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Disease on EC 2.1.1.319 - type I protein arginine methyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Coronary Syndrome
Coactivator-associated arginine methyltransferase 1 targeted by miR-15a regulates inflammation in acute coronary syndrome.
Adenocarcinoma
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.
CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.
Comprehensive analysis of histone modification-associated genes on differential gene expression and prognosis in gastric cancer.
PRMT1 promotes pancreatic cancer growth and predicts poor prognosis.
Adenocarcinoma of Lung
PFKFB4 promotes lung adenocarcinoma progression via phosphorylating and activating transcriptional coactivator SRC-2.
PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18.
Adenoma
Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.
Amyotrophic Lateral Sclerosis
Roles of protein arginine methyltransferase 1 (PRMT1) in brain development and disease.
Anemia
Protein arginine methyltransferase 1 is required for maintenance of normal adult hematopoiesis.
Angiodysplasia
Angiodysplasia in embryo lacking protein arginine methyltransferase 1 (PRMT1) in vascular endothelial cells.
Anorectal Malformations
Analyses of PRMT1 proteins in human colon tissues from Hirschsprung disease patients.
Asthma
Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling.
PRMT1 Modulates Processing of Asthma-Related Primary MicroRNAs (Pri-miRNAs) into Mature miRNAs in Lung Epithelial Cells.
PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation.
Protein arginine methyltransferase 1 contributes to the development of allergic rhinitis by promoting the production of epithelial-derived cytokines.
Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation.
TGF-? Upregulated Mitochondria Mass through the SMAD2/3?C/EBP??PRMT1 Signal Pathway in Primary Human Lung Fibroblasts.
Upregulated Protein Arginine Methyltransferase 1 by IL-4 Increases Eotaxin-1 Expression in Airway Epithelial Cells and Participates in Antigen-Induced Pulmonary Inflammation in Rats.
Atherosclerosis
Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice.
LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2.
PRMT2 inhibits the formation of foam cell induced by ox-LDL in RAW 264.7 macrophage involving ABCA1 mediated cholesterol efflux.
Azoospermia
Association Study Between Polymorphisms of PRMT6, PEX10, SOX5, and Non-obstructive Azoospermia in the Han Chinese Population.
PEX10, SIRPA-SIRPG, and SOX5 gene polymorphisms are strongly associated with nonobstructive azoospermia susceptibility.
Bone Diseases, Metabolic
Asymmetrical methyltransferase PRMT3 regulates human mesenchymal stem cell osteogenesis via miR-3648.
Bone Resorption
PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice.
Brain Neoplasms
Arginine methylation: the promise of a 'silver bullet' for brain tumours?
PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.
Breast Neoplasms
A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.
A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor ?-dependent transcriptional activation and breast carcinogenesis.
A TR-FRET-based functional assay for screening activators of CARM1.
Alternative splicing yields protein arginine methyltransferase 1 isoforms with distinct activity, substrate specificity, and subcellular localization.
Alternatively spliced protein arginine methyltransferase 1 isoform PRMT1v2 promotes the survival and invasiveness of breast cancer cells.
Arginine methylation-dependent regulation of ASK1 signaling by PRMT1.
Arginine Methyltransferase PRMT1 Regulates p53 Activity in Breast Cancer.
CARM1 Is an Important Determinant of ER{alpha}-Dependent Breast Cancer Cell Differentiation and Proliferation in Breast Cancer Cells.
CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.
CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1.
CARMA: CARM1 methylation of SWI/SNF in breast cancer.
Clinical evaluation of PRMT1 gene expression in breast cancer.
Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene.
Correction: A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.
Correction: differential CARM1 isoform expression in subcellular compartments and among malignant and benign breast tumors.
DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.
Differential CARM1 Isoform Expression in Subcellular Compartments and among Malignant and Benign Breast Tumors.
Disease biomarker identification from gene network modules for metastasized breast cancer.
Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors.
Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity.
Functional interplay between YY1 and CARM1 promotes oral carcinogenesis.
Genomic organization, physical mapping, and expression analysis of the human protein arginine methyltransferase 1 gene.
Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition.
Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma.
Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer.
Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6.
Macrophages-stimulated PRMT1-mediated EZH2 methylation promotes breast cancer metastasis.
MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs.
Methylation of C/EBP? by PRMT1 Inhibits Its Tumor-Suppressive Function in Breast Cancer.
Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Modulating the expression of Chtop, a versatile regulator of gene-specific transcription and mRNA export.
Novel alternative splice variants of the human protein arginine methyltransferase 1 (PRMT1) gene, discovered using next-generation sequencing.
Novel CARM1-Interacting Protein, DZIP3, Is a Transcriptional Coactivator of Estrogen Receptor-?.
Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein.
Nucleo-cytoplasmic shuttling of protein arginine methyltransferase 1 (PRMT1) requires enzymatic activity.
Overexpression of CARM1 in breast cancer is correlated with poorly characterized clinicopathologic parameters and molecular subtypes.
p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.
PELP1 oncogenic functions involve CARM1 regulation.
PRMT1 Is Critical for the Transcriptional Activity and the Stability of the Progesterone Receptor.
PRMT1-dependent methylation of BRCA1 contributes to the epigenetic defense of breast cancer cells against ionizing radiation.
PRMT2 and ROR? expression are associated with breast cancer survival outcomes.
PRMT2?, a C-terminal splice variant of PRMT2, inhibits the growth of breast cancer cells.
PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: Its implication in motility and invasion.
Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 gene during acquired multidrug resistant.
Protein arginine methyltransferase 6 enhances ligand-dependent and -independent activity of estrogen receptor ? via distinct mechanisms.
Protein arginine methyltransferase 6 regulates multiple aspects of gene expression.
Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes.
Protein arginine N-methyltransferase 2 reverses tamoxifen resistance in breast cancer cells through suppression of ER-?36.
RNA binding protein RALY promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells.
Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.
Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1.
The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer.
The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1.
The oestrogen receptor coactivator CARM1 has an oncogenic effect and is associated with poor prognosis in breast cancer.
Bulbo-Spinal Atrophy, X-Linked
Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.
Carcinogenesis
A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor ?-dependent transcriptional activation and breast carcinogenesis.
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.
Arginine Methyltransferase PRMT1 Regulates p53 Activity in Breast Cancer.
Arginine methyltransferase PRMT3 promote tumorigenesis through regulating c-MYC stabilization in colorectal cancer.
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.
Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers.
Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.
Erratum: PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis.
Functional interplay between YY1 and CARM1 promotes oral carcinogenesis.
Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer.
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis.
Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6.
Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases.
Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein.
p53 mediated regulation of Coactivator associated arginine methyltransferase 1 (CARM1) expression is critical for suppression of adipogenesis.
PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis.
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.
PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin.
PRMT1 potentiates chondrosarcoma development through activation of YAP activity.
PRMT2 accelerates tumorigenesis of hepatocellular carcinoma by activating Bcl2 via histone H3R8 methylation.
PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma.
PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.
Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma.
The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1.
The protein arginine methyltransferases (PRMTs) PRMT1 and CARM1 as candidate epigenetic drivers in prostate cancer progression.
WDR5 promotes the tumorigenesis of oral squamous cell carcinoma via CARM1/?-catenin axis.
Carcinoma
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.
BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1.
CARM1 and PRMT1 are dysregulated in lung cancer without hierarchical features.
Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.
PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance.
PRMT1 expression predicts sensitivity to platinum-based chemotherapy in patients with ovarian serous carcinoma.
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.
PRMT1 regulates the tumour-initiating properties of esophageal squamous cell carcinoma through histone H4 arginine methylation coupled with transcriptional activation.
Protein arginine methyltransferase 1 interacts with Gli1 and regulates its transcriptional activity.
Protein arginine methyltransferase 1 promoted the growth and migration of cancer cells in esophageal squamous cell carcinoma.
Protein arginine methyltransferase 1 promotes epithelial-mesenchymal transition via TGF-?1/Smad pathway in hepatic carcinoma cells.
SWI/SNF Complexes in Ovarian Cancer: Mechanistic Insights and Therapeutic Implications.
The long noncoding RNA ST7-AS1 promotes laryngeal squamous cell carcinoma by stabilizing CARM1.
The prognostic significance of protein arginine methyltransferase 6 expression in colon cancer.
UCP2 and PRMT1 are key prognostic markers for lung carcinoma patients.
Carcinoma, Ductal
Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein.
Carcinoma, Hepatocellular
CRAF methylation by PRMT6 regulates aerobic glycolysis driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation.
Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.
Hepatocellular Protein Arginine Methyltransferase 1 Suppresses Alcohol-Induced Hepatocellular Carcinoma Formation by Inhibition of Inducible Nitric Oxide Synthase.
Inhibition of alpha interferon signaling by hepatitis B virus.
Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription.
miR-503 suppresses metastasis of hepatocellular carcinoma cell by targeting PRMT1.
PGC1? TRANSCRIPTIONAL ADAPTOR FUNCTION GOVERNS HEPATITIS B VIRUS REPLICATION BY CONTROLLING HBcAg/p21 PROTEIN MEDIATED CAPSID FORMATION.
PRMT1 Promoted HCC Growth and Metastasis In Vitro and In Vivo via Activating the STAT3 Signalling Pathway.
PRMT2 accelerates tumorigenesis of hepatocellular carcinoma by activating Bcl2 via histone H3R8 methylation.
PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis.
PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability.
PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.
S-adenosylmethionine:protein methyltransferases in hepatomas.
The polymorphism rs975484 in the protein arginine methyltransferase 1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma.
The Protective Function of PRMT1 in Alcohol-Induced Hepatocellular Carcinoma.
Carcinoma, Non-Small-Cell Lung
CARM1 promotes non-small cell lung cancer progression through upregulating CCNE2 expression.
Inhibition of Nonsmall Cell Lung Cancer Cell Migration by Protein Arginine Methyltransferase 1-small Hairpin RNA Through Inhibiting Epithelial-mesenchymal Transition, Extracellular Matrix Degradation, and Src Phosphorylation In Vitro.
PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer.
Carcinoma, Renal Cell
BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1.
PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance.
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.
Carcinoma, Small Cell
SWI/SNF Complexes in Ovarian Cancer: Mechanistic Insights and Therapeutic Implications.
Cardiomegaly
Protein arginine methyltransferase 6 mediates cardiac hypertrophy by differential regulation of histone H3 arginine methylation.
Cardiomyopathies
Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1? by PRMT1 and SIRT1.
Cardiomyopathy, Dilated
Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation.
PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products.
Cardiomyopathy, Hypertrophic
The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart.
Cardiovascular Diseases
A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity.
Detection of PRMT1 inhibitors with stopped flow fluorescence.
Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: synthesis and biological evaluation.
Hepatocellular Protein Arginine Methyltransferase 1 Suppresses Alcohol-Induced Hepatocellular Carcinoma Formation by Inhibition of Inducible Nitric Oxide Synthase.
Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1.
Cholestasis, Intrahepatic
Bile salt excretory pump: biology and pathobiology.
Chondrosarcoma
PRMT1 potentiates chondrosarcoma development through activation of YAP activity.
Cleft Palate
Protein Arginine Methyltransferase PRMT1 Is Essential for Palatogenesis.
Colonic Neoplasms
Colon cancer and protein arginine methyltransferase 1 gene expression.
Downregulation of PRMT1, a histone arginine methyltransferase, by sodium propionate induces cell apoptosis in colon cancer.
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Novel alternative splice variants of the human protein arginine methyltransferase 1 (PRMT1) gene, discovered using next-generation sequencing.
