Reference on EC 2.3.1.17 - aspartate N-acetyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Goldstein, F.B.
Biosynthesis of N-acetyl-L-aspartic acid
J. Biol. Chem.
234
2702-2706
1959
Rattus norvegicus
-
Knizley, H.Jr.
The enzymatic synthesis of N-acetyl-L-aspartic acid by a water-insoluble preparation of a cat brain acetone powder
J. Biol. Chem.
242
4619-4622
1967
Felis catus
Truckenmiller, M.E.; Namboodiri, M.A.A.; Brownstein, M.J.; Neale, J.H.
N-Acetylation of L-aspartate in the nervous system: differential distribution of a specific enzyme
J. Neurochem.
45
1658-1662
1985
Rattus norvegicus
Moreno, A.; Ross, B.D.; Bluml, S.
Direct determination of the N-acetyl-L-aspartate synthesis rate in the human brain by (13)C MRS and [1-(13)C]glucose infusion
J. Neurochem.
77
347-350
2001
Homo sapiens
Lu, Z.H.; Chakraborty, G.; Ledeen, R.W.; Yahya, D.; Wu, G.
N-Acetylaspartate synthase is bimodally expressed in microsomes and mitochondria of brain
Brain Res. Mol. Brain Res.
122
71-78
2004
Rattus norvegicus
Madhavarao, C.N.; Chinopoulos, C.; Chandrasekaran, K.; Namboodiri, M.A.
Characterization of the N-acetylaspartate biosynthetic enzyme from rat brain
J. Neurochem.
86
824-835
2003
Rattus norvegicus
Wiame, E.; Tyteca, D.; Pierrot, N.; Collard, F.; Amyere, M.; Noel, G.; Desmedt, J.; Nassogne, M.C.; Vikkula, M.; Octave, J.N.; Vincent, M.F.; Courtoy, P.J.; Boltshauser, E.; van Schaftingen, E.
Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia
Biochem. J.
425
127-136
2010
Danio rerio, Mus musculus, Homo sapiens (Q8N9F0), Homo sapiens
Tahay, G.; Wiame, E.; Tyteca, D.; Courtoy, P.J.; Van Schaftingen, E.
Determinants of the enzymatic activity and the subcellular localization of aspartate N-acetyltransferase
Biochem. J.
441
105-112
2012
Homo sapiens (Q8N9F0)
Ariyannur, P.S.; Moffett, J.R.; Manickam, P.; Pattabiraman, N.; Arun, P.; Nitta, A.; Nabeshima, T.; Madhavarao, C.N.; Namboodiri, A.M.
Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS
Brain Res.
1335
1-13
2010
Mus musculus (Q3UGX3), Homo sapiens (Q8N9F0), Homo sapiens
Wang, Q.; Zhao, M.; Parungao, G.G.; Viola, R.E.
Purification and characterization of aspartate N-acetyltransferase: a critical enzyme in brain metabolism
Protein Expr. Purif.
119
11-18
2016
Homo sapiens (Q8N9F0), Homo sapiens
Huber, K.; Hofer, D.C.; Trefely, S.; Pelzmann, H.J.; Madreiter-Sokolowski, C.; Duta-Mare, M.; Schlager, S.; Trausinger, G.; Stryeck, S.; Graier, W.F.; Kolb, D.; Magnes, C.; Snyder, N.W.; Prokesch, A.; Kratky, D.; Madl, T.; Wellen, K.E.; Bogner-Strauss, J.G.
N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes
Biochim. Biophys. Acta
1866
337-348
2019
Mus musculus (Q3UGX3)
Thangavelu, B.; Mutthamsetty, V.; Wang, Q.; Viola, R.E.
Design and optimization of aspartate N-acetyltransferase inhibitors for the potential treatment of Canavan disease
Bioorg. Med. Chem.
25
870-885
2017
Homo sapiens (Q8N9F0), Homo sapiens
Mutthamsetty, V.; Dahal, G.P.; Wang, Q.; Viola, R.E.
Development of bisubstrate analog inhibitors of aspartate N-acetyltransferase, a critical brain enzyme
Chem. Biol. Drug Des.
95
48-57
2020
Homo sapiens (Q8N9F0), Homo sapiens
Zand, B.; Previs, R.A.; Zacharias, N.M.; Rupaimoole, R.; Mitamura, T.; Nagaraja, A.S.; Guindani, M.; Dalton, H.J.; Yang, L.; Baddour, J.; Achreja, A.; Hu, W.; Pecot, C.V.; Ivan, C.; Wu, S.Y.; McCullough, C.R.; Gharpure, K.M.; Shoshan, E.; Pradeep, S.; Mangala, L.S.; Rodriguez-Aguayo, C.; Wang, Y.; Nick, A.M.
Role of increased N-acetylaspartate levels in cancer
J. Natl. Cancer Inst.
108
djv426
2016
Homo sapiens (Q8N9F0), Homo sapiens
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