Reference on EC 2.2.1.6 - acetolactate synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ryan, E.D.; Kohlhaw, G.B.
Subcellular localization of isoleucine-valine biosynthetic enzymes in yeast
J. Bacteriol.
120
631-637
1974
Saccharomyces cerevisiae
Singh, B.K.; Stidham, M.A.; Shaner, D.L.
Separation and characterization of two forms of acetohydroxy acid synthase from black mexican sweet corn cells
J. Chromatogr.
444
251-261
1988
Zea mays
-
Singh, B.K.; Stidham, M.A.; Shaner, D.L.
Assay of acetohydroxyacid synthase
Anal. Biochem.
171
173-179
1988
Zea mays
Mazur, B.J.; Chui, C.F.; Smith, J.K.
Isolation and characterization of plant genes coding for acetolactate synthase, the target enzyme for two classes of herbicides
Plant Physiol.
85
1110-1117
1987
Arabidopsis thaliana, Nicotiana tabacum
Riccardi, G.; DeRossi, E.; Nielsen, E.; DeFelice, M.
Detection and characterization of acetohydroxy acid synthase in Spirulina platensis
FEMS Microbiol. Lett.
49
13-17
1988
Arthrospira platensis
-
Xing, R.; Whitman, W.B.
Sulfometuron methyl-sensitive and -resistant acetolactate synthases of the archaebacteria Methanococcus spp.
J. Bacteriol.
169
4486-4492
1987
Methanococcus aeolicus, Methanococcus maripaludis, Methanothermococcus thermolithotrophicus, Methanococcus voltae
Barak, Z.; Chipman, D.M.; Gollop, N.
Physiological implications of the specificity of acetohydroxy acid synthase isozymes of enteric bacteria
J. Bacteriol.
169
3750-3756
1987
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Muhitch, M.J.; Shaner, D.L.; Stidham, M.A.
Imidazolinones and acetohydroxyacid synthase from higher plants
Plant Physiol.
83
451-456
1987
Zea mays
Huppatz, J.L.; Casida, J.E.
Acetohydroxyacid synthase inhibitors: N-phthalyl-L-valine and related compounds
Z. Naturforsch. C
40
652-656
1985
Zea mays
Schloss, J.V.; VanDyk, D.E.; Vasta, J.F.; Kutny, R.M.
Purification and properties of Salmonella typhimurium acetolactate synthase isozyme II from Escherichia coli HB101/pDU9
Biochemistry
24
4952-4959
1985
Salmonella enterica subsp. enterica serovar Typhimurium
Shaner, D.L.; Anderson, P.C.; Stidham, M.A.
Imidazolinones. Potent inhibitors of acetohydroxyacid synthase
Plant Physiol.
76
545-546
1984
Zea mays
Eoyang, L.; Silverman, P.M.
Purification and subunit composition of acetohydroxyacid synthase I from Escherichia coli K-12
J. Bacteriol.
157
184-189
1984
Escherichia coli
Gollop, N.; Chipman, D.M.; Barak, Z.
Inhibition of acetohydroxy acid synthase by leucine
Biochim. Biophys. Acta
748
34-39
1983
Escherichia coli
Oda, Y.; Nakano, Y.; Kitaoka, S.
Properties and regulation of valine-sensitive acetolactate synthase from mitochondria of Euglena gracilis
J. Gen. Microbiol.
128
1211-1216
1982
Euglena gracilis
-
DeFelice, M.; Lago, C.T.; Squires, C.H.; Calvo, J.M.
Acetohydroxy acid synthase isoenzymes of Escherichia coli K12 and Salmonella typhimurium
Ann. Microbiol.
133A
251-256
1982
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
-
Grimminger, H.; Umbarger, H.E.
Acetohydroxy acid synthase I of Escherichia coli: purification and properties
J. Bacteriol.
137
846-853
1979
Escherichia coli
Semeraro, R.J.; Wixom, R.L.
Studies in valine biosynthesis. X. The acetolactate synthase from Rhodopseudomonas spheroides
Microbios
20
7-14
1977
Cereibacter sphaeroides
DeFelice, M.; Squires, C.; Levinthal, M.
