Reference on EC 2.1.1.28 - phenylethanolamine N-methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Axelrod, J.
Purification and properties of phenylethanolamine-N-methyltransferase
J. Biol. Chem.
237
1657-1660
1962
Bos taurus, Cavia porcellus, Oryctolagus cuniculus, Felis catus, Macaca mulatta, Rattus norvegicus
Connett, R.J.; Kirshner, N.
Purification and properties of bovine phenylethanolamine N-methyltransferase
J. Biol. Chem.
245
329-334
1970
Bos taurus
Lee, H.S.; Schulz, A.R.; Fuller, R.W.
Isolation of multiple forms of rabbit-adrenal norepinephrine N-methyltransferase
Arch. Biochem. Biophys.
163
735-741
1974
Oryctolagus cuniculus
Pohorecky, L.A.; Baliga, B.S.
Purification and properties of rat adrenal phenylethanolamine-N-methyl transferase
Arch. Biochem. Biophys.
156
703-711
1973
Bos taurus, Rattus norvegicus
Lee, H.S.; Schulz, A.R.; Fuller, R.W.
Isolation and purification of rabbit adrenal norephinephrine N-methyl transferase isozymes
Arch. Biochem. Biophys.
185
222-227
1978
Oryctolagus cuniculus
Lee, H.S.; Schulz, A.R.; Fuller, R.W.
The interaction of rabbit adrenal norepinephrine N-methyl transferase isozymes with substrates
Arch. Biochem. Biophys.
185
228-238
1978
Oryctolagus cuniculus
Lee, H.S.; Schulz, A.R.; Fuller, R.W.
Product inhibition studies and the reaction sequence of rabbit adrenal norepinephrine N-methyl transferase isozymes
Arch. Biochem. Biophys.
185
239-250
1978
Oryctolagus cuniculus
Harralson, J.D.; Brown, F.C.
Phenylethanolamine-N-methyltransferase:alcohol and the mechanism of action
Arch. Biochem. Biophys.
221
354-360
1983
Bos taurus
Hurst, J.H.; Guchhait, R.B.; Billingsley, M.L.; Stolk, J.M.; Lovenberg, W.
Phenylethanolamine N-methyltransferase: notes on its purification from bovine adrenal medulla and separation from protein carboxymethyltransferase
Biochem. Biophys. Res. Commun.
112
1061-1068
1983
Bos taurus
Fuller, R.W.
Norepinephrine N-methyltransferase from rabbit adrenal glands
Methods Enzymol.
142
655-660
1987
Oryctolagus cuniculus
Fuller, R.W.; Hemrick, S.K.
m-Octopamine as a substrate for norepinephrine n-methyltransferase
IRCS Med. Sci. Libr. Compend.
8
284
1980
Oryctolagus cuniculus
-
Fuller, R.W.; Nagarajan, R.
Inhibition of methyltransferases by some new analogs of S-adenosylhomocysteine
Biochem. Pharmacol.
27
1981-1983
1978
Oryctolagus cuniculus
Park, D.H.; Wessel, T.; Baker, H.; Joh, T.H.; Samanta, H.
Characterization of recombinant bovine phenylethanolamine N-methyltransferase expressed in a mouse C127 cell line
Mol. Brain Res.
10
213-218
1991
Bos taurus
Wong, D.L.; Yamasaki, L.; Ciaranello, R.D.
Characterization of the isozymes of bovine adrenal medullary phenylethanolamine N-methyltransferase
Brain Res.
410
32-44
1987
Bos taurus
Padbury, J.F.; Lam, R.W.; Hobel, C.J.; Fisher, D.A.
Identification and partial purification of phenylethanolamine N-methyl transferase in the developing ovine lung
Pediatr. Res.
17
362-367
1983
Ovis aries
Fuller, R.W.; Hemrick, S.K.
Properties of norepinephrine N-methyltransferase from pigeon brain
Pharmacol. Biochem. Behav.
11
563-566
1979
Columba livia
Fuller, R.W.; Molloy, B.B.
Inhibition in vitro of norepinephrine N-methyltransferase by 2-aminotetralins, analogs of phenylethylamines with rigid conformation
Biochem. Pharmacol.
26
446-447
1977
Oryctolagus cuniculus
Hoffman, A.R.; Ciaranello, R.D.; Axelrod, J.
Substrate and inhibitor kinetics of bovine phenylethanolamine-N-methyltransferase
Biochem. Pharmacol.
24
544-546
1975
Bos taurus
Cubeddu, L.; Gimenez, M.; Goldstein, D.J.
Inhibition of phenylethanolamine-N-methyltransferase by human cerebrospinal fluid - a sodium chloride effect
Biochem. Pharmacol.
25
2537-2538
1976
Bos taurus
Begun, J.; McLeish, M.J.; Caine, J.M.; Palant, E.; Grunewald, G.L.; Martin, J.L.
