Reference on EC 2.3.1.22 - 2-acylglycerol O-acyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Manganaro, F.; Kuksis, A.
Rapid isolation of a triacylglycerol synthetase complex from rat intestinal mucosa
Can. J. Biochem. Cell Biol.
63
107-114
1985
Rattus norvegicus
Loirdighi, N.; Menard, D.; Delvin, E.; Levy, E.
Ontogeny and location of HMG-CoA reductase, ACAT, and MGAT in human small intestine
Am. J. Physiol.
273
G62-G67
1997
Homo sapiens
Manganaro, F.; Kuksis, A.
Purification and preliminary characterization of 2-monoacylglycerol acyltransferase from rat intestinal villus cells
Can. J. Biochem. Cell Biol.
63
341-347
1985
Rattus norvegicus
Coleman, R.A.; Walsh, J.P.; Millington, D.S.; Maltby, D.A.
Stereospecificity of monoacylglycerol acyltransferase activity from rat intestine and suckling rat liver
J. Lipid Res.
27
158-165
1986
Rattus norvegicus
Bierbach, H.
Triacylglycerol biosynthesis in human small intestinal mucosa. Acyl-CoA: monoglyceride acyltransferase
Digestion
28
138-147
1983
Homo sapiens
Cao, J.; Lockwood, J.; Burn, P.; Shi, Y.
Cloning and functional characterization of a mouse intestinal acyl-CoA: monoacylglycerol acyltransferase, MGAT2
J. Biol. Chem.
278
13860-13866
2003
Mus musculus
Bhat, B.G.; Bardes, E.S.G.; Coleman, R.A.
Solubilization and partial purification of neonatally expressed rat hepatic microsomal monoacylglycerol acyltransferase
Arch. Biochem. Biophys.
300
663-669
1993
Rattus norvegicus
Waite, M.; Sisson, P.
Utilization of serum lipoprotein lipids by the monoacylglycerol acyltransferase
Biochim. Biophys. Acta
450
301-310
1976
Rattus norvegicus
Tietz, A.; Weintraub, H.; Peled, Y.
Utilization of 2-acyl-sn-glycerol by locust fat body microsomes. Specificity of the acyltransferase system
Biochim. Biophys. Acta
388
165-170
1975
Locusta migratoria
Manganaro, F.; Kuksis, A.; Myher, J.J.
Radioassay of the stereospecificity of 2-monoacylglycerol acyltransferase
Anal. Biochem.
119
4-11
1982
Rattus norvegicus
Short, V.; Brindley, D.N.; Dils, R.
A new assay procedure for monoglyceride acyltransferase
Biochem. J.
141
407-411
1974
Cavia porcellus
Coleman, R.A.; Haynes, E.B.
Monoacylglycerol acyltransferase. Evidence that the activities from rat intestine and suckling liver are tissue-specific isoenzymes
J. Biol. Chem.
261
224-228
1986
Rattus norvegicus
Lehner, R.; Kuksis, A.; Itabashi, Y.
Stereospecificity of monoacylglycerol and diacylglycerol acyltransferases from rat intestine as determined by chiral phase high-performance liquid chromatography
Lipids
28
29-34
1993
Rattus norvegicus
Yen, C.L.E.; Stone, S.J.; Cases, S.; Zhou, P.; Farese, R.V., Jr.
Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase
Proc. Natl. Acad. Sci. USA
99
8512-8517
2002
Mus musculus (Q91ZV4)
Tumaney, A.W.; Shekar, S.; Rajasekharan, R.
Identification, purification, and characterization of monoacylglycerol acyltransferase from developing peanut cotyledons
J. Biol. Chem.
276
10847-10852
2001
Arachis hypogaea
Mostafa, N.; Bhat, B.G.; Coleman, R.A.
Increased hepatic monoacylglycerol acyltransferase activity in streptozotocin-induced diabetes: characterization and comparison with activities from adult and neonatal rat liver
Biochim. Biophys. Acta
1169
189-195
1993
Rattus norvegicus
Bhat, B.G.; Wang, P.; Coleman, R.A.
