Information on EC 2.3.1.25 - plasmalogen synthase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.3.1.25
-
RECOMMENDED NAME
GeneOntology No.
plasmalogen synthase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + 1-O-(alk-1-enyl)glycero-3-phosphocholine = CoA + plasmenylcholine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Ether lipid metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:1-O-(alk-1-enyl)-glycero-3-phosphocholine 2-O-acyltransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
37257-10-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
guinea pig
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
show the reaction diagram
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
show the reaction diagram
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
show the reaction diagram
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
show the reaction diagram
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-acyl-glycero-3-phosphorylcholine
-
non competitive
Ca2+
-
mitochondrial enzyme
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ca2+
-
enhances activity of microsomal enzyme
Mg2+
-
enhances activity of microsomal enzyme
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0265 - 0.0297
1-alkenyl-glycero-3-phosphorylcholine
0.00077 - 0.00091
oleoyl-CoA
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
-
no activity in rabbit brain and heart
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20
-
60 min stable
55
-
90% loss of activity after 1 min
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial