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Disease on EC 2.3.1.43 - phosphatidylcholine-sterol O-acyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abetalipoproteinemia
Gene therapy for dyslipidemia: clinical prospects.
Molecular species of phosphatidylcholine in abetalipoproteinemia: effect of lecithin:cholesterol acyltransferase and lysolecithin acyltransferase.
Substrate specificity of plasma lecithin: cholesterol acyltransferase in abetalipoproteinemia.
The relationship between serum lipoproteins and red cell membranes in abetalipoproteinemia: deficiency of lecithin:cholesterol acyltransferase.
[Lecithin cholesterol acyltransferase level in 2 cases of abetalipoproteinemia]
Abnormalities, Multiple
Lipoprotein composition in insulin-dependent diabetes mellitus with chronic renal failure: effect of kidney and pancreas transplantation.
adenine phosphoribosyltransferase deficiency
An aid to the diagnosis of genetic disorders underlying adult-onset renal failure: a literature review.
Alagille Syndrome
Cholesterol efflux from Fu5AH cells to the serum of patients with Alagille syndrome. Importance of the hdl-phospholipids/free cholesterol ratio and of the hdl size distribution.
Glomerular mesangiolipidosis in Alagille syndrome (arteriohepatic dysplasia).
Lipoprotein pattern and plasma lecithin cholesterol acyl transferase activity in children with Alagille syndrome.
The role of lipids in nephrosclerosis and glomerulosclerosis.
alpha 1-Antitrypsin Deficiency
Combined liver-kidney transplantation for rare diseases.
Alzheimer Disease
Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease.
Amyloidosis
The effects of altered apolipoprotein A-I structure on plasma HDL concentration.
Anemia
Amelioration of circulating lipoprotein profile and proteinuria in a patient with LCAT deficiency due to a novel mutation (Cys74Tyr) in the lid region of LCAT under a fat-restricted diet and ARB treatment.
An unusual presentation of LCAT deficiency as nephrotic syndrome with normal serum HDL-C level.
Characterization of a new LCAT mutation causing familial LCAT deficiency (FLD) and the role of APOE as a modifier gene of the FLD phenotype.
Familial Lecithin:cholesterol acyltransferase deficiency with renal failure in two siblings. First case report from India.
Familial lecithin:cholesterol acyltransferase deficiency: First-in-human treatment with enzyme replacement.
Lecithin-cholesterol acyltransferase (LCAT) deficiency without mutations in the coding sequence: a case report and literature review.
Lecithin:Cholesterol Acyltransferase Activation by Sulfhydryl-Reactive Small Molecules: Role of Cysteine-31.
Marked HDL deficiency and premature coronary heart disease.
Sex dimorphism in serum lecithin: cholesterol acyltransferase and lipoprotein lipase activities in adult sickle cell anaemia patients with proteinuria.
Therapeutic management of a new case of LCAT deficiency with a multifactorial long-term approach based on high doses of angiotensin II receptor blockers (ARBs).
[Corneal opacity as the leading symptom of hereditary lecithin-cholesterol acyltransferase (LCAT) deficiency. Case report and a review of the literature]
Anemia, Hemolytic
Corticosteroid treatment of kidney disease in a patient with familial lecithin-cholesterol acyltransferase deficiency.
Novel Missense LCAT Gene Mutation Associated with an Atypical Phenotype of Familial LCAT Deficiency in Two Portuguese Brothers.
Point mutation (C to T) of the LCAT gene resulting in A140C substitution.
Proteinuria in early childhood due to familial LCAT deficiency caused by loss of a disulfide bond in lecithin:cholesterol acyl transferase.
Two novel mutations of lecithin:cholesterol acyltransferase (LCAT) gene and the influence of APOE genotypes on clinical manifestations.
[Characteristics of red cell membrane disorders in the Japanese population]
Anemia, Sickle Cell
Depletion of HDL3 high density lipoprotein and altered functionality of HDL2 in blood from sickle cell patients.
Sex dimorphism in serum lecithin: cholesterol acyltransferase and lipoprotein lipase activities in adult sickle cell anaemia patients with proteinuria.
Atherosclerosis
Analysis of glomerulosclerosis and atherosclerosis in lecithin cholesterol acyltransferase-deficient mice.
ApoA-II expression in CETP transgenic mice increases VLDL production and impairs VLDL clearance.
Association of lecithin-cholesterol acyltransferase activity and low-density lipoprotein heterogeneity with atherosclerotic cardiovascular disease risk: a longitudinal pilot study.
Atherosclerosis in aged mice over-expressing the reverse cholesterol transport genes.
Carriers of lecithin cholesterol acyltransferase gene mutations have accelerated atherogenesis as assessed by carotid 3.0-T magnetic resonance imaging [corrected].
Cholesteryl ester transfer protein corrects dysfunctional high density lipoproteins and reduces aortic atherosclerosis in lecithin cholesterol acyltransferase transgenic mice.
Controversial Role of Lecithin:Cholesterol Acyltransferase in the Development of Atherosclerosis: New Insights From an LCAT Activator.
Decreased activation of lecithin:cholesterol acyltransferase by glycated apolipoprotein A-I.
Effect of GBOT on blood lipid and blood glucose metabolism in rats with atherosclerosis.
Effects of diazepam (Valium) on aortic atherogenesis and plasma lecithin: cholesterol acyltransferase activity in cockerels fed an atherogenic diet.
Endotoxin-lipoprotein complex formation as a factor in atherogenesis: associations with hyperlipidemia and with lecithin:cholesterol acyltransferase activity.
Evidence that lipid hydroperoxides inhibit plasma lecithin:cholesterol acyltransferase activity.
Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice.
High-Density Lipoprotein, Lecithin: Cholesterol Acyltransferase, and Atherosclerosis.
Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpression.
Infection and inflammation-induced proatherogenic changes of lipoproteins.
Inhibition of lecithin: cholesterol acyltransferase activity in human blood plasma by cigarette smoke extract and reactive aldehydes.
LCAT cholesterol esterification is associated with the increase of ApoE/ApoA-I ratio during atherosclerosis progression in rabbit.
LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptors in transgenic rabbits.
Lecithin Cholesterol Acyltransferase: An Anti- or Pro-atherogenic Factor?
Lecithin-cholesterol acryltransferase activity in patients with coronary artery disease examined by coronary angiography.
Lecithin-cholesterol acyltransferase: role in lipoprotein metabolism, reverse cholesterol transport and atherosclerosis.
Lecithin: cholesterol acyltransferase and atherosclerosis: another high-density lipoprotein story that doesn't quite follow the script.
Lecithin: cholesterol acyltransferase--from biochemistry to role in cardiovascular disease.
Lecithin:cholesterol acyltransferase activity in patients with acute myocardial infarction and coronary heart disease.
Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice.
Loss of LCAT Activity in the Golden Syrian Hamster Elicits Pro-atherogenic Dyslipidemia and Enhanced Atherosclerosis.
Marked atherosclerosis in a patient with familiar lecithin: cholesterol acyltransferase deficiency associated with end-stage renal disease and diabetes mellitus.
Methionine sulfoxide reductase A attenuates atherosclerosis via repairing dysfunctional HDL in scavenger receptor class B type I deficient mice.
Mice overexpressing human lecithin: cholesterol acyltransferase are not protected against diet-induced atherosclerosis.
Molecular defect in familial lecithin:cholesterol acyltransferase (LCAT) deficiency: a single nucleotide insertion in LCAT gene causes a complete deficient type of the disease.
Molecular diagnosis of lecithin: cholesterol acyltransferase deficiency in a presymptomatic proband.
Mouse models of disturbed HDL metabolism.
Oral nicotine impairs clearance of plasma low density lipoproteins.
Overexpression of human lecithin:cholesterol acyltransferase in mice offers no protection against diet-induced atherosclerosis.
Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis.
Plasma lecithin: cholesterol acyltransferase activity is elevated in metabolic syndrome and is an independent marker of increased carotid artery intima media thickness.
Plasma low density lipoprotein composition in relation to atherosclerosis in nutritionally defined Vervet monkeys.
Recombinant human Lecithin-Cholesterol acyltransferase in patients with atherosclerosis: Phase 2a primary results and phase 2b design.
Relationship of endogenous hyperleptinemia to serum paraoxonase 1, cholesteryl ester transfer protein, and lecithin cholesterol acyltransferase in obese individuals.
Specificity of lecithin:cholesterol acyltransferase and atherogenic risk: comparative studies on the plasma composition and in vitro synthesis of cholesteryl esters in 14 vertebrate species.
Structure and function of lamellar bodies, lipid-protein complexes involved in storage and secretion of cellular lipids.
Structure and function of lecithin cholesterol acyl transferase: new insights from structural predictions and animal models.
Studies on regression of atherosclerosis--role of lipid containers.
Very low levels of HDL cholesterol and atherosclerosis, a variable relationship--a review of LCAT deficiency.
[Effect of alpha-tocopherol and hyperbaric oxygenation on lipid fatty-acid composition of the plasma in hypercholesteremic rabbits]
[The importance of lecithin-cholesterol acyltransferase (LCAT) in the detection of early forms of atherosclerosis]
Balkan Nephropathy
Partial lecithin:cholesterol acyltransferase (LCAT) deficiency in Balkan endemic nephropathy.