PRMT1 inhibition induces differentiation of colon cancer cells.
Protein arginine methyltransferase 8 gene enhances the colon cancer stem cell (CSC) function by upregulating the pluripotency transcription factor.
The PRMT1 gene expression pattern in colon cancer.
The prognostic significance of protein arginine methyltransferase 6 expression in colon cancer.
Colorectal Neoplasms
A coactivator role of CARM1 in the dysregulation of {beta}-catenin activity in colorectal cancer cell growth and gene expression.
Arginine methyltransferase PRMT3 promote tumorigenesis through regulating c-MYC stabilization in colorectal cancer.
Coactivator-associated arginine methyltransferase 1 promotes cell growth and is targeted by microRNA-195-5p in human colorectal cancer.
Differential CARM1 expression in prostate and colorectal cancers.
FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.
miR-195 enhances the radiosensitivity of colorectal cancer cells by suppressing CARM1.
Old dog, new tricks: extracellular domain arginine methylation regulates EGFR function.
PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer.
PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling.
Significant association of PRMT6 hypomethylation with colorectal cancer.
The prognostic significance of protein arginine methyltransferase 6 expression in colon cancer.
The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells.
The roles of microbial products in the development of colorectal cancer: a review.
Coronary Disease
Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies.
Diabetes Mellitus
PRMT1 promotes glucose toxicity-induced ? cell dysfunction by regulating the nucleo-cytoplasmic trafficking of PDX-1 in a FOXO1-dependent manner in INS-1 cells.
Diabetes Mellitus, Type 1
A critical role for hepatic protein arginine methyltransferase 1 isoform 2 in glycemic control.
Diabetes Mellitus, Type 2
A critical role for hepatic protein arginine methyltransferase 1 isoform 2 in glycemic control.
Impaired PRMT1 activity in the liver and pancreas of type 2 diabetic Goto-Kakizaki rats.
PRMT1 promotes glucose toxicity-induced ? cell dysfunction by regulating the nucleo-cytoplasmic trafficking of PDX-1 in a FOXO1-dependent manner in INS-1 cells.
The co-activator-associated arginine methyltransferase 1 (CARM1) gene is overexpressed in type 2 diabetes.
Diabetic Nephropathies
Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression.
Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy.
Diabetic Retinopathy
High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: role in diabetic retinopathy.
MiR-542-5p regulates the progression of diabetic retinopathy by targeting CARM1.
PRMT-1 and DDAHs-induced ADMA upregulation is involved in ROS- and RAS-mediated diabetic retinopathy.
PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners.
Down Syndrome
The telomeric part of the human chromosome 21 from CSTB to prmt2 is not necessarry for the locomotor and short-term memory deficits observed in the tc1 mouse model of down syndrome.
Dyslexia
Polymorphisms in DCDC2 and S100B associate with developmental dyslexia.
Edema, Cardiac
The predominant protein arginine methyltransferase PRMT1 is critical for zebrafish convergence and extension during gastrulation.
Encephalomyelitis
PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5.
Encephalomyelitis, Autoimmune, Experimental
PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5.
Endometrial Neoplasms
Genetic Variants in ER Cofactor Genes and Endometrial Cancer Risk.
PRMT6 promotes endometrial cancer via AKT/mTOR signaling and indicates poor prognosis.
Endometriosis
Arginine methyltransferases mediate an epigenetic ovarian response to endometriosis.
Endometritis
Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats.
Epstein-Barr Virus Infections
Arginine Methyltransferases Are Regulated by Epstein-Barr Virus in B Cells and Are Differentially Expressed in Hodgkin's Lymphoma.
Esophageal Neoplasms
Status of epigenetic chromatin modification enzymes and esophageal squamous cell carcinoma risk in northeast Indian population.
Esophageal Squamous Cell Carcinoma
PRMT1 regulates the tumour-initiating properties of esophageal squamous cell carcinoma through histone H4 arginine methylation coupled with transcriptional activation.
Protein arginine methyltransferase 1 interacts with Gli1 and regulates its transcriptional activity.
Protein arginine methyltransferase 1 promoted the growth and migration of cancer cells in esophageal squamous cell carcinoma.
Fatty Liver
CDKN2A deregulation in fatty liver disease and its accelerative role in the process of lipogenesis.
Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice.
PRMT3 regulates hepatic lipogenesis through direct interaction with LXR?.
Frontotemporal Dementia
Roles of protein arginine methyltransferase 1 (PRMT1) in brain development and disease.
Geographic Atrophy
Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration.
Glioblastoma
5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
PRMT1 and PRMT8 Regulate Retinoic Acid-Dependent Neuronal Differentiation with Implications to Neuropathology.
PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma.
PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.
PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer.
The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells.
WDR5-Myc axis promotes the progression of glioblastoma and neuroblastoma by transcriptional activating CARM1.
Glioma
Concerted action of histone methyltransferases G9a and PRMT-1 regulates PGC-1?-RIG-I axis in IFN? treated glioma cells.
LncRNA NNT-AS1 promote glioma cell proliferation and metastases through miR-494-3p/PRMT1 axis.
PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma.
Screening of substrates of protein arginine methyltransferase 1 in glioma.
The role of protein arginine-methyltransferase 1 in gliomagenesis.
Glucose Intolerance
Impaired PRMT1 activity in the liver and pancreas of type 2 diabetic Goto-Kakizaki rats.
Glycogen Storage Disease
CARM1/PRMT4 is necessary for the glycogen gene expression programme in skeletal muscle cells.
Glycogen Storage Disease Type II
CARM1/PRMT4 is necessary for the glycogen gene expression programme in skeletal muscle cells.
Head and Neck Neoplasms
PRMT1 expression is elevated in head and neck cancer and inhibition of protein arginine methylation by adenosine dialdehyde or PRMT1 knockdown downregulates proliferation and migration of oral cancer cells.