A comparative study of the acetohydroxy acid synthase isoenzymes of Escherichia coli K-12
Biochim. Biophys. Acta
541
9-17
1978
Escherichia coli
-
Asada, Y.; Okuzawa, Y.; Yamaguchi, K.
The existence of three types of acetohydroxy acid synthetase in an isoleucine-requiring mutant of Aerobacter aerogenes
Biochim. Biophys. Acta
429
1029-1035
1976
Klebsiella aerogenes, Klebsiella aerogenes 01. Dez
Holtzclaw, W.D.; Chapman, L.F
Degradative acetolactate synthase of Bacillus subtilis: purification and properties
J. Bacteriol.
121
917-922
1975
Bacillus subtilis
Kuwana, H.; Date, M.
Solubilization of valine-sensitive acetohydroxy acid synthetase from Neurospora mitochondria
J. Biochem.
77
257-259
1975
Neurospora crassa
Arfin, S.M.; Koziell, D.A.
Acetolactate synthase of Pseudomonas aeruginosa I. Purification and allosteric properties
Biochim. Biophys. Acta
321
348-355
1973
Pseudomonas aeruginosa
Arfin, S.M.; Koziell, D.A.
Acetolactate synthase of Pseudomonas aeruginosa. II. Evidence for the presence of two nonidentical subunits
Biochim. Biophys. Acta
321
356-360
1973
Pseudomonas aeruginosa
Chin, N.W.; Trela, J.M.
Comparison of acetohydroxy-acid synthetases from two extreme thermophilic bacteria
J. Bacteriol.
114
674-678
1973
Bacillus sp. (in: Bacteria), Thermus aquaticus
McDonald, R.A.; Satyanarayana, T.; Kaplan, J.G.
Biosynthesis of branched-chain amino acids in Schizosaccharomyces pombe: properties of acetohydroxy acid synthetase
J. Bacteriol.
114
332-340
1973
Schizosaccharomyces pombe
Glatzer, L.; Eakin, E.; Wagner, R.P.
Acetohydroxy acid synthetase with a pH optimum of 7.5 from Neurospora crassa mitochondria: characterization and partial purification
J. Bacteriol.
112
453-464
1972
Neurospora crassa
Huseby, N.E.; Christensen, T.B.; Olsen, B.R.; Strmer, F.C.
The pH6 acetolactate-forming enzyme from Aerobacter aerogenes. Subunit structure
Eur. J. Biochem.
20
209-214
1971
Klebsiella aerogenes
Strmer, F.C.; Solberg, Y.; Hovig, T.
The pH 6 acetolactate-forming enzyme from Aerobacter aerogenes. Molecular properties
Eur. J. Biochem.
10
251-260
1969
Klebsiella aerogenes
O'Neill, J.P.; Freundlich, M.
Two forms of biosynthetic acetohydroxy acid synthetase in Salmonella typhimurium
Biochem. Biophys. Res. Commun.
48
437-443
1972
Salmonella enterica subsp. enterica serovar Typhimurium
Blatt, J.M.; Pledger, W.J.; Umbarger, H.E.
Isoleucine and valine metabolism in Escherichia coli. XX. Multiple forms of acetohydroxy acid synthetase
Biochem. Biophys. Res. Commun.
48
444-450
1972
Escherichia coli
Squires, C.H.; DeFelice, M.; Devereux, J.; Calvo, J.M.
Molecular structure of ilvIH and its evolutionary relationship to ilvG in Escherichia coli K12
Nucleic Acids Res.
11
5299-5313
1983
Escherichia coli
Chang, A.K.; Duggleby, R.G.
Expression, purification and characterization of Arabidopsis thaliana acetohydroxyacid synthase
Biochem. J.
327
161-169
1997
Arabidopsis thaliana
-
Chang, A.K.; Duggleby, R.G.
Herbicide-resistant forms of Arabidopsis thaliana acetohydroxyacid synthase: characterization of the catalytic properties and sensitivity to inhibitors of four defined mutants
Biochem. J.
333
765-777
1998
Arabidopsis thaliana
-
Hill, C.H.; Pang, S.S.; Duggleby, R.G.
Purification of Escherichia coli acetohydroxyacid synthase isoenzyme II and reconstitution of active enzyme from its individual pure subunits
Biochem. J.
327
891-898
1997
Escherichia coli
Delfourne, E.; Bastide, J.; Badon, R.; Rachon, A.; Genix, P.
Specificity of plant acetohydroxyacid synthase: formation of products and inhibition by herbicides
Plant Physiol. Biochem.
32
473-477
1994
Hordeum vulgare, Spinacia oleracea
-
Roux, C.; Delfourne, E.; Bastide, J.
Activation and inhibition of maize acetohydroxyacid synthase by thiamine analogues
Plant Physiol. Biochem.
34
293-299
1996
Zea mays
-
Bekkaoui, F.; Schorr, P.; Crosby, W.L.
Acetolactate synthase from Brassica napus: immunological characterization and quarternary structure of the native enzyme
Physiol. Plant.
88
475-484
1993
Brassica napus
-
Southan, M.D.; Copeland, L.
Physical and kinetic properties of acetohydroxyacid synthase from wheat leaves
Physiol. Plant.
98
824-832
1996
Triticum aestivum
-
Singh, B.; Szamosi, I.; Hand, J.M.; Misra, R.
Arabidopsis acetohydroxyacid synthase expressed in Escherichia coli is insensitive to the feedback inhibitors
Plant Physiol.
99
812-815
1992
Arabidopsis thaliana
Durner, J.; Bger, P.
Acetolactate synthase from barley (Hordeum vulgare L.): purification and partial characterization
Z. Naturforsch. C
43
850-856
1988
Hordeum vulgare
-
Kil, M.W.; Chang, S.I.
Expression in Escherichia coli, purification, and characterization of the tobacco sulfonylurea herbicide-resistant recombinant acetolactate synthase and its interaction with the triazolopyrimidine herbicides
J. Biochem. Mol. Biol.
31
287-295
1998
Nicotiana tabacum
-
Joo, H.S.; Kim, S.S.
Purification and characterization of the catabolic alpha-acetolactate synthase from Serratia marcescens
J. Biochem. Mol. Biol.
31
37-43
1998
Serratia marcescens
-
Yang, J.; Kim, S.
Effect of pyrimidylsalicylate on the valine sensitive acetolactate synthase purified from Serratia marcescens
J. Biochem. Mol. Biol.
30
13-17
1997
Serratia marcescens
-
Maier, W.; Luthra, R.; Grger, D.
Acetohydroxyacid synthase from Claviceps purpurea: partial purification and characterization
J. Basic Microbiol.
29
483-490
1989
Claviceps purpurea
-
Poulsen, C.; Stougaard, P.
Purification and properties of Saccharomyces cerevisiae acetolactate synthase from recombinant Escherichia coli
Eur. J. Biochem.
185
433-439
1989
Saccharomyces cerevisiae
Chong, C.K.; Chang, S.I.; Choi, J.D.
Purification and characterization of acetolactate synthase from barley
J. Biochem. Mol. Biol.
30
274-279
1997
Hordeum vulgare
-
Eoyang, L.; Silverman, P.M.
Purification and assays of acetolactate synthase I from Escherichia coli K-12
Methods Enzymol.
166
435-445
1988
Escherichia coli
Phalip, V.; Schmitt, P.; Divies, C.
Purification and characterization of the catabolic alpha-acetolactate synthase from Leuconostoc mesenteroides subsp. cremonis
Curr. Microbiol.
31
316-321
1995
Leuconostoc mesenteroides
-
Carroll, N.M.; Sheehan, D.; Cogan, T.M.
Purification of alpha-acetolactate synthase from Leuconostoc lactis NCW1
Biochem. Soc. Trans.
23
366S
1995
Leuconostoc lactis, Leuconostoc lactis NCW1
Chang, S.I.; Kang, M.K.; Choi, J.D.; Namgoong, S.K.
Soluble overexpression in Escherichia coli, and purification and characterization of wild-type recombinant tobacco acetolactate synthase
Biochem. Biophys. Res. Commun.