Crystallization of PNMT, the adrenaline-synthesizing enzyme, is critically dependent on a high protein concentration
Acta Crystallogr. Sect. D
58
314-315
2002
Homo sapiens
Warthan, M.D.; Freeman, J.G.; Loesser, K.E.; Lewis, C.W.; Hong, M.; Conway, C.M.; Stewart, J.K.
Phenylethanolamine N-methyltransferase expression in mouse thymus and spleen
Brain Behav. Immun.
16
493-499
2002
Mus musculus (P40935)
Kaneda, N.; Hikita, K.; Naruse, Y.; Fukuo, T.; Matsubara, K.; Nagatsu, T.
Identification of the essential cysteinyl residue located in the active site of human phenylethanolamine N-methyltransferase
Biochem. Biophys. Res. Commun.
249
405-409
1998
Homo sapiens
Ebert, S.N.; Baden, J.M.; Mathers, L.H.; Siddall, B.J.; Wong, D.L.
Expression of phenylethanolamine N-methyltransferase in the embryonic rat heart
J. Mol. Cell. Cardiol.
28
1653-1658
1996
Rattus norvegicus
Gearhart, D.A.; Neafsey, E.J.; Collins, M.A.
Phenylethanolamine N-methyltransferase has beta-carboline 2N-methyltransferase activity: hypothetical relevance to Parkinson's disease
Neurochem. Int.
40
611-620
2002
Homo sapiens
Senthilkumaran, B.; Joy, K.P.
Changes in hypothalamic catecholamines, dopamine-beta-hydroxylase, and phenylethanolamine-N-methyltransferase in the catfish Heteropneustes fossilis in relation to season, raised photoperiod and temperature, ovariectomy, and estradiol-17beta replacement
Gen. Comp. Endocrinol.
97
121-134
1995
Heteropneustes fossilis
Grunewald, G.L.; Caldwell, T.M.; Li, Q.; Slavica, M.; Criscione, K.R.; Borchardt, R.T.; Wang, W.
Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor
J. Med. Chem.
42
3588-3601
1999
Bos taurus
Grunewald, G.L.; Dahanukar, V.H.; Jalluri, R.K.; Criscione, K.R.
Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the a2-adrenoceptor
J. Med. Chem.
42
118-134
1999
Bos taurus
Grunewald, G.L.; Caldwell, T.M.; Li, Q.; Criscione, K.R.
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor
J. Med. Chem.
42
3315-3323
1999
Bos taurus
Grunewald, G.L.; Dahanukar, V.H.; Ching, P.; Criscione, K.R.
Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase
J. Med. Chem.
39
3539-3546
1996
Bos taurus
Grunewald, G.L.; Romero, F.A.; Chieu, A.D.; Fincham, K.J.; Bhat, S.R.; Criscione, K.R.
Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors
Bioorg. Med. Chem.
13
1261-1273
2005
Homo sapiens
Wu, Q.; Criscione, K.R.; Grunewald, G.L.; McLeish, M.J.
Phenylethanolamine N-methyltransferase inhibition: re-evaluation of kinetic data
Bioorg. Med. Chem. Lett.
14
4217-4220
2004
Homo sapiens
McMillan, F.M.; Archbold, J.; McLeish, M.J.; Caine, J.M.; Criscione, K.R.; Grunewald, G.L.; Martin, J.L.
Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase
J. Med. Chem.
47
37-44
2004
Homo sapiens (P11086), Homo sapiens
Gee, C.L.; Tyndall, J.D.; Grunewald, G.L.; Wu, Q.; McLeish, M.J.; Martin, J.L.
Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis
Biochemistry
44
16875-16885
2005
Homo sapiens (P11086), Homo sapiens
Gee, C.L.; Nourse, A.; Hsin, A.Y.; Wu, Q.; Tyndall, J.D.; Grunewald, G.L.; McLeish, M.J.; Martin, J.L.
Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active
Biochim. Biophys. Acta
1750
82-92
2005
Homo sapiens
Grunewald, G.L.; Seim, M.R.; Regier, R.C.; Criscione, K.R.
Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors
Bioorg. Med. Chem.
15
1298-1310
2007
Homo sapiens, Rattus norvegicus
Grunewald, G.L.; Romero, F.A.; Seim, M.R.; Criscione, K.R.; Deupree, J.D.; Spackman, C.C.; Bylund, D.B.
Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines
Bioorg. Med. Chem. Lett.
15
1143-1147
2005
Homo sapiens
Grunewald, G.L.; Lu, J.; Criscione, K.R.; Okoro, C.O.
Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity
Bioorg. Med. Chem. Lett.
15
5319-5323
2005
Homo sapiens
Cleary, S.; Brouwers, F.M.; Eisenhofer, G.; Pacak, K.; Christie, D.L.; Lipski, J.; McNeil, A.R.; Phillips, J.K.