Sphingosine inhibits rat hepatic monoacylglycerol acyltransferase in Triton X-100 mixed micelles and isolated hepatocytes
Biochemistry
34
11237-11244
1995
Rattus norvegicus
Mostafa, N.; Bhat, B.G.; Coleman, R.A.
Adipose monoacylglycerol:acyl-conenzyme A acyltransferase activity in the white-throated sparrow (Zonotrichia albicollis): characterization and function in an migratory bird
Lipids
29
785-791
1994
Zonotrichia albicollis
Coleman, R.A.; Wang, P.; Bhat, B.G.
Diradylglycerols alter fatty acid inhibition of monoacylglycerol acyltransferase activity in Triton X-100 mixed micelles
Biochemistry
37
5916-5922
1998
Rattus norvegicus
Yen, C.L.; Farese, R.V., Jr.
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine
J. Biol. Chem.
5
1-24
2003
Homo sapiens, Mus musculus
-
Lockwood, J.F.; Cao, J.; Burn, P.; Shi, Y.
Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity
Am. J. Physiol.
285
E927-937
2003
Homo sapiens (Q3SYC2), Homo sapiens
Stoveken, T.; Kalscheuer, R.; Malkus, U.; Reichelt, R.; Steinbuchel, A.
The wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase from Acinetobacter sp. strain ADP1: characterization of a novel type of acyltransferase
J. Bacteriol.
187
1369-1376
2005
Acinetobacter sp., Acinetobacter sp. ADP1
Cheng, D.; Nelson, T.C.; Chen, J.; Walker, S.G.; Wardwell-Swanson, J.; Meegalla, R.; Taub, R.; Billheimer, J.T.; Ramaker, M.; Feder, J.N.
Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption
J. Biol. Chem.
278
13611-13614
2003
Homo sapiens (Q86VF5), Homo sapiens
Cao, J.; Hawkins, E.; Brozinick, J.; Liu, X.; Zhang, H.; Burn, P.; Shi, Y.
A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet
J. Biol. Chem.
279
18878-18886
2004
Mus musculus
Yen, C.L.; Brown Iv, C.H.; Monetti, M.; Farese, R.V., Jr.
A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters
J. Lipid Res.
46
2388-2397
2005
Homo sapiens
Orland, M.D.; Anwar, K.; Cromley, D.; Chu, C.; Chen, L.; Billheimer, J.T.; Hussain, M.M.; Cheng, D.
Acyl coenzyme A dependent retinol esterification by acyl coenzyme A:diacylglycerol acyltransferase 1
Biochim. Biophys. Acta
1737
76-82
2005
Homo sapiens
Oxley, A.; Torstensen, B.E.; Rustan, A.C.; Olsen, R.E.
Enzyme activities of intestinal triacylglycerol and phosphatidylcholine biosynthesis in Atlantic salmon (Salmo salar L.)
Comp. Biochem. Physiol. B
141B
77-87
2005
Salmo salar
-
Yen, C.L.; Monetti, M.; Burri, B.J.; Farese, R.V.
The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters
J. Lipid Res.
46
1502-1511
2005
Mus musculus
Shi, Y.; Cheng, D.
Beyond triglyceride synthesis: The dynamic functional roles of MGAT and DGAT enzymes in energy metabolism
Am. J. Physiol. Endocrinol. Metab.
297
E10-8
2009
Mammalia, no activity in Rodentia
Holmes, R.
Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT)
Comp. Biochem. Physiol. D
5
45-54
2010
Monodelphis domestica, Danio rerio (A2BHM7), Danio rerio (B0JZB3), Danio rerio (Q5XJR1), Danio rerio
Hiramine, Y.; Emoto, H.; Takasuga, S.; Hiramatsu, R.
