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Reference on EC 2.1.3.3 - ornithine carbamoyltransferase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Srivenugopal, K.S.; Adiga, P.R.
Enzymic conversion of agmatine to putrescine in Lathyrus sativus seedlings. Purification and properties of a multifunctional enzyme (putrescine synthase)
J. Biol. Chem.
256
9532-9541
1981
Lathyrus sativus
Manually annotated by BRENDA team
Bishop, S.H.; Grisolia, S.
Crystalline ornithine transcarbamylase
Biochim. Biophys. Acta
139
344-348
1967
Streptococcus sp., Streptococcus sp. D10
Manually annotated by BRENDA team
Marshall, M.; Cohen, P.P.
Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. I. Isolation and subunit structure
J. Biol. Chem.
247
1641-1653
1972
Bos taurus, Enterococcus faecalis
Manually annotated by BRENDA team
Marshall, M.; Cohen, P.P.
Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. II. Multiple binding sites for carbamyl-P and L-norvaline, correlation with steady state kinetics
J. Biol. Chem.
247
1654-1668
1972
Bos taurus, Enterococcus faecalis
Manually annotated by BRENDA team
Marshall, M.; Cohen, P.P.
Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. 3. Effects of chemical modifications of specific residues on ligand binding and enzymatic activity
J. Biol. Chem.
247
1669-1682
1972
Bos taurus, Enterococcus faecalis
Manually annotated by BRENDA team
Ahmad, S.; Bhatnagar, R.K.; Venkitasubramanian, T.A.
Ornithine transcarbamylase from Mycobacterium smegmatis ATCC 14468: purification, properties, and reaction mechanism
Biochem. Cell Biol.
64
1349-1355
1986
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Tsuji, S.; Kanazawa, S.; Fukushina, T.; Oda, S.
Some characteristics of hepatic ornithine transcarbamylase from the house musk shrew, Suncus murinus
Nippon Chikusan Gakkai Ho
56
962-970
1985
Bos taurus, Gallus gallus, Oryctolagus cuniculus, Rattus norvegicus, Dipturus trachyderma, shark, Suncus murinus
-
Manually annotated by BRENDA team
Glenn, E.; Maretzki, A.
Properties and subcellular distribution of two partially purified ornithine transcarbamoylases in cell suspensions of sugarcane
Plant Physiol.
60
122-126
1977
Arundinaria sp.
Manually annotated by BRENDA team
Boggess, S.F.; Naylor, A.W.
Partial purification and properties of ornithine transcarbamoylase from Nostoc muscorum
Plant Physiol.
56
640-644
1975
Desmonostoc muscorum
Manually annotated by BRENDA team
Barash, I.; Mor, H.
Control and properties of onithine transcarbamylase in germinated spores of Geotrichum candidum
Plant Cell Physiol.
13
119-130
1972
Geotrichum candidum
-
Manually annotated by BRENDA team
Legrain, C.; Stalon, V.
Ornithine carbamoyltransferase from Escherichia coli W. Purification, structure and steady-state kinetic analysis
Eur. J. Biochem.
63
289-301
1976
Escherichia coli
Manually annotated by BRENDA team
Penninckx, M.; Simon, J.P.; Wiame, J.M.
Interaction between arginase and L-ornithine carbamoyltransferase in Saccharomyces cerevisiae. Purification of S. cerevisiae enzymes and evidence that these enzymes as well as rat-liver arginase are trimers
Eur. J. Biochem.
49
429-442
1974
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Tam, L.Q.; Patil, S.S.
Mode of action of the toxin from Pseudomonas phaseolicola. II. Mechanism of inhibition of bean ornithine carbamoyltransferase
Plant Physiol.
49
808-812
1972
Phaseolus vulgaris
Manually annotated by BRENDA team
Laliberte, G.; Hellebust, J.A.
Partial characterization of ornithine carbamoyltransferase in three microalgae
Plant Physiol.
93
62-66
1990
Chlorella vulgaris var. autotrophica, Chloroidium saccharophilum, Dunaliella tertiolecta
Manually annotated by BRENDA team
Cohen, N.S.; Cheung, C.W.; Sijuwade, E.; Raijman, L.
Kinetic properties of carbamoyl-phosphate synthase (ammonia) and ornithine carbamoyltransferase in permeabilized mitochondria
Biochem. J.
282
173-180
1992
Rattus norvegicus
-
Manually annotated by BRENDA team
Siocum, R.D.; Richardson, D.P.
Purification and characterization of ornithine transcarbamoylase from pea (Pisum sativum L.)
Plant Physiol.
96
262-268
1991
Pisum sativum
Manually annotated by BRENDA team
Jahn, O.; Sauerstein, J.; Reuter, G.
Characterization of two ornithine carbamoyltransferases from Pseudomonas syringae pv. phaseolicola, the producer of phaseolotoxin
Arch. Microbiol.
147
174-178
1987
Pseudomonas syringae
Manually annotated by BRENDA team
Roubelakis, K.A.; Kliewer, W.M.
Enzymes of Krebs-Henseleit cycle in Vitis vinifera L.
Plant Physiol.
62
337-339
1978
Vitis vinifera
Manually annotated by BRENDA team
De Ruiter, H.; Kollffel, C.