Hearing Loss
Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death.
Heart Diseases
Activity-Based Protein Profiling of Protein Arginine Methyltransferase 1.
Mechanistic Studies on Transcriptional Coactivator Protein Arginine Methyltransferase 1.
Understanding protein arginine methyltransferase 1 (PRMT1) product specificity from molecular dynamics.
Using Unnatural Amino Acid Mutagenesis To Probe the Regulation of PRMT1.
Heart Failure
Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation.
Hepatitis B
Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription.
Hepatitis B, Chronic
Inhibition of alpha interferon signaling by hepatitis B virus.
Hepatitis C
The arginine-1493 residue in QRRGRTGR1493G motif IV of the hepatitis C virus NS3 helicase domain is essential for NS3 protein methylation by the protein arginine methyltransferase 1.
Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1.
Hepatitis C, Chronic
Hepatitis C virus-induced up-regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair.
Herpes Simplex
Protein arginine methyltransferase 1 regulates herpes simplex virus replication through ICP27 RGG-box methylation.
Hirschsprung Disease
Analyses of PRMT1 proteins in human colon tissues from Hirschsprung disease patients.
Hodgkin Disease
Arginine Methyltransferases Are Regulated by Epstein-Barr Virus in B Cells and Are Differentially Expressed in Hodgkin's Lymphoma.
Huntington Disease
AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3.
Huntingtin-mediated axonal transport requires arginine methylation by PRMT6.
Hyperalgesia
Blocking the Spinal Fbxo3/CARM1/K+ Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief.
Dorsal Root Ganglia Coactivator-associated Arginine Methyltransferase 1 Contributes to Peripheral Nerve Injury-induced Pain Hypersensitivities.
Hyperglycemia
A critical role for hepatic protein arginine methyltransferase 1 isoform 2 in glycemic control.
PRMT1 promotes hyperglycemia in a FoxO1-dependent manner, affecting glucose metabolism, during hypobaric hypoxia exposure, in rat model.
Hypersensitivity
Dorsal Root Ganglia Coactivator-associated Arginine Methyltransferase 1 Contributes to Peripheral Nerve Injury-induced Pain Hypersensitivities.
Infections
Critical role for arginine methylation in adenovirus-infected cells.
Protein arginine methyltransferase 1 modulates innate immune responses through regulation of peroxisome proliferator-activated receptor ?-dependent macrophage differentiation.
Infertility
Arginine methyltransferases mediate an epigenetic ovarian response to endometriosis.
Inflammatory Bowel Diseases
The roles of microbial products in the development of colorectal cancer: a review.
Insulin Resistance
Arginine methylation of CRTC2 is critical in the transcriptional control of hepatic glucose metabolism.
Insulin-induced CARM1 upregulation facilitates hepatocyte proliferation.
PRMT1 promotes hyperglycemia in a FoxO1-dependent manner, affecting glucose metabolism, during hypobaric hypoxia exposure, in rat model.
Kidney Diseases
Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: synthesis and biological evaluation.
Protein arginine methyltransferase 1 mediates renal fibroblast activation and fibrogenesis through activation of Smad3 signaling.
Leukemia
CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.
Correlation of SRSF1 and PRMT1 expression with clinical status of pediatric acute lymphoblastic leukemia.
Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation.
Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: synthesis and biological evaluation.
PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential.
PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia.
PRMT1-RBM15 axis regulates megakaryocytic differentiation of human umbilical cord blood CD34
Properly Substituted Cyclic Bis-(2-bromobenzylidene) Compounds Behaved as Dual p300/CARM1 Inhibitors and Induced Apoptosis in Cancer Cells.
Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.
Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells.
Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors.
Leukemia, Erythroblastic, Acute
Modulating the expression of Chtop, a versatile regulator of gene-specific transcription and mRNA export.
Leukemia, Megakaryoblastic, Acute
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.
Leukemia, Myeloid
PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex.
Leukemia, Myeloid, Acute
CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.
Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.
Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.
PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex.
Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.
Leukopenia
Protein arginine methyltransferase 1 is required for maintenance of normal adult hematopoiesis.
Lipodystrophy
Depletion of Prmt1 in Adipocytes Impairs Glucose Homeostasis in Diet-Induced Obesity.
Liver Cirrhosis
Characterization and sub-cellular localization of GalNAc-binding proteins isolated from human hepatic stellate cells.
Liver Diseases
Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice.
Liver Neoplasms
CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer.
CARM1 Preferentially Methylates H3R17 over H3R26 through a Random Kinetic Mechanism.
Epigenetic Induction of Mitochondrial Fission Is Required for Maintenance of Liver Cancer-Initiating Cells.
Lung Diseases
Detection of PRMT1 inhibitors with stopped flow fluorescence.
Oxidative stress destabilizes protein arginine methyltransferase 4 via glycogen synthase kinase 3? to impede lung epithelial cell migration.
PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts.
PRMT1 mediates podocyte injury and glomerular fibrosis through phosphorylation of ERK pathway.
TGF-? Upregulated Mitochondria Mass through the SMAD2/3?C/EBP??PRMT1 Signal Pathway in Primary Human Lung Fibroblasts.
Lung Injury
Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia.
Lung Neoplasms
CARM1 and PRMT1 are dysregulated in lung cancer without hierarchical features.
CARM1 promotes non-small cell lung cancer progression through upregulating CCNE2 expression.
CRISPR/Cas9 library screening uncovered methylated PKP2 as a critical driver of lung cancer radioresistance by stabilizing ?-catenin.
Developing protein arginine methyltransferase 1 (PRMT1) inhibitor TC-E-5003 as an antitumor drug using INEI drug delivery systems.
ESRP1 regulates alternative splicing of CARM1 to sensitize small cell lung cancer cells to chemotherapy by inhibiting TGF-?/Smad signaling.
