Reference on EC 2.1.1.72 - site-specific DNA-methyltransferase (adenine-specific)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Roberts, R.J.; Vincze, T.; Posfai, J.; Macelis, D.
REBASE: restriction enzymes and methyltransferases
Nucleic Acids Res.
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418-420
2003
Bacteria
Fedoreyeva, L.I.; Vanyushin, B.F.
N6-Adenine DNA-methyltransferase in wheat seedlings
FEBS Lett.
514
305-308
2002
Triticum aestivum
Malygin, E.G.; Evdokimov, A.A.; Zinoviev, V.V.; Ovechkina, L.G.; Lindstrom, W.M.; Reich, N.O.; Schlagman, S.L.; Hattman, S.
A dual role for substrate S-adenosyl-L-methionine in the methylation reaction with bacteriophage T4 Dam DNA-[N6-adenine]-methyltransferase
Nucleic Acids Res.
29
2361-2369
2001
Tequatrovirus T4
Kossykh, V.G.; Schlagman, S.L.; Hattman, S.
Phage T4 DNA [N6-adenine]methyltransferase. Overexpression, purification, and characterization
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270
14389-14393
1995
Tequatrovirus T4
Malygin, E.G.; Ovechkina, L.G.; Evdokimov, A.A.; Zinoviev, V.V.
Single turnover kinetics of methylation by T4 DNA-(N6-adenine)-methyltransferase
Mol. Biol.
35
56-68
2001
Tequatrovirus T4
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Evdokimov, A.A.; Zinoviev, V.V.; Malygin, E.G.; Schlagman, S.L.; Hattman, S.
Bacteriophage T4 Dam DNA-[N6-adenine]methyltransferase. Kinetic evidence for a catalytically essential conformational change in the ternary complex
J. Biol. Chem.
277
279-286
2002
Tequatrovirus T4
Malygin, E.G.; Lindstrom, W.M., Jr.; Schlagman, S.L.; Hattman, S.; Reich, N.O.
Pre-steady state kinetics of bacteriophage T4 Dam DNA-[N6-adenine] methyltransferase: interaction with native (GATC) or modified sites
Nucleic Acids Res.
28
4207-4211
2000
Tequatrovirus T4
Berdis, A.J.; Lee, I.; Coward, J.K.; Stephens, C.; Wright, R.; Shapiro, L.; Benkovic, S.J.
A cell cycle-regulated adenine DNA methyltransferase from Caulobacter crescentus processively methylates GANTC sites on hemimethylated DNA
Proc. Natl. Acad. Sci. USA
95
2874-2879
1998
Caulobacter vibrioides
Thielking, V.; Du Bois, S.; Eritja, R.; Guschlbauer, W.
Dam methyltransferase from Escherichia coli. Kinetic studies using modified DNA oligomers. Nonmethylated substrates
Biol. Chem.
378
407-415
1997
Escherichia coli
Zinoviev, V.V.; Evdokimov, A.A.; Gorbunov, Y.A.; Malygin, E.G.; Kossykh, V.G.; Hattman, S.
Phage T4 DNA [N6-adenine] methyltransferase. Kinetic studies using oligonucleotides containing native or modified recognition sites
Biol. Chem.
379
481-488
1998
Tequatrovirus T4
Petrov, N.A.; Gorbunov, Y.A.; Malygin, E.G.
Interaction of T4 phage DNA-[N6-adenine]-methyltransferase with substrates containing defective recognition sites
Mol. Biol.
31
827-831
1997
Tequatrovirus T4
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Degtyarev, S.K.; Prikhodko, E.A.; Rechkunova, N.I.; Prikhodko, G.G.; Krasnykh, V.N.
Biochemical characterization of VspI methyltransferase
Gene
157
65-66
1995
Escherichia phage T2, Tequatrovirus T4, Vibrio sp.
Kossykh, V.G.; Schlagman, S.L.; Hattman, S.
Comparative studies of the phage T2 and T4 DNA (N6-adenine)methyltransferases: amino acid changes that affect catalytic activity
J. Bacteriol.
179
3239-3243
1997
Escherichia phage T2, Tequatrovirus T4
Marzabal, S.; DuBois, S.; Thielking, V.; Cano, A.; Eritja, R.; Guschlbauer, W.
