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Reference on EC 2.1.3.2 - aspartate carbamoyltransferase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Coleman, P.F.; Suttle, D.P.; Stark, G.R.
Purification of a multifunctional protein bearing carbamyl-phosphate synthase, aspartate transcarbamylase, and dihydroorotase enzyme activities from mutant hamster cells
Methods Enzymol.
51
121-134
1978
Mesocricetus auratus
Manually annotated by BRENDA team
Mori, M.; Tatibana, M.
A multienzyme complex of carbamoyl-phosphate synthase (glutamine):aspartate carbamoyltransferase:dihydroorotase (rat ascites hepatoma cells and rat liver)
Methods Enzymol.
51
111-121
1978
Mesocricetus auratus, Rattus norvegicus
Manually annotated by BRENDA team
Sheperdson, M.; Pardee, A.B.
Production and crystallization of aspartate transcarbamylase
J. Biol. Chem.
235
3233-3237
1960
Escherichia coli
-
Manually annotated by BRENDA team
Lowenstein, J.M.; Cohen, P.P.
Studies on the biosynthesis of carbamylaspartic acid
J. Biol. Chem.
220
57-70
1956
Pigeon, Rattus norvegicus
Manually annotated by BRENDA team
Jacobson, G.R.; Stark, G.R.
Aspartate transcarbamylases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
9
225-308
1973
Azotobacter vinelandii, Klebsiella aerogenes, Bacillus subtilis, Saccharomyces cerevisiae, Citrobacter freundii, Oryctolagus cuniculus, Escherichia coli, Enterococcus faecalis, Halobacterium salinarum, Lactuca sativa, Mus musculus, Neurospora crassa, Vigna radiata var. radiata, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas vulgaris, Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens, Triticum aestivum
-
Manually annotated by BRENDA team
Allewell, N.M.
Escherichia coli aspartate transcarbamoylase: structure, energetics, and catalytic and regulatory mechanisms
Annu. Rev. Biophys. Biophys. Chem.
18
71-92
1989
Escherichia coli
Manually annotated by BRENDA team
Kantrowitz, E.R.; Lipscomb, W.N.
Escherichia coli aspartate transcarbamoylase: the molecular basis for a concerted allosteric transition
Trends Biochem. Sci.
15
53-59
1990
Escherichia coli
Manually annotated by BRENDA team
England, P.; Herve, G.
Synergistic inhibition of Escherichia coli aspartate transcarbamylase by CTP and UTP: binding studies using continuous-flow dialysis
Biochemistry
31
9725-9732
1992
Escherichia coli
Manually annotated by BRENDA team
Mort, J.S.; Chan, W.W.C.
Subunit interactions in aspartate transcarbamylase. Characterization of a complex between the catalytic and the regulatory subunits
J. Biol. Chem.
250
653-660
1975
Escherichia coli
Manually annotated by BRENDA team
Zhang, Y.; Kantrowitz, E.R.
The synergistic inhibition of Escherichia coli aspartate carbamoyltransferase by UTP in the presence of CTP is due to the binding of UTP to the low affinity CTP sites
J. Biol. Chem.
266
22154-22158
1991
Escherichia coli
Manually annotated by BRENDA team
Laing, N.; Chan, W.W.C.; Hutchinson, D.W.; berg, B.
Phosphorus-containing inhibitors of aspartate transcarbamoylase from Escherichia coli
FEBS Lett.
260
206-208
1990
Escherichia coli
Manually annotated by BRENDA team
Nowlan, S.C.; Kantrowitz, E.R.
Superproduction and rapid purification of Escherichia coli aspartate transcarbamylase and its catalytic subunit under extreme derepression of the pyrimidine pathway
J. Biol. Chem.
260
14712-14716
1985
Escherichia coli
Manually annotated by BRENDA team
Swyryd, E.A.; Seaver, S.S.; Stark, G.R.
N-(phosphonacetyl)-L-aspartate, a potent transition state analog inhibitor of aspartate transcarbamylase, blocks proliferation of mammalian cells in culture
J. Biol. Chem.
249
6945-6950
1974
Escherichia coli, Mesocricetus auratus, Mus musculus
Manually annotated by BRENDA team
Enns, C.A.; Chan, W.W.C.
Chemical stabilization of conformational states of aspartate transcarbamoylase
Methods Enzymol.
135
569-577
1987
Escherichia coli
Manually annotated by BRENDA team
Yon, R.J.
Wheat-germ aspartate transcarbamoylase: potentiation of end-product inhibition in vitro by deoxycholate
Biochem. Soc. Trans.
1
676-678
1973
Triticum aestivum
-
Manually annotated by BRENDA team
Rao, G.S.J.; Savithri, H.S.; Seethalakshmi, S.; Rao, N.A.
Plant aspartate transcarbamylase: an affinity chromatographic method for the purification of the enzyme from germinated seedings
Anal. Biochem.
95
401-405
1979
Eleusine coracana, Lathyrus sativus, Trigonella foenum-graecum, Vigna radiata var. radiata
Manually annotated by BRENDA team
Brabson, J.S.; Switzer, R.L.
Purification and properties of Bacillus subtilis aspartate transcarbamylase
J. Biol. Chem.
250
8664-8669
1975
Bacillus subtilis
Manually annotated by BRENDA team
Yon, R.J.
Versatility of mixed-function adsorbents in biospecific protein desorption: accidental affinity and an improved purification of aspartate transcarbamoylase from wheat germ
Anal. Biochem.
113
219-228
1981
Triticum aestivum
Manually annotated by BRENDA team
Grayson, J.E.; Yon, R.J.; Butterworth, P.J.
Wheat-germ aspartate transcarbamoylase. Purification and cold-lability
Biochem. J.
183
239-245
1979
Triticum aestivum
Manually annotated by BRENDA team
Grayson, D.R.; Evans, D.R.
The isolation and characterization of the aspartate transcarbamylase domain of the multifunctional protein, CAD
J. Biol. Chem.
258
4123-4129
1983
Mesocricetus auratus
Manually annotated by BRENDA team
Jacobson, G.R.; Stark, G.R.
Aspartate transcarbamylase of Escherichia coli. Mechanisms of inhibition and activation by dicarboxylic acids and other anions
J. Biol. Chem.
250
6852-6860
1975
Escherichia coli
Manually annotated by BRENDA team
Mathieu, M.
Partial characterization of aspartate transcarbamylase from the mantle of the mussel Mytilus edulis
Comp. Biochem. Physiol. B
82
667-674
1985
Mytilus edulis
Manually annotated by BRENDA team
Prasad, P.V.; Rao, N.A.
Purification and regulation of aspartate transcarbamylase from germinated mung bean (Vigna radiata) seedlings
J. Biosci.
6
233-248
1984
Vigna radiata var. radiata
-
Manually annotated by BRENDA team
Savithri, H.S.; Vaidyanathan, C.S.; Rao, N.A.
Plant aspartate transcarbamylase: kinetic properies of the enzyme from mung bean (Phaseolus aureus) seedlings
Proc. Indian Acad. Sci. Sect. B
87B
81-94
1978
Vigna radiata var. radiata
-
Manually annotated by BRENDA team
Brabson, J.S.; Maurizi, M.R.; Switzer, R.L.
Aspartate transcarbamylase from Bacillus subtilis
Methods Enzymol.
113
627-635
1985
Bacillus subtilis
Manually annotated by BRENDA team
Chang, T.Y.; Prescott, L.M.; Jones, M.E.
Aspartate carbamyltransferase (Streptococcus faecalis)
Methods Enzymol.
51
41-50
1978
Enterococcus faecalis
Manually annotated by BRENDA team
Adair, L.B.; Jones, M.E.
Aspartate carbamyltransferase (Pseudomonas fluorescens)
Methods Enzymol.
51
51-58
1978
Pseudomonas fluorescens
Manually annotated by BRENDA team
Chang, T.Y.; Jones, M.E.
Aspartate transcarbamylase from Streptococcus faecalis. Purification, properties, and nature of an allosteric activator site
Biochemistry
13
629-638
1974
Enterococcus faecalis
Manually annotated by BRENDA team
Chang, T.Y.; Jones, M.E.
Aspartate transcarbamylase from Streptococcus faecalis. Steady-state kinetic analysis
Biochemistry
13
638-645
1974
Enterococcus faecalis
Manually annotated by BRENDA team
Achar, B.S.; Savithri, H.S.; Vaidyanathan, C.S.; Rao, N.A.
Studies on plant aspartate transcarbamylase. Purification and properties of the enzyme from mung-bean (Phaseolus aureus) seedlings
Eur. J. Biochem.
47
15-22
1974
Vigna radiata var. radiata
Manually annotated by BRENDA team
Ong, B.L.; Jackson, J.F.
Aspartate transcarbmoylase from Phaseolus aureus
Biochem. J.
129
571-581
1972
Vigna radiata var. radiata
Manually annotated by BRENDA team
Jarry, B.P.
Purification of aspartate transcarbamylase from Drosophila melanogaster
Eur. J. Biochem.
87
533-540
1978
Drosophila melanogaster
Manually annotated by BRENDA team
Adair, L.B.; Jones, M.E.
Purification and characteristics of aspartate transcarbamylase from Pseudomonas fluorescens
J. Biol. Chem.
247
2308-2315
1972
Pseudomonas fluorescens
Manually annotated by BRENDA team
Masood, R.; Venkitasubramanian, T.A.
Purification and properties of aspartate transcarbamylase from Mycobacterium smegmatis
Biochim. Biophys. Acta
953
106-113
1988
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Purcarea, C.; Erauso, G.; Prieur, D.; Herve, G.
The catalytic and regulatory properties of aspartate transcarbamoylase from Pyrococcus abyssi, a new deep-sea hyperthermophilic archaeobacterium
Microbiology
140
1967-1975
1994
Pyrococcus abyssi
-
Manually annotated by BRENDA team
Xi, X.G.; De Staercke, C.; Van Vliet, F.; Triniolles, F.; Jacobs, A.; Stas, P.P.; Ladjimi, M.M.; Simon, V.; Cunin, R.; Herve, G.
The activation of Escherichia coli aspartate transcarbamylase by ATP. Specific involvement of helix H2' at the hydrophobic interface between the two domains of the regulatory chains
J. Mol. Biol.
242
139-149
1994
Escherichia coli
Manually annotated by BRENDA team
Lee, B.H.; Ley, B.W.; Kantrowitz, E.R.; O'Leary, M.H.; Wedler, F.C.
Domain closure in the catalytic chains of Escherichia coli aspartate transcarbamoylase influences the kinetic mechanism
J. Biol. Chem.
270
15620-15627
1995
Escherichia coli
Manually annotated by BRENDA team
Baker, D.P.; Aucoin, J.M.; Williams, M.K.; DeMello, L.A.; Kantrowitz, E.R.
Overexpression and purification of the trimeric aspartate transcarbamoylase from Bacillus subtilis
Protein Expr. Purif.
6
679-684
1995
Bacillus subtilis, Escherichia coli
Manually annotated by BRENDA team
Khan, A.; Chowdhry, B.Z.; Yon, R.J.
Effects of lipids on nucleotide inhibition of wheat-germ aspartate transcarbamoylase: evidence of an additional level of control?
Biochem. J.
313
669-673
1996
Triticum aestivum
-
Manually annotated by BRENDA team
Yuan, X.; LiCata, V.J.; Allewell, N.M.
Effects of assembly and mutations outside the active site on the functional pH dependence of Escherichia coli aspartate transcarbamylase
J. Biol. Chem.
271
1285-1294
1996
Escherichia coli
Manually annotated by BRENDA team
Burns, B.P.; Mendz, G.L.; Hazell, S.L.
In situ properties of Helicobacter pylori aspartate carbamoyltransferase
Arch. Biochem. Biophys.
347
119-125
1997
Helicobacter pylori
Manually annotated by BRENDA team
Xu, Y.; Zhang, Y.; Liang, Z.; Van de Casteele, M.; Legrain, C.; Glansdorff, N.
Aspartate carbamoyltransferase from a psychrophilic deep-sea bacterium, Vibrio strain 2693: properties of the enzyme, genetic organization and synthesis in Escherichia coli
Microbiology
144
1435-1441
1998
Vibrio natriegens, Vibrio sp., Vibrio sp. 2693
-
Manually annotated by BRENDA team
Liu, L.; Wales, M.E.; Wild, J.R.
Temperature effects on the allosteric responses of native and chimeric aspartate transcarbamoylases
J. Mol. Biol.
282
891-901
1998
Escherichia coli, Serratia marcescens
Manually annotated by BRENDA team
Khan, A.I.; Chowdhry, B.Z.; Yon, R.J.
Wheat germ aspartate transcarbamoylase: revised purification, stability and re-evaluation of regulatory kinetics in terms of the Monod-Wyman-Changeux model
Eur. J. Biochem.
259
71-78
1999
Triticum aestivum
Manually annotated by BRENDA team
Durbecq, V.; Thia-Toong, T.L.; Charlier, D.; Villeret, V.; Roovers, M.; Wattiez, R.; Legrain, C.; Glansdorff, N.
Aspartate carbamoyltransferase from the thermoacidophilic archaeon Sulfolobus acidocaldarius cloning, sequence analysis, enzyme purification and characterization
Eur. J. Biochem.
264
233-241
1999
Sulfolobus acidocaldarius, Sulfolobus acidocaldarius (Q55338)
Manually annotated by BRENDA team
Vorisek, J.; Noaillac-Depeyre, J.; Denis-Duphil, M.
Life-cycle-dependent changes of aspartate carbamoyltransferase localization in membranes of Saccharomyces cerevisiae - centrifugal elutriation and ultracytochemical study
Folia Microbiol. (Praha)
44
289-294
1999
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Jin, L.; Stec, B.; Lipscomb, W.N.; Kantrowitz, E.R.
Insights into the mechanisms of catalysis and heterotropic regulation of Escherichia coli aspartate transcarbamoylase based upon a structure of the enzyme complexed with the bisubstrate analogue N-phosphonacetyl-L-aspartate at 2.1.ANG
Proteins Struct. Funct. Genet.
37
729-742
1999
Escherichia coli
Manually annotated by BRENDA team
Hack, E.S.; Vorobyova, T.; Sakash, J.B.; West, J.M.; Macol, C.P.; Herve, G.; Williams, M.K.; Kantrowitz, E.R.
Characterization of the aspartate transcarbamoylase from Methanococcus jannaschii
J. Biol. Chem.
275
15820-15827
2000
Escherichia coli, Methanocaldococcus jannaschii (Q58976), Methanocaldococcus jannaschii
Manually annotated by BRENDA team
Endrizzi, J.A.; Beernink, P.T.; Alber, T.; Schachman, H.K.
Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation
Proc. Natl. Acad. Sci. USA
97
5077-5082
2000
Escherichia coli (P0A786), Escherichia coli
Manually annotated by BRENDA team
Fetler, L.; Tauc, P.; Baker, D.P.; Macol, C.P.; Kantrowitz, E.R.; Vachette, P.
Replacement of Asp-162 by Ala prevents the cooperative transition by the substrates while enhancing the effect of the allosteric activator ATP on E. coli aspartate transcarbamoylase
Protein Sci.
11
1074-1081
2002
Escherichia coli
Manually annotated by BRENDA team
West, J.M.; Tsuruta, H.; Kantrowitz, E.R.
Stabilization of the R allosteric structure of Escherichia coli aspartate transcarbamoylase by disulfide bond formation
J. Biol. Chem.
277
47300-47304
2002
Escherichia coli
Manually annotated by BRENDA team
Vickrey, J.F.; Herve, G.; Evans, D.R.
Pseudomonas aeruginosa aspartate transcarbamoylase. Characterization of its catalytic and regulatory properties
J. Biol. Chem.
277
24490-24498
2002
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Van Boxstael, S.; Cunin, R.; Khan, S.; Maes, D.
Aspartate transcarbamylase from the hyperthermophilic archaeon Pyrococcus abyssi: thermostability and 1.8 A resolution crystal structure of the catalytic subunit complexed with the bisubstrate analogue N-phosphonacetyl-L-aspartate
J. Mol. Biol.
326
203-216
2003
Pyrococcus abyssi (P77918), Pyrococcus abyssi
Manually annotated by BRENDA team
De Vos, D.; Hulpiau, P.; Vergauwen, B.; Savvides, S.N.; Van Beeumen, J.
Expression, purification, crystallization and preliminary X-ray crystallographic studies of a cold-adapted aspartate carbamoyltransferase from Moritella profunda
Acta Crystallogr. Sect. F
61
279-281
2005
Moritella profunda
Manually annotated by BRENDA team
Huang, J.; Lipscomb, W.N.
Aspartate transcarbamylase (ATCase) of Escherichia coli: a new crystalline R-state bound to PALA, or to product analogues citrate and phosphate
Biochemistry
43
6415-6421
2004
Escherichia coli
Manually annotated by BRENDA team
Neelon, K.; Schreier, H.J.; Meekins, H.; Robinson, P.M.; Roberts, M.F.
Compatible solute effects on thermostability of glutamine synthetase and aspartate transcarbamoylase from Methanococcus jannaschii
Biochim. Biophys. Acta
1753
164-173
2005
Escherichia coli, Methanocaldococcus jannaschii
Manually annotated by BRENDA team
Herve, G.; Schmitt, B.; Serre, V.
Cooperativity and high pressure: stabilization of the R conformation of the allosteric aspartate transcarbamylase under the influence of pressure
Cell. Mol. Biol.
50
347-352
2004
Escherichia coli
Manually annotated by BRENDA team
Etchian, O.A.; Pellerin, J.
Characterization of aspartate transcarbamylase activity from gonads of the soft shell clam, Mya arenaria
Comp. Biochem. Physiol. B
134
615-629
2003
Mya arenaria
Manually annotated by BRENDA team
Etchian, O.A.; Pellerin, J.; Audet, C.; Mathieu, M.
Sexual maturation and related changes in aspartate transcarbamylase activity of gonad tissues in the soft shell clam (Mya arenaria)
Comp. Biochem. Physiol. B
139
287-297
2004
Mya arenaria
Manually annotated by BRENDA team
Van Boxstael, S.; Maes, D.; Cunin, R.
Aspartate transcarbamylase from the hyperthermophilic archaeon Pyrococcus abyssi. Insights into cooperative and allosteric mechanisms
Febs J.
272
2670-2683
2005
Pyrococcus abyssi
Manually annotated by BRENDA team
Santiago, M.F.; West, T.P.
Comparison of aspartate transcarbamoylase regulation in Pseudomonas alcaligenes and Pseudomonas mendocina
J. Basic Microbiol.
43
75-79
2003
Pseudomonas alcaligenes, Pseudomonas mendocina
Manually annotated by BRENDA team
Purcarea, C.; Ahuja, A.; Lu, T.; Kovari, L.; Guy, H.I.; Evans, D.R.
Aquifex aeolicus aspartate transcarbamoylase, an enzyme specialized for the efficient utilization of unstable carbamoyl phosphate at elevated temperature
J. Biol. Chem.
278
52924-52934
2003
Aquifex aeolicus
Manually annotated by BRENDA team
Alam, N.; Stieglitz, K.A.; Caban, M.D.; Gourinath, S.; Tsuruta, H.; Kantrowitz, E.R.
240s loop interactions stabilize the T state of Escherichia coli aspartate transcarbamoylase
J. Biol. Chem.
279
23302-23310
2004
Escherichia coli
Manually annotated by BRENDA team
De Vos, D.; Van Petegem, F.; Remaut, H.; Legrain, C.; Glansdorff, N.; Van Beeumen, J.J.
Crystal structure of T state aspartate carbamoyltransferase of the hyperthermophilic archaeon Sulfolobus acidocaldarius
J. Mol. Biol.
339
887-900
2004
Sulfolobus acidocaldarius
Manually annotated by BRENDA team
Stieglitz, K.; Stec, B.; Baker, D.P.; Kantrowitz, E.R.
Monitoring the transition from the T to the R state in E.coli aspartate transcarbamoylase by X-ray crystallography: crystal structures of the E50A mutant enzyme in four distinct allosteric states
J. Mol. Biol.
341
853-868
2004
Escherichia coli
Manually annotated by BRENDA team
Tsuruta, H.; Kihara, H.; Sano, T.; Amemiya, Y.; Vachette, P.
Influence of nucleotide effectors on the kinetics of the quaternary structure transition of allosteric aspartate transcarbamylase
J. Mol. Biol.
348
195-204
2005
Escherichia coli
Manually annotated by BRENDA team
Stieglitz, K.A.; Pastra-Landis, S.C.; Xia, J.; Tsuruta, H.; Kantrowitz, E.R.
A single amino acid substitution in the active site of Escherichia coli aspartate transcarbamoylase prevents the allosteric transition
J. Mol. Biol.
349
413-423
2005
Escherichia coli
Manually annotated by BRENDA team
Bassett, E.V.; Bouchet, B.Y.; Carr, J.M.; Williamson, C.L.; Slocum, R.D.
PALA-mediated pyrimidine starvation increases expression of aspartate transcarbamoylase (pyrB) in Arabidopsis seedlings
Plant Physiol. Biochem.
41
695-703
2003
Arabidopsis thaliana
-
Manually annotated by BRENDA team
Wang, J.; Stieglitz, K.A.; Cardia, J.P.; Kantrowitz, E.R.
Structural basis for ordered substrate binding and cooperativity in aspartate transcarbamoylase
Proc. Natl. Acad. Sci. USA
102
8881-8886
2005
Escherichia coli
Manually annotated by BRENDA team
Zanotti, J.; Herve, G.; Bellissent-Funel, M.
Picosecond dynamics of T and R forms of aspartate transcarbamylase: A neutron scattering study
Biochim. Biophys. Acta
1764
1527-1535
2006
Escherichia coli
Manually annotated by BRENDA team
Stec, B.; Williams, M.K.; Stieglitz, K.A.; Kantrowitz, E.R.
Comparison of two T-state structures of regulatory-chain mutants of Escherichia coli aspartate transcarbamoylase suggests that His20 and Asp19 modulate the response to heterotropic effectors
Acta Crystallogr. Sect. D
63
1243-1253
2007
Escherichia coli
Manually annotated by BRENDA team
Annoura, T.; Sariego, I.; Nara, T.; Makiuchi, T.; Fujimura, T.; Taka, H.; Mineki, R.; Murayama, K.; Aoki, T.
Dihydroorotate dehydrogenase arises from novel fused gene product with aspartate carbamoyltransferase in Bodo saliens
Biochem. Biophys. Res. Commun.
358
253-258
2007
Neobodo saliens
Manually annotated by BRENDA team
De Vos, D.; Xu, Y.; Aerts, T.; Van Petegem, F.; Van Beeumen, J.J.
Crystal structure of Sulfolobus acidocaldarius aspartate carbamoyltransferase in complex with its allosteric activator CTP
Biochem. Biophys. Res. Commun.
372
40-44
2008
Sulfolobus acidocaldarius
Manually annotated by BRENDA team
Rabinowitz, J.D.; Hsiao, J.J.; Gryncel, K.R.; Kantrowitz, E.R.; Feng, X.J.; Li, G.; Rabitz, H.
Dissecting enzyme regulation by multiple allosteric effectors: nucleotide regulation of aspartate transcarbamoylase
Biochemistry
47
5881-5888
2008
Escherichia coli
Manually annotated by BRENDA team
Eldo, J.; Heng, S.; Kantrowitz, E.R.
Design, synthesis, and bioactivity of novel inhibitors of Escherichia coli aspartate transcarbamoylase
Bioorg. Med. Chem. Lett.
17
2086-2090
2007
Escherichia coli
Manually annotated by BRENDA team
Balbaa, M.; Abdel-Megeed, M.; Diab, T.; Mansour, H.
Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives
J. Enzyme Inhib. Med. Chem.
23
483-492
2008
Mus musculus
Manually annotated by BRENDA team
De Vos, D.; Xu, Y.; Hulpiau, P.; Vergauwen, B.; Van Beeumen, J.J.
Structural investigation of cold activity and regulation of aspartate carbamoyltransferase from the extreme psychrophilic bacterium Moritella profunda
J. Mol. Biol.
365
379-395
2007
Moritella profunda
Manually annotated by BRENDA team
Wang, J.; Eldo, J.; Kantrowitz, E.R.
Structural model of the R state of Escherichia coli aspartate transcarbamoylase with substrates bound
J. Mol. Biol.
371
1261-1273
2007
Escherichia coli
Manually annotated by BRENDA team
Chen, C.T.; Slocum, R.D.
Expression and functional analysis of aspartate transcarbamoylase and role of de novo pyrimidine synthesis in regulation of growth and development in Arabidopsis
Plant Physiol. Biochem.
46
150-159
2008
Arabidopsis thaliana
Manually annotated by BRENDA team
Fetler, L.; Kantrowitz, E.R.; Vachette, P.
Direct observation in solution of a preexisting structural equilibrium for a mutant of the allosteric aspartate transcarbamoylase
Proc. Natl. Acad. Sci. USA
104
495-500
2007
Escherichia coli
Manually annotated by BRENDA team
Vitali, J.; Colaneri, M.J.; Kantrowitz, E.
Crystal structure of the catalytic trimer of Methanococcus jannaschii aspartate transcarbamoylase
Proteins
71
1324-1334
2008
Methanocaldococcus jannaschii (Q58976), Methanocaldococcus jannaschii
Manually annotated by BRENDA team
Stieglitz, K.A.; Xia, J.; Kantrowitz, E.R.
The first high pH structure of Escherichia coli aspartate transcarbamoylase
Proteins
74
318-327
2008
Escherichia coli
Manually annotated by BRENDA team
Cardia, J.P.; Eldo, J.; Xia, J.; ODay, E.M.; Tsuruta, H.; Gryncel, K.R.; Kantrowitz, E.R.
Use of L-asparagine and N-phosphonacetyl-L-asparagine to investigate the linkage of catalysis and homotropic cooperativity in E. coli aspartate transcarbamoylase
Proteins Struct. Funct. Bioinform.
71
1088-1096
2008
Escherichia coli
-
Manually annotated by BRENDA team
McPhail, D.; Cheung, M.K.; Brown, J.; Shepherdson, M.
Factors accelerating pyrimidine production in Deinococcus radiophilus
Arch. Microbiol.
191
73-82
2009
Deinococcus radiophilus
Manually annotated by BRENDA team
Matoba, K.; Nara, T.; Aoki, T.; Honma, T.; Tanaka, A.; Inoue, M.; Matsuoka, S.; Inaoka, D.K.; Kita, K.; Harada, S.
Crystallization and preliminary X-ray analysis of aspartate transcarbamoylase from the parasitic protist Trypanosoma cruzi
Acta Crystallogr. Sect. F
65
933-936
2009
Trypanosoma cruzi
Manually annotated by BRENDA team
Zhang, P.; Martin, P.D.; Purcarea, C.; Vaishnav, A.; Brunzelle, J.S.; Fernando, R.; Guy-Evans, H.I.; Evans, D.R.; Edwards, B.F.
Dihydroorotase from the hyperthermophile Aquifex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis
Biochemistry
48
766-778
2009
Aquifex aeolicus (O66726), Aquifex aeolicus
Manually annotated by BRENDA team
Coudray, L.; Kantrowitz, E.R.; Montchamp, J.L.
Submicromolar phosphinic inhibitors of Escherichia coli aspartate transcarbamoylase
Bioorg. Med. Chem. Lett.
19
900-902
2009
Escherichia coli
Manually annotated by BRENDA team
Coudray, L.; Pennebaker, A.F.; Montchamp, J.L.
Synthesis and in vitro evaluation of aspartate transcarbamoylase inhibitors
Bioorg. Med. Chem.
17
7680-7689
2009
Escherichia coli
Manually annotated by BRENDA team
Velyvis, A.; Schachman, H.K.; Kay, L.E.
Assignment of Ile, Leu, and Val methyl correlations in supra-molecular systems: an application to aspartate transcarbamoylase
J. Am. Chem. Soc.
131
16534-16543
2009
Escherichia coli
Manually annotated by BRENDA team
West, J.M.; Xia, J.; Tsuruta, H.; Guo, W.; ODay, E.M.; Kantrowitz, E.R.
Time evolution of the quaternary structure of Escherichia coli aspartate transcarbamoylase upon reaction with the natural substrates and a slow, tight-binding inhibitor
J. Mol. Biol.
384
206-218
2008
Escherichia coli
Manually annotated by BRENDA team
Velyvis, A.; Schachman, H.K.; Kay, L.E.
Application of methyl-TROSY NMR to test allosteric models describing effects of nucleotide binding to aspartate transcarbamoylase
J. Mol. Biol.
387
540-547
2009
Escherichia coli
Manually annotated by BRENDA team
Wang, Q.; Xia, J.; Guallar, V.; Krilov, G.; Kantrowitz, E.R.
Mechanism of thermal decomposition of carbamoyl phosphate and its stabilization by aspartate and ornithine transcarbamoylases
Proc. Natl. Acad. Sci. USA
105
16918-16923
2008
Escherichia coli
Manually annotated by BRENDA team
Santiago, M.; West, T.
Regulation of aspartate transcarbamoylase activity in Pseudomonas putida biovar B
Res. J. Microbiol.
3
331-335
2008
Pseudomonas putida
-
Manually annotated by BRENDA team
Lipscomb, W.N.; Kantrowitz, E.R.