234
549-553
1997
Nicotiana tabacum
Xing, R.; Whitman, W.B.
Purification and characterization of the oxygen-sensitive acetohydroxy acid synthase from the archaebacterium Methanococcus aeolicus
J. Bacteriol.
176
1207-1213
1994
Methanococcus aeolicus
Snoep, J.L.; Teixeira de Mattos, M.J.; Starrenburg, M.J.C.; Hugenholtz, J.
Isolation, characterization, and physiological role of the pyruvate dehydrogenase complex and alpha-acetolactate synthase of Lactococcus lactis subsp. lactis bv. diacetylactis
J. Bacteriol.
174
4838.-4841
1992
Lactococcus lactis
Yang, J.H.; Kim, S.S.
Purification and characterization of the valine sensitive acetolactate synthase from Serratia marcescens ATCC 25419
Biochim. Biophys. Acta
1157
178-184
1993
Serratia marcescens
Kisrieva, Y.S.; Serebrennikov, V.M.; Eneiskaya, E.V.; Zagustina, N.A.; Bezborodov, A.M.
Isolation, purification, and characterization of acetolactate synthase from a Lactococcus lactis culture
Appl. Biochem. Microbiol.
37
201-205
2001
Lactococcus lactis
-
Kopecky, J.; Janata, J.; Pospisil, S.; Felsberg, J.; Spizek, J.
Mutations in two distinct regions of acetolactate synthase regulatory subunit from Streptomyces cinnamonensis result in the lack of sensitivity to end-product inhibition
Biochem. Biophys. Res. Commun.
266
162-166
1999
Streptomyces virginiae (Q9RFQ7)
Shin, H.J.; Chong, C.K.; Chang, S.I.; Choi, J.D.
Structural and functional role of cysteinyl residues in tobacco acetolactate synthase
Biochem. Biophys. Res. Commun.
271
801-806
2000
Nicotiana tabacum
Oh, K.J.; Park, E.J.; Yoon, M.Y.; Han, T.R.; Choi, J.D.
Roles of histidine residues in tobacco acetolactate synthase
Biochem. Biophys. Res. Commun.
282
1237-1243
2001
Nicotiana tabacum
Yoon, T.Y.; Chung, S.M.; Chang, S.I.; Yoon, M.Y.; Hahn, T.R.; Choi, J.D.
Roles of lysine 219 and 255 residues in tobacco acetolactate synthase
Biochem. Biophys. Res. Commun.
293
433-439
2002
Nicotiana tabacum
Kim, J.; Beak, D.G.; Kim, Y.T.; Choi, J.D.; Yoon, M.Y.
Effects of deletions at the C-terminus of tobacco acetohydroxyacid synthase on the enzyme activity and cofactor binding
Biochem. J.
384
59-68
2004
Nicotiana tabacum
Pang, S.S.; Duggleby, R.G.
Expression, purification, characterization, and reconstitution of the large and small subunits of yeast acetohydroxyacid synthase
Biochemistry
38
5222-5231
1999
Saccharomyces cerevisiae
Bar-Ilan, A.; Balan, V.; Tittmann, K.; Golbik, R.; Vyazmensky, M.; Hubner, G.; Barak, Z.; Chipman, D.M.
Binding and activation of thiamin diphosphate in acetohydroxyacid synthase
Biochemistry
40
11946-11954
2001
Escherichia coli
Le, D.T.; Yoon, M.Y.; Tae Kim, Y.; Choi, J.D.
Two consecutive aspartic acid residues conferring herbicide resistance in tobacco acetohydroxy acid synthase
Biochim. Biophys. Acta
1749
103-112
2005
Nicotiana tabacum
Lee, B.W.; Choi, J.D.; Yoon, M.Y.
Steady-state kinetics of the recombinant acetohydroxy acid synthase from tobacco
Bull. Korean Chem. Soc.
23
765-768
2002
Nicotiana tabacum
-
Hwang, J.; Kim, J.; Kim, Y.t.; Choi, J.d.; Yoon, M.y.