Dam methylase from Escherichia coli: kinetic studies using modified DNA oligomers: hemimethylated substrates
Nucleic Acids Res.
23
3648-3655
1995
Escherichia coli
Jeltsch, A.; Christ, F.; Fatemi, M.; Roth, M.
On the substrate specificity of DNA methyltransferases. Adenine-N6 DNA methyltransferases also modify cytosine residues at position N4
J. Biol. Chem.
274
19538-19544
1999
Escherichia coli, Planomicrobium okeanokoites
Degtyarev, S.K.; Prikhodko, E.A.; Prikhodko, G.G.; Krasnykh, V.N.
VspI methylase belongs to m6A-gamma class of adenine methylase
Nucleic Acids Res.
21
2015
1993
Vibrio sp.
Horton, J.R.; Liebert, K.; Hattman, S.; Jeltsch, A.; Cheng, X.
Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase
Cell
121
349-361
2005
Tequatrovirus T4, Escherichia coli
Simala-Grant, J.L.; Lam, E.; Keelan, M.; Taylor, D.E.
Characterization of the DNA adenine 5'-GATC-3' methylase HpyIIIM from Helicobacter pylori
Curr. Microbiol.
49
47-54
2004
Helicobacter pylori
Kossykh, V.G.; Lloyd, R.S.
A DNA adenine methyltransferase of Escherichia coli that is cell cycle regulated and essential for viability
J. Bacteriol.
186
2061-2067
2004
Escherichia coli
Malygin, E.G.; Zinoviev, V.V.; Evdokimov, A.A.; Lindstrom, W.M., Jr.; Reich, N.O.; Hattman, S.
DNA (cytosine-N4-)- and -(adenine-N6-)-methyltransferases have different kinetic mechanisms but the same reaction route. A comparison of M.BamHI and T4 Dam
J. Biol. Chem.
278
15713-15719
2003
Bacillus amyloliquefaciens
Thomas, C.B.; Scavetta, R.D.; Gumport, R.I.; Churchill, M.E.
Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding
J. Biol. Chem.
278
26094-26101
2003
Cereibacter sphaeroides (P14751)
Malygin, E.G.; Lindstrom, W.M., Jr.; Zinoviev, V.V.; Evdokimov, A.A.; Schlagman, S.L.; Reich, N.O.; Hattman, S.
Bacteriophage T4Dam (DNA-(adenine-N6)-methyltransferase): evidence for two distinct stages of methylation under single turnover conditions
J. Biol. Chem.
278
41749-41755
2003
Tequatrovirus T4
Zinoviev, V.V.; Evdokimov, A.A.; Malygin, E.G.; Schlagman, S.L.; Hattman, S.
Bacteriophage T4 Dam DNA-(N6-adenine)-methyltransferase. Processivity and orientation to the methylation target
J. Biol. Chem.
278
7829-7833
2003
Tequatrovirus T4
Bheemanaik, S.; Chandrashekaran, S.; Nagaraja, V.; Rao, D.N.
Kinetic and catalytic properties of dimeric KpnI DNA methyltransferase
J. Biol. Chem.
278
7863-7874
2003
Klebsiella pneumoniae
Mashhoon, N.; Carroll, M.; Pruss, C.; Eberhard, J.; Ishikawa, S.; Estabrook, R.A.; Reich, N.
Functional characterization of Escherichia coli DNA adenine methyltransferase, a novel target for antibiotics
J. Biol. Chem.
279
52075-52081
2004
Escherichia coli
Liebert, K.; Hermann, A.; Schlickenrieder, M.; Jeltsch, A.
Stopped-flow and mutational analysis of base flipping by the Escherichia coli Dam DNA-(adenine-N6)-methyltransferase
J. Mol. Biol.
341
443-454
2004
Escherichia coli
Zinoviev, V.V.; Evdokimov, A.A.; Hattman, S.; Malygin, E.G.
Molecular enzymology of phage T4 Dam DNA methyltransferase
Mol. Biol.
38
737-751
2004
Tequatrovirus T4
-
Hernday, A.D.; Braaten, B.A.; Low, D.A.