The role of lecithin cholesterol acyltransferase and organic substances from coal in the etiology of Balkan endemic nephropathy: A new hypothesis.
Bloom Syndrome
Hereditary lecithin-cholesterol acyltransferase deficiency and Bloom syndrome in the same individual.
Breast Neoplasms
Impaired cholesterol esterification in the plasma in patients with breast cancer.
Lecithin: cholesterol acyltransferase and na(+)-k(+)-ATPase activity in patients with breast cancer.
Carcinoma, Hepatocellular
Detection of lecithin: cholesterol acyltransferase (LCAT) in a human hepatoma cell line.
Influence of lecithin:cholesterol acyltransferase on cholesterol metabolism in hepatoma cells and hepatocytes.
Plasma lecithin: cholesterol acyltransferase activity in liver disease.
Synthesis and secretion of lecithin-cholesterol acyltransferase by the human hepatoma cell line HepG2.
Cardiovascular Diseases
A simple and precise method to detect sterol esterification activity of lecithin/cholesterol acyltransferase by high-performance liquid chromatography.
Association of lecithin-cholesterol acyltransferase activity and low-density lipoprotein heterogeneity with atherosclerotic cardiovascular disease risk: a longitudinal pilot study.
Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease.
Lecithin: cholesterol acyltransferase activity, HDL-cholesterol and apolipoprotein A in serum of patients undergoing chronic haemodialysis.
Lecithin: cholesterol acyltransferase--from biochemistry to role in cardiovascular disease.
Markedly accelerated catabolism of apolipoprotein A-II (ApoA-II) and high density lipoproteins containing ApoA-II in classic lecithin: cholesterol acyltransferase deficiency and fish-eye disease.
Moderate dietary intake of myristic and alpha-linolenic acids increases lecithin-cholesterol acyltransferase activity in humans.
Premature and severe cardiovascular disease in a Mexican male with markedly low high-density-lipoprotein-cholesterol levels and a mutation in the lecithin:cholesterol acyltransferase gene: A family study.
Carotid Artery Diseases
Low levels of high-density lipoprotein cholesterol due to lecithin:cholesterol acyltransferase mutations increase carotid atherosclerosis.
Cerebral Infarction
[Lecithin-cholesterol acyltransferase gene 608C/T polymorphism associated with atherosclerotic cerebral infarction]
Cholecystolithiasis
A longitudinal analysis of alteration in lecithin-cholesterol acyltransferase and paraoxonase activities following laparoscopic cholecystectomy relative to other parameters of HDL function and the acute phase response.
Cholelithiasis
STUDY OF SERUM AND BILE FROM PATIENTS OF CHOLELITHIASIS IN NORTH-EASTERN INDIA.
Cholestasis
Apolipoprotein and lipid distribution between vesicles and HDL-like particles formed during lipolysis of human very low density lipoproteins by perfused rat heart.
Controversy over the atherogenicity of lipoprotein-X.
Depletion of high-density lipoprotein and appearance of triglyceride-rich low-density lipoprotein in a Japanese patient with FIC1 deficiency manifesting benign recurrent intrahepatic cholestasis.
Effect of heparin on lecithin: cholesterol acyltransferase and lipids in cholestasis.
Hypercholesterolemia Due to Lipoprotein X: Case Report and Thematic Review.
Plasma lecithin cholesterol acyl transferase activity, high density lipoprotein cholesterol and cholesterol ester in cholestasis.
Rapid normalization of severe hypercholesterolemia mediated by lipoprotein X after liver transplantation in a patient with cholestasis - a case report.
Serum lecithin: cholesterol acyltransferase activity in the bile duct-ligated rat.
Structure and function of lamellar bodies, lipid-protein complexes involved in storage and secretion of cellular lipids.
[Cholesterol metabolism and plasma lecithin-cholesterol acyl transferase in experimental hepatitis and cholestasis in the rat]
[Lipoprotein X and lecithin: cholesterol acyltransferase (LCAT) in cholestasis]
Cholestasis, Intrahepatic
A critical examination of the value of combined determinations of lecithin:cholesterol acyltransferase and lipoprotein-X in the differential diagnosis of liver disease.
Cholesterol Ester Storage Disease
Cholesteryl ester storage disease with secondary lecithin cholesterol acyl transferase deficiency.
Colorectal Neoplasms
Changes in lecithin: cholesterol acyltransferase, cholesteryl ester transfer protein and paraoxonase-1 activities in patients with colorectal cancer.
Corneal Opacity
Amelioration of circulating lipoprotein profile and proteinuria in a patient with LCAT deficiency due to a novel mutation (Cys74Tyr) in the lid region of LCAT under a fat-restricted diet and ARB treatment.
An unusual presentation of LCAT deficiency as nephrotic syndrome with normal serum HDL-C level.
Characterization of a new LCAT mutation causing familial LCAT deficiency (FLD) and the role of APOE as a modifier gene of the FLD phenotype.
Corneal opacification and lecithin-cholesterol acyltransferase (LCAT) deficiency: a case report.
Corticosteroid treatment of kidney disease in a patient with familial lecithin-cholesterol acyltransferase deficiency.
Familial Lecithin:cholesterol acyltransferase deficiency with renal failure in two siblings. First case report from India.
Familial lecithin:cholesterol acyltransferase deficiency: First-in-human treatment with enzyme replacement.
Lecithin-cholesterol acyltransferase (LCAT) deficiency without mutations in the coding sequence: a case report and literature review.
Marked HDL deficiency and premature coronary heart disease.
Molecular defect in familial lecithin:cholesterol acyltransferase (LCAT) deficiency: a single nucleotide insertion in LCAT gene causes a complete deficient type of the disease.
Point mutation (C to T) of the LCAT gene resulting in A140C substitution.
Therapeutic management of a new case of LCAT deficiency with a multifactorial long-term approach based on high doses of angiotensin II receptor blockers (ARBs).
Two novel mutations of lecithin:cholesterol acyltransferase (LCAT) gene and the influence of APOE genotypes on clinical manifestations.
[Corneal opacity as the leading symptom of hereditary lecithin-cholesterol acyltransferase (LCAT) deficiency. Case report and a review of the literature]
Coronary Artery Disease
A unique genetic and biochemical presentation of fish-eye disease.
An unusual presentation of LCAT deficiency as nephrotic syndrome with normal serum HDL-C level.
Effect of mild aerobic exercise on serum lipids and apolipoproteins in patients with coronary artery disease.
Effect of the cholesterol content of reconstituted LpA-I on lecithin:cholesterol acyltransferase activity.
Genetic contributions to quantitative lipoprotein traits associated with coronary artery disease: analysis of a large pedigree from the Bogalusa Heart Study.
Glycation of Apoprotein A-I Is Associated With Coronary Artery Plaque Progression in Type 2 Diabetic Patients.
Lecithin: cholesterol acyltransferase and lysolecithin in coronary atherosclerosis.
Plasma concentrations of LPL and LCAT are in putative association with females and alcohol use which are independent negative risk factors for coronary atherosclerosis among Japanese.
Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women - a prospective case-control analysis nested in the EPIC-Norfolk population study.
Coronary Disease
A study of carbohydrate and lipid metabolism in cases of hyperlipidemia and coronary heart disease. II. Preliminary observations on plasma lecithin cholesterol acyl transferase.
Beta2-adrenergic activity modulates vascular tone regulation in lecithin:cholesterol acyltransferase knockout mice.
High-density lipoprotein metabolism, composition, function, and deficiency.
Lecithin:cholesterol acyltransferase activity in patients with acute myocardial infarction and coronary heart disease.
MEDI6012: Recombinant Human Lecithin Cholesterol Acyltransferase, High-Density Lipoprotein, and Low-Density Lipoprotein Receptor-Mediated Reverse Cholesterol Transport.
Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol.
Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E knockout background in association with a reduction in atherosclerosis.
Safety and Tolerability of ACP-501, a Recombinant Human Lecithin:Cholesterol Acyltransferase, in a Phase 1 Single-Dose Escalation Study.
Cystic Fibrosis
Lipoprotein abnormalities associated with cholesteryl ester transfer activity in cystic fibrosis patients: the role of essential fatty acid deficiency.
Cystinosis
An aid to the diagnosis of genetic disorders underlying adult-onset renal failure: a literature review.
Demyelinating Diseases
A possible mechanism for cholesteryl ester formation during demyelination: lecithin:cholesterol acyltransferase (LCAT) activity in rat brain.
Lecithin cholesterol acyltransferase in human cerebrospinal fluid: reduced level in patients with multiple sclerosis and evidence of direct synthesis in the brain.
Diabetes Complications
NO levels in diabetes mellitus: Effects of l-NAME and insulin on LCAT, Na(+)/K(+) ATPase activity and lipid profile.
Diabetes Mellitus
Alterations in high-density lipoprotein metabolism and reverse cholesterol transport in insulin resistance and type 2 diabetes mellitus: role of lipolytic enzymes, lecithin:cholesterol acyltransferase and lipid transfer proteins.
Apolipoproteins (A-I, A-II, B), Lp(a) lipoprotein and lecithin: cholesterol acyltransferase activity in diabetes mellitus.
