Information on EC 2.3.1.125 - 1-alkyl-2-acetylglycerol O-acyltransferase

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The expected taxonomic range for this enzyme is: Homo sapiens

EC NUMBER
COMMENTARY hide
2.3.1.125
-
RECOMMENDED NAME
GeneOntology No.
1-alkyl-2-acetylglycerol O-acyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + 1-O-alkyl-2-acetyl-sn-glycerol = CoA + 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Ether lipid metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase
A number of acyl-CoAs can act as acyl donor; maximum activity is obtained with linoleoyl-CoA. Not identical with EC 2.3.1.20 diacylglycerol O-acyltransferase.
CAS REGISTRY NUMBER
COMMENTARY hide
114704-90-4
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
linoleoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol
CoA + 1-O-hexadecyl-2-acetyl-3-linoleoyl-sn-glycerol
show the reaction diagram
-
best substrate, not acetyl-CoA
-
?
additional information
?
-
-
related to platelet-activating factor metabolism
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
related to platelet-activating factor metabolism
-
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
no metal ion requirement
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-O-Hexadecyl-2-oleoyl-sn-glycerol
-
competitive inhibitor of 1-hexadecyl-2-acetyl-3-acyl-sn-glycerol synthesis
1-Oleoyl-2-acetyl-sn-glycerol
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mixed-type inhibition
Ca2+
-
6% inhibition at 2 mM
Cu2+
-
96% inhibition at 2 mM
dithiothreitol
-
-
Mn2+
-
35% inhibition at 2 mM
Zn2+
-
93% inhibition at 2 mM
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
bovine serum albumin
-
activation, molar ratio substrate linoleoyl-CoA/albumin: 2:4:1
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0085
linoleoyl-CoA
-
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.032
1-O-Hexadecyl-2-oleoyl-sn-glycerol
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45
-
stable below
58
-
50% activity after 15 min
65
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inactivation