High Expression of CARM1 Inhibits Lung Cancer Progression by Targeting TP53 by Regulating CTNNB1.
Inhibition of Nonsmall Cell Lung Cancer Cell Migration by Protein Arginine Methyltransferase 1-small Hairpin RNA Through Inhibiting Epithelial-mesenchymal Transition, Extracellular Matrix Degradation, and Src Phosphorylation In Vitro.
Long Non-coding RNA PVT1 Competitively Binds MicroRNA-424-5p to Regulate CARM1 in Radiosensitivity of Non-Small-Cell Lung Cancer.
PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer.
PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells.
PRMT1 loss sensitizes cells to PRMT5 inhibition.
PRMT6 Promotes Lung Tumor Progression via the Alternate Activation of Tumor-Associated Macrophages.
Structural basis of arginine asymmetrical dimethylation by PRMT6.
The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells.
Lymphatic Metastasis
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.
PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18.
Lymphoma
CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.
Mastitis
Identification of splice variants, expression analysis and single nucleotide polymorphisms of the PRMT2 gene in dairy cattle.
Megacolon
Analyses of PRMT1 proteins in human colon tissues from Hirschsprung disease patients.
Melanoma
Deregulation of protein methylation in melanoma.
PRMT1 regulates tumor growth and metastasis of human melanoma via targeting ALCAM.
Memory Disorders
The telomeric part of the human chromosome 21 from CSTB to prmt2 is not necessarry for the locomotor and short-term memory deficits observed in the tc1 mouse model of down syndrome.
Metabolic Diseases
Genome-wide Transcriptional Sequencing Identifies Novel Mutations in Metabolic Genes in Human Hepatocellular Carcinoma.
Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator?activated receptor ? activity.
Mouth Neoplasms
Functional interplay between YY1 and CARM1 promotes oral carcinogenesis.
PRMT1 expression is elevated in head and neck cancer and inhibition of protein arginine methylation by adenosine dialdehyde or PRMT1 knockdown downregulates proliferation and migration of oral cancer cells.
WDR5 promotes the tumorigenesis of oral squamous cell carcinoma via CARM1/?-catenin axis.
Multiple Myeloma
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.
Muscle Spasticity
Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage.
Muscular Atrophy
CARM1 contributes to skeletal muscle wasting by mediating FoxO3 activity and promoting myofiber autophagy.
Chrysanthemi Zawadskii var. Latilobum Attenuates Obesity-Induced Skeletal Muscle Atrophy via Regulation of PRMTs in Skeletal Muscle of Mice.
Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.
Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis.
Muscular Atrophy, Spinal
A novel role for CARM1 in promoting nonsense-mediated mRNA decay: potential implications for spinal muscular atrophy.
KH-type splicing regulatory protein interacts with survival motor neuron protein and is misregulated in spinal muscular atrophy.
The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing.
Myelodysplastic Syndromes
Methylation of dual-specificity phosphatase 4 controls cell differentiation.
Myocardial Infarction
Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies.
PRMT4 overexpression aggravates cardiac remodeling following myocardial infarction by promoting cardiomyocyte apoptosis.
Neoplasm Metastasis
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.
CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis.
Disease biomarker identification from gene network modules for metastasized breast cancer.
Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells.
LncRNA NNT-AS1 promote glioma cell proliferation and metastases through miR-494-3p/PRMT1 axis.
Macrophages-stimulated PRMT1-mediated EZH2 methylation promotes breast cancer metastasis.
Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
miR-503 suppresses metastasis of hepatocellular carcinoma cell by targeting PRMT1.
PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer.
PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer.
PRMT1 Promoted HCC Growth and Metastasis In Vitro and In Vivo via Activating the STAT3 Signalling Pathway.
PRMT1 regulates tumor growth and metastasis of human melanoma via targeting ALCAM.
PRMT2 and ROR? expression are associated with breast cancer survival outcomes.
PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.
PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18.
Protein arginine methyltransferase 1 promoted the growth and migration of cancer cells in esophageal squamous cell carcinoma.
RNA binding protein RALY promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells.
The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1.
Neoplasms
A coactivator role of CARM1 in the dysregulation of {beta}-catenin activity in colorectal cancer cell growth and gene expression.
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6.
A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor ?-dependent transcriptional activation and breast carcinogenesis.
A novel splicing isoform of Protein Arginine Methyltransferase 1 (PRMT1) that lacks the dimerization arm and correlates with cellular malignancy.
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.
Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor.
Activity-Based Protein Profiling of Protein Arginine Methyltransferase 1.
Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers.
AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3.
Arginine Methylation Increases the Stability of HIV-1 Tat.
Arginine methylation regulates telomere length and stability.
Arginine Methyltransferase PRMT1 Regulates p53 Activity in Breast Cancer.
Arginine methyltransferases mediate an epigenetic ovarian response to endometriosis.
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.
Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression.
CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer.
CARM1 and PRMT1 are dysregulated in lung cancer without hierarchical features.
CARM1 but not Its Enzymatic Activity Is Required for Transcriptional Coactivation of NF-kappaB-Dependent Gene Expression.
CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells.
CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.
CARM1 Is an Important Determinant of ER{alpha}-Dependent Breast Cancer Cell Differentiation and Proliferation in Breast Cancer Cells.
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.
CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis.
CARM1 Preferentially Methylates H3R17 over H3R26 through a Random Kinetic Mechanism.
CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity.
CARM1/PRMT4: Making Its Mark beyond Its Function as a Transcriptional Coactivator.
CARMA: CARM1 methylation of SWI/SNF in breast cancer.
Clinical evaluation of PRMT1 gene expression in breast cancer.
Colon cancer and protein arginine methyltransferase 1 gene expression.
Design and synthesis of novel PRMT1 inhibitors and investigation of their binding preferences using molecular modelling.
Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.
Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1).
Detection of PRMT1 inhibitors with stopped flow fluorescence.