The mechanism by which DNA adenine methylase and PapI activate the pap epigenetic switch
Mol. Cell
12
947-957
2003
Escherichia coli
Yang, Z.; Horton, J.R.; Zhou, L.; Zhang, X.J.; Dong, A.; Zhang, X.; Schlagman, S.L.; Kossykh, V.; Hattman, S.; Cheng, X.
Structure of the bacteriophage T4 DNA adenine methyltransferase
Nat. Struct. Biol.
10
849-855
2003
Tequatrovirus T4 (P04392)
Zinoviev, V.V.; Yakishchik, S.I.; Evdokimov, A.A.; Malygin, E.G.; Hattman, S.
Symmetry elements in DNA structure important for recognition/methylation by DNA [amino]-methyltransferases
Nucleic Acids Res.
32
3930-3934
2004
Tequatrovirus T4, Escherichia coli
Baskunov, V.B.; Subach, F.V.; Kolbanovskiy, A.; Kolbanovskiy, M.; Eremin, S.A.; Johnson, F.; Bonala, R.; Geacintov, N.E.; Gromova, E.S.
Effects of benzo[a]pyrene-deoxyguanosine lesions on DNA methylation catalyzed by EcoRII DNA methyltransferase and on DNA cleavage effected by EcoRII restriction endonuclease
Biochemistry
44
1054-1066
2005
Escherichia coli
Kapetaniou, E.G.; Kotsifaki, D.; Providaki, M.; Rina, M.; Bouriotis, V.; Kokkinidis, M.
Purification, crystallization and preliminary X-ray analysis of the BseCI DNA methyltransferase from Bacillus stearothermophilus in complex with its cognate DNA
Acta Crystallogr. Sect. F
63
12-14
2007
Geobacillus stearothermophilus (P43423), Geobacillus stearothermophilus
Bheemanaik, S.; Reddy, Y.V.; Rao, D.N.
Structure, function and mechanism of exocyclic DNA methyltransferases
Biochem. J.
399
177-190
2006
Enterobacter cloacae, Caulobacter vibrioides, Escherichia coli, Klebsiella pneumoniae, Streptococcus pneumoniae (P04043), Tequatrovirus T4 (P04392), Thermus aquaticus (P14385), Cereibacter sphaeroides (P14751), Moraxella bovis (P23192)
Hattman, S.
DNA-[adenine] methylation in lower eukaryotes
Biochemistry (Moscow)
70
550-558
2005
Anopheles gambiae, Arabidopsis thaliana, Saccharomyces cerevisiae, Caenorhabditis elegans, Chlamydomonas reinhardtii, Chlorella sp., Drosophila melanogaster, Homo sapiens, Leishmania major, Paramecium aurelia, Plasmodium falciparum, Plasmodium knowlesi, Plasmodium yoelii, Schizosaccharomyces pombe, Tetrahymena thermophila, Oxytricha fallax, Stylonychia mytilus, Peridinium triquetrum
Erova, T.E.; Pillai, L.; Fadl, A.A.; Sha, J.; Wang, S.; Galindo, C.L.; Chopra, A.K.
DNA adenine methyltransferase influences the virulence of Aeromonas hydrophila
Infect. Immun.
74
410-424
2006
Aeromonas hydrophila, Aeromonas hydrophila SSU
Erova, T.E.; Fadl, A.A.; Sha, J.; Khajanchi, B.K.; Pillai, L.L.; Kozlova, E.V.; Chopra, A.K.
Mutations within the catalytic motif of DNA adenine methyltransferase (Dam) of Aeromonas hydrophila cause the virulence of the Dam-overproducing strain to revert to that of the wild-type phenotype
Infect. Immun.
74
5763-5772
2006
Aeromonas hydrophila, Aeromonas hydrophila SSU
Robbins-Manke, J.L.; Zdraveski, Z.Z.; Marinus, M.; Essigmann, J.M.
Analysis of global gene expression and double-strand-break formation in DNA adenine methyltransferase- and mismatch repair-deficient Escherichia coli
J. Bacteriol.
187
7027-7037
2005
Escherichia coli
Faelker, S.; Schmidt, M.A.; Heusipp, G.
