Reference on EC 2.1.1.228 - tRNA (guanine37-N1)-methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Brule, H.; Elliott, M.; Redlak, M.; Zehner, Z.E.; Holmes, W.M.
Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein
Biochemistry
43
9243-9255
2004
Escherichia coli (P0A873), Escherichia coli, Homo sapiens (Q32P41), Homo sapiens
Ahn, H.J.; Kim, H.W.; Yoon, H.J.; Lee, B.I.; Suh, S.W.; Yang, J.K.
Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition
EMBO J.
22
2593-2603
2003
Haemophilus influenzae (P43912), Haemophilus influenzae
O'Dwyer, K.; Watts, J.M.; Biswas, S.; Ambrad, J.; Barber, M.; Brule, H.; Petit, C.; Holmes, D.J.; Zalacain, M.; Holmes, W.M.
Characterization of Streptococcus pneumoniae TrmD, a tRNA methyltransferase essential for growth
J. Bacteriol.
186
2346-2354
2004
Streptococcus pneumoniae
Christian, T.; Evilia, C.; Williams, S.; Hou, Y.M.
Distinct origins of tRNA(m1G37) methyltransferase
J. Mol. Biol.
339
707-719
2004
Methanocaldococcus jannaschii (Q58293), Methanocaldococcus jannaschii
Takeda, H.; Toyooka, T.; Ikeuchi, Y.; Yokobori, S.; Okadome, K.; Takano, F.; Oshima, T.; Suzuki, T.; Endo, Y.; Hori, H.
The substrate specificity of tRNA (m1G37) methyltransferase (TrmD) from Aquifex aeolicus
Genes Cells
11
1353-1365
2006
Aquifex aeolicus
Lee, C.; Kramer, G.; Graham, D.E.; Appling, D.R.
Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase
J. Biol. Chem.
282
27744-27753
2007
Saccharomyces cerevisiae (P38793), Saccharomyces cerevisiae
Goto-Ito, S.; Ito, T.; Ishii, R.; Muto, Y.; Bessho, Y.; Yokoyama, S.
Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5
Proteins
72
1274-1289
2008
Methanocaldococcus jannaschii (Q58293), Methanocaldococcus jannaschii
Kim, H.W.; Ahn, H.J., Yoon, H.J.; Kim, H.W., Baek, S.H.; Suh, S.W.
Crystallization and preliminary X-ray crystallographic analysis of tRNA(m1G37)methyltransferase from Haemophilus influenzae
Acta Crystallogr. Sect. D
59
183-184
2002
Haemophilus influenzae
Christian, T.; Evilia, C.; Hou, Y.M.
Catalysis by the second class of tRNA(m1G37) methyl transferase requires a conserved proline
Biochemistry
45
7463-7473
2006
Methanocaldococcus jannaschii (Q58293)
Toyooka, T.; Awai, T.; Kanai, T.; Imanaka, T.; Hori, H.
Stabilization of tRNA (mG37) methyltransferase [TrmD] from Aquifex aeolicus by an intersubunit disulfide bond formation
Genes Cells
13
807-816
2008
Aquifex aeolicus (O67463)
Elkins, P.A.; Watts, J.M.; Zalacain, M.; van Thiel, A.; Vitazka, P.R.; Redlak, M.; Andraos-Selim, C.; Rastinejad, F.; Holmes, W.M.
Insights into catalysis by a knotted TrmD tRNA methyltransferase
J. Mol. Biol.
333
931-949
2003
Escherichia coli (P0A873), Escherichia coli
Christian, T.; Hou, Y.M.
Distinct determinants of tRNA recognition by the TrmD and Trm5 methyl transferases
J. Mol. Biol.
373
623-632
2007
Escherichia coli, Methanocaldococcus jannaschii (Q58293)
Liu, J.; Wang, W.; Shin, D.H.; Yokota, H.; Kim, R., Kim, S.H.
Crystal structure of tRNA (m1G37) methyltransferase from Aquifex aeolicus at 2.6 A resolution: a novel methyltransferase fold
Proteins
53
326-328
2003
Aquifex aeolicus (O67463), Aquifex aeolicus
Christian, T.; Lahoud, G.; Liu, C.; Hou, Y.M.
Control of catalytic cycle by a pair of analogous tRNA modification enzymes
J. Mol. Biol.
400
204-217
2010
Escherichia coli, Methanocaldococcus jannaschii
Christian, T.; Lahoud, G.; Liu, C.; Hoffmann, K.; Perona, J.J.; Hou, Y.M.
Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5
RNA
16
2484-2492
2010
Methanocaldococcus jannaschii (Q58293)
Lahoud, G.; Goto-Ito, S.; Yoshida, K.; Ito, T.; Yokoyama, S.; Hou, Y.M.
Differentiating analogous tRNA methyltransferases by fragments of the methyl donor
RNA
17
1236-1246
2011
Escherichia coli, Methanocaldococcus jannaschii
Sakaguchi, R.; Giessing, A.; Dai, Q.; Lahoud, G.; Liutkeviciute, Z.; Klimasauskas, S.; Piccirilli, J.; Kirpekar, F.; Hou, Y.M.
Recognition of guanosine by dissimilar tRNA methyltransferases
RNA
18
1687-1701
2012
Escherichia coli, Methanocaldococcus jannaschii
Kawamura, T.; Anraku, R.; Hasegawa, T.; Tomikawa, C.; Hori, H.
Transfer RNA methyltransferases from Thermoplasma acidophilum, a thermoacidophilic archaeon
Int. J. Mol. Sci.
16
91-113
2014
Thermoplasma acidophilum, Thermoplasma acidophilum HO-62
Powell, C.A.; Kopajtich, R.; DSouza, A.R.; Rorbach, J.; Kremer, L.S.; Husain, R.A.; Dallabona, C.; Donnini, C.; Alston, C.L.; Griffin, H.; Pyle, A.; Chinnery, P.F.; Strom, T.M.; Meitinger, T.; Rodenburg, R.J.; Schottmann, G.; Schuelke, M.; Romain, N.; Haller, R.G.; Ferrero, I.; Haack, T.B.; Taylor, R.W.; Pr, P.r.o.
TRMT5 mutations cause a defect in post-transcriptional modification of mitochondrial tRNA associated with multiple respiratory-chain deficiencies
Am. J. Hum. Genet.
97
319-328
2015
Homo sapiens
Sakaguchi, R.; Lahoud, G.; Christian, T.; Gamper, H.; Hou, Y.M.
A divalent metal ion-dependent N1-methyl transfer to G37-tRNA
Chem. Biol.
21
1351-1360
2014
Escherichia coli
Masuda, I.; Sakaguchi, R.; Liu, C.; Gamper, H.; Hou, Y.M.
The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD)
J. Biol. Chem.
288
28987-28996
2013
Escherichia coli (P0A873), Escherichia coli
Ito, T.; Masuda, I.; Yoshida, K.; Goto-Ito, S.; Sekine, S.; Suh, S.W.; Hou, Y.M.; Yokoyama, S.
Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD
Proc. Natl. Acad. Sci. USA
112
E4197-E4205
2015
Haemophilus influenzae, Thermotoga maritima, Haemophilus influenzae DSM 11121
Christian, T.; Gamper, H.; Hou, Y.M.
Conservation of structure and mechanism by Trm5 enzymes
RNA
19
1192-1199
2013
Homo sapiens (Q32P41), Homo sapiens
Paris, Z.; Horakova, E.; Rubio, M.A.; Sample, P.; Fleming, I.M.; Armocida, S.; Lukes, J.; Alfonzo, J.D.
The T. brucei TRM5 methyltransferase plays an essential role in mitochondrial protein synthesis and function
RNA
19
649-658
2013
Trypanosoma brucei brucei (Q57X10), Trametes pubescens 927 / 4 GUTat10.1 / TREU927 (Q57X10)
Zhong, W.; Koay, A.; Ngo, A.; Li, Y.; Nah, Q.; Wong, Y.H.; Chionh, Y.H.; Ng, H.Q.; Koh-Stenta, X.; Poulsen, A.; Foo, K.; McBee, M.; Choong, M.L.; El Sahili, A.; Kang, C.; Matter, A.; Lescar, J.; Hill, J.; Dedon, P.
Targeting the bacterial epitranscriptome for antibiotic development discovery of novel tRNA-(N1G37) methyltransferase (TrmD) inhibitors
ACS Infect. Dis.
5
326-335
2019
Pseudomonas aeruginosa (Q02RL6), Pseudomonas aeruginosa, Pseudomonas aeruginosa UCBPP-PA14 (Q02RL6)
Wu, J.; Jia, Q.; Wu, S.; Zeng, H.; Sun, Y.; Wang, C.; Ge, R.; Xie, W.