Differential CARM1 expression in prostate and colorectal cancers.
Differential mRNA expression levels of human histone-modifying enzymes in normal karyotype B cell pediatric acute lymphoblastic leukemia.
Discovery and structure-activity analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors.
Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor.
Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors.
Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells.
Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes.
Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers.
Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.
Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways.
Epigenetic Induction of Mitochondrial Fission Is Required for Maintenance of Liver Cancer-Initiating Cells.
Erratum to: FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion and colony formation.
Esophageal Squamous Cell Carcinoma Is Accompanied by Local and Systemic Changes in L-arginine/NO Pathway.
Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors.
Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: synthesis and biological evaluation.
Expression and localisation of methylthioadenosine phosphorylase (MTAP) in oral squamous cell carcinoma and their significance in epithelial-to-mesenchymal transition.
Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity.
FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.
FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion, and colony formation.
Functional insights from high resolution structures of mouse protein arginine methyltransferase 6.
Geranylgeranylacetone promotes human osteosarcoma cell apoptosis by inducing the degradation of PRMT1 through the E3 ubiquitin ligase CHIP.
Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition.
Hepatocellular Protein Arginine Methyltransferase 1 Suppresses Alcohol-Induced Hepatocellular Carcinoma Formation by Inhibition of Inducible Nitric Oxide Synthase.
Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter.
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.
Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays.
Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators.
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
L-Arginine/Nitric Oxide Pathway Is Altered in Colorectal Cancer and Can Be Modulated by Novel Derivatives from Oxicam Class of Non-Steroidal Anti-Inflammatory Drugs.
Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6.
M-TAP Dance: Targeting PRMT1 and PRMT5 Family Members to Push Cancer Cells Over the Edge.
Mechanistic Studies on Transcriptional Coactivator Protein Arginine Methyltransferase 1.
MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs.
Melatonin Inhibits Osteoclastogenesis and Bone Loss in Ovariectomized Mice by Regulating PRMT1-Mediated Signaling.
Methylation of C/EBP? by PRMT1 Inhibits Its Tumor-Suppressive Function in Breast Cancer.
Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics.
Morphologic and molecular correlates of EZH2 as a predictor of platinum resistance in high-grade ovarian serous carcinoma.
Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases.
mRNA expression profiling of histone modifying enzymes in pediatric acute monoblastic leukemia.
Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity.
Novel alternative splice variants of the human protein arginine methyltransferase 1 (PRMT1) gene, discovered using next-generation sequencing.
Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein.
Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients.
Overexpressing PRMT1 Inhibits Proliferation and Invasion in Pancreatic Cancer by Inverse Correlation of ZEB1.
Overexpression of CARM1 in breast cancer is correlated with poorly characterized clinicopathologic parameters and molecular subtypes.
p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.
PELP1 oncogenic functions involve alternative splicing via PRMT6.
Phospho-?Np63?/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure.
PRMT1 and PRMT8 Regulate Retinoic Acid-Dependent Neuronal Differentiation with Implications to Neuropathology.
PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer.
PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance.
PRMT1 expression is elevated in head and neck cancer and inhibition of protein arginine methylation by adenosine dialdehyde or PRMT1 knockdown downregulates proliferation and migration of oral cancer cells.
PRMT1 expression predicts response to neoadjuvant chemotherapy for locally advanced uterine cervical cancer.
PRMT1 expression predicts sensitivity to platinum-based chemotherapy in patients with ovarian serous carcinoma.
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.
PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer.
PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells.
PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin.
PRMT1 potentiates chondrosarcoma development through activation of YAP activity.
PRMT1 Promoted HCC Growth and Metastasis In Vitro and In Vivo via Activating the STAT3 Signalling Pathway.
PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP.
PRMT1 promotes pancreatic cancer growth and predicts poor prognosis.
PRMT1 promotes the tumor suppressor function of p14ARF and is indicative for pancreatic cancer prognosis.
Prmt1 regulates craniofacial bone formation upstream of Msx1.
PRMT1 regulates tumor growth and metastasis of human melanoma via targeting ALCAM.
PRMT1-dependent macrophage IL6 production is required for alcohol-induced HCC progression.
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma.
PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.
PRMT2 accelerates tumorigenesis of hepatocellular carcinoma by activating Bcl2 via histone H3R8 methylation.
PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma.
PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis.
PRMT6 activates cyclin D1 expression in conjunction with the transcription factor LEF1.
PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability.
PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents.
PRMT6 mediates inflammation via activation of the NF-?B/p65 pathway on a cigarette smoke extract-induced murine emphysema model.
PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: Its implication in motility and invasion.
PRMT6 promotes endometrial cancer via AKT/mTOR signaling and indicates poor prognosis.
PRMT6 Promotes Lung Tumor Progression via the Alternate Activation of Tumor-Associated Macrophages.
PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.
PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer.
Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling.
Protein arginine methyltransferase 1 coordinates the epithelial-mesenchymal transition/proliferation dichotomy in gastric cancer cells.
Protein arginine methyltransferase 1 interacts with Gli1 and regulates its transcriptional activity.
Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma.
Protein arginine methyltransferase 1 is required for maintenance of normal adult hematopoiesis.
Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 gene during acquired multidrug resistant.
Protein arginine methyltransferase 1 promoted the growth and migration of cancer cells in esophageal squamous cell carcinoma.
Protein arginine methyltransferase 1 promotes epithelial-mesenchymal transition via TGF-?1/Smad pathway in hepatic carcinoma cells.
Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer.
Protein arginine methyltransferase 8 gene enhances the colon cancer stem cell (CSC) function by upregulating the pluripotency transcription factor.
Protein arginine methyltransferase-1 deficiency restrains depression-like behavior of mice by inhibiting inflammation and oxidative stress via Nrf-2.
Protein arginine-methyltransferase-dependent oncogenesis.
Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics.