Altered Ca(2+) regulation of Yop secretion in Yersinia enterocolitica after DNA adenine methyltransferase overproduction is mediated by Clp-dependent degradation of LcrG
J. Bacteriol.
188
7072-7081
2006
Yersinia enterocolitica
Horton, J.R.; Liebert, K.; Bekes, M.; Jeltsch, A.; Cheng, X.
Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase
J. Mol. Biol.
358
559-570
2006
Escherichia coli (P0AEE8), Escherichia coli
Faelker, S.; Schmidt, M.A.; Heusipp, G.
DNA methylation in Yersinia enterocolitica: role of the DNA adenine methyltransferase in mismatch repair and regulation of virulence factors
Microbiology
151
2291-2299
2005
Escherichia coli, Yersinia enterocolitica
Obarska, A.; Blundell, A.; Feder, M.; Vejsadova, S.; Sisakova, E.; Weiserova, M.; Bujnicki, J.M.; Firman, K.
Structural model for the multisubunit Type IC restriction-modification DNA methyltransferase M.EcoR124I in complex with DNA
Nucleic Acids Res.
34
1992-2005
2006
Escherichia coli (P10484)
Thomas, C.B.; Gumport, R.I.
Dimerization of the bacterial RsrI N6-adenine DNA methyltransferase
Nucleic Acids Res.
34
806-815
2006
Cereibacter sphaeroides
Seshasayee, A.S.
An assessment of the role of DNA adenine methyltransferase on gene expression regulation in E. coli
PLoS ONE
2
e273
2007
Escherichia coli
Radlinska, M.; Piekarowicz, A.; Galimand, M.; Bujnicki, J.M.
Cloning and preliminary characterization of a GATC-specific beta2-class DNA:m6A methyltransferase encoded by transposon Tn1549 from Enterococcus spp
Pol. J. Microbiol.
54
249-252
2005
Enterococcus faecalis (Q9L8Y0)
Mruk, I.; Kaczorowski, T.
A rapid and efficient method for cloning genes of type II restriction-modification systems by use of a killer plasmid
Appl. Environ. Microbiol.
73
4286-4293
2007
Geobacillus stearothermophilus (Q32WE7), Citrobacter sp. (Q32WH2), Geobacillus stearothermophilus 14P (Q32WE7), Citrobacter sp. RFL231 (Q32WH2)
Bogdanova, E.; Djordjevic, M.; Papapanagiotou, I.; Heyduk, T.; Kneale, G.; Severinov, K.
Transcription regulation of the type II restriction-modification system AhdI
Nucleic Acids Res.
36
1429-1442
2008
Aeromonas hydrophila
Morgan, R.D.; Bhatia, T.K.; Lovasco, L.; Davis, T.B.
MmeI: a minimal Type II restriction-modification system that only modifies one DNA strand for host protection
Nucleic Acids Res.
36
6558-6570
2008
Methylophilus methylotrophus (B2MU09)
Humbert, O.; Salama, N.R.
The Helicobacter pylori HpyAXII restriction-modification system limits exogenous DNA uptake by targeting GTAC sites but shows asymmetric conservation of the DNA methyltransferase and restriction endonuclease components
Nucleic Acids Res.
36
6893-6906
2008
Helicobacter pylori, Helicobacter pylori NSH57
Jois, P.; Madhu, N.; Rao, D.
Role of histidine residues in EcoP15I DNA methyltransferase activity as probed by chemical modification and site-directed mutagenesis
Biochem. J.
410
543-553
2008
Escherichia coli
Coffin, S.R.; Reich, N.O.
Escherichia coli DNA adenine methyltransferase: intrasite processivity and substrate-induced dimerization and activation
Biochemistry
48
7399-7410
2009
Escherichia coli
Kumar, R.; Srivastava, R.; Singh, R.; Surolia, A.; Rao, D.
Activation and inhibition of DNA methyltransferases by S-adenosyl-L-homocysteine analogues
Bioorg. Med. Chem.
16
2276-2285
2008
Escherichia coli
Elsawy, H.; Podobinschi, S.; Chahar, S.; Jeltsch, A.
Transition from EcoDam to T4Dam DNA recognition mechanism without loss of activity and specificity
ChemBioChem
10
2488-2493
2009
Escherichia coli
Low, D.; Casadesus, J.