Novel acyl-coenzyme A:monoacylglycerol acyltransferase (MGAT) plays an important role in hepatic triacylglycerol secretion
J. Lipid Res.
51
1424-1431
2010
Mus musculus
Yen, C.L.; Cheong, M.L.; Grueter, C.; Zhou, P.; Moriwaki, J.; Wong, J.S.; Hubbard, B.; Marmor, S.; Farese, R.V.
Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding
Nat. Med.
15
442-446
2009
Mus musculus
Parthibane, V.; Rajakumari, S.; Venkateshwari, V.; Iyappan, R.; Rajasekharan, R.
Oleosin is bifunctional enzyme that has both monoacylglycerol acyltransferase and phospholipase activities
J. Biol. Chem.
287
1946-1954
2012
Arachis hypogaea
Hall, A.M.; Kou, K.; Chen, Z.; Pietka, T.A.; Kumar, M.; Korenblat, K.M.; Lee, K.; Ahn, K.; Fabbrini, E.; Klein, S.; Goodwin, B.; Finck, B.N.
Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver
J. Lipid Res.
53
990-999
2012
Homo sapiens (Q3SYC2), Homo sapiens (Q86VF5), Homo sapiens (Q96PD6), Homo sapiens
Yue, Y.G.; Chen, Y.Q.; Zhang, Y.; Wang, H.; Qian, Y.W.; Arnold, J.S.; Calley, J.N.; Li, S.D.; Perry, W.L.; Zhang, H.Y.; Konrad, R.J.; Cao, G.
The acyl coenzymeA:monoacylglycerol acyltransferase 3 (MGAT3) gene is a pseudogene in mice but encodes a functional enzyme in rats
Lipids
46
513-520
2011
Mus musculus, Rattus norvegicus
Vijayaraj, P.; Jashal, C.B.; Vijayakumar, A.; Rani, S.H.; Venkata Rao, D.K.; Rajasekharan, R.
A bifunctional enzyme that has both monoacylglycerol acyltransferase and acyl hydrolase activities
Plant Physiol.
160
667-683
2012
Arachis hypogaea (H9LBH7)
Petrie, J.R.; Vanhercke, T.; Shrestha, P.; El Tahchy, A.; White, A.; Zhou, X.R.; Liu, Q.; Mansour, M.P.; Nichols, P.D.; Singh, S.P.
Recruiting a new substrate for triacylglycerol synthesis in plants: the monoacylglycerol acyltransferase pathway
PLoS ONE
7
e35214
2012
Arabidopsis thaliana, Mus musculus
Yu, J.H.; Lee, Y.J.; Kim, H.J.; Choi, H.; Choi, Y.; Seok, J.W.; Kim, J.W.
Monoacylglycerol O-acyltransferase 1 is regulated by peroxisome proliferator-activated receptor gamma in human hepatocytes and increases lipid accumulation
Biochem. Biophys. Res. Commun.
460
715-720
2015
Homo sapiens (Q96PD6), Homo sapiens
Barlind, J.G.; Buckett, L.K.; Crosby, S.G.; Davidsson, O.e.; Emtenaes, H.; Ertan, A.; Jurva, U.; Lemurell, M.; Gutierrez, P.M.; Nilsson, K.; OMahony, G.; Petersson, A.U.; Redzic, A.; Wagberg, F.; Yuan, Z.Q.
Identification and design of a novel series of MGAT2 inhibitors
Bioorg. Med. Chem. Lett.
23
2721-2726
2013
Homo sapiens (Q3SYC2)
Jin, Y.; McFie, P.J.; Banman, S.L.; Brandt, C.; Stone, S.J.
Diacylglycerol acyltransferase-2 (DGAT2) and monoacylglycerol acyltransferase-2 (MGAT2) interact to promote triacylglycerol synthesis
J. Biol. Chem.
289
28237-28248
2014
Homo sapiens (Q3SYC2)
Gao, Y.; Nelson, D.W.; Banh, T.; Yen, M.I.; Yen, C.L.