Expression of the noradrenaline transporter and phenylethanolamine N-methyltransferase in normal human adrenal gland and phaeochromocytoma
Cell Tissue Res.
322
443-453
2005
Homo sapiens, Rattus norvegicus
Kvetnansky, R.; Kubovcakova, L.; Tillinger, A.; Micutkova, L.; Krizanova, O.; Sabban, E.L.
Gene expression of phenylethanolamine N-methyltransferase in corticotropin-releasing hormone knockout mice during stress exposure
Cell. Mol. Neurobiol.
26
735-754
2006
Mus musculus, Rattus norvegicus
Evinger, M.J.; Powers, J.F.; Tischler, A.S.
Transcriptional silencing of glucocorticoid-inducible phenylethanolamine N-methyltransferase expression by sequential signaling events
Exp. Cell Res.
313
772-781
2007
Mus musculus
Wu, Q.; Gee, C.L.; Lin, F.; Tyndall, J.D.; Martin, J.L.; Grunewald, G.L.; McLeish, M.J.
Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase
J. Med. Chem.
48
7243-7252
2005
Homo sapiens (P11086), Homo sapiens
Grunewald, G.L.; Seim, M.R.; Lu, J.; Makboul, M.; Criscione, K.R.
Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluorinatio
J. Med. Chem.
49
2939-2952
2006
Homo sapiens
Grunewald, G.L.; Seim, M.R.; Regier, R.C.; Martin, J.L.; Gee, C.L.; Drinkwater, N.; Criscione, K.R.
Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase
J. Med. Chem.
49
5424-5433
2006
Homo sapiens (P11086), Homo sapiens
Goncalvesova, E.; Krizanova, O.; Micutkova, L.; Mravec, B.; Ksinantova, L.; Fabian, J.; Kvetnansky, R.
Phenylethanolamine N-methyltransferase gene expression in transplanted human heart
Transplant. Proc.
37
1340-1342
2005
Homo sapiens
Grunewald, G.L.; Seim, M.R.; Bhat, S.R.; Wilson, M.E.; Criscione, K.R.
Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase
Bioorg. Med. Chem.
16
542-559
2008
Homo sapiens
Bao, X.; Lu, C.M.; Liu, F.; Gu, Y.; Dalton, N.D.; Zhu, B.Q.; Foster, E.; Chen, J.; Karliner, J.S.; Ross, J.; Simpson, P.C.; Ziegler, M.G.
Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse
Circulation
116
1024-1031
2007
Mus musculus, Mus musculus C57BL/6
Yamano, E.; Isowa, T.; Nakano, Y.; Matsuda, F.; Hashimoto-Tamaoki, T.; Ohira, H.; Kosugi, S.
Association study between reward dependence temperament and a polymorphism in the phenylethanolamine N-methyltransferase gene in a Japanese female population
Compr. Psychiatry
49
503-507
2008
Homo sapiens
Gee, C.L.; Drinkwater, N.; Tyndall, J.D.; Grunewald, G.L.; Wu, Q.; McLeish, M.J.; Martin, J.L.
Enzyme adaptation to inhibitor binding: A cryptic binding site in phenylethanolamine N-methyltransferase
J. Med. Chem.
50
6441
2007
Homo sapiens
-
Grobe, N.; Ren, X.; Kutchan, T.M.; Zenk, M.H.
An (R)-specific N-methyltransferase involved in human morphine biosynthesis
Arch. Biochem. Biophys.
506
42-47
2011
Homo sapiens
Drinkwater, N.; Vu, H.; Lovell, K.M.; Criscione, K.R.; Collins, B.M.; Prisinzano, T.E.; Poulsen, S.A.; McLeish, M.J.; Grunewald, G.L.; Martin, J.L.
Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors
Biochem. J.
431
51-61
2010
Homo sapiens
Hou, Q.Q.; Wang, J.H.; Gao, J.; Liu, Y.J.; Liu, C.B.
QM/MM studies on the catalytic mechanism of phenylethanolamine N-methyltransferase
Biochim. Biophys. Acta
1824
533-541
2012
Homo sapiens
Kang, D.I.; Lee, J.Y.; Kim, W.; Jeong, K.W.; Shin, S.; Yang, J.; Park, E.; Chae, Y.K.; Kim, Y.
Discovery of novel human phenylethanolamine N-methyltransferase (hPNMT) inhibitors using 3D pharmacophore-based in silico, biophysical screening and enzymatic activity assays
Mol. Cells
29
595-602
2010
Homo sapiens
Qin, N.; Peitzsch, M.; Menschikowski, M.; Siegert, G.; Pacak, K.; Eisenhofer, G.
Double stable isotope ultra performance liquid chromatographic-tandem mass spectrometric quantification of tissue content and activity of phenylethanolamine N-methyltransferase, the crucial enzyme responsible for synthesis of epinephrine
Anal. Bioanal. Chem.
405
1713-1719
2013
Homo sapiens
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