SCF-FBXO24 regulates cell proliferation by mediating ubiquitination and degradation of PRMT6.
Significant association of PRMT6 hypomethylation with colorectal cancer.
Status of epigenetic chromatin modification enzymes and esophageal squamous cell carcinoma risk in northeast Indian population.
Structural basis of arginine asymmetrical dimethylation by PRMT6.
Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.
Surface-enhanced Raman spectroscopic studies of coactivator-associated arginine methyltransferase 1.
Targeting PRMT1-Mediated FLT3 Methylation Disrupts Maintenance of MLL- rearranged Acute Lymphoblastic Leukemia.
Targeting the IRE1?/XBP1s pathway suppresses CARM1-expressing ovarian cancer.
The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer.
The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes.
The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.
The complex CBX7-PRMT1 has a critical role in regulating E-cadherin gene expression and cell migration.
The Development of Tetrazole Derivatives as Protein Arginine Methyltransferase I (PRMT I) Inhibitors.
The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1.
The oestrogen receptor coactivator CARM1 has an oncogenic effect and is associated with poor prognosis in breast cancer.
The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3?/?-Catenin/cyclinD1 Signaling Pathway.
The polymorphism rs975484 in the protein arginine methyltransferase 1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma.
The roles of microbial products in the development of colorectal cancer: a review.
Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1.
Thrombospondin-1 is a transcriptional repression target of PRMT6.
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.
Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.
Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells.
Understanding protein arginine methyltransferase 1 (PRMT1) product specificity from molecular dynamics.
Using Unnatural Amino Acid Mutagenesis To Probe the Regulation of PRMT1.
Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors.
WDR5 promotes the tumorigenesis of oral squamous cell carcinoma via CARM1/?-catenin axis.
Neural Tube Defects
CBP/p300 and associated transcriptional co-activators exhibit distinct expression patterns during murine craniofacial and neural tube development.
Neuralgia
Blocking the Spinal Fbxo3/CARM1/K+ Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief.
Dorsal Root Ganglia Coactivator-associated Arginine Methyltransferase 1 Contributes to Peripheral Nerve Injury-induced Pain Hypersensitivities.
[Transcription of protein arginine N-methyltransferase genes in mouse dorsal root ganglia following peripheral nerve injury].
Neuroblastoma
Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells.
Iron-induced oxidative stress activates AKT and ERK1/2 and decreases Dyrk1B and PRMT1 in neuroblastoma SH-SY5Y cells.
PRMT1 promotes neuroblastoma cell survival through ATF5.
Prognostic significance of MYCN related genes in pediatric neuroblastoma: a study based on TARGET and GEO datasets.
Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma.
WDR5-Myc axis promotes the progression of glioblastoma and neuroblastoma by transcriptional activating CARM1.
Neurodegenerative Diseases
Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons.
Roles of protein arginine methyltransferase 1 (PRMT1) in brain development and disease.
Neuroinflammatory Diseases
Protein arginine methyltransferase 8 modulates mitochondrial bioenergetics and neuroinflammation after hypoxic stress.
Non-alcoholic Fatty Liver Disease
PRMT3 regulates hepatic lipogenesis through direct interaction with LXR?.
Obesity
Arginine methylation of CRTC2 is critical in the transcriptional control of hepatic glucose metabolism.
Comparative transcriptome analysis identifies CARM1 and DNMT3A as genes associated with osteoporosis.
Depletion of Prmt1 in Adipocytes Impairs Glucose Homeostasis in Diet-Induced Obesity.
Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation.
Genome-wide Transcriptional Sequencing Identifies Novel Mutations in Metabolic Genes in Human Hepatocellular Carcinoma.
Oligospermia
The arginine methyltransferase CARM1 represses p300•ACT•CREM? activity and is required for spermiogenesis.
Osteoporosis
Comparative transcriptome analysis identifies CARM1 and DNMT3A as genes associated with osteoporosis.
Melatonin Inhibits Osteoclastogenesis and Bone Loss in Ovariectomized Mice by Regulating PRMT1-Mediated Signaling.
PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice.
Osteoporosis, Postmenopausal
PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice.
Osteosarcoma
Cell Cycle Regulation by the PRMT6 Arginine Methyltransferase through Repression of Cyclin-Dependent Kinase Inhibitors.
Geranylgeranylacetone promotes human osteosarcoma cell apoptosis by inducing the degradation of PRMT1 through the E3 ubiquitin ligase CHIP.
PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.
The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3?/?-Catenin/cyclinD1 Signaling Pathway.
Thrombospondin-1 is a transcriptional repression target of PRMT6.
Ototoxicity
Cisplatin-induced ototoxicity involves interaction of PRMT3 and cannabinoid system.
Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death.
Ovarian Neoplasms
Cancer-related transcription regulator protein NAC1 forms a protein complex with CARM1 for ovarian cancer progression.
FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.
FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion, and colony formation.
PRMT1 expression predicts sensitivity to platinum-based chemotherapy in patients with ovarian serous carcinoma.
PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin.
PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer.
SWI/SNF Complexes in Ovarian Cancer: Mechanistic Insights and Therapeutic Implications.
Targeting CARM1 in ovarian cancer with EZH2 and PARP inhibitors.
Targeting the IRE1?/XBP1s pathway suppresses CARM1-expressing ovarian cancer.
Pancreatic Neoplasms
Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer.
Author Correction: PRMT1 promotes pancreatic cancer growth and predicts poor prognosis.
Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics.
Overexpressing PRMT1 Inhibits Proliferation and Invasion in Pancreatic Cancer by Inverse Correlation of ZEB1.
PRMT1 loss sensitizes cells to PRMT5 inhibition.
PRMT1 promotes pancreatic cancer growth and predicts poor prognosis.
PRMT1 promotes the tumor suppressor function of p14ARF and is indicative for pancreatic cancer prognosis.
