Disease on EC 2.1.1.319 - type I protein arginine methyltransferase
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Acute Coronary Syndrome
Coactivator-associated arginine methyltransferase 1 targeted by miR-15a regulates inflammation in acute coronary syndrome.
Adenocarcinoma
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.
Adenocarcinoma
CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.
Adenocarcinoma
Comprehensive analysis of histone modification-associated genes on differential gene expression and prognosis in gastric cancer.
Adenocarcinoma of Lung
PFKFB4 promotes lung adenocarcinoma progression via phosphorylating and activating transcriptional coactivator SRC-2.
Adenocarcinoma of Lung
PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18.
Adenoma
Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.
Amyotrophic Lateral Sclerosis
Roles of protein arginine methyltransferase 1 (PRMT1) in brain development and disease.
Anemia
Protein arginine methyltransferase 1 is required for maintenance of normal adult hematopoiesis.
Angiodysplasia
Angiodysplasia in embryo lacking protein arginine methyltransferase 1 (PRMT1) in vascular endothelial cells.
Anorectal Malformations
Analyses of PRMT1 proteins in human colon tissues from Hirschsprung disease patients.
Asthma
Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling.
Asthma
PRMT1 Modulates Processing of Asthma-Related Primary MicroRNAs (Pri-miRNAs) into Mature miRNAs in Lung Epithelial Cells.
Asthma
PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation.
Asthma
Protein arginine methyltransferase 1 contributes to the development of allergic rhinitis by promoting the production of epithelial-derived cytokines.
Asthma
Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation.
Asthma
TGF-? Upregulated Mitochondria Mass through the SMAD2/3?C/EBP??PRMT1 Signal Pathway in Primary Human Lung Fibroblasts.
Asthma
Upregulated Protein Arginine Methyltransferase 1 by IL-4 Increases Eotaxin-1 Expression in Airway Epithelial Cells and Participates in Antigen-Induced Pulmonary Inflammation in Rats.
Atherosclerosis
Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice.
Atherosclerosis
LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2.
Atherosclerosis
PRMT2 inhibits the formation of foam cell induced by ox-LDL in RAW 264.7 macrophage involving ABCA1 mediated cholesterol efflux.
Azoospermia
Association Study Between Polymorphisms of PRMT6, PEX10, SOX5, and Non-obstructive Azoospermia in the Han Chinese Population.
Azoospermia
PEX10, SIRPA-SIRPG, and SOX5 gene polymorphisms are strongly associated with nonobstructive azoospermia susceptibility.
Bone Diseases, Metabolic
Asymmetrical methyltransferase PRMT3 regulates human mesenchymal stem cell osteogenesis via miR-3648.
Bone Resorption
PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice.
Brain Neoplasms
PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.
Breast Neoplasms
A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.
Breast Neoplasms
A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor ?-dependent transcriptional activation and breast carcinogenesis.
Breast Neoplasms
Alternative splicing yields protein arginine methyltransferase 1 isoforms with distinct activity, substrate specificity, and subcellular localization.
Breast Neoplasms
Alternatively spliced protein arginine methyltransferase 1 isoform PRMT1v2 promotes the survival and invasiveness of breast cancer cells.
Breast Neoplasms
CARM1 Is an Important Determinant of ER{alpha}-Dependent Breast Cancer Cell Differentiation and Proliferation in Breast Cancer Cells.
Breast Neoplasms
CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.
Breast Neoplasms
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.
Breast Neoplasms
CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1.
Breast Neoplasms
Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene.
Breast Neoplasms
Correction: A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.
Breast Neoplasms
Correction: differential CARM1 isoform expression in subcellular compartments and among malignant and benign breast tumors.
Breast Neoplasms
DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.
Breast Neoplasms
Differential CARM1 Isoform Expression in Subcellular Compartments and among Malignant and Benign Breast Tumors.
Breast Neoplasms
Disease biomarker identification from gene network modules for metastasized breast cancer.
Breast Neoplasms
Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors.
Breast Neoplasms
Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity.
Breast Neoplasms
Genomic organization, physical mapping, and expression analysis of the human protein arginine methyltransferase 1 gene.
Breast Neoplasms
Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition.
Breast Neoplasms
Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma.
Breast Neoplasms
Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer.
Breast Neoplasms
Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6.
Breast Neoplasms
Macrophages-stimulated PRMT1-mediated EZH2 methylation promotes breast cancer metastasis.
Breast Neoplasms
MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs.
Breast Neoplasms
Methylation of C/EBP? by PRMT1 Inhibits Its Tumor-Suppressive Function in Breast Cancer.
Breast Neoplasms
Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Breast Neoplasms
Modulating the expression of Chtop, a versatile regulator of gene-specific transcription and mRNA export.
Breast Neoplasms
Novel alternative splice variants of the human protein arginine methyltransferase 1 (PRMT1) gene, discovered using next-generation sequencing.
Breast Neoplasms
Novel CARM1-Interacting Protein, DZIP3, Is a Transcriptional Coactivator of Estrogen Receptor-?.
Breast Neoplasms
Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein.
Breast Neoplasms
Nucleo-cytoplasmic shuttling of protein arginine methyltransferase 1 (PRMT1) requires enzymatic activity.
Breast Neoplasms
Overexpression of CARM1 in breast cancer is correlated with poorly characterized clinicopathologic parameters and molecular subtypes.
Breast Neoplasms
p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.
Breast Neoplasms
PRMT1 Is Critical for the Transcriptional Activity and the Stability of the Progesterone Receptor.
Breast Neoplasms
PRMT1-dependent methylation of BRCA1 contributes to the epigenetic defense of breast cancer cells against ionizing radiation.
Breast Neoplasms
PRMT2 and ROR? expression are associated with breast cancer survival outcomes.
Breast Neoplasms
PRMT2?, a C-terminal splice variant of PRMT2, inhibits the growth of breast cancer cells.
Breast Neoplasms
PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: Its implication in motility and invasion.
Breast Neoplasms
Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 gene during acquired multidrug resistant.
Breast Neoplasms
Protein arginine methyltransferase 6 enhances ligand-dependent and -independent activity of estrogen receptor ? via distinct mechanisms.
Breast Neoplasms
Protein arginine methyltransferase 6 regulates multiple aspects of gene expression.
Breast Neoplasms
Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes.
Breast Neoplasms
Protein arginine N-methyltransferase 2 reverses tamoxifen resistance in breast cancer cells through suppression of ER-?36.
Breast Neoplasms
RNA binding protein RALY promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells.
Breast Neoplasms
Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.
Breast Neoplasms
Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1.
Breast Neoplasms
The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer.
Breast Neoplasms
The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1.
Breast Neoplasms
The oestrogen receptor coactivator CARM1 has an oncogenic effect and is associated with poor prognosis in breast cancer.
Bulbo-Spinal Atrophy, X-Linked
Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.
Carcinogenesis
A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor ?-dependent transcriptional activation and breast carcinogenesis.
Carcinogenesis
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.
Carcinogenesis
Arginine methyltransferase PRMT3 promote tumorigenesis through regulating c-MYC stabilization in colorectal cancer.
Carcinogenesis
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.
Carcinogenesis
Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers.
Carcinogenesis
Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.
Carcinogenesis
Erratum: PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis.
Carcinogenesis
Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer.
Carcinogenesis
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.
Carcinogenesis
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Carcinogenesis
Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis.
Carcinogenesis
Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6.
Carcinogenesis
Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases.
Carcinogenesis
Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein.
Carcinogenesis
p53 mediated regulation of Coactivator associated arginine methyltransferase 1 (CARM1) expression is critical for suppression of adipogenesis.
Carcinogenesis
PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis.
Carcinogenesis
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.
Carcinogenesis
PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin.
Carcinogenesis
PRMT1 potentiates chondrosarcoma development through activation of YAP activity.
Carcinogenesis
PRMT2 accelerates tumorigenesis of hepatocellular carcinoma by activating Bcl2 via histone H3R8 methylation.
Carcinogenesis
PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma.
Carcinogenesis
PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.
Carcinogenesis
Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma.
Carcinogenesis
The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1.
Carcinogenesis
The protein arginine methyltransferases (PRMTs) PRMT1 and CARM1 as candidate epigenetic drivers in prostate cancer progression.
Carcinogenesis
WDR5 promotes the tumorigenesis of oral squamous cell carcinoma via CARM1/?-catenin axis.
Carcinoma
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.
Carcinoma
BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1.
Carcinoma
Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.
Carcinoma
PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance.
Carcinoma
PRMT1 expression predicts sensitivity to platinum-based chemotherapy in patients with ovarian serous carcinoma.
Carcinoma
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.
Carcinoma
PRMT1 regulates the tumour-initiating properties of esophageal squamous cell carcinoma through histone H4 arginine methylation coupled with transcriptional activation.
Carcinoma
Protein arginine methyltransferase 1 interacts with Gli1 and regulates its transcriptional activity.
Carcinoma
Protein arginine methyltransferase 1 promoted the growth and migration of cancer cells in esophageal squamous cell carcinoma.
Carcinoma
Protein arginine methyltransferase 1 promotes epithelial-mesenchymal transition via TGF-?1/Smad pathway in hepatic carcinoma cells.
Carcinoma
SWI/SNF Complexes in Ovarian Cancer: Mechanistic Insights and Therapeutic Implications.
Carcinoma
The long noncoding RNA ST7-AS1 promotes laryngeal squamous cell carcinoma by stabilizing CARM1.
Carcinoma
The prognostic significance of protein arginine methyltransferase 6 expression in colon cancer.
Carcinoma, Ductal
Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein.
Carcinoma, Hepatocellular
CRAF methylation by PRMT6 regulates aerobic glycolysis driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation.
Carcinoma, Hepatocellular
Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.
Carcinoma, Hepatocellular
Hepatocellular Protein Arginine Methyltransferase 1 Suppresses Alcohol-Induced Hepatocellular Carcinoma Formation by Inhibition of Inducible Nitric Oxide Synthase.
Carcinoma, Hepatocellular
Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription.
Carcinoma, Hepatocellular
miR-503 suppresses metastasis of hepatocellular carcinoma cell by targeting PRMT1.
Carcinoma, Hepatocellular
PGC1? TRANSCRIPTIONAL ADAPTOR FUNCTION GOVERNS HEPATITIS B VIRUS REPLICATION BY CONTROLLING HBcAg/p21 PROTEIN MEDIATED CAPSID FORMATION.
Carcinoma, Hepatocellular
PRMT1 Promoted HCC Growth and Metastasis In Vitro and In Vivo via Activating the STAT3 Signalling Pathway.
Carcinoma, Hepatocellular
PRMT2 accelerates tumorigenesis of hepatocellular carcinoma by activating Bcl2 via histone H3R8 methylation.
Carcinoma, Hepatocellular
PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis.
Carcinoma, Hepatocellular
PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability.
Carcinoma, Hepatocellular
PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.
Carcinoma, Hepatocellular
The polymorphism rs975484 in the protein arginine methyltransferase 1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma.
Carcinoma, Hepatocellular
The Protective Function of PRMT1 in Alcohol-Induced Hepatocellular Carcinoma.
Carcinoma, Non-Small-Cell Lung
CARM1 promotes non-small cell lung cancer progression through upregulating CCNE2 expression.
Carcinoma, Non-Small-Cell Lung
Inhibition of Nonsmall Cell Lung Cancer Cell Migration by Protein Arginine Methyltransferase 1-small Hairpin RNA Through Inhibiting Epithelial-mesenchymal Transition, Extracellular Matrix Degradation, and Src Phosphorylation In Vitro.
Carcinoma, Non-Small-Cell Lung
PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer.
Carcinoma, Renal Cell
BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1.
Carcinoma, Renal Cell
PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance.
Carcinoma, Renal Cell
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.
Carcinoma, Small Cell
SWI/SNF Complexes in Ovarian Cancer: Mechanistic Insights and Therapeutic Implications.
Cardiomegaly
Protein arginine methyltransferase 6 mediates cardiac hypertrophy by differential regulation of histone H3 arginine methylation.
Cardiomyopathies
Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1? by PRMT1 and SIRT1.
Cardiomyopathy, Dilated
Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation.
Cardiomyopathy, Dilated
PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products.
Cardiomyopathy, Hypertrophic
The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart.
Cardiovascular Diseases
A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity.
Cardiovascular Diseases
Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: synthesis and biological evaluation.
Cardiovascular Diseases
Hepatocellular Protein Arginine Methyltransferase 1 Suppresses Alcohol-Induced Hepatocellular Carcinoma Formation by Inhibition of Inducible Nitric Oxide Synthase.
Cardiovascular Diseases
Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1.
Chondrosarcoma
PRMT1 potentiates chondrosarcoma development through activation of YAP activity.