Clinofibrate therapy raises high-density lipoprotein levels and lowers atherogenic index in diabetes mellitus patients.
Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, decreases cholesteryl ester transfer protein in type 2 diabetes mellitus.
Glycaemia and body mass as determinants of plasma lecithin: cholesterol acyltransferase activity in Nigerian patients with non-insulin dependent diabetes mellitus.
Lecithin-cholesterol acyltransferase activity in diabetes mellitus and the effect of insulin on these cases.
Marked atherosclerosis in a patient with familiar lecithin: cholesterol acyltransferase deficiency associated with end-stage renal disease and diabetes mellitus.
NO levels in diabetes mellitus: Effects of l-NAME and insulin on LCAT, Na(+)/K(+) ATPase activity and lipid profile.
Oxidized Low-Density Lipoprotein Is Negatively Correlated With Lecithin-Cholesterol Acyltransferase Activity in Type 2 Diabetes Mellitus.
Plasma levels of Apolipoprotein A1 and Lecithin:Cholesterol Acyltransferase in type 2 diabetes mellitus: Correlations with haptoglobin phenotypes.
Reduced lecithin: cholesterol acyltransferase (LCAT) and Na+, K+, ATPase activity in diabetic patients.
Role of lipases, lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in abnormal high density lipoprotein metabolism in insulin resistance and type 2 diabetes mellitus.
[Lecithin-cholesterol acyltransferase (LCAT) activities in diabetes mellitus]
[The lipoprotein metabolism in arterial hypertension, type II diabetes mellitus, and metabolic syndrome]
Diabetes Mellitus, Type 1
Fetal macrosomia related to maternal poorly controlled type 1 diabetes strongly impairs serum lipoprotein concentrations and composition.
Lipoprotein composition in insulin-dependent diabetes mellitus with chronic renal failure: effect of kidney and pancreas transplantation.
Diabetes Mellitus, Type 2
Alterations in high-density lipoprotein metabolism and reverse cholesterol transport in insulin resistance and type 2 diabetes mellitus: role of lipolytic enzymes, lecithin:cholesterol acyltransferase and lipid transfer proteins.
Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, decreases cholesteryl ester transfer protein in type 2 diabetes mellitus.
Fasting and postprandial determinants for the occurrence of small dense LDL species in non-insulin-dependent diabetic patients with and without hypertriglyceridaemia: the involvement of insulin, insulin precursor species and insulin resistance.
Oxidized Low-Density Lipoprotein Is Negatively Correlated With Lecithin-Cholesterol Acyltransferase Activity in Type 2 Diabetes Mellitus.
Plasma levels of Apolipoprotein A1 and Lecithin:Cholesterol Acyltransferase in type 2 diabetes mellitus: Correlations with haptoglobin phenotypes.
Plasma lipoprotein composition and cholesteryl ester transfer from high density lipoproteins to very low density and low density lipoproteins in patients with non-insulin-dependent diabetes mellitus.
Role of lipases, lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in abnormal high density lipoprotein metabolism in insulin resistance and type 2 diabetes mellitus.
Digestive System Diseases
Lecithin: cholesterol acyltransferase levels in plasma of patients with hepatobiliary disease.
Dirofilariasis
Studies on serum free cholesterol concentration and serum lecithin cholesterol acyltransferase activity in canine dirofilariasis.
Down Syndrome
DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels.
Lecithin: cholesterol acyltransferase in Down's syndrome.
Dyslipidemias
Alterations in the fatty acyl composition of plasma cholesteryl esters in Brazilian patients with hepatosplenic schistosomiasis mansoni.
An optimized method for measuring lecithin : cholesterol acyltransferase activity, independent of the concentration and quality of the physiological substrate.
Cholesterol: the good, the bad, and the ugly - therapeutic targets for the treatment of dyslipidemia.
Corneal opacity in LCAT disease.
Familial splenomegaly: macrophage hypercatabolism of lipoproteins associated with apolipoprotein E mutation [apolipoprotein E (delta149 Leu)].
Lecithin-cholesterol acyltransferase (LCAT) deficiency without mutations in the coding sequence: a case report and literature review.
Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4.
Novel P143L polymorphism of the LCAT gene is associated with dyslipidemia in Chinese patients who have coronary atherosclerotic heart disease.
Splenomegaly with sea-blue histiocytosis, dyslipidemia, and nephropathy in a patient with lecithin-cholesterol acyltransferase deficiency: a clinicopathologic correlation.
Endometrial Neoplasms
Effects of high dose progestin on serum lipids and lipid metabolizing enzymes in patients with endometrial cancer.
Eye Diseases
Alpha-lecithin:cholesterol acyltransferase deficiency. Lack of both phospholipase A2 and acyltransferase activities characteristic of high density lipoprotein lecithin:cholesterol acyltransferase in fish eye disease.
Evidence for the presence in human plasma of lecithin: cholesterol acyltransferase activity (beta-LCAT) specifically esterifying free cholesterol of combined pre-beta- and beta-lipoproteins. Studies of fish eye disease patients and control subjects.
Fabry Disease
An aid to the diagnosis of genetic disorders underlying adult-onset renal failure: a literature review.
The role of lipids in nephrosclerosis and glomerulosclerosis.
[Glomerular lipidosis].
Fatty Liver
Decreased serum lecithin:cholesterol acyltransferase activity in spontaneous cases of fatty liver in cows.
Relevance of apolipoproteins in the development of fatty liver and fatty liver-related peripartum diseases in dairy cows.
The activity of lecithin:cholesterol acyltransferase in the serum of cows at parturition or with fatty liver.
The association between lecithin-cholesterol acyltransferase activity and fatty liver index.
Fibrosarcoma
Effect of intralipid infusion on serum high- and low-density lipoprotein cholesterol, lecithin:cholesterol acyltransferase, and lipoprotein lipase in tumor-bearing rats.
Friedreich Ataxia
Lecithin: cholesterol acyltransferase activity and fatty acid composition of erythrocyte phospholipids in Friedreich's ataxia.
Gaucher Disease
[Glomerular lipidosis].
Genetic Diseases, Inborn
Amelioration of circulating lipoprotein profile and proteinuria in a patient with LCAT deficiency due to a novel mutation (Cys74Tyr) in the lid region of LCAT under a fat-restricted diet and ARB treatment.
Arterial hypertension and hyperlipidemia as determinants of glomerulosclerosis.
Co-existence of classic familial lecithin-cholesterol acyl transferase deficiency and fish eye disease in the same family.
Corticosteroid treatment of kidney disease in a patient with familial lecithin-cholesterol acyltransferase deficiency.
LCAT protects against Lipoprotein-X formation in a murine model of drug-induced intrahepatic cholestasis.
Lecithin-cholesterol acyltransferase (LCAT) deficiency without mutations in the coding sequence: a case report and literature review.
Marked atherosclerosis in a patient with familiar lecithin: cholesterol acyltransferase deficiency associated with end-stage renal disease and diabetes mellitus.
Recombinant lecithin:cholesterol acyltransferase containing a Thr123-->Ile mutation esterifies cholesterol in low density lipoprotein but not in high density lipoprotein.
The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes.
The role of lipids in nephrosclerosis and glomerulosclerosis.
Two different allelic mutations in a Finnish family with lecithin:cholesterol acyltransferase deficiency.
Glomerulonephritis
Effect of polyenoic phospholipid therapy on lecithin cholesterol acyltransferase activity in the human serum.
Glomerulonephritis, Membranoproliferative
Hypocomplementemic type II membranoproliferative glomerulonephritis in a male patient with familial lecithin-cholesterol acyltransferase deficiency due to two different allelic mutations.
glycerol kinase deficiency
Endocrine Dysfunctions in Patients with Inherited Metabolic Diseases.
Glycogen Storage Disease
Combined liver-kidney transplantation for rare diseases.
Graft vs Host Disease
Hypercholesterolemia Due to Lipoprotein X: Case Report and Thematic Review.
Rapid normalization of severe hypercholesterolemia mediated by lipoprotein X after liver transplantation in a patient with cholestasis - a case report.
Heart Arrest
Using Literature Based Discovery to Gain Insights Into the Metabolomic Processes of Cardiac Arrest.
Heart Diseases
[Study on the association of lecithin cholesterol acyltransferase gene polymorphisms with the lipid metabolism in coronary atherosclerotic heart disease]
Hepatic Encephalopathy
Serum apoproteins A and B and the lecithin: cholesterol acyl transferase activities in liver cirrhosis and hepatic coma patients.
Hepatitis
Altered lipid composition and differential changes in activities of membrane-bound enzymes of erythrocytes in hepatic cirrhosis.
D-galactosamine induced hepatitis in the rabbit: effect on lecithin:cholesterol acyltransferase activity, plasma lipid transfer protein activity and high density lipoproteins.
Plasma lecithin: cholesterol acyltransferase activity in acute hepatitis.
Plasma lecithin: cholesterol acyltransferase activity in liver disease.
Serum total lipids, lipoprotein cholesterol, and apolipoprotein A in acute viral hepatitis and chronic liver disease.
Studies on human hepatic cholesterol ester hydrolase in liver disease.
