Information on EC 2.3.1.163 - 10-hydroxytaxane O-acetyltransferase

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The expected taxonomic range for this enzyme is: Taxus cuspidata

EC NUMBER
COMMENTARY hide
2.3.1.163
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RECOMMENDED NAME
GeneOntology No.
10-hydroxytaxane O-acetyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + 10-desacetyltaxuyunnanin C = CoA + taxuyunnanin C
show the reaction diagram
Acts on a number of related taxane diterpenoids with a free 10beta-hydroxy group. May be identical to EC 2.3.1.167, 10-deacetylbaccatin III 10-O-acetyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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-
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:taxan-10beta-ol O-acetyltransferase
Acts on a number of related taxane diterpenoids with a free 10beta-hydroxy group. May be identical to EC 2.3.1.167, 10-deacetylbaccatin III 10-O-acetyltransferase.
CAS REGISTRY NUMBER
COMMENTARY hide
227465-96-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,5,10,14-desacetyltaxuyunnanin C
CoA + 2,5,10-desacetyltaxuyunnanin C
show the reaction diagram
-
-
-
?
acetyl-CoA + 10-desacetyltaxuyunnanin C
CoA + taxuyunnanin C
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + 10-desacetyltaxuyunnanin C
CoA + taxuyunnanin C
show the reaction diagram
-
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.061
acetyl-CoA
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-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
71000
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gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
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1 * 70900, SDS-PAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pharmacology
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use in synthesis of taxol for anticnacer treatment