The crystal structure of the Pyrococcus abyssi mono-functional methyltransferase PaTrm5b
Biochem. Biophys. Res. Commun.
493
240-245
2017
Pyrococcus abyssi (Q9V0Q0), Pyrococcus abyssi
Li, Y.; Zhong, W.; Koay, A.Z.; Ng, H.Q.; Nah, Q.; Wong, Y.H.; Hill, J.; Lescar, J.; Dedon, P.C.; Kang, C.
Backbone resonance assignment for the full length tRNA-(N1G37) methyltransferase of Pseudomonas aeruginosa
Biomol. NMR Assign.
13
327-332
2019
Pseudomonas aeruginosa (Q02RL6), Pseudomonas aeruginosa, Pseudomonas aeruginosa UCBPP-PA14 (Q02RL6)
Li, Y.; Zhong, W.; Koay, A.Z.; Ng, H.Q.; Koh-Stenta, X.; Nah, Q.; Lim, S.H.; Larsson, A.; Lescar, J.; Hill, J.; Dedon, P.C.; Kang, C.
Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N1G37) methyltransferase
Biomol. NMR Assign.
13
49-53
2019
Pseudomonas aeruginosa (Q02RL6), Pseudomonas aeruginosa, Pseudomonas aeruginosa UCBPP-PA14 (Q02RL6)
Goto-Ito, S.; Ito, T.; Yokoyama, S.
Trm5 and TrmD two enzymes from distinct origins catalyze the identical tRNA modification, m1G37
Biomolecules
7
32
2017
Escherichia coli (P0A873), Haemophilus influenzae (P43912), Methanocaldococcus jannaschii (Q58293), Pyrococcus abyssi (Q9V2G1), Pyrococcus abyssi Orsay (Q9V2G1), Methanocaldococcus jannaschii NBRC 100440 (Q58293), Haemophilus influenzae RD (P43912), Methanocaldococcus jannaschii DSM 2661 (Q58293), Methanocaldococcus jannaschii ATCC 43067 (Q58293), Methanocaldococcus jannaschii JAL-1 (Q58293), Haemophilus influenzae DSM 11121 (P43912), Haemophilus influenzae KW20 (P43912), Haemophilus influenzae ATCC 51907 (P43912), Methanocaldococcus jannaschii JCM 10045 (Q58293)
Hori, H.
Transfer RNA methyltransferases with a SpoU-TrmD (SPOUT) fold and their modified nucleosides in tRNA
Biomolecules
7
E23
2017
Haemophilus influenzae (A0A0D0GZF5), Aquifex aeolicus (O67463), Escherichia coli (P0A873)
Hou, Y.; Matsubara, R.; Takase, R.; Masuda, I.; Sulkowska, J.
TrmD A methyl transferase for tRNA methylation with m1G37
Enzymes
41
89-115
2017
Haemophilus influenzae (A0A0D0GZF5), Aquifex aeolicus (O67463), Escherichia coli (P0A873), Salmonella enterica subsp. enterica serovar Typhimurium (P36245), Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 (P36245), Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (P36245)
Hou, Y.; Masuda, I.; Gamper, H.
Codon-specific translation by m1G37 methylation of tRNA
Front. Genet.
10
713
2019
Escherichia coli (P0A873), Salmonella enterica subsp. enterica serovar Typhimurium (P36245), Saccharomyces cerevisiae (P38793), Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 (P36245), Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (P36245), Saccharomyces cerevisiae ATCC 204508 (P38793)
Zhou, M.; Xue, L.; Chen, Y.; Li, H.; He, Q.; Wang, B.; Meng, F.; Wang, M.; Guan, M.X.
A hypertension-associated mitochondrial DNA mutation introduces an m1G37 modification into tRNAMet, altering its structure and function
J. Biol. Chem.
293
1425-1438
2018
Methanocaldococcus jannaschii (Q58293), Methanocaldococcus jannaschii NBRC 100440 (Q58293), Methanocaldococcus jannaschii DSM 2661 (Q58293), Methanocaldococcus jannaschii ATCC 43067 (Q58293), Methanocaldococcus jannaschii JAL-1 (Q58293), Methanocaldococcus jannaschii JCM 10045 (Q58293)
Whitehouse, A.J.; Thomas, S.E.; Brown, K.P.; Fanourakis, A.; Chan, D.S.; Libardo, M.D.J.; Mendes, V.; Boshoff, H.I.M.; Floto, R.A.; Abell, C.; Blundell, T.L.; Coyne, A.G.
Development of inhibitors against Mycobacterium abscessus tRNA (m1G37) methyltransferase (TrmD) using fragment-based approaches
J. Med. Chem.
62
7210-7232
2019
Mycobacteroides abscessus
Zhong, W.; Pasunooti, K.K.; Balamkundu, S.; Wong, Y.H.; Nah, Q.; Gadi, V.; Gnanakalai, S.; Chionh, Y.H.; McBee, M.E.; Gopal, P.; Lim, S.H.; Olivier, N.; Buurman, E.T.; Dick, T.; Liu, C.F.; Lescar, J.; Dedon, P.C.
Thienopyrimidinone derivatives that inhibit bacterial tRNA (guanine37-N1)-methyltransferase (TrmD) by restructuring the active site with a tyrosine-flipping mechanism
J. Med. Chem.
62
7788-7805
2019
Staphylococcus aureus, Mycobacterium tuberculosis, Pseudomonas aeruginosa
Hou, Y.M.; Masuda, I.
Kinetic analysis of tRNA methyltransferases
Methods Enzymol.
560
91-116
2015
Escherichia coli (P0A873), Haemophilus influenzae (P43912), Homo sapiens (Q32P41), Methanocaldococcus jannaschii (Q58293), Methanocaldococcus jannaschii NBRC 100440 (Q58293), Haemophilus influenzae RD (P43912), Methanocaldococcus jannaschii DSM 2661 (Q58293), Methanocaldococcus jannaschii ATCC 43067 (Q58293), Methanocaldococcus jannaschii JAL-1 (Q58293), Haemophilus influenzae DSM 11121 (P43912), Haemophilus influenzae KW20 (P43912), Haemophilus influenzae ATCC 51907 (P43912), Methanocaldococcus jannaschii JCM 10045 (Q58293)
Christian, T.; Sakaguchi, R.; Perlinska, A.; Lahoud, G.; Ito, T.; Taylor, E.; Yokoyama, S.; Sulkowska, J.; Hou, Y.
Methyl transfer by substrate signaling from a knotted protein fold
Nat. Struct. Mol. Biol.
23
941-948
2016
Haemophilus influenzae (A0A0D0GZF5)
Jin, X.; Lv, Z.; Gao, J.; Zhang, R.; Zheng, T.; Yin, P.; Li, D.; Peng, L.; Cao, X.; Qin, Y.; Persson, S.; Zheng, B.; Chen, P.
AtTrm5a catalyses 1-methylguanosine and 1-methylinosine formation on tRNAs and is important for vegetative and reproductive growth in Arabidopsis thaliana
Nucleic Acids Res.
47
883-898
2019
Arabidopsis thaliana (Q93YU6), Arabidopsis thaliana
Urbonavicius, J.; Rutkiene, R.; Lopato, A.; Tauraite, D.; Stankeviciute, J.; Aucynaite, A.; Kaliniene, L.; van Tilbeurgh, H.; Meskys, R.
Evolution of tRNAPhe imG2 methyltransferases involved in the biosynthesis of wyosine derivatives in Archaea
RNA
22
1871-1883
2016
Nanoarchaeum equitans (Q74NE4), Pyrococcus abyssi (Q9V2G1), Pyrococcus abyssi Orsay (Q9V2G1)
Jaroensuk, J.; Wong, Y.H.; Zhong, W.; Liew, C.W.; Maenpuen, S.; Sahili, A.E.; Atichartpongkul, S.; Chionh, Y.H.; Nah, Q.; Thongdee, N.; McBee, M.E.; Prestwich, E.G.; DeMott, M.S.; Chaiyen, P.; Mongkolsuk, S.; Dedon, P.C.; Lescar, J.; Fuangthong, M.
Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa
RNA
25
1481-1496
2019
Pseudomonas aeruginosa (Q02RL6), Pseudomonas aeruginosa, Pseudomonas aeruginosa UCBPP-PA14 (Q02RL6)
Wang, C.; Jia, Q.; Zeng, J.; Chen, R.; Xie, W.
Structural insight into the methyltransfer mechanism of the bifunctional Trm5
Sci. Adv.
3
e1700195
2017
Methanocaldococcus jannaschii (Q58293), Pyrococcus abyssi (Q9V2G1), Methanocaldococcus jannaschii DSM 2661 (Q58293)
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