[Cholesterol metabolism and plasma lecithin-cholesterol acyl transferase in experimental hepatitis and cholestasis in the rat]
[The behavior of lecithin cholesterol acyltransferase (LCAT) in acute viral hepatitis and post-hepatitis cirrhosis]
Hepatitis A
Lipoprotein abnormalities in galactosamine hepatitis: a model of experimental lecithin:cholesterol acyltransferase deficiency.
Hepatitis, Alcoholic
Plasma lipoprotein composition in alcoholic hepatitis: accumulation of apolipoprotein E-rich high density lipoprotein and preferential reappearance of "light'-HDL during partial recovery.
The role of lecithin:cholesterol acyltransferase deficiency in the apoprotein metabolism of alcoholic hepatitis.
Hereditary Sensory and Motor Neuropathy
Lipid abnormalities in hereditary neuropathy. Part I. Serum non-polar lipids.
Histiocytosis
Histiocytic and Nonhistiocytic Glomerular Lesions: Foam Cells and Their Mimickers.
Homozygous Familial Hypercholesterolemia
Gene therapy for dyslipidemia: clinical prospects.
Rapid normalization of severe hypercholesterolemia mediated by lipoprotein X after liver transplantation in a patient with cholestasis - a case report.
Hyaline Membrane Disease
Plasma lecithin-cholesterol acyltransferase deficiency in a child with terminal pulmonary hyaline membrane disease.
Hypercholesterolemia
An unusual presentation of LCAT deficiency as nephrotic syndrome with normal serum HDL-C level.
Effect of hypercholesteremia on the activity of serum lecithin-cholesterol acyltransferase.
Effects of HMG-CoA reductase inhibition on hepatic expression of key cholesterol-regulatory enzymes and receptors in nephrotic syndrome.
Effects of probucol and pravastatin on plasma lipids, activities of postheparin lipoprotein lipase, and lecithin cholesterol acyltransferase and apo A-I containing lipoproteins with and without apo A-II in patients with moderate hypercholesterolemia.
Effects of vitamin E and HMG-CoA reductase inhibition on cholesteryl ester transfer protein and lecithin-cholesterol acyltransferase in hypercholesterolemia.
New model of atherosclerosis in insulin resistant sand rats: hypercholesterolemia combined with D2 vitamin.
Prebeta-migrating high density lipoprotein: quantitation in normal and hyperlipidemic plasma by solid phase radioimmunoassay following electrophoretic transfer.
Rapid normalization of severe hypercholesterolemia mediated by lipoprotein X after liver transplantation in a patient with cholestasis - a case report.
Serum activity and hepatic secretion of lecithin:cholesterol acyltransferase in experimental hypothyroidism and hypercholesterolemia.
[Role of lipids in adaptive responses of the body to extreme exposure]
Hyperhomocysteinemia
Corrective effects of hepatotoxicity by hepatic Dyrk1a gene delivery in mice with intermediate hyperhomocysteinemia.
Hyperinsulinism
Influence of insulin sensitivity and the TaqIB cholesteryl ester transfer protein gene polymorphism on plasma lecithin:cholesterol acyltransferase and lipid transfer protein activities and their response to hyperinsulinemia in non-diabetic men.
New model of atherosclerosis in insulin resistant sand rats: hypercholesterolemia combined with D2 vitamin.
Hyperlipidemia, Familial Combined
Evidence against alterations in Lecithin:cholesterol acyltransferase (LCAT) activity in familial combined hyperlipidemia.
Linkage of a candidate gene locus to familial combined hyperlipidemia: lecithin:cholesterol acyltransferase on 16q.
Hyperlipidemias
A novel homozygous mutation causing lecithin-cholesterol acyltransferase deficiency in a proband of Romanian origin with a record of extreme gestational hyperlipidemia.
A study of carbohydrate and lipid metabolism in cases of hyperlipidemia and coronary heart disease. II. Preliminary observations on plasma lecithin cholesterol acyl transferase.
Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome.
Characteristic, polymorphism and expression distribution of LCAT gene in a Mongolian gerbil model for hyperlipidemia.
Cholesteryl ester flux from HDL to VLDL-1 is preferentially enhanced in type IIB hyperlipidemia in the postprandial state.
Effect of simian virus 40 subcutaneous tumors on circulating lipids and lipoproteins in the Syrian hamster.
Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet.
Endotoxin-lipoprotein complex formation as a factor in atherogenesis: associations with hyperlipidemia and with lecithin:cholesterol acyltransferase activity.
Evidence against alterations in Lecithin:cholesterol acyltransferase (LCAT) activity in familial combined hyperlipidemia.
High density lipoproteins with differing apolipoproteins: relationships to postprandial lipemia, cholesteryl ester transfer protein, and activities of lipoprotein lipase, hepatic lipase, and lecithin: cholesterol acyltransferase.
Linkage of a candidate gene locus to familial combined hyperlipidemia: lecithin:cholesterol acyltransferase on 16q.
Metabolism of lysolecithin in vivo: effects of hyperlipemia and atherosclerosis in squirrel monkeys.
Regulation of plasma lecithin:cholesterol acyltransferase in man. III. Role of high density lipoprotein cholesteryl esters in the activating effect of a high-fat test meal.
Regulation of plasma lecithin:cholesterol acyltransferase. II. Activation during alimentary lipemia.
The lipemia in familial plasma lecithin: cholesterol acyltransferase deficiency.
Thrombin binding and response in platelets from patients with dyslipoproteinemias: increased stimulus-response coupling in type II hyperlipoproteinemia.
[Effect of Astragalus Angelica Mixture on lipoprotein lipase and lecithin cholesterol acyltransferase of nephrotic rats]
[Heparin role in food lipidemia formation]
[Hyperlipemia and plasma lecithin-cholesterol acyltransferase activity]
Hyperlipoproteinemia Type I
Concentrations of electrophoretic and size subclasses of apolipoprotein A-I-containing particles in human peripheral lymph.
Gene therapy for dyslipidemia: clinical prospects.
Hyperlipoproteinemia Type II
Decrease of plasma large, light LDL (LDL1), HDL2 and HDL3 levels with concomitant increase of cholesteryl ester transfer protein (CETP) activity by probucol in type II hyperlipoproteinemia.
Effects of pravastatin on lipid transfer protein and lecithin cholesterol acyltransferase in heterozygous familial hypercholesterolemia.
Lecithin: cholesterol acyltransferase activity in familial hypercholesterolemia treated with simvastatin and simvastatin plus low-dose colestipol.
Low-dose colestipol plus fenofibrate: effects on plasma lipoproteins, lecithin:cholesterol acyltransferase, and postheparin lipases in familial hypercholesterolemia.
Hyperlipoproteinemia Type III
Characterization of guinea pig plasma lipoproteins: the appearance of new lipoproteins in response to dietary cholesterol.
Hyperlipoproteinemias
Abnormal lipoprotein and apolipoprotein pattern in lipoprotein glomerulopathy.
Characterization of guinea pig plasma lipoproteins: the appearance of new lipoproteins in response to dietary cholesterol.
Decrease of plasma large, light LDL (LDL1), HDL2 and HDL3 levels with concomitant increase of cholesteryl ester transfer protein (CETP) activity by probucol in type II hyperlipoproteinemia.
Determination of apolipoprotein A and its constitutive A-I and A-II polypeptides by separate electroimmunoassays.
Effects of bezafibrate therapy on subfractions of plasma low-density lipoprotein and high-density lipoprotein, and on activities of lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in patients with hyperlipoproteinemia.
Hyperlipoproteinemia in Nagase analbuminemic rats: effects of pravastatin on plasma (apo)lipoproteins and lecithin:cholesterol acyltransferase activity.
Lecithin:cholesterol acyltransferase as a possible diagnostic tool in ischemic heart disease.
Regulation of plasma lecithin:cholesterol acyltransferase in man. I. Increased activity in primary hypertriglyceridemia.
Similar behaviour of lecithin:cholesterol acyltransferase and pseudocholinesterase in liver disease and hyperlipoproteinemia.
[Glomerular lipidosis].
[Relationship between the activity of lecithin cholesterol acyltransferase, hyperlipoproteinemia type and the indicators of the system of hemostasis in chronic ischemic heart disease]
Hyperoxaluria, Primary
An aid to the diagnosis of genetic disorders underlying adult-onset renal failure: a literature review.
Hypertension
Lecithin:cholesterol acyltransferase as a possible diagnostic tool in ischemic heart disease.
Serum lecithin: cholesterol acyltransferase activity, HDL2 and HDL3 composition in hypertensive mothers and their small for gestational age newborns.
[Basal lecithin:cholesterol acyltransferase activity in patients with hypertension (author's transl)]
[The lipoprotein metabolism in arterial hypertension, type II diabetes mellitus, and metabolic syndrome]
Hypertension, Pregnancy-Induced
Serum lecithin: cholesterol acyltransferase activity, HDL2 and HDL3 composition in hypertensive mothers and their small for gestational age newborns.
Hyperthyroidism
Lecithin: cholesterol acyl transfer rate in hypothyroidism and hyperthyroidism.
Plasma lecithin: cholesterol acyltransferase activity in hypo- and hyperthyroidism.
