Information on EC 2.3.1.155 - acetyl-CoA C-myristoyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
2.3.1.155
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RECOMMENDED NAME
GeneOntology No.
acetyl-CoA C-myristoyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
myristoyl-CoA + acetyl-CoA = CoA + 3-oxopalmitoyl-CoA
show the reaction diagram
A peroxisomal enzyme involved in branched chain fatty acid beta-oxidation in peroxisomes. It differs from EC 2.3.1.154, propionyl-CoA C2-trimethyldecanoyltransferase, in not being active towards 3-oxopristanoyl-CoA
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
(8E,10E)-dodeca-8,10-dienol biosynthesis
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Spodoptera littoralis pheromone biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
myristoyl-CoA:acetyl-CoA C-myristoyltransferase
A peroxisomal enzyme involved in branched chain fatty acid beta-oxidation in peroxisomes. It differs from EC 2.3.1.154 (propionyl-CoA C2-trimethyldecanoyltransferase) in not being active towards 3-oxopristanoyl-CoA.
CAS REGISTRY NUMBER
COMMENTARY hide
9029-97-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
cucumber
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
human
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Wistar
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Manually annotated by BRENDA team
yeast
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Manually annotated by BRENDA team
pig
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-ketohexadecanoylCoA + H2O
acetyl-CoA + tetradecanoyl-CoA
show the reaction diagram
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-
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r
3-oxodecanoyl-CoA + CoA
acetyl-CoA + octanoyl-CoA
show the reaction diagram
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-
-
-
?
3-oxododecanoyl-CoA + CoA
acetyl-CoA + decanoyl-CoA
show the reaction diagram
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-
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?
3-oxohexanoyl-CoA + CoA
acetyl-CoA + butyryl-CoA
show the reaction diagram
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-
-
-
?
3-oxooctanoyl-CoA + CoA
acetyl-CoA + hexanoyl-CoA
show the reaction diagram
acetoacetyl-CoA + CoA
acetyl-CoA + acetyl-CoA
show the reaction diagram
myristoyl-CoA + acetyl-CoA
3-oxopalmitoyl-CoA + CoA
show the reaction diagram
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-
?
tetradecanoyl-CoA + acetyl-CoA
3-ketohexadecanoyl-CoA + CoA
show the reaction diagram
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myristoyl-CoA
3-oxopalmitoyl-CoA
r
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
myristoyl-CoA + acetyl-CoA
3-oxopalmitoyl-CoA + CoA
show the reaction diagram
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?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.008
3-ketodecanoyl-CoA
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0.003
3-ketododecanoyl-CoA
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0.0019
3-ketohexadecanoyl-CoA
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0.0106
3-ketohexanoyl-CoA
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0.0086
3-ketoocatanoyl-CoA
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0.014
acetoacetyl-CoA
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
38000
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gel filtration conducted at 6°C
41070
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mature enzyme, amino acid sequence
48700
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calculated from amino acid sequence
53000
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SDS-PAGE
76000
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gel filtration conducted at 28°C
78000
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peroxisomal bifunctional protein, gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tetramer
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4 * 38500
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
cold lability
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
recombinant protein, heterologous expressed in Escherichia coli
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
cDNA clones of peroxisomal 3-ketoacyl-CoA thiolase isolated and sequenced
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full-length cDNA of glyoxysomal 3-ketoacyl-CoA thiolase cloned and expressed in Escherichia coli
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