Clocks and switches: bacterial gene regulation by DNA adenine methylation
Curr. Opin. Microbiol.
11
106-112
2008
Caulobacter vibrioides, Escherichia coli, Salmonella enterica, Yersinia pseudotuberculosis
Adamczyk-Poplawska, M.; Lower, M.; Piekarowicz, A.
Characterization of the NgoAXP: phase-variable type III restriction-modification system in Neisseria gonorrhoeae
FEMS Microbiol. Lett.
300
25-35
2009
Neisseria gonorrhoeae, Neisseria gonorrhoeae FA 1090
Marinus, M.G.; Casadesus, J.
Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more
FEMS Microbiol. Rev.
33
488-503
2009
Aggregatibacter actinomycetemcomitans, Aeromonas hydrophila, Brucella abortus, Campylobacter jejuni, Caulobacter vibrioides, Escherichia coli, Salmonella enterica, Klebsiella pneumoniae, Pasteurella multocida, Yersinia enterocolitica, Vibrio cholerae serotype O1
Lopez-Garrido, J.; Casadesus, J.
Regulation of Salmonella enterica pathogenicity island 1 (SPI-1) by DNA adenine methylation
Genetics
184
637-649
2009
Salmonella enterica
Bang, J.; Bae, S.H.; Park, C.J.; Lee, J.H.; Choi, B.S.
Structural and dynamics study of DNA dodecamer duplexes that contain un-, hemi-, or fully methylated GATC sites
J. Am. Chem. Soc.
130
17688-17696
2008
Escherichia coli
Jakomin, M.; Chessa, D.; Baeumler, A.J.; Casadesus, J.
Regulation of the Salmonella enterica std fimbrial operon by DNA adenine methylation, SeqA, and HdfR
J. Bacteriol.
190
7406-7413
2008
Salmonella enterica
Coffin, S.R.; Reich, N.O.
Modulation of Escherichia coli DNA methyltransferase activity by biologically derived GATC-flanking sequences
J. Biol. Chem.
283
20106-20116
2008
Escherichia coli (P0AEE8), Escherichia coli
Coffin, S.R.; Reich, N.O.
Escherichia coli DNA adenine methyltransferase: the structural basis of processive catalysis and indirect read-out
J. Biol. Chem.
284
18390-18400
2009
Escherichia coli (P0AEE9)
Jeon, T.J.
DNA adenine methylation of sams1 gene in symbiont-bearing Amoeba proteus
J. Microbiol.
46
564-570
2008
Amoeba proteus, Amoeba proteus D
Peterson, S.N.; Reich, N.O.
Competitive Lrp and Dam assembly at the pap regulatory region: implications for mechanisms of epigenetic regulation
J. Mol. Biol.
383
92-105
2008
Escherichia coli
Chahar, S.; Elsawy, H.; Ragozin, S.; Jeltsch, A.
Changing the DNA recognition specificity of the EcoDam DNA-(adenine-N6)-methyltransferase by directed evolution
J. Mol. Biol.
395
79-88
2010
Escherichia coli
Furmanek-Blaszk, B.; Boratynski, R.; Zolcinska, N.; Sektas, M.
M1.Mboll and M2.Mboll type IIS methyltransferases: different specificities, the same target
Microbiology
155
1111-1121
2009
Moraxella bovis
Chernukhin, V.; Seggewiss, J.; Kashirina, Y.; Gonchar, D.; Degtyarev, S.
Purification and properties of recombinant DNA methyltransferase M2.BstSE of the BstSEI nickase-modification system
Mol. Biol.
43
8-15
2009
Geobacillus stearothermophilus, Geobacillus stearothermophilus SE-589
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Ahlert, D.; Stegemann, S.; Kahlau, S.; Ruf, S.; Bock, R.
Insensitivity of chloroplast gene expression to DNA methylation
Mol. Gen. Genet.
282
17-24
2009
Synechocystis sp.
Morgan, R.D.; Dwinell, E.A.; Bhatia, T.K.; Lang, E.M.; Luyten, Y.A.
The MmeI family: type II restriction-modification enzymes that employ single-strand modification for host protection
Nucleic Acids Res.