Hypertriglyceridemia
ApoA-II expression in CETP transgenic mice increases VLDL production and impairs VLDL clearance.
Approach to the patient with extremely low HDL-cholesterol.
Charge-based heterogeneity of human plasma lipoproteins at hypertriglyceridemia: capillary isotachophoresis study.
Clinical presentation, laboratory values, and coronary heart disease risk in marked high-density lipoprotein-deficiency states.
Clinical, biochemical, and genetic features in familial disorders of high density lipoprotein deficiency.
Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism.
Familial splenomegaly: macrophage hypercatabolism of lipoproteins associated with apolipoprotein E mutation [apolipoprotein E (delta149 Leu)].
Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance.
Impaired metabolism of high density lipoprotein in uremic patients.
Lecithin-cholesterol acyltransferase activity in carbohydrate-induced hypertriglyceridemia in mice.
Prebeta-migrating high density lipoprotein: quantitation in normal and hyperlipidemic plasma by solid phase radioimmunoassay following electrophoretic transfer.
Regulation of plasma lecithin:cholesterol acyltransferase in man. I. Increased activity in primary hypertriglyceridemia.
Similar behaviour of lecithin:cholesterol acyltransferase and pseudocholinesterase in liver disease and hyperlipoproteinemia.
Hypoalbuminemia
Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome.
Hypoalphalipoproteinemias
Analysis of apolipoprotein A-I, lecithin:cholesterol acyltransferase and glucocerebrosidase genes in hypoalphalipoproteinemia.
Beta2-adrenergic activity modulates vascular tone regulation in lecithin:cholesterol acyltransferase knockout mice.
Clinical variant of Tangier disease in Japan: mutation of the ABCA1 gene in hypoalphalipoproteinemia with corneal lipidosis.
Correction of hypoalphalipoproteinemia in LDL receptor-deficient rabbits by lecithin:cholesterol acyltransferase.
Functional Lecithin: Cholesterol Acyltransferase Is Not Required for Efficient Atheroprotection in Humans.
Functional lecithin: cholesterol acyltransferase is not required for efficient atheroprotection in humans.
Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia.
Molecular genetic study of Finns with hypoalphalipoproteinemia and hyperalphalipoproteinemia: a novel Gly230 Arg mutation (LCAT[Fin]) of lecithin:cholesterol acyltransferase (LCAT) accounts for 5% of cases with very low serum HDL cholesterol levels.
Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E knockout background in association with a reduction in atherosclerosis.
[Familial alpha lipoprotein deficiency. Tangier disease, familial hypoalphalipoproteinemia and familial deficiency of lecithin cholesterol acyltransferase deficiency]
Hypobetalipoproteinemias
Novel missense variants in LCAT and APOB genes in an Italian kindred with familial lecithin:cholesterol acyltransferase deficiency and hypobetalipoproteinemia.
Hypothyroidism
A case of congenital nephrotic syndrome associated with partial deficiency of lecithin cholesterol acyltransferase (LCAT) and hypothyroidism.
Serum activity and hepatic secretion of lecithin:cholesterol acyltransferase in experimental hypothyroidism and hypercholesterolemia.
Infections
A Lipolytic Lecithin:Cholesterol Acyltransferase Secreted by Toxoplasma Facilitates Parasite Replication and Egress.
Insulin Resistance
Alterations in high-density lipoprotein metabolism and reverse cholesterol transport in insulin resistance and type 2 diabetes mellitus: role of lipolytic enzymes, lecithin:cholesterol acyltransferase and lipid transfer proteins.
Fasting and postprandial determinants for the occurrence of small dense LDL species in non-insulin-dependent diabetic patients with and without hypertriglyceridaemia: the involvement of insulin, insulin precursor species and insulin resistance.
Influence of insulin sensitivity and the TaqIB cholesteryl ester transfer protein gene polymorphism on plasma lecithin:cholesterol acyltransferase and lipid transfer protein activities and their response to hyperinsulinemia in non-diabetic men.
Lecithin cholesterol acyltransferase (LCAT) null mice are protected from diet-induced obesity and insulin resistance in a gender specific manner through multiple pathways.
Lecithin cholesterol acyltransferase deficiency protects from diet-induced insulin resistance and obesity--novel insights from mouse models.
Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice.
Lipoprotein metabolism following gastroplasty in obese women.
Role of lipases, lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in abnormal high density lipoprotein metabolism in insulin resistance and type 2 diabetes mellitus.
Kearns-Sayre Syndrome
Endocrine Dysfunctions in Patients with Inherited Metabolic Diseases.
Ketosis
Decreased concentration of serum apolipoprotein C-III in cows with fatty liver, ketosis, left displacement of the abomasum, milk fever and retained placenta.
Lecithin cholesterol acyltransferase (LCAT) activity as a predictor for ketosis and parturient haemoglobinuria in Egyptian water buffaloes.
Reduced activity of lecithin:cholesterol acyltransferase in the serum of cows with ketosis and left displacement of the abomasum.
Reduction in serum lecithin:cholesterol acyltransferase activity prior to the occurrence of ketosis and milk fever in cows.
Kidney Diseases
Corticosteroid treatment of kidney disease in a patient with familial lecithin-cholesterol acyltransferase deficiency.
High-Density Lipoproteins and the Kidney.
Kidney Failure, Chronic
Changes in lipoprotein profile and urinary albumin excretion in familial LCAT deficiency with lipid lowering therapy.
Changes in plasma lecithin: cholesterol acyltransferase activity, HDL(2), HDL(3) amounts and compositions in patients with chronic renal failure after different times of hemodialysis.
Down-regulation of hepatic lecithin:cholesterol acyltransferase gene expression in chronic renal failure.
Effect of long-term hemodialysis on plasma lecithin: cholesterol acyltransferase activity and the amounts and compositions of HDL2 and HDL3 in hemodialysis-treated patients with chronic renal failure: a 9-year longitudinal study.
Effect of recombinant human lecithin cholesterol acyltransferase infusion on lipoprotein metabolism in mice.
Effect of treatment with simvastatin on serum cholesteryl ester transfer in patients on dialysis. PERFECT Study Collaborative Group.
Familial Lecithin:cholesterol acyltransferase deficiency with renal failure in two siblings. First case report from India.
Hyperlipidemia of chronic renal failure.
Impaired metabolism of high density lipoprotein in uremic patients.
Lecithin-cholesterol acyltransferase (LCAT) deficiency without mutations in the coding sequence: a case report and literature review.
Marked atherosclerosis in a patient with familiar lecithin: cholesterol acyltransferase deficiency associated with end-stage renal disease and diabetes mellitus.
Plasma phospholipid transfer protein, cholesteryl ester transfer protein and lecithin:cholesterol acyltransferase in end-stage renal disease (ESRD).
Sequential kidney-liver transplantation from the same living donor for lecithin cholesterol acyl transferase (LCAT) deficiency.
Therapeutic management of a new case of LCAT deficiency with a multifactorial long-term approach based on high doses of angiotensin II receptor blockers (ARBs).
Kwashiorkor
Plasma lecithin-cholesterol acyltransferase activity and plasma lipoprotein composition and concentrations in kwashiorkor.
Lecithin Cholesterol Acyltransferase Deficiency
A case of acquired lecithin:cholesterol acyltransferase deficiency with sarcoidosis that remitted spontaneously.
A molecular defect causing fish eye disease: an amino acid exchange in lecithin-cholesterol acyltransferase (LCAT) leads to the selective loss of alpha-LCAT activity.
A new case of familial LCAT deficiency.
A new molecular defect in the lecithin: cholesterol acyltransferase (LCAT) gene associated with fish eye disease.
A novel frameshift mutation of the lecithin:cholesterol acyltransferase (LCAT) gene associated with renal failure in familial LCAT deficiency.
A novel missense mutation (Asn5-->Ile) in lecithin: cholesterol acyltransferase (LCAT) gene in a Japanese patient with LCAT deficiency.
A proteomic approach to identify novel disease biomarkers in LCAT deficiency.
A review on lecithin:cholesterol acyltransferase deficiency.
A study of the small spherical high density lipoproteins of patients afflicted with familial lecithin: cholesterol acyltransferase deficiency.
A study of the structure of the gene for lecithin: cholesterol acyltransferase in four unrelated individuals with familial lecithin: cholesterol acyltransferase deficiency.
Abnormal lipoprotein appearing in plasma of patients who received a ten percent soybean oil emulsion infusion.
Abnormalities in lipoproteins of d < 1.006 g/ml in familial lecithin:cholesterol acyltransferase deficiency.
Abnormalities in plasma lipoprotein in familial partial lecithin:cholesterol acyltransferase deficiency.
Acquired lecithin:cholesterol acyltransferase deficiency as a major factor in lowering plasma HDL levels in chronic kidney disease.
Activation of lipoprotein lipase by lipoprotein fractions of human serum.
Alpha-lecithin:cholesterol acyltransferase deficiency. Lack of both phospholipase A2 and acyltransferase activities characteristic of high density lipoprotein lecithin:cholesterol acyltransferase in fish eye disease.
Amino acid composition of serum high density lipoprotein in patients with familial lecithin:cholesterol acyltransferase deficiency.