Properties of ornithine carbamoyltransferase from Pisum sativum L.
Plant Physiol.
77
695-699
1985
Pisum sativum
Manually annotated by BRENDA team
Szilagyi, I.; Vargha, G.; Szabo, G.
Ornithine carbamoyltransferase of Streptomyces fradiae: purification and properties
FEMS Microbiol. Lett.
48(1)
115-119
1987
Streptomyces fradiae
-
Manually annotated by BRENDA team
Kurtin, W.E.; Bishop, S.H.; Himoe, A.
Ornithine transcarbamylase: steady-state kinetic properties
Biochem. Biophys. Res. Commun.
45
551-556
1971
Enterococcus faecalis
Manually annotated by BRENDA team
Mori, M.; Aoyagi, K.; Tatibana, M.; Ishikawa, T.; Ishii, H.
N delta-(phosphonacetyl)-L-ornithine, a potent transition state analogue inhibitor of ornithine carbamoyltransferase
Biochem. Biophys. Res. Commun.
76
900-904
1977
Bos taurus
Manually annotated by BRENDA team
Eid, S.; Waly, Y.; Abdelal, A.T.
Separation and properties of two ornithine carbamoyltransferases from Pisum sativum seedlings
Phytochemistry
13
99-102
1974
Pisum sativum
-
Manually annotated by BRENDA team
Abdelal, A.T.H.; Kennedy, E.H.; Nainan, O.
Ornithine transcarbamylase from Salmonella typhimurium: purification, subunit composition, kinetic analysis, and immunological cross-reactivity
J. Bacteriol.
129
1387-1396
1977
Pisum sativum, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Hoogenraad, N.J.; Sutherland, T.M.; Howlett, G.J.
Purification of ornithine transcarbamylase from rat liver by affinity chromatography with immobilized transition-state analog
Anal. Biochem.
101
97-102
1980
Rattus norvegicus
Manually annotated by BRENDA team
Martin, F.; Hirel, B.; Gadal, P.
Purification and properties of ornithine carbamoyltransferase 1 from Alnus glutinosa root nodules
Z. Pflanzenphysiol.
111
413-422
1983
Alnus glutinosa
-
Manually annotated by BRENDA team
Hoogenraad, N.J.
Synthesis and properties of delta-N-(phosphonacetyl)-L-ornithine. A transition-state analog inhibitor of ornithine transcarbamylase
Arch. Biochem. Biophys.
188
137-144
1978
Rattus norvegicus
Manually annotated by BRENDA team
Powers, C.N.; Pierson, D.L.
Stabilization and purification of ornithine transcarbamylase from Neisseria gonorrhoeae
J. Bacteriol.
141
544-549
1980
Neisseria gonorrhoeae
Manually annotated by BRENDA team
Baker, S.R.; Yon, R.J.
Characterization of ornithine carbamoyltransferase from cultured carrot cells of low embryogenic potential
Phytochemistry
22
2171-2174
1983
Daucus carota
-
Manually annotated by BRENDA team
Miller, N.T.; Feibush, B.; Corina, K.; Powers-Lee, S.; Karger, B.L.
High-performance hydrophobic interaction chromatography: purification of rat liver carbamoylphosphate synthetase I and ornithine transcarbamoylase
Anal. Biochem.
148
510-517
1985
Rattus norvegicus
Manually annotated by BRENDA team
Bates, M.; Weiss, R.L.; Clarke, S.
Ornithine transcarbamylase from Neurospora crassa: purification and properties
Arch. Biochem. Biophys.
239
172-183
1985
Neurospora crassa
Manually annotated by BRENDA team
Tsuji, S.
Chicken ornithine transcarbamylase: purification and some properties
J. Biochem.
94
1307-1315
1983
Gallus gallus
Manually annotated by BRENDA team
Templeton, M.D.; Sullivan, P.A.; Sheperd, M.G.
The inhibition of ornithine transcarbamoylase from Escherichia coli W by phaseolotoxin
Biochem. J.
224
379-388
1984
Escherichia coli
Manually annotated by BRENDA team
Neway, J.O.; Switzer, R.L.
Purification, characterization, and physiological function of Bacillus subtilis ornithine transcarbamylase
J. Bacteriol.
155
512-521
1983
Bacillus subtilis, Bacillus subtilis 168
Manually annotated by BRENDA team
Xiong, X.; Anderson, P.M.
Purification and properties of ornithine carbamoyl transferase from liver of Squalus acanthias
Arch. Biochem. Biophys.
270
198-207
1989
Squalus acanthias
Manually annotated by BRENDA team
Lusty, C.J.; Jilka, R.L.; Nietsch, E.H.
Ornithine transcarbamylase of rat liver. Kinetic, physical, and chemical properties
J. Biol. Chem.
254
10030-10036
1979
Rattus norvegicus
Manually annotated by BRENDA team
Marshall, M.; Cohen, P.P.
The essential sulfhydryl group of ornithine transcarbamylases. Reaction with anionic, aromatic disulfides and properties of its cyano derivative
J. Biol. Chem.
255
7291-7295
1980
Bos taurus, Enterococcus faecalis
Manually annotated by BRENDA team
Eisenstein, E.; Osborn, J.C.; Chaiken, I.M.; Hensley, P.
Purification and characterization of ornithine transcarbamoylase from Saccharomyces cerevisiae
J. Biol. Chem.
259
5139-5145
1984
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Pierson, D.L.; Cox, S.L.; Gilbert, B.E.
Human ornithine transcarbamylase. Purification and characterization of the enzyme from normal liver and the liver of a Reyes syndrome patient
J. Biol. Chem.
252
6464-6469
1977
Homo sapiens
Manually annotated by BRENDA team
Kalousek, F.; Francois, B.; Rosenberg, L.E.
Isolation and characterization of ornithine transcarbamylase from normal human liver
J. Biol. Chem.
253
3939-3944
1978
Homo sapiens
Manually annotated by BRENDA team
Koger, J.B.; Howell, R.G.; Kelly, M.; Jones, E.E.
Purification and properties of porcine liver ornithine transcarbamylase
Arch. Biochem. Biophys.
309
293-299
1994
Sus scrofa
Manually annotated by BRENDA team
Tricot, C.; Schmid, S.; Baur, H.; Villeret, V.; Dideberg, O.; Haas, D.; Stalon, V.
Catabolic ornithine carbamoyltransferase of Pseudomonas aeruginosa. Changes of allosteric properties resulting from modifications at the C-terminus
Eur. J. Biochem.
221
555-561
1994
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Ruepp, A.; Mueller, H.N.; Lottspeich, F.; Soppa, J.
Catabolic ornithine transcarbamylase of Halobacterium halobium (salinarium): purification, characterization, sequence determination, and evolution
J. Bacteriol.
177
1129-1136
1995
Halobacterium salinarum (Q48296), Halobacterium salinarum
Manually annotated by BRENDA team
Legrain, C.; Villeret, V.; Roovers, M.; Gigot, D.; Dideberg, O.; Pierard, A.; Glansdorff, N.
Biochemical characterization of ornithine carbamoyltransferase from Pyrococcus furiosus
Eur. J. Biochem.
247
1046-1055
1997
Pyrococcus furiosus
Manually annotated by BRENDA team
Morizono, H.; Tuchman, M.; Rajagopal, B.S.; McCann, M.T.; Listrom, C.D.; Yuan, X.; Venugopal, D.; Barany, G.; Allewell, N.M.
Expression, purification and kinetic characterization of wild-type human ornithine transcarbamylase and a recurrent mutant that produces 'late onset' hyperammonemia
Biochem. J.
322
625-631
1997
Homo sapiens
-
Manually annotated by BRENDA team
Sanchez, R.; Baetens, M.; Van De Casteele, M.; Roovers, M.; Legrain, C.; Glansdorff, N.
Ornithine carbamoyltransferase from the extreme thermophile Thermus thermophilus. Analysis of the gene and characterization of the protein
Eur. J. Biochem.
248
466-474
1997
Thermus thermophilus
Manually annotated by BRENDA team
Lee, Y.; Jun, B.O.; Kim, S.G.; Kwon, Y.M.
Purification of ornithine carbamyltransferase from kidney bean (Phaseolus vulgaris) leaves and comparison of the properties of the enzyme from canavanine-containing and -deficient plants
Planta
205
375-379
1998
Brassica juncea, Canavalia brasiliensis, Canavalia gladiata, Canavalia lineata, Canavalia rosea, Oryctolagus cuniculus, Macropsychanthus megacarpus, Lablab purpureus, Glycine max, Solanum lycopersicum, Mus musculus, Perilla frutescens, Phaseolus vulgaris, Pisum sativum, Solanum melongena, Wisteria floribunda
Manually annotated by BRENDA team
Villeret, V.; Clantin, B.; Tricot, C.; Legrain, C.; Roovers, M.; Stalon, V.; Glansdorff, N.; Van Beeumen, J.
The crystal structure of Pyrococcus furiosus ornithine carbamoyltransferase reveals a key role for oligomerization in enzyme stability at extremely high temperatures
Proc. Natl. Acad. Sci. USA
95
2801-2806
1998
Pyrococcus furiosus
Manually annotated by BRENDA team
Tricot, C.; Villeret, V.; Sainz, G.; Dideberg, O.; Stalon, V.
Allosteric regulation in Pseudomonas aeruginosa catabolic ornithine carbamoyltransferase revisited: association of concerted homotropic cooperative interactions and local heterotropic effects
J. Mol. Biol.
283
695-704
1998
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Sainz, G.; Tricot, C.; Foray, M.F.; Marion, D.; Dideberg, O.; Stalon, V.
Kinetic studies of allosteric catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa
Eur. J. Biochem.
251
528-533
1998
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Sainz, G.; Vicat, J.; Kahn, R.; Tricot, C.; Stalon, V.; Dideberg, O.
Purification, crystallization and preliminary X-ray analysis of catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa
Acta Crystallogr. Sect. D
55
1591-1593
1999
Pseudomonas aeruginosa
-
Manually annotated by BRENDA team
Langley, D.B.; Templeton, M.D.; Fields, B.A.; Mitchell, R.E.; Collyer, C.A.
Mechanism of inactivation of ornithine transcarbamoylase by Nd-(N'-sulfodiaminophosphinyl)-L-ornithine, a true transition state analogue? Crystal structure and implications for catalytic mechanism
J. Biol. Chem.
275
20012-20019
2000
Escherichia coli (P04391), Escherichia coli
Manually annotated by BRENDA team
Lee, Y.; Kwon, Y.M.
Identification of an isoform of ornithine carbamoyltransferase that can effectively utilize canaline as a substrate from the leaves of Canavalia lineata
Plant Sci.
151
145-151
2000
Canavalia lineata
Manually annotated by BRENDA team
Shi, D.; Morizono, H.; Yu, X.; Tong, L.; Allewell, N.M.; Tuchman, M.
Human ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changes
Biochem. J.
354
501-509
2001
Homo sapiens (P00480), Homo sapiens
Manually annotated by BRENDA team
Roovers, M.; Sanchez, R.; Legrain, C.; Glansdorff, N.
Experimental evolution of enzyme temperature activity profile: selection in vivo and characterization of low-temperature-adapted mutants of Pyrococcus furiosus ornithine carbamoyltransferase
J. Bacteriol.
183
1101-1105
2001
Pyrococcus furiosus
Manually annotated by BRENDA team
Lee, Y.; Choi, Y.A.; Hwang, I.D.; Kim, S.G.; Kwon, Y.M.
cDNA cloning of two isoforms of ornithine carbamoyltransferase from Canavalia lineata leaves and the effect of site-directed mutagenesis of the carbamoyl phosphate binding site
Plant Mol. Biol.
46
651-660
2001
Canavalia lineata
Manually annotated by BRENDA team
Bellocco, E.; Di Salvo, C.; Lagana, G.; Leuzzi, U.; Tellone, E.; Kotyk, A.; Galtieri, A.
Purification and properties of ornithine carbamoyltransferase from loggerhead turtle liver
Physiol. Res.
51
151-158
2002
Caretta caretta
Manually annotated by BRENDA team
Bellocco, E.; Di Salvo, C.; Lagana, G.; Galtieri, A.; Ficarra, S.; Kotyk, A.; Leuzzi, U.
Ornithine carbamoyltransferase from Spinacia oleracea: purification and characterization
Biol. Plant.
45
533-538
2002
Spinacia oleracea
-
Manually annotated by BRENDA team
Coque, J.J.R.; Perez-Llarena, F.J.; Enguita, F.J.; Fuente, J.L.; Martin, J.F.; Liras, P.
Characterization of the cmcH genes of Nocardia lactamdurans and Streptomyces clavuligerus encoding a functional 3'-hydroxymethylcephem O-carbamoyltransferase for cephamycin biosynthesis
Gene
162
21-27
1995
Amycolatopsis lactamdurans, Streptomyces clavuligerus
Manually annotated by BRENDA team
Massant, J.; Wouters, J.; Glansdorff, N.
Refined structure of Pyrococcus furiosus ornithine carbamoyltransferase at 1.87 A
Acta Crystallogr. Sect. D
59
2140-2149
2003
Pyrococcus furiosus
Manually annotated by BRENDA team
Templeton, M.D.; Reinhardt, L.A.; Collyer, C.A.; Mitchell, R.E.; Cleland, W.W.
Kinetic analysis of the L-L-ornithine transcarbamoylase from Pseudomonas savastanoi pv. phaseolicola that is resistant to the transition state analogue (R)-N delta-(N'-sulfodiaminophosphinyl)-L-L-ornithine
Biochemistry
44
4408-4415
2005
Pseudomonas savastanoi
Manually annotated by BRENDA team
Xu, Y.; Feller, G.; Gerday, C.; Glansdorff, N.
Metabolic enzymes from psychrophilic bacteria: challenge of adaptation to low temperatures in L-ornithine carbamoyltransferase from Moritella abyssi
J. Bacteriol.
185
2161-2168
2003
Moritella abyssi
Manually annotated by BRENDA team
Lopez-Lopez, K.; Hernandez-Flores, J.L.; Cruz-Aguilar, M.; Alvarez-Morales, A.
In Pseudomonas syringae pv. phaseolicola, expression of the argK gene, encoding the phaseolotoxin-resistant ornithine carbamoyltransferase, is regulated indirectly by temperature and directly by a precursor resembling carbamoylphosphate
J. Bacteriol.
186
146-153
2004
Pseudomonas syringae
Manually annotated by BRENDA team
El Alami, M.; Dubois, E.; Oudjama, Y.; Tricot, C.; Wouters, J.; Stalon, V.; Messenguy, F.
Yeast epiarginase regulation, an enzyme-enzyme activity control: identification of residues of L-ornithine carbamoyltransferase and arginase responsible for enzyme catalytic and regulatory activities
J. Biol. Chem.
278
21550-21558
2003
Saccharomyces cerevisiae
Manually annotated by BRENDA team
De Gregorio, A.; Battistutta, R.; Arena, N.; Panzalorto, M.; Francescato, P.; Valentini, G.; Bruno, G.; Zanotti, G.
Functional and structural characterization of ovine ornithine transcarbamoylase
Org. Biomol. Chem.
1
3178-3185
2003
Ovis aries
Manually annotated by BRENDA team
Baur, H.; Stalon, V.; Falmagne, P.; Luethi, E.; Haas, D.
Primary and quaternary structure of the catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa. Extensive sequence homology with the anabolic ornithine carbamoyltransferases of Escherichia coli
Eur. J. Biochem.
166
111-117
1987
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Itoh, Y.; Soldati, L.; Stalon, V.; Falmagne, P.; Terawaki, Y.; Leisinger, T.; Haas, D.
Anabolic ornithine carbamoyltransferase of Pseudomonas aeruginosa: nucleotide sequence and transcriptional control of the argF structural gene
J. Bacteriol.
170
2725-2734
1988
Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO
Manually annotated by BRENDA team
Baur, H.; Tricot, C.; Stalon, V.; Haas, D.
Converting catabolic ornithine carbamoyltransferase to an anabolic enzyme
J. Biol. Chem.
265
14728-14731
1990
Escherichia coli, Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO532
Manually annotated by BRENDA team
Marcq, S.; Diaz-Ruano, A.; Charlier, P.; Dideberg, O.; Tricot, C.; Pierard, A.; Stalon, V.
Molecular size and symmetry of Pseudomonas aeruginosa catabolic ornithine carbamoyltransferase. An X-ray crystallography analysis
J. Mol. Biol.
220
9-12
1991
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Haas, D.; Evans, R.
Genetic and physiological characterization of Pseudomonas aeruginosa mutants affected in the catabolic ornithine carbamoyltransferase
J. Bacteriol.
139
713 - 720
1979
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Shi, D.; Morizono, H.
1.85-A resolution crystal structure of human ornithine transcarbamoylase complexed with N-phosphoacetyl-L-ornithine
J. Biol. Chem.
273
34247-34254
1998
Homo sapiens
Manually annotated by BRENDA team
Timm, J.; Van Rompaey, I.; Tricot, C.; Massaer, M.; Haeseleer, F.; Fauconnier, A.; Stalon, V.; Bollen, A.; Jacobs, P.
Molecular cloning, characterization and purification of ornithine carbamoyltransferase from Mycobacterium bovis BCG
Mol. Gen. Genet.
234
475-480
1992
Mycobacterium tuberculosis variant bovis
Manually annotated by BRENDA team
Villeret, V.; Tricot, C.; Stalon, V.; Dideberg, O.
Crystal structure of Pseudomonas aeruginosa catabolic ornithine transcarbamoylase at 3.0-A resolution: a different oligomeric organization in the transcarbamoylase family
Proc. Natl. Acad. Sci. USA
92
10762-10766
1995
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Murayama, H.; Ikemoto, M.; Fukuda, Y.; Tsunekawa, S.; Nagata, A.
Serum level of ornithine carbamoyltransferase is influenced by the state of Kupffer cells
Clin. Chim. Acta
380
170-174
2007
Rattus norvegicus
Manually annotated by BRENDA team
Yamaguchi, S.; Brailey, L.L.; Morizono, H.; Bale, A.E.; Tuchman, M.
Mutations and polymorphisms in the human ornithine transcarbamylase (OTC) gene
Hum. Mutat.
27
626-632
2006
Homo sapiens
Manually annotated by BRENDA team
Beck, B.; Ciszek, M.; Polaniak, R.; Beyga, Z.; Krol, W.; Drozdz, M.; Shani, J.
The activity of ornithine transcarbamoylase and arginase during mechanical jaundice in the rat model
J. Surg. Res.
126
19-26
2005
Rattus norvegicus
Manually annotated by BRENDA team
Spano, G.; Massa, S.; Arena, M.E.; Manca de Nadra, M.C.
Arginine metabolism in wine Lactobacillus plantarum: in vitro activities of the enzymes arginine deiminase (ADI) and ornithine transcarbamilase (OTCase).
Ann. Microbiol.
57
67-70
2007
Lactiplantibacillus plantarum, Lactiplantibacillus plantarum Lp60
Manually annotated by BRENDA team
de Las Rivas, B.; Rodriguez, H.; Angulo, I.; Munoz, R.; Mancheno, J.M.
Overexpression, purification, crystallization and preliminary structural studies of catabolic ornithine transcarbamylase from Lactobacillus hilgardii
Acta Crystallogr. Sect. F
63
563-567
2007
Lentilactobacillus hilgardii, Lentilactobacillus hilgardii CETC 4786 / ATCC 8290
Manually annotated by BRENDA team
Sankaranarayanan, R.; Cherney, M.M.; Cherney, L.T.; Garen, C.R.; Moradian, F.; James, M.N.
The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzymes catalytic mechanism
J. Mol. Biol.
375
1052-1063
2008
Mycobacterium tuberculosis (P9WIT9), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIT9)
Manually annotated by BRENDA team
Murayama, H.; Ikemoto, M.; Fukuda, Y.; Nagata, A.
Superiority of serum type-I arginase and ornithine carbamyltransferase in the detection of toxicant-induced acute hepatic injury in rats
Clin. Chim. Acta
391
31-35
2008
Rattus norvegicus
Manually annotated by BRENDA team
Murayama, H.; Ikemoto, M.; Hamaoki, M.
Ornithine carbamyltransferase is a sensitive marker for alcohol-induced liver injury
Clin. Chim. Acta
401
100-104
2009
Rattus norvegicus
Manually annotated by BRENDA team
Quental, R.; Azevedo, L.; Rubio, V.; Diogo, L.; Amorim, A.
Molecular mechanisms underlying large genomic deletions in ornithine transcarbamylase (OTC) gene
Clin. Genet.
75
457-464
2009
Homo sapiens
Manually annotated by BRENDA team
Napolitano, D.R.; Pollock, N.; Kashino, S.S.; Rodrigues, V.; Campos-Neto, A.
Identification of Mycobacterium tuberculosis ornithine carboamyltransferase in urine as a possible molecular marker of active pulmonary tuberculosis
Clin. Vaccine Immunol.
15
638-643
2008
Mycobacterium tuberculosis (P9WIT9), Mycobacterium tuberculosis H37Rv (P9WIT9)
Manually annotated by BRENDA team
Monzani, P.S.; Moraes, G.
Urea cycle enzymes through the development of pacu (Piaractus mesopotamicus): the role of ornithine carbamoyl transferase
Fish Physiol. Biochem.
34
139-149
2008
Piaractus mesopotamicus
Manually annotated by BRENDA team
Barreca, D.; Bellocco, E.; Lagana, G.; Leuzzi, U.; Magazu, S.; Migliardo, F.; Galtieri, A.
Spectroscopic investigation of structure-breakers and structure-makers on ornithine carbamoyltransferase
Food Chem.
106
1438-1442
2008
Alopias vulpinus
Manually annotated by BRENDA team
Tokushige, K.; Hashimoto, E.; Noto, H.; Yatsuji, S.; Tobari, M.; Torii, N.; Taniai, M.; Shiratori, K.; Murayama, H.
Clinical significance of serum ornithine carbamoyltransferase in patients with non-alcoholic steatohepatitis
Hepatol. Res.
39
939-943
2009
Homo sapiens
Manually annotated by BRENDA team
Yu, W.; Lin, Y.; Yao, J.; Huang, W.; Lei, Q.; Xiong, Y.; Zhao, S.; Guan, K.L.
Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals
J. Biol. Chem.
284
13669-13675
2009
Homo sapiens
Manually annotated by BRENDA team
Laberge, T.; Walsh, P.J.; McDonald, M.D.
Effects of crowding on ornithine-urea cycle enzyme mRNA expression and activity in gulf toadfish (Opsanus beta)
J. Exp. Biol.
212
2394-2402
2009
Opsanus beta
Manually annotated by BRENDA team
de Las Rivas, B.; Fox, G.C.; Angulo, I.; Ripoll, M.M.; Rodriguez, H.; Munoz, R.; Mancheno, J.M.
Crystal structure of the hexameric catabolic ornithine transcarbamylase from Lactobacillus hilgardii: Structural insights into the oligomeric assembly and metal binding
J. Mol. Biol.
393
425-434
2009
Lentilactobacillus hilgardii (Q8G998), Lentilactobacillus hilgardii
Manually annotated by BRENDA team
Bensemain, F.; Hot, D.; Ferreira, S.; Dumont, J.; Bombois, S.; Maurage, C.; Huot, L.; Hermant, X.; Levillain, E.; Hubans, C.; Hansmannel, F.; Chapuis, J.; Hauw, J.; Schraen, S.; Lemoine, Y.; Buee, L.; Berr, C.; Mann, D.; Pasquier, F.; Amouyel, P.; Lambert, J.C.
Evidence for induction of the ornithine transcarbamylase expression in Alzheimers disease
Mol. Psychiatry
14
106-116
2009
Homo sapiens
Manually annotated by BRENDA team
Mishima, E.; Hosokawa, A.; Imaizumi-Anraku, H.; Saito, K.; Kawaguchi, M.; Saeki, K.
Requirement for Mesorhizobium loti ornithine transcarbamoylase for successful symbiosis with Lotus japonicus as revealed by an unexpected long-range genome deletion
Plant Cell Physiol.
49
301-313
2008
Mesorhizobium loti (Q98BB6), Mesorhizobium loti
Manually annotated by BRENDA team
Wang, Q.; Xia, J.; Guallar, V.; Krilov, G.; Kantrowitz, E.R.
Mechanism of thermal decomposition of carbamoyl phosphate and its stabilization by aspartate and ornithine transcarbamoylases
Proc. Natl. Acad. Sci. USA
105
16918-16923
2008
Escherichia coli
Manually annotated by BRENDA team
Galkin, A.; Kulakova, L.; Wu, R.; Gong, M.; Dunaway-Mariano, D.; Herzberg, O.
X-ray structure and kinetic properties of ornithine transcarbamoylase from the human parasite Giardia lamblia
Proteins Struct. Funct. Bioinform.
76
1049-1053
2009
Giardia intestinalis
Manually annotated by BRENDA team
Sulkowska, J.I.; Sulkowski, P.; Szymczak, P.; Cieplak, M.
Stabilizing effect of knots on proteins
Proc. Natl. Acad. Sci. USA
105
19714-19719
2008
Homo sapiens (P00480)
Manually annotated by BRENDA team
Shabalin, I.G.; Porebski, P.J.; Cooper, D.R.; Grabowski, M.; Onopriyenko, O.; Grimshaw, S.; Savchenko, A.; Chruszcz, M.; Minor, W.