Lag time of the recombinant acetohydroxy acid synthase from tobacco
Bull. Korean Chem. Soc.
24
1856-1858
2003
Nicotiana tabacum
-
Carroll, N.M.; Ross, R.P.; Kelly, S.M.; Price, N.C.; Sheehan, D.; Cogan, T.M.
Characterization of recombinant acetolactate synthase from Leuconostoc lactis NCW1
Enzyme Microb. Technol.
25
61-67
1999
Leuconostoc lactis, Leuconostoc lactis NCW1
-
Yoon, M.Y.; Hwang, J.H.; Choi, M.K.; Baek, D.K.; Kim, J.; Kim, Y.T.; Choi, J.D.
The active site and mechanism of action of recombinant acetohydroxy acid synthase from tobacco
FEBS Lett.
555
185-191
2003
Nicotiana tabacum
Yoon, J.M.; Yoon, M.Y.; Kim, Y.T.; Choi, J.D.
Characterization of two forms of acetolactate synthase from barley
J. Biochem. Mol. Biol.
36
456-461
2003
Hordeum vulgare
Duggleby, R.G.
Suicide inhibition of acetohydroxyacid synthase by hydroxypyruvate
J. Enzyme Inhib. Med. Chem.
20
1-4
2005
Escherichia coli
Tanaka, Y.
Properties of acetolactate synthase from sulfonylurea-resistant Scirpus juncoides Roxb. var. ohwianus T. Koyama
Pestic. Biochem. Physiol.
77
147-153
2003
Schoenoplectiella juncoides
-
Hershey, H.P.; Schwartz, L.J.; Gale, J.P.; Abell, L.M.
Cloning and functional expression of the small subunit of acetolactate synthase from Nicotiana plumbaginifolia
Plant Mol. Biol.
40
795-806
1999
Nicotiana plumbaginifolia
Tittmann, K.; Vyazmensky, M.; Hubner, G.; Barak, Z.; Chipman, D.M.
The carboligation reaction of acetohydroxyacid synthase II: steady-state intermediate distributions in wild type and mutants by NMR
Proc. Natl. Acad. Sci. USA
102
553-558
2005
Escherichia coli
Kaushal, A.; Pabbi, S.; Sharma, P.
Characterization of 2,3-butanediol-forming and valine-sensitive alpha-acetolactate synthase of Enterobacter cloacae
World J. Microbiol. Biotechnol.
19
487-493
2003
Enterobacter cloacae
-
Elisakova, V.; Patek, M.; Holatko, J.; Nesvera, J.; Leyval, D.; Goergen, J.L.; Delaunay, S.
Feedback-resistant acetohydroxy acid synthase increases valine production in Corynebacterium glutamicum
Appl. Environ. Microbiol.
71
207-213
2005
Corynebacterium glutamicum
Vinogradov, M.; Kaplun, A.; Vyazmensky, M.; Engel, S.; Golbik, R.; Tittmann, K.; Uhlemann, K.; Meshalkina, L.; Barak, Z.; Huebner, G.; Chipman, D.M.
Monitoring the acetohydroxy acid synthase reaction and related carboligations by circular dichroism spectroscopy
Anal. Biochem.
342
126-133
2005
Escherichia coli
Lee, Y.T.; Duggleby, R.G.
Mutations in the regulatory subunit of yeast acetohydroxyacid synthase affect its activation by MgATP
Biochem. J.
395
331-336
2006
Saccharomyces cerevisiae
Vinogradov, V.; Vyazmensky, M.; Engel, S.; Belenky, I.; Kaplun, A.; Kryukov, O.; Barak, Z.; Chipman, D.M.
Acetohydroxyacid synthase isozyme I from Escherichia coli has unique catalytic and regulatory properties
Biochim. Biophys. Acta
1760
356-363
2006
Escherichia coli
Wang, J.G.; Xiao, Y.J.; Li, Y.H.; Ma, Y.; Li, Z.M.
Identification of some novel AHAS inhibitors via molecular docking and virtual screening approach
Bioorg. Med. Chem.
15
374-380
2007
Brassica rapa subsp. oleifera
Kim, J.; Choi, J.; Kim, B.; Yoon, M.
Characterization of the catalytic properties of recombinant acetohydroxyacid synthase from tobacco
Bull. Korean Chem. Soc.
26
260-264
2005
Nicotiana tabacum
-
Le, D.T.; Choi, J.
FAD-independent and herbicide-resistant mutants of tobacco acetohydroxy acid synthase
Bull. Korean Chem. Soc.
26
916-920
2005
Nicotiana tabacum
-
Choi, K.; Noh, K.M.; Choi, J.; Park, J.; Won, H.; Kim, J.; Kim, J.; Yoon, M.
Sulfonylurea is a non-competitive inhibitor of acetohydroxyacid synthase from Mycobacterium tuberculosis
Bull. Korean Chem. Soc.
27
1697-1700
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
-
Karim, M.; Shim, M.; Kim, J.; Choi, K.; Kim, J.; Choi, J.; Yoon, M.
The catalytic role of the W573 in the mobile loop of recombinant acetohydroxyacid synthase from tobacco
Bull. Korean Chem. Soc.
27
549-555
2006
Nicotiana tabacum
-
Chipman, D.M.; Duggleby, R.G.; Tittmann, K.
Mechanisms of acetohydroxyacid synthases
Curr. Opin. Chem. Biol.
10
88
2006
Escherichia coli
-
Choi, K.J.; Yu, Y.G.; Hahn, H.G.; Choi, J.D.; Yoon, M.Y.
Characterization of acetohydroxyacid synthase from Mycobacterium tuberculosis and the identification of its new inhibitor from the screening of a chemical library
FEBS Lett.
579
4903-4910
2005
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Zhu, Y.; Chen, X.; Chen, T.; Zhao, X.
Enhancement of riboflavin production by overexpression of acetolactate synthase in a pta mutant of Bacillus subtilis
FEMS Microbiol. Lett.
266
224-230
2007
Bacillus subtilis, Bacillus subtilis RH33::[pRB63]n
Li, Y.X.; Luo, Y.P.; Xi, Z.; Niu, C.; He, Y.Z.; Yang, G.F.
Design and syntheses of novel phthalazin-1(2H)-one derivatives as acetohydroxyacid synthase inhibitors
J. Agric. Food Chem.
54
9135-9139
2006
Arabidopsis thaliana
Le, D.T.; Yoon, M.Y.; Kim, Y.T.; Choi, J.D.
Roles of three well-conserved arginine residues in mediating the catalytic activity of tobacco acetohydroxy acid synthase
J. Biochem.
138
35-40
2005
Nicotiana tabacum
Kaplun, A.; Vyazmensky, M.; Zherdev, Y.; Belenky, I.; Slutzker, A.; Mendel, S.; Barak, Z.; Chipman, D.M.; Shaanan, B.
Structure of the regulatory subunit of acetohydroxyacid synthase isozyme III from Escherichia coli
J. Mol. Biol.
357
951-963
2006
Escherichia coli
Lee, C.R.; Koo, B.M.; Cho, S.H.; Kim, Y.J.; Yoon, M.J.; Peterkofsky, A.; Seok, Y.J.
Requirement of the dephospho-form of enzyme IIANtr for derepression of Escherichia coli K-12 ilvBN expression
Mol. Microbiol.
58
334-344
2005
Escherichia coli K-12
Chatterjee, A.; Dastidar, K.G.; Maitra, S.; Das-Chatterjee, A.; Dihazi, H.; Eschrich, K.; Majumder, A.L.
sll1981, an acetolactate synthase homologue of Synechocystis sp. PCC6803, functions as L-myo-inositol 1-phosphate synthase
Planta
224
367-379
2006
Synechocystis sp.
McCourt, J.A.; Duggleby, R.G.
How an enzyme answers multiple-choice questions
Trends Biochem. Sci.
30
222-225
2005
Escherichia coli, Saccharomyces cerevisiae (P07342)
Liu, F.; Zhang, F.; Jin, Z.; He, Y.; Fang, H.; Ye, Q.; Zhou, W.