An amino acid exchange in exon I of the human lecithin: cholesterol acyltransferase (LCAT) gene is associated with fish eye disease.
An intronic mutation in a lariat branchpoint sequence is a direct cause of an inherited human disorder (fish-eye disease).
An unusual case of nephrotic syndrome.
Analysis of familial hypoalphalipoproteinemia syndromes.
ApoA-II expression in CETP transgenic mice increases VLDL production and impairs VLDL clearance.
Apolipoprotein AIMilano. Partial lecithin:cholesterol acyltransferase deficiency due to low levels of a functional enzyme.
Apolipoprotein and lipid distribution between vesicles and HDL-like particles formed during lipolysis of human very low density lipoproteins by perfused rat heart.
Apolipoproteins and lipoprotein families in familial lecithin: cholesterol acyltransferase deficiency.
Cardiac surgery for a patient with familial lecithin: cholesterol acyltransferase deficiency.
Case Report: Management of Corneal Clouding from Lecithin: Cholesterol Acyltransferase Deficiency.
Catalytically inactive lecithin: cholesterol acyltransferase (LCAT) caused by a Gly 30 to Ser mutation in a family with LCAT deficiency.
Changes in lipoprotein profile and urinary albumin excretion in familial LCAT deficiency with lipid lowering therapy.
Characterization of a new LCAT mutation causing familial LCAT deficiency (FLD) and the role of APOE as a modifier gene of the FLD phenotype.
Characterization of apolipoprotein E-rich high density lipoproteins in familial lecithin:cholesterol acyltransferase deficiency.
Characterization of guinea pig plasma lipoproteins: the appearance of new lipoproteins in response to dietary cholesterol.
Characterization of subspecies of apolipoprotein A-I-containing lipoprotein in homozygotes for familial lecithin:cholesterol acyltransferase deficiency.
Characterization of subspecies of lipoprotein containing apolipoprotein A-I in heterozygotes for familial lecithin:cholesterol acyltransferase deficiency.
Characterization of the effects of mutations in the putative branchpoint sequence of intron 4 on the splicing within the human lecithin:cholesterol acyltransferase gene.
Classical LCAT deficiency resulting from a novel homozygous dinucleotide deletion in exon 4 of the human lecithin: cholesterol acyltransferase gene causing a frameshift and stop codon at residue 144.
Co-existence of classic familial lecithin-cholesterol acyl transferase deficiency and fish eye disease in the same family.
Combined liver-kidney transplantation for rare diseases.
Compound heterozygosity (G71R/R140H) in the lecithin:cholesterol acyltransferase (LCAT) gene results in an intermediate phenotype between LCAT-deficiency and fish-eye disease.
Concentrations of electrophoretic and size subclasses of apolipoprotein A-I-containing particles in human peripheral lymph.
Corneal changes in the dislipoproteinaemias.
Decreased sodium influx and abnormal red cell membrane lipids in a patient with familial plasma lecithin: cholesterol acyltransferase deficiency.
Demonstration of intact intracellular cholesterol esterification and normal low-density lipoprotein pathway in fibroblasts from a patient with lecithin:cholesterol acyltransferase deficiency.
Detection of erythrocyte membrane structural abnormalities in lecithin: cholesterol acyltransferase deficiency using a spin label approach.
Determination of apolipoprotein A and its constitutive A-I and A-II polypeptides by separate electroimmunoassays.
Different substrate specificities of plasma lecithin: cholesterol acyl transferase in fish eye disease and Tangier disease.
Differential diagnosis of Schnyder corneal dystrophy.
Differential phenotypic expression by three mutant alleles in familial lecithin:cholesterol acyltransferase deficiency.
Disturbed apolipoprotein A-I-containing lipoproteins in fish-eye disease are improved by the lecithin:cholesterol acyltransferase produced by gene-transduced adipocytes in vitro.
Effect of early enteral feeding on apolipoprotein AI levels and high-density lipoprotein heterogeneity in preterm infants.
Effects of long-term, low-fat diet on plasma apo E in familial LCAT deficiency.
Effects of plasma infusion on plasma lipids, apoproteins and plasma enzyme activities in familial lecithin: cholesterol acyltransferase deficiency.
Enzymic esterification of cholesterol in rat intestinal mucosa catalyzed by acyl-CoA: cholesterol acyltransferase.
Erythrocyte alterations in praseodymium-induced lecithin:cholesterol acyltransferase (LCAT) deficiency in the rat: comparison with familial LCAT deficiency in man.
Erythrocyte membrane alterations in lecithin:cholesterol acyltransferase deficiency.
Evidence for deficiency of high density lipoprotein lecithin: cholesterol acyltransferase activity (alpha-LCAT) in fish eye disease.
Evidence for impaired cellular cholesterol removal mediated by apo A-I containing lipoproteins in patients with familial lecithin: cholesterol acyltransferase deficiency.
Evidence for the presence in human plasma of lecithin: cholesterol acyltransferase activity (beta-LCAT) specifically esterifying free cholesterol of combined pre-beta- and beta-lipoproteins. Studies of fish eye disease patients and control subjects.
Familial hypoalphalipoproteinemias.
Familial LCAT deficiency and fish-eye disease.
Familial lecithin-cholesterol acyltransferase deficiency in a Japanese family: evidence for functionally defective enzyme in homozygotes and obligate heterozygotes.
Familial lecithin-cholesterol acyltransferase: identification of heterozygotes with half-normal enzyme activity and mass.
Familial lecithin: cholesterol acyltransferase deficiency complicated with unconjugated hyperbilirubinemia and peripheral neuropathy. The first reported cases in the Far East.
Familial lecithin: cholesterol acyltransferase deficiency. Study of two new patients and their close relatives.
Familial lecithin:cholesterol acyltransferase deficiency - a new metabolic disease with renal involvement.
Familial Lecithin:cholesterol acyltransferase deficiency with renal failure in two siblings. First case report from India.
Familial lecithin:cholesterol acyltransferase deficiency. Biochemistry of the cornea.
Familial lecithin:cholesterol acyltransferase deficiency. Further studies on plasma lipoproteins and plasma postheparin lipase activity of a patient with normal renal function.
Familial lecithin:cholesterol acyltransferase deficiency. Report of a fourth family from northwestern Norway.
Familial lecithin:cholesterol acyltransferase deficiency. Report of a third Norwegian family with two afflicted members.
Familial lecithin:cholesterol acyltransferase deficiency. Studies on lipid composition and morphology of tissues.
Familial lecithin:cholesterol acyltransferase deficiency. Ultrastructural studies on lipid deposition and tissue reactions.
Familial lecithin:cholesterol acyltransferase deficiency: First-in-human treatment with enzyme replacement.
Familial lecithin:cholesterol acyltransferase deficiency: further resolution of lipoprotein particle heterogeneity in the low density interval.
Familial lecithin:cholesterol acyltransferase deficiency: molecular analysis of a compound heterozygote: LCAT (Arg147 --> Trp) and LCAT (Tyr171 --> Stop).
Familial plasma lecithin: cholesterol acyltransferase deficiency.
Familial plasma lecithin: cholesterol acyltransferase deficiency. A new family with partial LCAT activity.
Familial plasma lecithin: cholesterol acyltransferase deficiency. A study of the platelets.
Familial splenomegaly: macrophage hypercatabolism of lipoproteins associated with apolipoprotein E mutation [apolipoprotein E (delta149 Leu)].
Finding a very rare mutation in non-Caucasian LCAT patients from Southwest Asia for the first time.
Free cholesterol deposition in the cornea of human apolipoprotein A-II transgenic mice with functional lecithin: cholesterol acyltransferase deficiency.
Functional Lecithin: Cholesterol Acyltransferase Is Not Required for Efficient Atheroprotection in Humans.
Functional lecithin: cholesterol acyltransferase is not required for efficient atheroprotection in humans.
Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II.
Genetic control of lecithin-cholesterol acyltransferase (LCAT): measurement of LCAT mass in a large kindred with LCAT deficiency.
Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease.
HDL Genetic Defects.
Hereditary lecithin cholesterol acyltransferase deficiency. Report of a new family with two afflicted sisters.
Hereditary lecithin-cholesterol acyltransferase deficiency and Bloom syndrome in the same individual.
Heterogeneity of nascent high density lipoproteins secreted by the hepatoma-derived cell line, Hep G2.
Human lecithin:cholesterol acyltransferase deficiency: in vivo kinetics of low-density lipoprotein and lipoprotein-X.
Hypoalphalipoproteinemia resembling fish eye disease.
Identification of lipoprotein families in familial lecithin: cholesterol acyltransferase deficiency.
Identification of the abnormal cholestatic lipoprotein (LP-X) in familial lecithin:Cholesterol acyltransferase deficiency.
In vitro effects of lecithin:cholesterol acyltransferase on apolipoprotein distribution in familial lecithin:cholesterol acyltransferase deficiency.
In vitro expression of natural mutants of human lecithin:cholesterol acyltransferase.
In vitro expression of structural defects in the lecithin-cholesterol acyltransferase gene.
In vitro normalization of cholesteryl ester content and particle size of fish eye disease high density lipoproteins.