Structure of anabolic ornithine carbamoyltransferase from Campylobacter jejuni at 2.7 A resolution
Acta Crystallogr. Sect. F
68
1018-1024
2012
Campylobacter jejuni (Q9PNU6), Campylobacter jejuni, Campylobacter jejuni NCTC 11168 (Q9PNU6)
Manually annotated by BRENDA team
Schneider, J.; Eberhardt, D.; Wendisch, V.F.
Improving putrescine production by Corynebacterium glutamicum by fine-tuning ornithine transcarbamoylase activity using a plasmid addiction system
Appl. Microbiol. Biotechnol.
95
169-178
2012
Corynebacterium glutamicum
Manually annotated by BRENDA team
Diaz-Munoz, M.; Hernandez-Munoz, R.
Molecular and biochemical features of the mitochondrial enzyme ornithine transcarbamylase: a possible new role as a signaling factor
Curr. Med. Chem.
17
2253-2260
2010
Homo sapiens
Manually annotated by BRENDA team
Lopes-Marques, M.; Pereira-Castro, I.; Amorim, A.; Azevedo, L.
Characterization of the human ornithine transcarbamylase 3 untranslated regulatory region
DNA Cell Biol.
31
427-433
2012
Homo sapiens (P00480), Homo sapiens
Manually annotated by BRENDA team
Tang, N.; Wang, Y.; Wang, X.; Zhou, L.; Zhang, F.; Li, X.; Chen, Y.
Stable overexpression of arginase I and ornithine transcarbamylase in HepG2 cells improves its ammonia detoxification
J. Cell. Biochem.
113
518-527
2012
Homo sapiens
Manually annotated by BRENDA team
Chen, J.; Cheng, C.; Xia, Y.; Zhao, H.; Fang, C.; Shan, Y.; Wu, B.; Fang, W.
Lmo0036, an ornithine and putrescine carbamoyltransferase in Listeria monocytogenes, participates in arginine deiminase and agmatine deiminase pathways and mediates acid tolerance
Microbiology
157
3150-3161
2011
Listeria monocytogenes, Listeria monocytogenes 10403S
Manually annotated by BRENDA team
Skrbic, T.; Micheletti, C.; Faccioli, P.
The role of non-native interactions in the folding of knotted proteins
PLoS Comput. Biol.
8
e1002504
2012
Methanocaldococcus jannaschii
Manually annotated by BRENDA team
Polo, L.M.; Gil-Ortiz, F.; Cantin, A.; Rubio, V.
New insight into the transcarbamylase family: the structure of putrescine transcarbamylase, a key catalyst for fermentative utilization of agmatine
PLoS ONE
7
e31528
2012
Enterococcus faecalis (Q837U7)
Manually annotated by BRENDA team
Massant, J.; Glansdorff, N.
Metabolic channelling of carbamoyl phosphate in the hyperthermophilic archaeon Pyrococcus furiosus: dynamic enzyme-enzyme interactions involved in the formation of the channelling complex
Biochem. Soc. Trans.
32
306-309
2004
Pyrococcus furiosus
Manually annotated by BRENDA team
Roovers, M.; Hethke, C.; Legrain, C.; Thomm, M.; Glansdorff, N.
Isolation of the gene encoding Pyrococcus furiosus ornithine carbamoyltransferase and study of its expression profile in vivo and in vitro
Eur. J. Biochem.
247
1038-1045
1997
Pyrococcus furiosus (Q51742), Pyrococcus furiosus
Manually annotated by BRENDA team
Purcarea, C.; Evans, D.R.; Herve, G.
Channeling of carbamoyl phosphate to the pyrimidine and arginine biosynthetic pathways in the deep sea hyperthermophilic archaeon Pyrococcus abyssi
J. Biol. Chem.
274
6122-6129
1999
Pyrococcus abyssi (O93656), Pyrococcus abyssi
Manually annotated by BRENDA team
Van de Casteele, M.; Demarez, M.; Legrain, C.; Glansdorff, N.; Pierard, A.
Pathways of arginine biosynthesis in extreme thermophilic archaeo- and eubacteria
J. Gen. Microbiol.
136
1177-1183
1990
Pyrococcus furiosus, Saccharolobus solfataricus, Saccharolobus solfataricus P1
-
Manually annotated by BRENDA team
Barreca, D.; Lagana, G.; Ficarra, S.; Tellone, E.; Leuzzi, U.; Galtieri, A.; Bellocco, E.
Ornithine carbamoyltransferase unfolding states in the presence of urea and guanidine hydrochloride
Appl. Biochem. Biotechnol.
172
854-866
2014
Alopias vulpinus
Manually annotated by BRENDA team
Sundaresan, R.; Ebihara, A.; Kuramitsu, S.; Yokoyama, S.; Kumarevel, T.; Ponnuraj, K.
Crystal structure analysis of ornithine transcarbamylase from Thermus thermophilus - HB8 provides insights on the plasticity of the active site
Biochem. Biophys. Res. Commun.
465
174-179
2015
Thermus thermophilus (Q5SJ15), Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SJ15)
Manually annotated by BRENDA team
Qiao, J.; Zhou, L.; Jin, R.; Yao, G.