Colonic Neoplasms
Downregulation of PRMT1, a histone arginine methyltransferase, by sodium propionate induces cell apoptosis in colon cancer.
Colonic Neoplasms
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Colonic Neoplasms
Novel alternative splice variants of the human protein arginine methyltransferase 1 (PRMT1) gene, discovered using next-generation sequencing.
Colonic Neoplasms
Protein arginine methyltransferase 8 gene enhances the colon cancer stem cell (CSC) function by upregulating the pluripotency transcription factor.
Colonic Neoplasms
The prognostic significance of protein arginine methyltransferase 6 expression in colon cancer.
Colorectal Neoplasms
A coactivator role of CARM1 in the dysregulation of {beta}-catenin activity in colorectal cancer cell growth and gene expression.
Colorectal Neoplasms
Arginine methyltransferase PRMT3 promote tumorigenesis through regulating c-MYC stabilization in colorectal cancer.
Colorectal Neoplasms
Coactivator-associated arginine methyltransferase 1 promotes cell growth and is targeted by microRNA-195-5p in human colorectal cancer.
Colorectal Neoplasms
FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.
Colorectal Neoplasms
miR-195 enhances the radiosensitivity of colorectal cancer cells by suppressing CARM1.
Colorectal Neoplasms
Old dog, new tricks: extracellular domain arginine methylation regulates EGFR function.
Colorectal Neoplasms
PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer.
Colorectal Neoplasms
PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling.
Colorectal Neoplasms
Significant association of PRMT6 hypomethylation with colorectal cancer.
Colorectal Neoplasms
The prognostic significance of protein arginine methyltransferase 6 expression in colon cancer.
Colorectal Neoplasms
The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells.
Colorectal Neoplasms
The roles of microbial products in the development of colorectal cancer: a review.
Coronary Disease
Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies.
Diabetes Mellitus
PRMT1 promotes glucose toxicity-induced ? cell dysfunction by regulating the nucleo-cytoplasmic trafficking of PDX-1 in a FOXO1-dependent manner in INS-1 cells.
Diabetes Mellitus, Type 1
A critical role for hepatic protein arginine methyltransferase 1 isoform 2 in glycemic control.
Diabetes Mellitus, Type 2
A critical role for hepatic protein arginine methyltransferase 1 isoform 2 in glycemic control.
Diabetes Mellitus, Type 2
Impaired PRMT1 activity in the liver and pancreas of type 2 diabetic Goto-Kakizaki rats.
Diabetes Mellitus, Type 2
PRMT1 promotes glucose toxicity-induced ? cell dysfunction by regulating the nucleo-cytoplasmic trafficking of PDX-1 in a FOXO1-dependent manner in INS-1 cells.
Diabetes Mellitus, Type 2
The co-activator-associated arginine methyltransferase 1 (CARM1) gene is overexpressed in type 2 diabetes.
Diabetic Nephropathies
Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression.
Diabetic Nephropathies
Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy.
Diabetic Retinopathy
High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: role in diabetic retinopathy.
Diabetic Retinopathy
MiR-542-5p regulates the progression of diabetic retinopathy by targeting CARM1.
Diabetic Retinopathy
PRMT-1 and DDAHs-induced ADMA upregulation is involved in ROS- and RAS-mediated diabetic retinopathy.
Diabetic Retinopathy
PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners.
Down Syndrome
The telomeric part of the human chromosome 21 from CSTB to prmt2 is not necessarry for the locomotor and short-term memory deficits observed in the tc1 mouse model of down syndrome.
Edema, Cardiac
The predominant protein arginine methyltransferase PRMT1 is critical for zebrafish convergence and extension during gastrulation.
Encephalomyelitis
PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5.
Encephalomyelitis, Autoimmune, Experimental
PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5.
Endometrial Neoplasms
PRMT6 promotes endometrial cancer via AKT/mTOR signaling and indicates poor prognosis.
Endometriosis
Arginine methyltransferases mediate an epigenetic ovarian response to endometriosis.
Endometritis
Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats.
Epstein-Barr Virus Infections
Arginine Methyltransferases Are Regulated by Epstein-Barr Virus in B Cells and Are Differentially Expressed in Hodgkin's Lymphoma.
Esophageal Neoplasms
Status of epigenetic chromatin modification enzymes and esophageal squamous cell carcinoma risk in northeast Indian population.
Esophageal Squamous Cell Carcinoma
PRMT1 regulates the tumour-initiating properties of esophageal squamous cell carcinoma through histone H4 arginine methylation coupled with transcriptional activation.
Esophageal Squamous Cell Carcinoma
Protein arginine methyltransferase 1 interacts with Gli1 and regulates its transcriptional activity.
Esophageal Squamous Cell Carcinoma
Protein arginine methyltransferase 1 promoted the growth and migration of cancer cells in esophageal squamous cell carcinoma.
Fatty Liver
CDKN2A deregulation in fatty liver disease and its accelerative role in the process of lipogenesis.
Fatty Liver
Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice.
Frontotemporal Dementia
Roles of protein arginine methyltransferase 1 (PRMT1) in brain development and disease.
Geographic Atrophy
Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration.
Glioblastoma
5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
Glioblastoma
PRMT1 and PRMT8 Regulate Retinoic Acid-Dependent Neuronal Differentiation with Implications to Neuropathology.
Glioblastoma
PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma.
Glioblastoma
PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.
Glioblastoma
PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer.
Glioblastoma
The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells.
Glioblastoma
WDR5-Myc axis promotes the progression of glioblastoma and neuroblastoma by transcriptional activating CARM1.
Glioma
Concerted action of histone methyltransferases G9a and PRMT-1 regulates PGC-1?-RIG-I axis in IFN? treated glioma cells.
Glioma
LncRNA NNT-AS1 promote glioma cell proliferation and metastases through miR-494-3p/PRMT1 axis.
Glioma
PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma.
Glucose Intolerance
Impaired PRMT1 activity in the liver and pancreas of type 2 diabetic Goto-Kakizaki rats.
Glycogen Storage Disease
CARM1/PRMT4 is necessary for the glycogen gene expression programme in skeletal muscle cells.
Glycogen Storage Disease Type II
CARM1/PRMT4 is necessary for the glycogen gene expression programme in skeletal muscle cells.
Head and Neck Neoplasms
PRMT1 expression is elevated in head and neck cancer and inhibition of protein arginine methylation by adenosine dialdehyde or PRMT1 knockdown downregulates proliferation and migration of oral cancer cells.