37
5208-5221
2009
Synechococcus sp. PCC 7002, Bacillus sp. (in: Bacteria), Deinococcus radiodurans, Deinococcus radiodurans (C0LTP9), Neisseria lactamica, Neisseria meningitidis, Corynebacterium striatum, Trueperella pyogenes, Marinobacter nauticus (A1U7P0), Psychrobacter sp. (A5WI42), Parvibaculum lavamentivorans (A7HWD2), Methylophilus methylotrophus (B2MU09), Rhodospirillum centenum (B6IW55), Pseudomonas sp. (C0LTP8), Rhodopseudomonas palustris (Q134M6), Nitrobacter hamburgensis (Q1QGU9), Sulfurimonas denitrificans (Q30TC2), Ruegeria pomeroyi (Q5LS45), Corynebacterium diphtheriae (Q6NFX9), Corynebacterium striatum M82B, Neisseria meningitidis Z2491, Rhodopseudomonas palustris BisB5 (Q134M6), Deinococcus radiodurans RI, Neisseria lactamica ST640 Sange, Rhodospirillum centenum SW (B6IW55), Deinococcus radiodurans NEB479 (C0LTP9), Bacillus sp. (in: Bacteria) NEB686, Nitrobacter hamburgensis X14 (Q1QGU9), Synechococcus sp. PCC 7002 PR-6, Pseudomonas sp. OM2164 (C0LTP8)
Sun, K.; Jiao, X.D.; Zhang, M.; Sun, L.
DNA adenine methylase is involved in the pathogenesis of Edwardsiella tarda
Vet. Microbiol.
141
149-154
2010
Edwardsiella tarda (D5FM16), Edwardsiella tarda, Edwardsiella tarda TXD1 (D5FM16)
Singh, D.; Pannier, A.; Zempleni, J.
Identification of holocarboxylase synthetase chromatin binding sites in human mammary cell lines using the DNA adenine methyltransferase identification technology
Anal. Biochem.
413
55-59
2011
Escherichia coli
Bonnist, E.Y.; Liebert, K.; Dryden, D.T.; Jeltsch, A.; Jones, A.C.
Using the fluorescence decay of 2-aminopurine to investigate conformational change in the recognition sequence of the EcoRV DNA-(adenine-N6)-methyltransferase on enzyme binding
Biophys. Chem.
160
28-34
2012
Escherichia coli
Ren, X.; Aleshin, M.; Jo, W.J.; Dills, R.; Kalman, D.A.; Vulpe, C.D.; Smith, M.T.; Zhang, L.
Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity
Environ. Health Perspect.
119
771-777
2011
Homo sapiens (Q9Y5N5), Homo sapiens
Kumar, R.; Mukhopadhyay, A.K.; Rao, D.N.
Characterization of an N6 adenine methyltransferase from Helicobacter pylori strain 26695 which methylates adjacent adenines on the same strand
FEBS J.
277
1666-1683
2010
Helicobacter pylori
Erova, T.E.; Kosykh, V.G.; Sha, J.; Chopra, A.K.
DNA adenine methyltransferase (Dam) controls the expression of the cytotoxic enterotoxin (act) gene of Aeromonas hydrophila via tRNA modifying enzyme-glucose-inhibited division protein (GidA)
Gene
498
280-287
2012
Aeromonas hydrophila
Pollak, A.J.; Reich, N.O.
Proximal recognition sites facilitate intrasite hopping by DNA adenine methyltransferase: Mechanistic exploration of epigenetic gene regulation
J. Biol. Chem.
287
22873-22881
2012
Escherichia coli
Albu, R.F.; Jurkowski, T.P.; Jeltsch, A.
The Caulobacter crescentus DNA-(adenine-N6)-methyltransferase CcrM methylates DNA in a distributive manner
Nucleic Acids Res.
40
1708-1716
2012
Caulobacter vibrioides
Drozdz, M.; Piekarowicz, A.; Bujnicki, J.M.; Radlinska, M.
Novel non-specific DNA adenine methyltransferases
Nucleic Acids Res.
40
2119-2130
2012
Haemophilus influenzae, Neisseria meningitidis, Haemophilus influenzae biotype aegyptius (G9C944), Neisseria meningitidis Z2491 (Pnme1), Haemophilus influenzae Rd (FluMu), Haemophilus influenzae biotype aegyptius ATCC 11116 (G9C944)
Clark, T.A.; Murray, I.A.; Morgan, R.D.; Kislyuk, A.O.; Spittle, K.E.; Boitano, M.; Fomenkov, A.; Roberts, R.J.; Korlach, J.
Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing
Nucleic Acids Res.
40
e29
2012
Escherichia coli
Banerjee, A.; Rao, D.N.
Functional analysis of an acid adaptive DNA adenine methyltransferase from Helicobacter pylori 26695
PLoS ONE
6
e16810
2011
Helicobacter pylori
Pollak, A.; Reich, N.
DNA adenine methyltransferase facilitated diffusion is enhanced by protein-DNA roadblock complexes that induce DNA looping
Biochemistry
54
2181-2192
2015
Escherichia coli
Elsawy, H.; Chahar, S.
Increasing DNA substrate specificity of the EcoDam DNA-(adenine N6)-methyltransferase by site-directed mutagenesis
Biochemistry
79
1262-1266
2014
Escherichia coli (P0AEE8)
Maier, J.; Albu, R.; Jurkowski, T.; Jeltsch, A.
Investigation of the C-terminal domain of the bacterial DNA-(adenine N6)-methyltransferase CcrM
Biochimie
119
60-67
2015
Caulobacter vibrioides
Aranda, J.; Zinovjev, K.; Roca, M.; Tunon, I.
Dynamics and reactivity in Thermus aquaticus N6-adenine methyltransferase
J. Am. Chem. Soc.
136
16227-16239
2014
Thermus aquaticus
Bochow, S.; Elliman, J.; Owens, L.
Bacteriophage adenine methyltransferase: A life cycle regulator? Modelled using Vibrio harveyi myovirus like
J. Appl. Microbiol.
113
1001-1013
2012
Aliivibrio fischeri, Treponema succinifaciens, Vibrio anguillarum, Vibrio parahaemolyticus, Vibrio vulnificus, Vibrio campbellii, Vibrio splendidus, Deinococcus proteolyticus, Vibrio phage VHML, Hapunavirus VP882, Vibrio cholerae serotype O1, Vibrio cholerae (A5F520), Paludibacter propionicigenes (E4T573), Paludibacter propionicigenes WB4T (E4T573), Treponema succinifaciens DSM 2489, Vibrio campbellii ATCC BAA-1116, Vibrio anguillarum 775, Vibrio vulnificus MO6-24/O, Vibrio splendidus LGP32, Vibrio cholerae O395 (A5F520), Deinococcus proteolyticus MRP, Vibrio parahaemolyticus RIMD
Horton, J.; Zhang, X.; Blumenthal, R.; Cheng, X.
Structures of Escherichia coli DNA adenine methyltransferase (Dam) in complex with a non-GATC sequence: Potential implications for methylation-independent transcriptional repression
Nucleic Acids Res.
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4296-4308
2015
Escherichia coli (P0AEE8), Escherichia coli
Kubicek-Sutherland, J.; Heithoff, D.; Ersoy, S.; Shimp, W.; Mahan, M.
Immunization with a DNA adenine methylase over-producing Yersinia pseudotuberculosis vaccine confers robust cross-protection against heterologous pathogenic serotypes
Vaccine
32
1451-1459
2014
Yersinia pseudotuberculosis
Greer, E.L.; Blanco, M.A.; Gu, L.; Sendinc, E.; Liu, J.; Aristizabal-Corrales, D.; Hsu, C.H.; Aravind, L.; He, C.; Shi, Y.
DNA methylation on N6-adenine in C. elegans
Cell
161
868-878
2015
Caenorhabditis elegans
Maynard-Smith, M.; McKelvie, J.; Wood, R.; Harmer, J.; Ranasinghe, R.; Williams, C.; Coomber, D.; Stares, A.; Roach, P.
Direct and continuous fluorescence-based measurements of Pyrococcus horikoshii DNA N-6 adenine methyltransferase activity
Anal. Biochem.
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2011
Pyrococcus horikoshii
Dedkov, V.; Gonchar, D.; Abdurashitov, M.; Udalyeva, S.; Urumceva, L.; Chernukhin, V.; Shiryaeva, E.; Degtyarev, S.