Inhibitory effect of normal high density lipoproteins on lecithin:cholesterol acyltransferase activity in fish eye disease plasma.
Isolated low HDL-cholesterol as an important risk factor for coronary heart disease.
LCAT Enzyme Replacement Therapy Reduces LpX and Improves Kidney Function in a Mouse Model of Familial LCAT Deficiency.
Lecithin cholesterol acyltransferase deficiency protects from diet-induced insulin resistance and obesity--novel insights from mouse models.
Lecithin cholesterol acyltransferase deficiency: ultrastructural examination of sequential renal biopsies.
Lecithin: cholesterol acyltransferase deficiency: identification of two defective alleles in fibroblast cDNA.
Lecithin: cholesterol acyltransferase--from biochemistry to role in cardiovascular disease.
Lecithin:Cholesterol Acyltransferase Activation by Sulfhydryl-Reactive Small Molecules: Role of Cysteine-31.
Lecithin:cholesterol acyltransferase deficiency and cell membrane lipids and function in human liver disease.
Lecithin:cholesterol acyltransferase deficiency associated with hepatic schistosomiasis mansoni.
Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice.
Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice.
Lecithin:cholesterol acyltransferase deficiency.
Lecithin:cholesterol acyltransferase deficiency: identification of a causative gene mutation and a co-inherited protein polymorphism.
Lipid and lipoprotein abnormalities in liver disease: the possible role of lecithin: cholesterol acyltransferase deficiency.
Lipoprotein abnormalities in galactosamine hepatitis: a model of experimental lecithin:cholesterol acyltransferase deficiency.
Lipoprotein and lecithin: cholesterol acyltransferase changes in galactosamine-induced rat liver injury.
Lipoprotein subfractions highly associated with renal damage in familial lecithin:cholesterol acyltransferase deficiency.
Long-term follow-up of a patient with lecithin cholesterol acyltransferase deficiency syndrome after kidney transplantation.
Lp8 is potentially associated with partial lecithin:cholesterol acyltransferase deficiency in a patient with primary biliary cirrhosis.
Management of lipoprotein X and its complications in a patient with primary sclerosing cholangitis.
Marked atherosclerosis in a patient with familiar lecithin: cholesterol acyltransferase deficiency associated with end-stage renal disease and diabetes mellitus.
Marked HDL deficiency and premature coronary heart disease.
Markedly accelerated catabolism of apolipoprotein A-II (ApoA-II) and high density lipoproteins containing ApoA-II in classic lecithin: cholesterol acyltransferase deficiency and fish-eye disease.
Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol.
Molecular diagnosis of lecithin: cholesterol acyltransferase deficiency in a presymptomatic proband.
Molecular pathways in the transformation of model discoidal lipoprotein complexes induced by lecithin:cholesterol acyltransferase.
Net lipid transfer between lipoproteins in fish-eye disease plasma supplemented with normal high density lipoproteins.
New in-vivo techniques for measuring lipoprotein metabolism.
Normalization of high density lipoprotein in fish eye disease plasma by purified normal human lecithin: cholesterol acyltransferase.
Novel Missense LCAT Gene Mutation Associated with an Atypical Phenotype of Familial LCAT Deficiency in Two Portuguese Brothers.
Novel missense variants in LCAT and APOB genes in an Italian kindred with familial lecithin:cholesterol acyltransferase deficiency and hypobetalipoproteinemia.
Ocular and Genetic Characteristics Observed in Two Cases of Fish-Eye Disease.
Ocular manifestations in familial lecithin: cholesterol acyltransferase deficiency.
Ophthalmic observations in lecithin cholesterol acyltransferase deficiency.
Paradoxical esterification of plasma cholesterol in fish eye disease.
Plasma beta-2-microglobulin and urinary albumin: creatinine ratio in lecithin: cholesterol acyltransferase deficiency.
Plasma lipoprotein abnormalities in heterozygotes for familial lecithin:cholesterol acyltransferase deficiency.
Plasma lipoprotein alterations and morphologic changes with lipid deposition in the kidney of patients with hepatorenal syndrome.
Plasma lipoprotein metabolism in familial lecithin:cholesterol acyltransferase deficiency.
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency. Further studies of very low and low density lipoprotein abnormalities.
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: effects of dietary manipulation.
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: effects of incubation with lecithin: cholesterol acyltransferase in vitro.
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: lipid composition and reactivity in vitro.
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: physical and chemical studies of low and high density lipoproteins.
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: structure of low and high density lipoproteins as revealed by elctron microscopy.
Plasma lipoproteins in patients with familial plasma lecithin: cholesterol acyltransferase deficiency: apolipoprotein composition of isolated fractions.
Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency.
Possible association between an abnormal low density lipoprotein and nephropathy in lecithin: cholesterol acyltransferase deficiency.
Possible induction of renal dysfunction in patients with lecithin:cholesterol acyltransferase deficiency by oxidized phosphatidylcholine in glomeruli.
Prebeta-migrating high density lipoprotein: quantitation in normal and hyperlipidemic plasma by solid phase radioimmunoassay following electrophoretic transfer.
Presence of (alpha)-1-lipoprotein in patients with familial plasma lecithin: cholesterol acyltransferase deficiency.
Promotion of sterol efflux and net transport by apolipoprotein E in lecithin:cholesterol acyltransferase deficiency.
Quantitative studies of lipoprotein-X in familial lecithin: cholesterol acyltransferase deficiency and during cholesterol esterification.
Rapid electrophoretic separation of pre-beta-migrating high density lipoproteins using automated PhastSystem: application to analysis of lecithin:cholesterol acyltransferase-deficient plasma.
Recognizing familial lecithin cholesterol acyltransferase deficiency at the slit lamp.
Recombinant lecithin:cholesterol acyltransferase containing a Thr123-->Ile mutation esterifies cholesterol in low density lipoprotein but not in high density lipoprotein.
Recurrence of lecithin cholesterol acyltransferase deficiency after kidney transplantation.
Recurrent glomerulopathy in a renal allograft due to lecithin cholesterol acyltransferase deficiency.
Relationship between structure and biochemical phenotype of lecithin:cholesterol acyltransferase (LCAT) mutants causing fish-eye disease.
Renal failure in familial lecithin: cholesterol acyltransferase deficiency.
Renal lipidosis associated with arteriohepatic dysplasia (Alagille's syndrome).
Reverse cholesterol transport in plasma of patients with different forms of familial HDL deficiency.
Sea-blue histiocytes in familial lecithin: cholesterol acyltransferase deficiency.
Self-adaptive modification of red-cell membrane lipids in lecithin: cholesterol acyltransferase deficiency. Lipid analysis and spin labeling.
Spin label studies of erythrocytes with abnormal lipid composition: comparison of red cells in a hereditary hemolytic syndrome and lecithin: cholesterol acyltransferase deficiency.
Splanchnic production of discoidal plasma high-density lipoprotein in man.
Structural and functional properties of two mutants of lecithin-cholesterol acyltransferase (T123I and N228K).
Structural differences between wild-type and fish eye disease mutant of lecithin:cholesterol acyltransferase.
Structural studies on serum lipoproteins in homozygotes and heterozygotes for the lecithin:cholesterol acyltransferase deficiency gene.
Studies on the pre-alpha-lipoprotein in patients with familial lecithin: cholesterol acyltransferase deficiency.
Studies on the protein moiety of serum high density lipoprotein from patients with familial lecithin: cholesterol acyltransferase deficiency.
Study of the components of reverse cholesterol transport in lecithin:cholesterol acyltransferase deficiency.
Substrate specificity of lecithin:cholesterol acyltransferase. Esterification of desmosterol, b-sitosterol, and cholecalciferol in human plasma.
Successful renal transplantation in a patient with familial lecithin:cholesterol acyltransferase deficiency.
T-->G or T-->A mutation introduced in the branchpoint consensus sequence of intron 4 of lecithin:cholesterol acyltransferase (LCAT) gene: intron retention causing LCAT deficiency.
T13M mutation of lecithin-cholesterol acyltransferase gene causes fish-eye disease.
Targeted disruption of the mouse lecithin:cholesterol acyltransferase (LCAT) gene. Generation of a new animal model for human LCAT deficiency.
The basic apolipoprotein A-I in the patients with familial lecithin:cholesterol acyltransferase deficiency.
The characterization of lipoproteins in the high density fraction obtained from patients with familial lecithin:cholesterol acyltransferase deficiency and their interaction with cultured human fibroblasts.
The effect of plasma transfusion on the plasma cholesterol esters in patients with familial plasma lecithin: cholesterol acyltransferase deficiency.
The genetic defect of the original Norwegian lecithin:cholesterol acyltransferase deficiency families.
The influence of plasma from patients with familial plasma lecithin: cholesterol acyltransferase deficiency on the lipid pattern of erythrocytes.
The lipemia in familial plasma lecithin: cholesterol acyltransferase deficiency.
The molecular basis of lecithin:cholesterol acyltransferase deficiency syndromes: a comprehensive study of molecular and biochemical findings in 13 unrelated Italian families.
The role of lecithin:cholesterol acyltransferase deficiency in the apoprotein metabolism of alcoholic hepatitis.