Intestine-specific expression of MOGAT2 partially restores metabolic efficiency in Mogat2-deficient mice
J. Lipid Res.
54
1644-1652
2013
Homo sapiens (Q3SYC2), Homo sapiens, Mus musculus (Q80W94), Mus musculus C57/BL6J (Q80W94)
Qi, J.; Lang, W.; Connelly, M.A.; Du, F.; Liang, Y.; Caldwell, G.W.; Martin, T.; Hansen, M.K.; Kuo, G.H.; Gaul, M.D.; Pocai, A.; Lee, S.
Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo
Anal. Biochem.
524
68-75
2017
Homo sapiens (Q3SYC2), Homo sapiens
McFie, P.J.; Izzard, S.; Vu, H.; Jin, Y.; Beauchamp, E.; Berthiaume, L.G.; Stone, S.J.
Membrane topology of human monoacylglycerol acyltransferase-2 and identification of regions important for its localization to the endoplasmic reticulum
Biochim. Biophys. Acta
1861
1192-1204
2016
Homo sapiens (Q3SYC2), Homo sapiens
Lee, Y.J.; Kim, J.W.
Monoacylglycerol O-acyltransferase 1 (MGAT1) localizes to the ER and lipid droplets promoting triacylglycerol synthesis
BMB Rep.
50
367-372
2017
Mus musculus (Q91ZV4), Mus musculus
Adachi, R.; Ishii, T.; Ogawa, K.; Matsumoto, S.; Satou, T.; Sakamoto, J.; Sato, K.; Kawamoto, T.
Pharmacological characterization of a series of aryl-sulfonamide derivatives that potently and selectively inhibit monoacylglycerol acyltransferase 2
Eur. J. Pharmacol.
791
569-577
2016
Homo sapiens (Q3SYC2), Homo sapiens, Mus musculus (Q80W94), Mus musculus
Mochida, T.; Take, K.; Maki, T.; Nakakariya, M.; Adachi, R.; Sato, K.; Kitazaki, T.; Takekawa, S.
Inhibition of MGAT2 modulates fat-induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high-fat diet
FEBS Open Bio
10
316-326
2020
Homo sapiens (Q3SYC2), Mus musculus (Q80W94)
Ma, Z.; Onorato, J.M.; Chen, L.; Nelson, D.W.; Yen, C.E.; Cheng, D.
Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases
J. Lipid Res.
58
1091-1099
2017
Homo sapiens (Q3SYC2), Homo sapiens (Q86VF5), Homo sapiens
Liss, K.H.H.; Lutkewitte, A.J.; Pietka, T.; Finck, B.N.; Franczyk, M.; Yoshino, J.; Klein, S.; Hall, A.M.
Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans
J. Lipid Res.
59
1630-1639
2018
Mus musculus (Q91ZV4), Homo sapiens (Q96PD6), Homo sapiens
Lutkewitte, A.J.; McCommis, K.S.; Schweitzer, G.G.; Chambers, K.T.; Graham, M.J.; Wang, L.; Patti, G.J.; Hall, A.M.; Finck, B.N.
Hepatic monoacylglycerol acyltransferase 1 is induced by prolonged food deprivation to modulate the hepatic fasting response
J. Lipid Res.
60
528-538
2019
Mus musculus (Q91ZV4)
Devasthale, P.; Cheng, D.
Monoacylglycerol acyltransferase 2 (MGAT2) inhibitors for the treatment of metabolic diseases and nonalcoholic steatohepatitis (NASH)
J. Med. Chem.
61
9879-9888
2018
Homo sapiens (Q3SYC2), Mus musculus (Q80W94)
Li, K.; Olsen, R.E.
Metabolism of sn-1(3)-monoacylglycerol and sn-2-monoacylglycerol in caecal enterocytes and hepatocytes of brown trout (Salmo trutta)
Lipids
52
61-71
2017
Salmo trutta
html completed