Determination of acetolactate synthase activity and protein content of oilseed rape (Brassica napus L.) leaves using visible/near-infrared spectroscopy
Anal. Chim. Acta
629
56-65
2008
Brassica napus
Nelson, D.; Duxbury, T.
The distribution of acetohydroxyacid synthase in soil bacteria
Antonie van Leeuwenhoek
93
123-132
2008
uncultured bacterium, Pseudomonas fluorescens, Rhodococcus erythropolis
Blombach, B.; Hans, S.; Bathe, B.; Eikmanns, B.J.
Acetohydroxyacid synthase, a novel target for improvement of L-lysine production by Corynebacterium glutamicum
Appl. Environ. Microbiol.
75
419-427
2009
Corynebacterium glutamicum
Atsumi, S.; Li, Z.; Liao, J.C.
Acetolactate synthase from Bacillus subtilis serves as a 2-ketoisovalerate decarboxylase for isobutanol biosynthesis in Escherichia coli
Appl. Environ. Microbiol.
75
6306-6311
2009
Bacillus subtilis, Bacillus subtilis (Q04789), Bacillus subtilis 168 (Q04789)
Choi, K.J.; Noh, K.M.; Kim, D.E.; Ha, B.H.; Kim, E.E.; Yoon, M.Y.
Identification of the catalytic subunit of acetohydroxyacid synthase in Haemophilus influenzae and its potent inhibitors
Arch. Biochem. Biophys.
466
24-30
2007
Haemophilus influenzae (P45261), Haemophilus influenzae
Vyazmensky, M.; Zherdev, Y.; Slutzker, A.; Belenky, I.; Kryukov, O.; Barak, Z.; Chipman, D.M.
Interactions between large and small subunits of different acetohydroxyacid synthase isozymes of Escherichia coli
Biochemistry
48
8731-8737
2009
Escherichia coli
Wada, M.; Hijikata, N.; Aoki, R.; Takesue, N.; Yokota, A.
Enhanced valine production in Corynebacterium glutamicum with defective H+-ATPase and C-terminal truncated acetohydroxyacid synthase
Biosci. Biotechnol. Biochem.
72
2959-2965
2008
Corynebacterium glutamicum
Yun, H.; Kim, B.G.
Asymmetric synthesis of (S)-alpha-methylbenzylamine by recombinant Escherichia coli co-expressing omega-transaminase and acetolactate synthase
Biosci. Biotechnol. Biochem.
72
3030-3033
2008
Bacillus subtilis
Choi, K.; Pham, C.N.; Jung, H.; Han, S.; Choi, J.; Kim, J.; Yoon, M.
Expression of acetohydroxyacid synthase from Bacillus anthracis and its potent inhibitors
Bull. Korean Chem. Soc.
28
1109-1113
2007
Bacillus anthracis
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Yu, Z.; Niu, C.; Ban, S.; Wen, X.; Xi, Z.
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Saccharomyces cerevisiae, Candida albicans
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Valine 375 and phenylalanine 109 confer affinity and specificity for pyruvate as donor substrate in acetohydroxy acid synthase isozyme II from Escherichia coli
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Escherichia coli
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Significant catalytic roles for Glu47 and Gln 110 in all four of the C-C bond-making and -breaking steps of the reactions of acetohydroxyacid synthase II
Biochemistry
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Escherichia coli
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Structural and functional evaluation of three well-conserved serine residues in tobacco acetohydroxyacid synthase
Biochimie
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Nicotiana tabacum
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Escherichia coli
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Mycobacterium tuberculosis (O06335), Mycobacterium tuberculosis (O53554), Mycobacterium tuberculosis (P9WG39), Mycobacterium tuberculosis (P9WG41), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WG39), Mycobacterium tuberculosis H37Rv (P9WG41)
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ChemBioChem
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Bacillus subtilis (Q04789), Bacillus subtilis, Bacillus subtilis PY79 (Q04789)
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Enterococcus faecalis (Q836A5), Enterococcus faecalis
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Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WG39), Mycobacterium tuberculosis H37Rv, Mycobacterium tuberculosis H37Rv (P9WG39)
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Structural and functional significance of the highly-conserved residues in Mycobacterium tuberculosis acetohydroxyacid synthase
Enzyme Microb. Technol.
