6-methyladenine37 in tRNA1(Val)
show the reaction diagram
P31825
modification of adenine37 in the anticodon loop. The methylation of m6A in tRNA1 Val by YfiC has little influence on the cell growth under standard conditions, the yfiC gene confers a growth advantage under conditions of osmotic and oxidative stress
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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