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IUBMB CommentsThe enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family.
The enzyme appears in viruses and cellular organisms
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FgaAT
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acetyl-CoA + fumigaclavine B = CoA + fumigaclavine A
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acetyl-CoA:fumigaclavine B O-acetyltransferase
The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family.
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acetyl-CoA + fumigaclavine B
CoA + fumigaclavine A
acetyl-CoA + fumigaclavine B
CoA + fumigaclavine A
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acetyl-CoA + fumigaclavine B
CoA + fumigaclavine A
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acetyl-CoA + fumigaclavine B
CoA + fumigaclavine A
acetyl-CoA + fumigaclavine B
CoA + fumigaclavine A
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acetyl-CoA + fumigaclavine B
CoA + fumigaclavine A
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Ca2+
22% activation at 5 mM
additional information
no effects by Na+ and K+ at 5 mM, the acetyl-transfer reaction catalysed by FgaAT is very likely independent of the presence of metal ions
additional information
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no effects by Na+ and K+ at 5 mM, the acetyl-transfer reaction catalysed by FgaAT is very likely independent of the presence of metal ions
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0.122
acetyl-CoA
pH not specified in the publication, 37°C, recombinant His6-tagged enzyme
0.147
fumigaclavine B
pH not specified in the publication, 37°C, recombinant His6-tagged enzyme
additional information
additional information
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additional information
additional information
the FgaAT reaction apparently follows Michaelis-Menten kinetics
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additional information
additional information
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the FgaAT reaction apparently follows Michaelis-Menten kinetics
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0.6
acetyl-CoA
pH not specified in the publication, 37°C, recombinant His6-tagged enzyme
0.6
fumigaclavine B
pH not specified in the publication, 37°C, recombinant His6-tagged enzyme
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gene AFUA_2G18020
UniProt
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gene AFUA_2G18020
UniProt
brenda
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physiological function
FgaAT catalyses the acetylation of fumigaclavine B, the conversion of fumigaclavine B to A, which belong to the ergot alkaloids of the clavine-type
physiological function
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FgaAT catalyses the acetylation of fumigaclavine B, the conversion of fumigaclavine B to A, which belong to the ergot alkaloids of the clavine-type
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IFGH_PENRF
Penicillium roqueforti (strain FM164)
484
0
53739
Swiss-Prot
other Location (Reliability: 4)
EASN_ASPFU
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
494
0
55007
Swiss-Prot
other Location (Reliability: 4)
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55000
1 * 55000, about, wild-type enzyme, sequence calculation, 1 * 56700, about, His6-tagged enzyme, sequence calculation, 1 * 57000, recombinant His6-tagged enzyme, SDS-PAGE
56700
1 * 55000, about, wild-type enzyme, sequence calculation, 1 * 56700, about, His6-tagged enzyme, sequence calculation, 1 * 57000, recombinant His6-tagged enzyme, SDS-PAGE
57000
1 * 55000, about, wild-type enzyme, sequence calculation, 1 * 56700, about, His6-tagged enzyme, sequence calculation, 1 * 57000, recombinant His6-tagged enzyme, SDS-PAGE
60800
recombinant His6-tagged enzyme, gel filtration
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monomer
1 * 55000, about, wild-type enzyme, sequence calculation, 1 * 56700, about, His6-tagged enzyme, sequence calculation, 1 * 57000, recombinant His6-tagged enzyme, SDS-PAGE
monomer
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1 * 55000, about, wild-type enzyme, sequence calculation, 1 * 56700, about, His6-tagged enzyme, sequence calculation, 1 * 57000, recombinant His6-tagged enzyme, SDS-PAGE
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gene AFUA_2G18020, DNA and amino acid seqquence determmination and analysis, sequence comparison, expression of His6-tagged FgaAT in Escherichia coli
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Liu, X.; Wang, L.; Steffan, N.; Yin, W.; Li, S.
Ergot alkaloid biosynthesis in Aspergillus fumigatus: FgaAT catalyses the acetylation of fumigaclavine B
ChemBioChem
10
2325-2328
2009
Aspergillus fumigatus (Q4WZ64), Aspergillus fumigatus, Aspergillus fumigatus Af293 (Q4WZ64)
brenda
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