Effect of carbon tetrachloride on total bile acid, alpha-glutathione-S-transferase, purinenucleoside phosphorylase and ornithine carbamyl transferase in serum of rats during early liver injury
Chin. J. Pharmacol. Toxicol.
27
650-656
2013
Rattus norvegicus, Rattus norvegicus Wistar
-
Manually annotated by BRENDA team
Zhao, W.; Zhou, X.; Lu, Y.; Peng, Y.; Lin, Z.; Lin, J.; Yang, L.; Yin, X.; Zhao, D.
Mycobacterium bovis ornithine carbamoyltransferase, MB1684, induces proinflammatory cytokine gene expression by activating NF-kappaB in macrophages
DNA Cell Biol.
33
311-319
2014
Mycobacterium tuberculosis variant bovis (P0A5M9), Mycobacterium tuberculosis variant bovis
Manually annotated by BRENDA team
Furihata, T.; Aizawa, T.; Koibuchi, A.; Zhu, M.; Yamasaki, Y.; Shibuya, M.; Chiba, K.
Characterization of release profile of ornithine carbamoyltransferase from primary rat hepatocytes treated with hepatotoxic drugs: implications for its unique potential as a drug-induced liver injury biomarker
Drug Metab. Pharmacokinet.
31
102-105
2016
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Chen, L.; Li, P.; Deng, Z.; Zhao, C.
Ornithine transcarbamylase ArgK plays a dual role for the self-defense of phaseolotoxin producing pseudomonas syringae pv. Phaseolicola
Sci. Rep.
5
12892-12901
2015
Pseudomonas savastanoi pv. phaseolicola (P68747), Pseudomonas savastanoi pv. phaseolicola 1448A (P68747)
Manually annotated by BRENDA team
Massant, J.; Verstreken, P.; Durbec, V.; Kholti, A.; Legrain, C.; Beeckmans, S.; Cornelis, P.; Glansdorff, N.
Metabolic channeling of carbamoyl phosphate, a thermolabile intermediate Evidence for physical interaction between carbamate kinase-like carbamoyl-phosphate synthetase and ornithine carbamoyltransferase from the hyperthermophile Pyrococcus furiosus
J. Biol. Chem.
277
18517-18522
2002
Pyrococcus furiosus (Q51742), Pyrococcus furiosus
Manually annotated by BRENDA team
Sriramoju, M.K.; Yang, T.J.; Hsu, S.D.
Comparative folding analyses of unknotted versus trefoil-knotted ornithine transcarbamylases suggest stabilizing effects of protein knots
Biochem. Biophys. Res. Commun.
503
822-829
2018
Escherichia coli
Manually annotated by BRENDA team
Hao, N.; Mu, J.; Hu, N.; Xu, S.; Shen, P.; Yan, M.; Li, Y.; Xu, L.
Implication of ornithine acetyltransferase activity on L-ornithine production in Corynebacterium glutamicum
Biotechnol. Appl. Biochem.
63
15-21
2016
no activity in Corynebacterium glutamicum 1006
Manually annotated by BRENDA team
Ohnishi, M.; Higuchi, A.; Matsumura, H.; Arakawa, Y.; Nakamura, H.; Nirei, K.; Yamamoto, T.; Yamagami, H.; Ogawa, M.; Gotoda, T.; Matsuoka, S.; Nakajima, N.; Sugitani, M.; Moriyama, M.; Murayama, H.
Involvement of ornithine carbamoyltransferase in the progression of chronic hepatitis C and liver cirrhosis
Int. J. Med. Sci.
14
629-638
2017
Homo sapiens
Manually annotated by BRENDA team
Wang, Y.; Yi, L.; Sun, L.; Liu, Y.; Wen, W.; Li, X.; Mei, J.; Ding, K.; Wu, T.; Grenier, D.
Identification and characterization of a Streptococcus suis immunogenic ornithine carbamoytransferase involved in bacterial adherence
J. Microbiol. Immunol. Infect.
53
234-239
2020
Streptococcus suis, Streptococcus suis ZY05719
Manually annotated by BRENDA team
Bernstein, H.G.; Dobrowolny, H.; Keilhoff, G.; Steiner, J.
In human brain ornithine transcarbamylase (OTC) immunoreactivity is strongly expressed in a small number of nitrergic neurons
Metab. Brain Dis.
32
2143-2147
2017
Homo sapiens
Manually annotated by BRENDA team
He, L.; Cai, X.; Cheng, S.; Zhou, H.; Zhang, Z.; Ren, J.; Ren, F.; Yang, Q.; Tao, N.; Chen, J.
Ornithine transcarbamylase downregulation is associated with poor prognosis in hepatocellular carcinoma
Oncol. Lett.
17
5030-5038
2019
Homo sapiens
Manually annotated by BRENDA team
Ngu, L.; Winters, J.N.; Nguyen, K.; Ramos, K.E.; DeLateur, N.A.; Makowski, L.; Whitford, P.C.; Ondrechen, M.J.; Beuning, P.J.
Probing remote residues important for catalysis in Escherichia coli ornithine transcarbamoylase
PLoS ONE
15
e0228487
2020
Escherichia coli (P04391), Escherichia coli
Manually annotated by BRENDA team