Cloning and study of new DNA methyltransferase M.AluBI modifying adenine in a recognition site AGCT
Biotecnol. Apl.
32
3211-3216
2015
Cellulosimicrobium cellulans, Cellulosimicrobium cellulans B
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Beh, L.Y.; Debelouchina, G.T.; Clay, D.M.; Thompson, R.E.; Lindblad, K.A.; Hutton, E.R.; Bracht, J.R.; Sebra, R.P.; Muir, T.W.; Landweber, L.F.
Identification of a DNA N6-adenine methyltransferase complex and its impact on chromatin organization
Cell
177
1781-1796
2019
Tetrahymena thermophila, Oxytricha trifallax, Oxytricha trifallax JRB310, Tetrahymena thermophila SB210
Woodcock, C.; Yu, D.; Hajian, T.; Li, J.; Huang, Y.; Dai, N.; Correa, I.J.; Wu, T.; Vedadi, M.; Zhang, X.; Cheng, X.
Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro
Cell Discov.
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63
2019
Homo sapiens
Payelleville, A.; Lanois, A.; Gislard, M.; Dubois, E.; Roche, D.; Cruveiller, S.; Givaudan, A.; Brillard, J.
DNA adenine methyltransferase (Dam) overexpression impairs Photorhabdus luminescens motility and virulence
Front. Microbiol.
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1671
2017
Photorhabdus luminescens, Photorhabdus luminescens TT01
Wons, E.; Mruk, I.; Kaczorowski, T.
Relaxed specificity of prokaryotic DNA methyltransferases results in DNA site-specific modification of RNA/DNA heteroduplexes
J. Appl. Genet.
56
539-546
2015
Escherichia coli, Lactococcus cremoris, Lactococcus cremoris W15, Escherichia coli E1585-68
Maier, J.A.H.; Jeltsch, A.
Design and application of 6mA-specific zinc-finger proteins for the readout of DNA methylation
Methods Mol. Biol.
1867
29-41
2018
Caulobacter vibrioides
Horton, J.R.; Woodcock, C.B.; Opot, S.B.; Reich, N.O.; Zhang, X.; Cheng, X.
The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site
Nat. Commun.
10
4600
2019
Caulobacter vibrioides (P0CAW2), Caulobacter vibrioides
Gupta, Y.K.; Chan, S.H.; Xu, S.Y.; Aggarwal, A.K.
Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I
Nat. Commun.
6
7363
2015
Caulobacter vibrioides, Escherichia coli
Wang, Y.; Sheng, Y.; Liu, Y.; Zhang, W.; Cheng, T.; Duan, L.; Pan, B.; Qiao, Y.; Liu, Y.; Gao, S.
A distinct class of eukaryotic MT-A70 methyltransferases maintain symmetric DNA N6-adenine methylation at the ApT dinucleotides as an epigenetic mark associated with transcription
Nucleic Acids Res.
47
11771-11789
2019
Tetrahymena thermophila, Tetrahymena thermophila SB210
Ma, B.; Ma, J.; Liu, D.; Guo, L.; Chen, H.; Ding, J.; Liu, W.; Zhang, H.
Biochemical and structural characterization of a DNA N6-adenine methyltransferase from Helicobacter pylori
Oncotarget
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40965-40977
2016
Helicobacter pylori, Helicobacter pylori 26695
Blaschke, U.; Suwono, B.; Zafari, S.; Ebersberger, I.; Skiebe, E.; Jeffries, C.M.; Svergun, D.I.; Wilharm, G.
Recombinant production of A1S_0222 from Acinetobacter baumannii ATCC 17978 and confirmation of its DNA-(adenine N6)-methyltransferase activity
Protein Expr. Purif.
151
78-85
2018
Acinetobacter baumannii, Acinetobacter baumannii ATCC 17978
Wons, E.; Mruk, I.; Kaczorowski, T.
Isospecific adenine DNA methyltransferases show distinct preferences towards DNA substrates
Sci. Rep.
8
8243
2018
Escherichia coli, Haemophilus influenzae, Lactococcus cremoris, Haemophilus influenzae RD, Lactococcus cremoris W15, Escherichia coli E1585-68
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