Hearing Loss
Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death.
Heart Diseases
Mechanistic Studies on Transcriptional Coactivator Protein Arginine Methyltransferase 1.
Heart Diseases
Understanding protein arginine methyltransferase 1 (PRMT1) product specificity from molecular dynamics.
Heart Failure
Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation.
Hepatitis B
Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription.
Hepatitis C
The arginine-1493 residue in QRRGRTGR1493G motif IV of the hepatitis C virus NS3 helicase domain is essential for NS3 protein methylation by the protein arginine methyltransferase 1.
Hepatitis C
Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1.
Hepatitis C, Chronic
Hepatitis C virus-induced up-regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair.
Herpes Simplex
Protein arginine methyltransferase 1 regulates herpes simplex virus replication through ICP27 RGG-box methylation.
Hirschsprung Disease
Analyses of PRMT1 proteins in human colon tissues from Hirschsprung disease patients.
Hodgkin Disease
Arginine Methyltransferases Are Regulated by Epstein-Barr Virus in B Cells and Are Differentially Expressed in Hodgkin's Lymphoma.
Huntington Disease
AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3.
Huntington Disease
Huntingtin-mediated axonal transport requires arginine methylation by PRMT6.
Hyperalgesia
Blocking the Spinal Fbxo3/CARM1/K+ Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief.
Hyperalgesia
Dorsal Root Ganglia Coactivator-associated Arginine Methyltransferase 1 Contributes to Peripheral Nerve Injury-induced Pain Hypersensitivities.
Hyperglycemia
A critical role for hepatic protein arginine methyltransferase 1 isoform 2 in glycemic control.
Hyperglycemia
PRMT1 promotes hyperglycemia in a FoxO1-dependent manner, affecting glucose metabolism, during hypobaric hypoxia exposure, in rat model.
Hypersensitivity
Dorsal Root Ganglia Coactivator-associated Arginine Methyltransferase 1 Contributes to Peripheral Nerve Injury-induced Pain Hypersensitivities.
Infections
Protein arginine methyltransferase 1 modulates innate immune responses through regulation of peroxisome proliferator-activated receptor ?-dependent macrophage differentiation.
Infertility
Arginine methyltransferases mediate an epigenetic ovarian response to endometriosis.
Inflammatory Bowel Diseases
The roles of microbial products in the development of colorectal cancer: a review.
Insulin Resistance
Arginine methylation of CRTC2 is critical in the transcriptional control of hepatic glucose metabolism.
Insulin Resistance
Insulin-induced CARM1 upregulation facilitates hepatocyte proliferation.
Insulin Resistance
PRMT1 promotes hyperglycemia in a FoxO1-dependent manner, affecting glucose metabolism, during hypobaric hypoxia exposure, in rat model.
Kidney Diseases
Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: synthesis and biological evaluation.
Kidney Diseases
Protein arginine methyltransferase 1 mediates renal fibroblast activation and fibrogenesis through activation of Smad3 signaling.
Leukemia
CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.
Leukemia
Correlation of SRSF1 and PRMT1 expression with clinical status of pediatric acute lymphoblastic leukemia.
Leukemia
Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation.
Leukemia
Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
Leukemia
Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: synthesis and biological evaluation.
Leukemia
PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential.
Leukemia
PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia.
Leukemia
PRMT1-RBM15 axis regulates megakaryocytic differentiation of human umbilical cord blood CD34
Leukemia
Properly Substituted Cyclic Bis-(2-bromobenzylidene) Compounds Behaved as Dual p300/CARM1 Inhibitors and Induced Apoptosis in Cancer Cells.
Leukemia
Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.
Leukemia
Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells.
Leukemia
Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors.
Leukemia, Erythroblastic, Acute
Modulating the expression of Chtop, a versatile regulator of gene-specific transcription and mRNA export.
Leukemia, Megakaryoblastic, Acute
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.
Leukemia, Myeloid
PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex.
Leukemia, Myeloid, Acute
CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.
Leukemia, Myeloid, Acute
Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.
Leukemia, Myeloid, Acute
PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex.
Leukemia, Myeloid, Acute
Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.
Leukopenia
Protein arginine methyltransferase 1 is required for maintenance of normal adult hematopoiesis.
Lipodystrophy
Depletion of Prmt1 in Adipocytes Impairs Glucose Homeostasis in Diet-Induced Obesity.
Liver Cirrhosis
Characterization and sub-cellular localization of GalNAc-binding proteins isolated from human hepatic stellate cells.
Liver Diseases
Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice.
Liver Neoplasms
CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer.
Liver Neoplasms
CARM1 Preferentially Methylates H3R17 over H3R26 through a Random Kinetic Mechanism.
Liver Neoplasms
Epigenetic Induction of Mitochondrial Fission Is Required for Maintenance of Liver Cancer-Initiating Cells.
Lung Diseases
Oxidative stress destabilizes protein arginine methyltransferase 4 via glycogen synthase kinase 3? to impede lung epithelial cell migration.
Lung Diseases
PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts.
Lung Diseases
PRMT1 mediates podocyte injury and glomerular fibrosis through phosphorylation of ERK pathway.
Lung Diseases
TGF-? Upregulated Mitochondria Mass through the SMAD2/3?C/EBP??PRMT1 Signal Pathway in Primary Human Lung Fibroblasts.
Lung Injury
Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia.
Lung Neoplasms
CARM1 and PRMT1 are dysregulated in lung cancer without hierarchical features.
Lung Neoplasms
CARM1 promotes non-small cell lung cancer progression through upregulating CCNE2 expression.
Lung Neoplasms
CRISPR/Cas9 library screening uncovered methylated PKP2 as a critical driver of lung cancer radioresistance by stabilizing ?-catenin.
Lung Neoplasms
Developing protein arginine methyltransferase 1 (PRMT1) inhibitor TC-E-5003 as an antitumor drug using INEI drug delivery systems.
Lung Neoplasms
ESRP1 regulates alternative splicing of CARM1 to sensitize small cell lung cancer cells to chemotherapy by inhibiting TGF-?/Smad signaling.
Lung Neoplasms
High Expression of CARM1 Inhibits Lung Cancer Progression by Targeting TP53 by Regulating CTNNB1.
Lung Neoplasms
Inhibition of Nonsmall Cell Lung Cancer Cell Migration by Protein Arginine Methyltransferase 1-small Hairpin RNA Through Inhibiting Epithelial-mesenchymal Transition, Extracellular Matrix Degradation, and Src Phosphorylation In Vitro.
Lung Neoplasms
Long Non-coding RNA PVT1 Competitively Binds MicroRNA-424-5p to Regulate CARM1 in Radiosensitivity of Non-Small-Cell Lung Cancer.
Lung Neoplasms
PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer.
Lung Neoplasms
PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells.
Lung Neoplasms
PRMT6 Promotes Lung Tumor Progression via the Alternate Activation of Tumor-Associated Macrophages.
Lung Neoplasms
The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells.
Lymphatic Metastasis
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.
Lymphatic Metastasis
PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18.
Lymphoma
CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.
Mastitis
Identification of splice variants, expression analysis and single nucleotide polymorphisms of the PRMT2 gene in dairy cattle.
Megacolon
Analyses of PRMT1 proteins in human colon tissues from Hirschsprung disease patients.
Melanoma
PRMT1 regulates tumor growth and metastasis of human melanoma via targeting ALCAM.
Memory Disorders
The telomeric part of the human chromosome 21 from CSTB to prmt2 is not necessarry for the locomotor and short-term memory deficits observed in the tc1 mouse model of down syndrome.
Metabolic Diseases
Genome-wide Transcriptional Sequencing Identifies Novel Mutations in Metabolic Genes in Human Hepatocellular Carcinoma.
Metabolic Diseases
Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator?activated receptor ? activity.
Mouth Neoplasms
PRMT1 expression is elevated in head and neck cancer and inhibition of protein arginine methylation by adenosine dialdehyde or PRMT1 knockdown downregulates proliferation and migration of oral cancer cells.
Mouth Neoplasms
WDR5 promotes the tumorigenesis of oral squamous cell carcinoma via CARM1/?-catenin axis.
Multiple Myeloma
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.
Multiple Myeloma
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.
Muscle Spasticity
Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage.
Muscular Atrophy
CARM1 contributes to skeletal muscle wasting by mediating FoxO3 activity and promoting myofiber autophagy.
Muscular Atrophy
Chrysanthemi Zawadskii var. Latilobum Attenuates Obesity-Induced Skeletal Muscle Atrophy via Regulation of PRMTs in Skeletal Muscle of Mice.
Muscular Atrophy
Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.
Muscular Atrophy
Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis.
Muscular Atrophy, Spinal
A novel role for CARM1 in promoting nonsense-mediated mRNA decay: potential implications for spinal muscular atrophy.
Muscular Atrophy, Spinal
KH-type splicing regulatory protein interacts with survival motor neuron protein and is misregulated in spinal muscular atrophy.
Muscular Atrophy, Spinal
The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing.
Myelodysplastic Syndromes
Methylation of dual-specificity phosphatase 4 controls cell differentiation.
Myocardial Infarction
Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies.
Myocardial Infarction
PRMT4 overexpression aggravates cardiac remodeling following myocardial infarction by promoting cardiomyocyte apoptosis.
Neoplasm Metastasis
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.
Neoplasm Metastasis
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.
Neoplasm Metastasis
CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis.
Neoplasm Metastasis
Disease biomarker identification from gene network modules for metastasized breast cancer.
Neoplasm Metastasis
Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells.
Neoplasm Metastasis
LncRNA NNT-AS1 promote glioma cell proliferation and metastases through miR-494-3p/PRMT1 axis.
Neoplasm Metastasis
Macrophages-stimulated PRMT1-mediated EZH2 methylation promotes breast cancer metastasis.
Neoplasm Metastasis
Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Neoplasm Metastasis
miR-503 suppresses metastasis of hepatocellular carcinoma cell by targeting PRMT1.
Neoplasm Metastasis
PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer.
Neoplasm Metastasis
PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer.
Neoplasm Metastasis
PRMT1 Promoted HCC Growth and Metastasis In Vitro and In Vivo via Activating the STAT3 Signalling Pathway.
Neoplasm Metastasis
PRMT1 regulates tumor growth and metastasis of human melanoma via targeting ALCAM.
Neoplasm Metastasis
PRMT2 and ROR? expression are associated with breast cancer survival outcomes.
Neoplasm Metastasis
PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.
Neoplasm Metastasis
PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18.
Neoplasm Metastasis
Protein arginine methyltransferase 1 promoted the growth and migration of cancer cells in esophageal squamous cell carcinoma.
Neoplasm Metastasis
RNA binding protein RALY promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells.
Neoplasm Metastasis
The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1.
Neoplasms
A coactivator role of CARM1 in the dysregulation of {beta}-catenin activity in colorectal cancer cell growth and gene expression.
Neoplasms
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6.
Neoplasms
A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor ?-dependent transcriptional activation and breast carcinogenesis.
Neoplasms
A novel splicing isoform of Protein Arginine Methyltransferase 1 (PRMT1) that lacks the dimerization arm and correlates with cellular malignancy.
Neoplasms
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.
Neoplasms
Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor.
Neoplasms
Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers.
Neoplasms
AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3.
Neoplasms
Arginine methyltransferases mediate an epigenetic ovarian response to endometriosis.
Neoplasms
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.
Neoplasms
Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression.
Neoplasms
CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer.
Neoplasms
CARM1 but not Its Enzymatic Activity Is Required for Transcriptional Coactivation of NF-kappaB-Dependent Gene Expression.
Neoplasms
CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells.
Neoplasms
CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.
Neoplasms
CARM1 Is an Important Determinant of ER{alpha}-Dependent Breast Cancer Cell Differentiation and Proliferation in Breast Cancer Cells.
Neoplasms
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.
Neoplasms
CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis.
Neoplasms
CARM1 Preferentially Methylates H3R17 over H3R26 through a Random Kinetic Mechanism.
Neoplasms
CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity.
Neoplasms
CARM1/PRMT4: Making Its Mark beyond Its Function as a Transcriptional Coactivator.
Neoplasms
Design and synthesis of novel PRMT1 inhibitors and investigation of their binding preferences using molecular modelling.
Neoplasms
Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.
Neoplasms
Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1).
Neoplasms
Differential mRNA expression levels of human histone-modifying enzymes in normal karyotype B cell pediatric acute lymphoblastic leukemia.
Neoplasms
Discovery and structure-activity analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors.
Neoplasms
Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor.
Neoplasms
Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors.
Neoplasms
Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells.
Neoplasms
Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes.
Neoplasms
Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers.
Neoplasms
Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.
Neoplasms
Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways.
Neoplasms
Epigenetic Induction of Mitochondrial Fission Is Required for Maintenance of Liver Cancer-Initiating Cells.
Neoplasms
Erratum to: FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion and colony formation.
Neoplasms
Esophageal Squamous Cell Carcinoma Is Accompanied by Local and Systemic Changes in L-arginine/NO Pathway.
Neoplasms
Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors.
Neoplasms
Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: synthesis and biological evaluation.
Neoplasms
Expression and localisation of methylthioadenosine phosphorylase (MTAP) in oral squamous cell carcinoma and their significance in epithelial-to-mesenchymal transition.
Neoplasms
Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity.
Neoplasms
FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.
Neoplasms
FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion, and colony formation.
Neoplasms
Functional insights from high resolution structures of mouse protein arginine methyltransferase 6.
Neoplasms
Geranylgeranylacetone promotes human osteosarcoma cell apoptosis by inducing the degradation of PRMT1 through the E3 ubiquitin ligase CHIP.
Neoplasms
Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition.
Neoplasms
Hepatocellular Protein Arginine Methyltransferase 1 Suppresses Alcohol-Induced Hepatocellular Carcinoma Formation by Inhibition of Inducible Nitric Oxide Synthase.
Neoplasms
Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter.
Neoplasms
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.
Neoplasms
Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays.
Neoplasms
Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators.
Neoplasms
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Neoplasms
L-Arginine/Nitric Oxide Pathway Is Altered in Colorectal Cancer and Can Be Modulated by Novel Derivatives from Oxicam Class of Non-Steroidal Anti-Inflammatory Drugs.
Neoplasms
M-TAP Dance: Targeting PRMT1 and PRMT5 Family Members to Push Cancer Cells Over the Edge.
Neoplasms
Mechanistic Studies on Transcriptional Coactivator Protein Arginine Methyltransferase 1.
Neoplasms
MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs.
Neoplasms
Melatonin Inhibits Osteoclastogenesis and Bone Loss in Ovariectomized Mice by Regulating PRMT1-Mediated Signaling.
Neoplasms
Methylation of C/EBP? by PRMT1 Inhibits Its Tumor-Suppressive Function in Breast Cancer.
Neoplasms
Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics.
Neoplasms
Morphologic and molecular correlates of EZH2 as a predictor of platinum resistance in high-grade ovarian serous carcinoma.
Neoplasms
Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases.
Neoplasms
mRNA expression profiling of histone modifying enzymes in pediatric acute monoblastic leukemia.
Neoplasms
Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity.
Neoplasms
Novel alternative splice variants of the human protein arginine methyltransferase 1 (PRMT1) gene, discovered using next-generation sequencing.
Neoplasms
Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein.
Neoplasms
Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients.
Neoplasms
Overexpressing PRMT1 Inhibits Proliferation and Invasion in Pancreatic Cancer by Inverse Correlation of ZEB1.
Neoplasms
Overexpression of CARM1 in breast cancer is correlated with poorly characterized clinicopathologic parameters and molecular subtypes.
Neoplasms
Phospho-?Np63?/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure.
Neoplasms
PRMT1 and PRMT8 Regulate Retinoic Acid-Dependent Neuronal Differentiation with Implications to Neuropathology.
Neoplasms
PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance.
Neoplasms
PRMT1 expression is elevated in head and neck cancer and inhibition of protein arginine methylation by adenosine dialdehyde or PRMT1 knockdown downregulates proliferation and migration of oral cancer cells.
Neoplasms
PRMT1 expression predicts response to neoadjuvant chemotherapy for locally advanced uterine cervical cancer.
Neoplasms
PRMT1 expression predicts sensitivity to platinum-based chemotherapy in patients with ovarian serous carcinoma.
Neoplasms
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.
Neoplasms
PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer.
Neoplasms
PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin.
Neoplasms
PRMT1 Promoted HCC Growth and Metastasis In Vitro and In Vivo via Activating the STAT3 Signalling Pathway.
Neoplasms
PRMT1 promotes the tumor suppressor function of p14ARF and is indicative for pancreatic cancer prognosis.
Neoplasms
PRMT1 regulates tumor growth and metastasis of human melanoma via targeting ALCAM.
Neoplasms
PRMT1-dependent macrophage IL6 production is required for alcohol-induced HCC progression.
Neoplasms
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma.
Neoplasms
PRMT2 accelerates tumorigenesis of hepatocellular carcinoma by activating Bcl2 via histone H3R8 methylation.
Neoplasms
PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma.
Neoplasms
PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis.
Neoplasms
PRMT6 activates cyclin D1 expression in conjunction with the transcription factor LEF1.
Neoplasms
PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability.
Neoplasms
PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents.
Neoplasms
PRMT6 mediates inflammation via activation of the NF-?B/p65 pathway on a cigarette smoke extract-induced murine emphysema model.
Neoplasms
PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: Its implication in motility and invasion.
Neoplasms
PRMT6 promotes endometrial cancer via AKT/mTOR signaling and indicates poor prognosis.
Neoplasms
PRMT6 Promotes Lung Tumor Progression via the Alternate Activation of Tumor-Associated Macrophages.
Neoplasms
PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.
Neoplasms
PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer.
Neoplasms
Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling.
Neoplasms
Protein arginine methyltransferase 1 coordinates the epithelial-mesenchymal transition/proliferation dichotomy in gastric cancer cells.
Neoplasms
Protein arginine methyltransferase 1 interacts with Gli1 and regulates its transcriptional activity.
Neoplasms
Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma.
Neoplasms
Protein arginine methyltransferase 1 is required for maintenance of normal adult hematopoiesis.
Neoplasms
Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 gene during acquired multidrug resistant.
Neoplasms
Protein arginine methyltransferase 1 promoted the growth and migration of cancer cells in esophageal squamous cell carcinoma.
Neoplasms
Protein arginine methyltransferase 1 promotes epithelial-mesenchymal transition via TGF-?1/Smad pathway in hepatic carcinoma cells.
Neoplasms
Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer.
Neoplasms
Protein arginine methyltransferase 8 gene enhances the colon cancer stem cell (CSC) function by upregulating the pluripotency transcription factor.
Neoplasms
Protein arginine methyltransferase-1 deficiency restrains depression-like behavior of mice by inhibiting inflammation and oxidative stress via Nrf-2.
Neoplasms
Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics.