Protein Arginine Methyltransferase 3 Enhances Chemoresistance in Pancreatic Cancer by Methylating hnRNPA1 to Increase ABCG2 Expression.
Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer.
Peripheral Nerve Injuries
Dorsal Root Ganglia Coactivator-associated Arginine Methyltransferase 1 Contributes to Peripheral Nerve Injury-induced Pain Hypersensitivities.
Peritonitis
Arginine methylation regulates c-Myc-dependent transcription by altering promoter recruitment of the acetyltransferase p300.
Immunoresolving actions of oral resolvin D1 include selective regulation of the transcription machinery in resolution-phase mouse macrophages.
Pneumonia
Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling.
Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia.
PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation.
Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation.
Upregulated Protein Arginine Methyltransferase 1 by IL-4 Increases Eotaxin-1 Expression in Airway Epithelial Cells and Participates in Antigen-Induced Pulmonary Inflammation in Rats.
Pre-Eclampsia
Altered methylation and expression patterns of genes regulating placental nitric oxide pathway in patients with severe preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Correlation of SRSF1 and PRMT1 expression with clinical status of pediatric acute lymphoblastic leukemia.
Prostatic Intraepithelial Neoplasia
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.
Prostatic Neoplasms
CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.
Differential CARM1 expression in prostate and colorectal cancers.
Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway.
Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer.
Inhibition of androgen receptor and ?-catenin activity in prostate cancer.
Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability.
PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: Its implication in motility and invasion.
Protein arginine methyltransferase 10 is required for androgen-dependent proliferation of LNCaP prostate cancer cells.
The protein arginine methyltransferases (PRMTs) PRMT1 and CARM1 as candidate epigenetic drivers in prostate cancer progression.
Pulmonary Disease, Chronic Obstructive
CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis.
Cigarette smoke extract induces airway epithelial cell death via repressing PRMT6/AKT signaling.
F-Box Protein FBXW17-Mediated Proteasomal Degradation of Protein Methyltransferase PRMT6 Exaggerates CSE-Induced Lung Epithelial Inflammation and Apoptosis.
The protective effect of PRMT6 overexpression on cigarette smoke extract-induced murine emphysema model.
Pulmonary Fibrosis
Elevated protein arginine methyltransferase 1 expression regulates fibroblast motility in pulmonary fibrosis.
Retinoblastoma
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Rhinitis, Allergic
Protein arginine methyltransferase 1 contributes to the development of allergic rhinitis by promoting the production of epithelial-derived cytokines.
Sarcoma, Ewing
Different methylation characteristics of protein arginine methyltransferase 1 and 3 toward the Ewing Sarcoma protein and a peptide.
Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.
Severe Combined Immunodeficiency
p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.
Small Cell Lung Carcinoma
ESRP1 regulates alternative splicing of CARM1 to sensitize small cell lung cancer cells to chemotherapy by inhibiting TGF-?/Smad signaling.
PRMT1 loss sensitizes cells to PRMT5 inhibition.
Squamous Cell Carcinoma of Head and Neck
The long noncoding RNA ST7-AS1 promotes laryngeal squamous cell carcinoma by stabilizing CARM1.
Starvation
C9orf72-dependent lysosomal functions regulate epigenetic control of autophagy and lipid metabolism.
CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer.
Epigenetic and transcriptional regulation of autophagy.
Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy.
Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response.
Stomach Neoplasms
Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression.
Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients.
PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer.
Protein arginine methyltransferase 1 coordinates the epithelial-mesenchymal transition/proliferation dichotomy in gastric cancer cells.
Stroke
Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies.
Thrombocytopenia
Methylation of dual-specificity phosphatase 4 controls cell differentiation.
Thrombosis
PRMT1 Promoted HCC Growth and Metastasis In Vitro and In Vivo via Activating the STAT3 Signalling Pathway.
Thymoma
Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis.
Tics
PRMT1 regulates the tumour-initiating properties of esophageal squamous cell carcinoma through histone H4 arginine methylation coupled with transcriptional activation.
Triple Negative Breast Neoplasms
Methylation of C/EBP? by PRMT1 Inhibits Its Tumor-Suppressive Function in Breast Cancer.
The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells.
type i protein arginine methyltransferase deficiency
A critical role for hepatic protein arginine methyltransferase 1 isoform 2 in glycemic control.
CRAF methylation by PRMT6 regulates aerobic glycolysis driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation.
PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products.
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.
Prmt1 regulates craniofacial bone formation upstream of Msx1.
PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability.
Protein arginine methyltransferase-1 deficiency restrains depression-like behavior of mice by inhibiting inflammation and oxidative stress via Nrf-2.
Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis.
The methyltransferase PRMT1 regulates ?-globin translation.
The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling.
type ii protein arginine methyltransferase deficiency
PRMT5 is required for cell-cycle progression and p53 tumor suppressor function.
Ureteral Obstruction
Protein arginine methyltransferase 1 mediates renal fibroblast activation and fibrogenesis through activation of Smad3 signaling.
Urinary Bladder Neoplasms
PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP.
Uterine Cervical Neoplasms
Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways.
miR-16-5p modulates the radiosensitivity of cervical cancer cells via regulating coactivator-associated arginine methyltransferase 1.
PRMT1 expression predicts response to neoadjuvant chemotherapy for locally advanced uterine cervical cancer.
PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer.
Virus Diseases
Molecular characterisation and inductive expression of a fish protein arginine methyltransferase 1 gene in response to virus infection.
The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling.
Zebrafish prmt3 negatively regulates antiviral responses.
Wilms Tumor
Transcriptomic Analyses of MYCN-Regulated Genes in Anaplastic Wilms' Tumour Cell Lines Reveals Oncogenic Pathways and Potential Therapeutic Vulnerabilities.
Wolff-Parkinson-White Syndrome
CARM1/PRMT4 is necessary for the glycogen gene expression programme in skeletal muscle cells.