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Mycobacterium tuberculosis (P9WG41), Mycobacterium tuberculosis H37Rv (P9WG41)
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Mutational analysis of critical residues of FAD-independent catabolic acetolactate synthase from Enterococcus faecalis V583
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Enterococcus faecalis (Q836A5), Enterococcus faecalis
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alpha-Acetolactate synthase of Lactococcus lactis contributes to pH homeostasis in acid stress conditions
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Lactococcus lactis, Lactococcus lactis (Q7DAV2), Lactococcus lactis IL1403, Lactococcus lactis IL1403 (Q7DAV2)
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Pyrococcus furiosus (Q8U2A4), Pyrococcus furiosus
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Pyricularia oryzae, Pyricularia oryzae (G4NC97 and G4MMK2), Pyricularia oryzae Guy11, Pyricularia oryzae Guy11 (G4NC97 and G4MMK2)
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Myosoton aquaticum, Myosoton aquaticum (V5Q0Z4)
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Thermus thermophilus (Q5SJ01), Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SJ01)
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Schoenoplectiella juncoides, Schoenoplectiella juncoides (Q14TG2), Schoenoplectiella juncoides (Q14TG4)
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Brassica napus
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Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
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Bacillus licheniformis, Bacillus licheniformis WX-02
Gardin, J.A.; Gouzy, J.; Carrere, S.; Delye, C.
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BMC Genomics
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Arabidopsis thaliana (P17597), Arabidopsis thaliana
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High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism
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Saccharomyces cerevisiae (P07342)
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Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
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Saccharomyces cerevisiae, Arabidopsis thaliana (P17597), Arabidopsis thaliana
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Arabidopsis thaliana
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Arabidopsis thaliana (P17597), Arabidopsis thaliana
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Oryza sativa
Vercellino, R.B.; Pandolfo, C.E.; Breccia, G.; Cantamutto, M.; Presotto, A.
AHAS Trp574Leu substitution in Raphanus sativus L. screening, enzyme activity and fitness cost
Pest Manag. Sci.
74
1600-1607
2018
Raphanus sativus
Yang, Q.; Deng, W.; Wang, S.; Liu, H.; Li, X.; Zheng, M.
Effects of resistance mutations of Pro197, Asp376 and Trp574 on the characteristics of acetohydroxyacid synthase (AHAS) isozymes
Pest Manag. Sci.
74
1870-1879
2018
Descurainia sophia
Scarabel, L.; Pernin, F.; Delye, C.
Occurrence, genetic control and evolution of non-target-site based resistance to herbicides inhibiting acetolactate synthase (ALS) in the dicot weed Papaver rhoeas
Plant Sci.
238
158-169
2015
Papaver rhoeas
Piao, Z.; Wang, W.; Wei, Y.; Zonta, F.; Wan, C.; Bai, J.; Wu, S.; Wang, X.; Fang, J.
Characterization of an acetohydroxy acid synthase mutant conferring tolerance to imidazolinone herbicides in rice (Oryza sativa)
Planta
247
693-703
2018
Oryza sativa Indica Group (A5X300), Oryza sativa Indica Group
Garcia, M.D.; Nouwens, A.; Lonhienne, T.G.; Guddat, L.W.
Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families
Proc. Natl. Acad. Sci. USA
114
E1091-E1100
2017
Arabidopsis thaliana (P17597), Arabidopsis thaliana
Lonhienne, T.; Garcia, M.D.; Pierens, G.; Mobli, M.; Nouwens, A.; Guddat, L.W.
Structural insights into the mechanism of inhibition of AHAS by herbicides
Proc. Natl. Acad. Sci. USA
115
E1945-E1954
2018
Saccharomyces cerevisiae (P07342), Arabidopsis thaliana (P17597)
Zheng, P.; Sun, X.; Guo, L.; Shen, J.
Cloning, expression, and characterization of an acetolactate synthase (ALS) gene from Anabaena azotica
Process Biochem.
50
1349-1356
2015
Anabaena azotica, Anabaena azotica FACHB-686
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