Neoplasms
SCF-FBXO24 regulates cell proliferation by mediating ubiquitination and degradation of PRMT6.
Neoplasms
Status of epigenetic chromatin modification enzymes and esophageal squamous cell carcinoma risk in northeast Indian population.
Neoplasms
Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.
Neoplasms
Surface-enhanced Raman spectroscopic studies of coactivator-associated arginine methyltransferase 1.
Neoplasms
Targeting PRMT1-Mediated FLT3 Methylation Disrupts Maintenance of MLL- rearranged Acute Lymphoblastic Leukemia.
Neoplasms
The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes.
Neoplasms
The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.
Neoplasms
The complex CBX7-PRMT1 has a critical role in regulating E-cadherin gene expression and cell migration.
Neoplasms
The Development of Tetrazole Derivatives as Protein Arginine Methyltransferase I (PRMT I) Inhibitors.
Neoplasms
The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1.
Neoplasms
The oestrogen receptor coactivator CARM1 has an oncogenic effect and is associated with poor prognosis in breast cancer.
Neoplasms
The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3?/?-Catenin/cyclinD1 Signaling Pathway.
Neoplasms
The polymorphism rs975484 in the protein arginine methyltransferase 1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma.
Neoplasms
The roles of microbial products in the development of colorectal cancer: a review.
Neoplasms
Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1.
Neoplasms
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.
Neoplasms
Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.
Neoplasms
Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells.
Neoplasms
Understanding protein arginine methyltransferase 1 (PRMT1) product specificity from molecular dynamics.
Neoplasms
Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors.
Neoplasms
WDR5 promotes the tumorigenesis of oral squamous cell carcinoma via CARM1/?-catenin axis.
Neural Tube Defects
CBP/p300 and associated transcriptional co-activators exhibit distinct expression patterns during murine craniofacial and neural tube development.
Neuralgia
Blocking the Spinal Fbxo3/CARM1/K+ Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief.
Neuralgia
Dorsal Root Ganglia Coactivator-associated Arginine Methyltransferase 1 Contributes to Peripheral Nerve Injury-induced Pain Hypersensitivities.
Neuralgia
[Transcription of protein arginine N-methyltransferase genes in mouse dorsal root ganglia following peripheral nerve injury].
Neuroblastoma
Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells.
Neuroblastoma
Iron-induced oxidative stress activates AKT and ERK1/2 and decreases Dyrk1B and PRMT1 in neuroblastoma SH-SY5Y cells.
Neuroblastoma
Prognostic significance of MYCN related genes in pediatric neuroblastoma: a study based on TARGET and GEO datasets.
Neuroblastoma
Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma.
Neuroblastoma
WDR5-Myc axis promotes the progression of glioblastoma and neuroblastoma by transcriptional activating CARM1.
Neurodegenerative Diseases
Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons.
Neurodegenerative Diseases
Roles of protein arginine methyltransferase 1 (PRMT1) in brain development and disease.
Neuroinflammatory Diseases
Protein arginine methyltransferase 8 modulates mitochondrial bioenergetics and neuroinflammation after hypoxic stress.
Non-alcoholic Fatty Liver Disease
PRMT3 regulates hepatic lipogenesis through direct interaction with LXR?.
Obesity
Arginine methylation of CRTC2 is critical in the transcriptional control of hepatic glucose metabolism.
Obesity
Comparative transcriptome analysis identifies CARM1 and DNMT3A as genes associated with osteoporosis.
Obesity
Depletion of Prmt1 in Adipocytes Impairs Glucose Homeostasis in Diet-Induced Obesity.
Obesity
Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation.
Obesity
Genome-wide Transcriptional Sequencing Identifies Novel Mutations in Metabolic Genes in Human Hepatocellular Carcinoma.
Oligospermia
The arginine methyltransferase CARM1 represses p300ACTCREM? activity and is required for spermiogenesis.
Osteoporosis
Comparative transcriptome analysis identifies CARM1 and DNMT3A as genes associated with osteoporosis.
Osteoporosis
Melatonin Inhibits Osteoclastogenesis and Bone Loss in Ovariectomized Mice by Regulating PRMT1-Mediated Signaling.
Osteoporosis
PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice.
Osteoporosis, Postmenopausal
PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice.
Osteosarcoma
Cell Cycle Regulation by the PRMT6 Arginine Methyltransferase through Repression of Cyclin-Dependent Kinase Inhibitors.
Osteosarcoma
Geranylgeranylacetone promotes human osteosarcoma cell apoptosis by inducing the degradation of PRMT1 through the E3 ubiquitin ligase CHIP.
Osteosarcoma
The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3?/?-Catenin/cyclinD1 Signaling Pathway.
Ototoxicity
Cisplatin-induced ototoxicity involves interaction of PRMT3 and cannabinoid system.
Ototoxicity
Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death.
Ovarian Neoplasms
Cancer-related transcription regulator protein NAC1 forms a protein complex with CARM1 for ovarian cancer progression.
Ovarian Neoplasms
FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.
Ovarian Neoplasms
FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion, and colony formation.
Ovarian Neoplasms
PRMT1 expression predicts sensitivity to platinum-based chemotherapy in patients with ovarian serous carcinoma.
Ovarian Neoplasms
PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin.
Ovarian Neoplasms
PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer.
Ovarian Neoplasms
SWI/SNF Complexes in Ovarian Cancer: Mechanistic Insights and Therapeutic Implications.
Ovarian Neoplasms
Targeting the IRE1?/XBP1s pathway suppresses CARM1-expressing ovarian cancer.
Pancreatic Neoplasms
Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer.
Pancreatic Neoplasms
Author Correction: PRMT1 promotes pancreatic cancer growth and predicts poor prognosis.
Pancreatic Neoplasms
Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics.
Pancreatic Neoplasms
Overexpressing PRMT1 Inhibits Proliferation and Invasion in Pancreatic Cancer by Inverse Correlation of ZEB1.
Pancreatic Neoplasms
PRMT1 promotes the tumor suppressor function of p14ARF and is indicative for pancreatic cancer prognosis.
Pancreatic Neoplasms
Protein Arginine Methyltransferase 3 Enhances Chemoresistance in Pancreatic Cancer by Methylating hnRNPA1 to Increase ABCG2 Expression.
Pancreatic Neoplasms
Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer.
Peripheral Nerve Injuries
Dorsal Root Ganglia Coactivator-associated Arginine Methyltransferase 1 Contributes to Peripheral Nerve Injury-induced Pain Hypersensitivities.