Structure and mechanisms of Escherichia coli aspartate transcarbamoylase
Acc. Chem. Res.
45
444-453
2012
Escherichia coli
Manually annotated by BRENDA team
Vitali, J.; Singh, A.K.; Soares, A.S.; Colaneri, M.J.
Structure of the catalytic chain of Methanococcus jannaschii aspartate transcarbamoylase in a hexagonal crystal form: insights into the path of carbamoyl phosphate to the active site of the enzyme
Acta Crystallogr. Sect. F
68
527-534
2012
Methanocaldococcus jannaschii (Q58801), Methanocaldococcus jannaschii (Q58976), Methanocaldococcus jannaschii
Manually annotated by BRENDA team
Kantrowitz, E.R.
Allostery and cooperativity in Escherichia coli aspartate transcarbamoylase
Arch. Biochem. Biophys.
519
81-90
2012
Escherichia coli
Manually annotated by BRENDA team
Nara, T.; Hashimoto, M.; Hirawake, H.; Liao, C.W.; Fukai, Y.; Suzuki, S.; Tsubouchi, A.; Morales, J.; Takamiya, S.; Fujimura, T.; Taka, H.; Mineki, R.; Fan, C.K.; Inaoka, D.K.; Inoue, M.; Tanaka, A.; Harada, S.; Kita, K.; Aoki, T.
Molecular interaction of the first 3 enzymes of the de novo pyrimidine biosynthetic pathway of Trypanosoma cruzi
Biochem. Biophys. Res. Commun.
418
140-143
2012
Trypanosoma cruzi
Manually annotated by BRENDA team
Peterson, A.W.; Cockrell, G.M.; Kantrowitz, E.R.
A second allosteric site in Escherichia coli aspartate transcarbamoylase
Biochemistry
51
4776-4778
2012
Escherichia coli (P0A786), Escherichia coli
Manually annotated by BRENDA team
Cockrell, G.M.; Kantrowitz, E.R.
Metal ion involvement in the allosteric mechanism of Escherichia coli aspartate transcarbamoylase
Biochemistry
51
7128-7137
2012
Escherichia coli (P0A786), Escherichia coli
Manually annotated by BRENDA team
Mendes, K.R.; Kantrowitz, E.R.
The pathway of product release from the R state of aspartate transcarbamoylase
J. Mol. Biol.
401
940-948
2010
Escherichia coli
Manually annotated by BRENDA team
Harris, K.M.; Cockrell, G.M.; Puleo, D.E.; Kantrowitz, E.R.
Crystallographic snapshots of the complete catalytic cycle of the unregulated aspartate transcarbamoylase from Bacillus subtilis
J. Mol. Biol.
411
190-200
2011
Bacillus subtilis (P05654), Bacillus subtilis
Manually annotated by BRENDA team
Guo, W.; West, J.M.; Dutton, A.S.; Tsuruta, H.; Kantrowitz, E.R.
Trapping and structure determination of an intermediate in the allosteric transition of aspartate transcarbamoylase
Proc. Natl. Acad. Sci. USA
109
7741-7746
2012
Escherichia coli (P0A786)
Manually annotated by BRENDA team
Massant, J.; Glansdorff, N.
Metabolic channelling of carbamoyl phosphate in the hyperthermophilic archaeon Pyrococcus furiosus: dynamic enzyme-enzyme interactions involved in the formation of the channelling complex
Biochem. Soc. Trans.
32
306-309
2004
Pyrococcus furiosus, Pyrococcus furiosus GE5
Manually annotated by BRENDA team
Purcarea, C.; Evans, D.R.; Herve, G.
Channeling of carbamoyl phosphate to the pyrimidine and arginine biosynthetic pathways in the deep sea hyperthermophilic archaeon Pyrococcus abyssi
J. Biol. Chem.
274
6122-6129
1999
Pyrococcus abyssi (P77918), Pyrococcus abyssi
Manually annotated by BRENDA team
Vitali, J.; Vorobyova, T.; Webster, G.; Kantrowitz, E.R.
Crystallization and structure determination of the catalytic trimer of Methanococcus jannaschii aspartate transcarbamoylase
Acta Crystallogr. Sect. D
56
1061-1063
2000
Methanocaldococcus jannaschii (Q58976), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q58976)
Manually annotated by BRENDA team
Vitali, J.; Colaneri, M.J.
Structure of the catalytic trimer of Methanococcus jannaschii aspartate transcarbamoylase in an orthorhombic crystal form
Acta Crystallogr. Sect. F
64
776-780
2008
Methanocaldococcus jannaschii (Q58976), Methanocaldococcus jannaschii
Manually annotated by BRENDA team
Ruiz-Ramos, A.; Lallous, N.; Grande-Garcia, A.; Ramon-Maiques, S.
Expression, purification, crystallization and preliminary X-ray diffraction analysis of the aspartate transcarbamoylase domain of human CAD
Acta Crystallogr. Sect. F
69
1425-1430
2013
Homo sapiens (P27708), Homo sapiens
Manually annotated by BRENDA team
Cockrell, G.M.; Zheng, Y.; Guo, W.; Peterson, A.W.; Truong, J.K.; Kantrowitz, E.R.
New paradigm for allosteric regulation of Escherichia coli aspartate transcarbamoylase
Biochemistry
52
8036-8047
2013
Escherichia coli (P0A786), Escherichia coli
Manually annotated by BRENDA team
Coxam, B.; Neyt, C.; Grassini, D.R.; Le Guen, L.; Smith, K.A.; Schulte-Merker, S.; Hogan, B.M.
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) regulates Notch signaling and vascular development in zebrafish
Dev. Dyn.
244
1-9
2015
Danio rerio
Manually annotated by BRENDA team
Sato, T.; Akasu, H.; Shimono, W.; Matsu, C.; Fujiwara, Y.; Shibagaki, Y.; Heard, J.J.; Tamanoi, F.; Hattori, S.
Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity
J. Biol. Chem.
290
1096-1105
2015
Mus musculus
Manually annotated by BRENDA team
Kanagarajan, S.; Mutharasappan, N.; Dhamodharan, P.; Jeyaraman, M.; Ramadas, K.; Jeyaraman, J.
Exploring the structural features of aspartate trans carbamoylase (TtATCase) from Thermus thermophilus HB8 through in silico approaches: a potential drug target for inborn error of pyrimidine metabolism
J. Biomol. Struct. Dyn.
32
591-601
2014
Thermus thermophilus (Q5SK66), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SK66)
Manually annotated by BRENDA team
Evans, H.G.; Fernando, R.; Vaishnav, A.; Kotichukkala, M.; Heyl, D.; Hachem, F.; Brunzelle, J.S.; Edwards, B.F.; Evans, D.R.
Intersubunit communication in the dihydroorotase-aspartate transcarbamoylase complex of Aquifex aeolicus
Protein Sci.
23
100-109
2014
Aquifex aeolicus
Manually annotated by BRENDA team
Chen, P.; Van Vliet, F.; Van De Casteele, M.; Legrain, C.; Cunin, R.; Glansdorff, N.
Aspartate transcarbamylase from the hyperthermophilic eubacterium Thermotoga maritima Fused catalytic and regulatory polypeptides form an allosteric enzyme
J. Bacteriol.
180
6389-6391
1998
Thermotoga maritima (P96111), Thermotoga maritima, Thermotoga maritima DSM 3109 (P96111)
Manually annotated by BRENDA team
Lunev, S.; Bosch, S.S.; Batista, F.d.e. .A.; Wrenger, C.; Groves, M.R.
Crystal structure of truncated aspartate transcarbamoylase from Plasmodium falciparum
Acta Crystallogr. Sect. F
72
523-533
2016
Plasmodium falciparum (O15804), Plasmodium falciparum
Manually annotated by BRENDA team
Lunev, S.; Bosch, S.S.; Batista, F.A.; Wang, C.; Li, J.; Linzke, M.; Kruithof, P.; Chamoun, G.; Doemling, A.S.S.; Wrenger, C.; Groves, M.R.
Identification of a non-competitive inhibitor of Plasmodium falciparum aspartate transcarbamoylase
Biochem. Biophys. Res. Commun.
497
835-842
2018
Plasmodium falciparum (O15804), Plasmodium falciparum
Manually annotated by BRENDA team
Lei, Z.; Wang, B.; Lu, Z.; Wang, N.; Tan, H.; Zheng, J.; Jia, Z.
New regulatory mechanism-based inhibitors of aspartate transcarbamoylase for potential anticancer drug development
FEBS J.
287
3579-3599
2020
Homo sapiens, Escherichia coli (P0A786)
Manually annotated by BRENDA team
Lei, Z.; Wang, N.; Tan, H.; Zheng, J.; Jia, Z.
Conformational plasticity of the active site entrance in E. coli aspartate transcarbamoylase and its implication in feedback regulation
Int. J. Mol. Sci.
21
320
2020
Escherichia coli (P0A786), Escherichia coli
Manually annotated by BRENDA team
Balbaa, M.; Hammoud, R.; Yusef, H.
Comparative study of the inhibition of E. coli and murine aspartate transcarbamylase by phenobarbital analogues
Lett. Drug Des. Discov.
13
276-281
2016
Escherichia coli, Mus musculus
-
Manually annotated by BRENDA team
Endrizzi, J.A.; Beernink, P.T.
Charge neutralization in the active site of the catalytic trimer of aspartate transcarbamoylase promotes diverse structural changes
Protein Sci.
26
2221-2228
2017
Escherichia coli (P0A786)
Manually annotated by BRENDA team
Ruiz-Ramos, A.; Velazquez-Campoy, A.; Grande-Garcia, A.; Moreno-Morcillo, M.; Ramon-Maiques, S.
Structure and functional characterization of human aspartate transcarbamoylase, the target of the anti-tumoral drug PALA
Structure
24
1081-1094
2016
Homo sapiens (P27708), Homo sapiens
Manually annotated by BRENDA team