Peritonitis
Arginine methylation regulates c-Myc-dependent transcription by altering promoter recruitment of the acetyltransferase p300.
Peritonitis
Immunoresolving actions of oral resolvin D1 include selective regulation of the transcription machinery in resolution-phase mouse macrophages.
Pneumonia
Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling.
Pneumonia
Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia.
Pneumonia
PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation.
Pneumonia
Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation.
Pneumonia
Upregulated Protein Arginine Methyltransferase 1 by IL-4 Increases Eotaxin-1 Expression in Airway Epithelial Cells and Participates in Antigen-Induced Pulmonary Inflammation in Rats.
Pre-Eclampsia
Altered methylation and expression patterns of genes regulating placental nitric oxide pathway in patients with severe preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Correlation of SRSF1 and PRMT1 expression with clinical status of pediatric acute lymphoblastic leukemia.
Prostatic Intraepithelial Neoplasia
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.
Prostatic Neoplasms
CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.
Prostatic Neoplasms
Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway.
Prostatic Neoplasms
Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer.
Prostatic Neoplasms
Inhibition of androgen receptor and ?-catenin activity in prostate cancer.
Prostatic Neoplasms
Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability.
Prostatic Neoplasms
PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: Its implication in motility and invasion.
Prostatic Neoplasms
Protein arginine methyltransferase 10 is required for androgen-dependent proliferation of LNCaP prostate cancer cells.
Prostatic Neoplasms
The protein arginine methyltransferases (PRMTs) PRMT1 and CARM1 as candidate epigenetic drivers in prostate cancer progression.
Pulmonary Disease, Chronic Obstructive
CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis.
Pulmonary Disease, Chronic Obstructive
Cigarette smoke extract induces airway epithelial cell death via repressing PRMT6/AKT signaling.
Pulmonary Disease, Chronic Obstructive
F-Box Protein FBXW17-Mediated Proteasomal Degradation of Protein Methyltransferase PRMT6 Exaggerates CSE-Induced Lung Epithelial Inflammation and Apoptosis.
Pulmonary Disease, Chronic Obstructive
The protective effect of PRMT6 overexpression on cigarette smoke extract-induced murine emphysema model.
Pulmonary Fibrosis
Elevated protein arginine methyltransferase 1 expression regulates fibroblast motility in pulmonary fibrosis.
Retinoblastoma
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Rhinitis, Allergic
Protein arginine methyltransferase 1 contributes to the development of allergic rhinitis by promoting the production of epithelial-derived cytokines.
Sarcoma, Ewing
Different methylation characteristics of protein arginine methyltransferase 1 and 3 toward the Ewing Sarcoma protein and a peptide.
Sarcoma, Ewing
Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.
Severe Combined Immunodeficiency
p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.
Small Cell Lung Carcinoma
ESRP1 regulates alternative splicing of CARM1 to sensitize small cell lung cancer cells to chemotherapy by inhibiting TGF-?/Smad signaling.
Squamous Cell Carcinoma of Head and Neck
The long noncoding RNA ST7-AS1 promotes laryngeal squamous cell carcinoma by stabilizing CARM1.
Starvation
C9orf72-dependent lysosomal functions regulate epigenetic control of autophagy and lipid metabolism.
Starvation
CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer.
Starvation
Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy.
Starvation
Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response.
Stomach Neoplasms
Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression.
Stomach Neoplasms
Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients.
Stomach Neoplasms
PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer.
Stomach Neoplasms
Protein arginine methyltransferase 1 coordinates the epithelial-mesenchymal transition/proliferation dichotomy in gastric cancer cells.
Stroke
Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies.
Thrombocytopenia
Methylation of dual-specificity phosphatase 4 controls cell differentiation.
Thrombosis
PRMT1 Promoted HCC Growth and Metastasis In Vitro and In Vivo via Activating the STAT3 Signalling Pathway.
Thymoma
Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis.
Tics
PRMT1 regulates the tumour-initiating properties of esophageal squamous cell carcinoma through histone H4 arginine methylation coupled with transcriptional activation.
Triple Negative Breast Neoplasms
Methylation of C/EBP? by PRMT1 Inhibits Its Tumor-Suppressive Function in Breast Cancer.
Triple Negative Breast Neoplasms
The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells.
type i protein arginine methyltransferase deficiency
A critical role for hepatic protein arginine methyltransferase 1 isoform 2 in glycemic control.
type i protein arginine methyltransferase deficiency
CRAF methylation by PRMT6 regulates aerobic glycolysis driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation.
type i protein arginine methyltransferase deficiency
PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products.
type i protein arginine methyltransferase deficiency
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.
type i protein arginine methyltransferase deficiency
Prmt1 regulates craniofacial bone formation upstream of Msx1.
type i protein arginine methyltransferase deficiency
PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability.
type i protein arginine methyltransferase deficiency
Protein arginine methyltransferase-1 deficiency restrains depression-like behavior of mice by inhibiting inflammation and oxidative stress via Nrf-2.
type i protein arginine methyltransferase deficiency
Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis.
type i protein arginine methyltransferase deficiency
The methyltransferase PRMT1 regulates ?-globin translation.
type i protein arginine methyltransferase deficiency
The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling.
type ii protein arginine methyltransferase deficiency
PRMT5 is required for cell-cycle progression and p53 tumor suppressor function.
Ureteral Obstruction
Protein arginine methyltransferase 1 mediates renal fibroblast activation and fibrogenesis through activation of Smad3 signaling.
Urinary Bladder Neoplasms
PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP.
Uterine Cervical Neoplasms
Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways.
Uterine Cervical Neoplasms
miR-16-5p modulates the radiosensitivity of cervical cancer cells via regulating coactivator-associated arginine methyltransferase 1.
Uterine Cervical Neoplasms
PRMT1 expression predicts response to neoadjuvant chemotherapy for locally advanced uterine cervical cancer.
Uterine Cervical Neoplasms
PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer.
Virus Diseases
Molecular characterisation and inductive expression of a fish protein arginine methyltransferase 1 gene in response to virus infection.
Virus Diseases
The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling.
Wilms Tumor
Transcriptomic Analyses of MYCN-Regulated Genes in Anaplastic Wilms' Tumour Cell Lines Reveals Oncogenic Pathways and Potential Therapeutic Vulnerabilities.
Wolff-Parkinson-White Syndrome
CARM1/PRMT4 is necessary for the glycogen gene expression programme in skeletal muscle cells.
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