The ultrastructure of plasma lipoproteins in lecithin:cholesterol acyltransferase deficiency.
Transmission of two novel mutations in a pedigree with familial lecithin:cholesterol acyltransferase deficiency: structure-function relationships and studies in a compound heterozygous proband.
Triglyceride lipases in acute hepatitis.
Two different allelic mutations in a Finnish family with lecithin:cholesterol acyltransferase deficiency.
Two different allelic mutations in the lecithin:cholesterol acyltransferase (LCAT) gene resulting in classic LCAT deficiency: LCAT (tyr83-->stop) and LCAT (tyr156-->asn).
Two novel frame shift mutations in lecithin:cholesterol acyltransferase (LCAT) gene associated with a familial LCAT deficiency phenotype.
Two novel molecular defects in the LCAT gene are associated with fish eye disease.
Two novel mutations of lecithin:cholesterol acyltransferase (LCAT) gene and the influence of APOE genotypes on clinical manifestations.
Two novel point mutations in the lecithin:cholesterol acyltransferase (LCAT) gene resulting in LCAT deficiency: LCAT (G873 deletion) and LCAT (Gly344-->Ser).
Unusual lipid composition of erythrocytes from the insectivorous bat Molossus molossus.
Unusual renal biopsy findings in a patient with familial lecithin:cholesterol acyltransferase deficiency.
[A case of familial lecithin: cholesterol acyltransferase deficiency]
[Atherosclerosis and sensitive determination of oxidized LDL using monoclonal antibody]
[Case of familial lecithin: cholesterol acyltransferase deficiency]
[Characteristics of red cell membrane disorders in the Japanese population]
[Familial alpha lipoprotein deficiency. Tangier disease, familial hypoalphalipoproteinemia and familial deficiency of lecithin cholesterol acyltransferase deficiency]
[Familial hypoalphalipoproteinemia. Vergani's disease]
[Familial lecithin cholesterol acyltransferase deficiency]
[Lecithin-cholesterol acyltransferase deficiency and fish eye disease]
[Lecithin: cholesterol acyltransferase (LCAT)--the genetic analysis of familial LCAT deficiency and fish eye disease]
Leptospirosis
Biomechanical and biochemical investigation of erythrocytes in late stage human leptospirosis.
Lipidoses
[Glomerular lipidosis].
lipoprotein lipase deficiency
Concentrations of electrophoretic and size subclasses of apolipoprotein A-I-containing particles in human peripheral lymph.
Gene therapy for dyslipidemia: clinical prospects.
Liver Cirrhosis
Altered lipid composition and differential changes in activities of membrane-bound enzymes of erythrocytes in hepatic cirrhosis.
Immunoaffinity-isolation of plasma lecithin-cholesterol acyltransferase (LCAT) from patients with hepatic cirrhosis.
Lipoproteins, HDL-apolipoproteins, activities of hepatic lipase and lecithin-cholesterol acyltransferase in the plasma of patients with post-alcoholic end-stage liver cirrhosis.
Plasma lecithin: cholesterol acyltransferase activity in liver disease.
Serum apoproteins A and B and the lecithin: cholesterol acyl transferase activities in liver cirrhosis and hepatic coma patients.
Liver Cirrhosis, Alcoholic
[Membrane cholesterol and insulin receptor in erythrocytes]
Liver Cirrhosis, Biliary
Characterization of guinea pig plasma lipoproteins: the appearance of new lipoproteins in response to dietary cholesterol.
Lipoprotein abnormalities in patients with early primary biliary cirrhosis.
Lp8 is potentially associated with partial lecithin:cholesterol acyltransferase deficiency in a patient with primary biliary cirrhosis.
Management of lipoprotein X and its complications in a patient with primary sclerosing cholangitis.
The electrophoretic mobility of lipoprotein X in postheparin plasma.
Liver Diseases
A critical examination of the value of combined determinations of lecithin:cholesterol acyltransferase and lipoprotein-X in the differential diagnosis of liver disease.
Effectiveness of orthotopic liver transplantation on the restoration of cholesterol metabolism in patients with end-stage liver disease.
In vivo evaluation of lipoprotein cholesterol ester metabolism in patients with liver disease.
Lecithin-cholesterol acyltransferase and lipid transfer protein activities in liver disease.
Lecithin-cholesterol acyltransferase and the lipoprotein abnormalities of parenchymal liver disease.
Lecithin: cholesterol acyltransferase activity in patients with chronic liver diseases and positive LP-X tests.
Lecithin: cholesterol acyltransferase in liver disease.
Lecithin:cholesterol acyltransferase and plasma proteins in liver diseases.
Lecithin:cholesterol acyltransferase as a component of enzyme patterns in acute and chronic liver disease. A preliminary report.
Lecithin:cholesterol acyltransferase deficiency and cell membrane lipids and function in human liver disease.
Lecithin:cholesterol acyltransferase in human liver disease.
Lipid and lipoprotein abnormalities in liver disease: the possible role of lecithin: cholesterol acyltransferase deficiency.
Lipoprotein-X: a substrate for lecithin: cholesterol acyltransferase.
Liver tissue lecithin: cholesterol acyltransferase activity in patients with liver disease.
Plasma lecithin-cholesterol acyltransferase and erythrocyte lipids in liver disease.
Plasma lecithin: cholesterol acyltransferase activity in liver disease.
Plasma lecithin:cholesterol acyltransferase activity and the lipoprotein abnormalities of liver disease.
Plasma lecithin:cholesterol acyltransferase and phospholipid transfer protein activity independently associate with nonalcoholic fatty liver disease.
Red cell lipids in liver disease: relationship to serum lipids and to lecithin-cholesterol acyltransferase.
Role of lecithin:cholesterol acyltransferase and apolipoprotein A-I in cholesterol esterification in lipoprotein-X in vitro.
Serum cholesterol esterification in human liver disease: role of lecithin-cholesterol acyltransferase and cholesterol ester hydrolase.
Serum cholesterol esterification in liver disease. Combined determinations of lecithin: cholesterol acyltransferase and lipoprotein-X.
Similar behaviour of lecithin:cholesterol acyltransferase and pseudocholinesterase in liver disease and hyperlipoproteinemia.
The influence of LP-X and other lipoproteins associated with hepatic dysfunction on the activity of lecithin:cholesterol acyltransferase.
The role of lipids in nephrosclerosis and glomerulosclerosis.
[Clinical significance of the changes in serum lecithin-cholesterol acyltransferase activity and lipids in patients with liver disease]
[Determination and clinical significance of plasma lecithin cholesterol acyltransferase activity in liver diseases (author's transl)]
[Plasma lecithin-cholesterol acyltransferase activity (LCAT) in late schistosomiasis and chronic liver disease]
Liver Diseases, Alcoholic
Abnormal plasma lipoproteins and lecithin-cholesterol acyltransferase deficiency in alcoholic liver disease.
Radioisotopic assay of lecithin: cholesterol acyltransferase (LCAT) in alcoholic liver diseases: effects of alcohol withdrawal in the LCAT activity.
Lymphoma
Reversible deficiency of serum high density lipoproteins in Hodgkin's disease.
Lymphoma, Non-Hodgkin
Severe high-density lipoprotein deficiency associated with autoantibodies against lecithin:cholesterol acyltransferase in non-Hodgkin lymphoma.
Malaria
Alterations of lecithin-cholesterol acyltransferase activity during Plasmodium chabaudi rodent malaria.
Massive Hepatic Necrosis
Plasma lecithin: cholesterol acyltransferase activity in liver disease.
Metabolic Diseases
Familial lecithin:cholesterol acyltransferase deficiency - a new metabolic disease with renal involvement.
Lecithin:Cholesterol Acyltransferase (LCAT) Deficiency: Renal Lesions with Early Graft Recurrence.
Metabolic Syndrome
Plasma lecithin: cholesterol acyltransferase activity is elevated in metabolic syndrome and is an independent marker of increased carotid artery intima media thickness.
[The lipoprotein metabolism in arterial hypertension, type II diabetes mellitus, and metabolic syndrome]
Metabolism, Inborn Errors
Studies on inborn errors of metabolism in Norway.
Multiple Sclerosis
Lecithin cholesterol acyltransferase in human cerebrospinal fluid: reduced level in patients with multiple sclerosis and evidence of direct synthesis in the brain.
Lecithin:cholesterol acyltransferase activity in plasma of patients with multiple sclerosis.
Myocardial Infarction
Alterations in plasma lecithin:cholesterol acyltransferase and myeloperoxidase in acute myocardial infarction: Implications for cardiac outcome.
Effects of smoking on HDL subfractions in myocardial infarction patients: effects on lecithin-cholesterol acyltransferase and hepatic lipase.
Lecithin:cholesterol acyltransferase activity in patients with acute myocardial infarction and coronary heart disease.
[Interrelation of cholesterol esters, phospholipids and lecithin cholesterol acyltransferase activity in the serum of men with myocardial infarction]
Myocardial Ischemia
High pre-beta1 HDL concentrations and low lecithin: cholesterol acyltransferase activities are strong positive risk markers for ischemic heart disease and independent of HDL-cholesterol.
Lecithin:cholesterol acyltransferase as a possible diagnostic tool in ischemic heart disease.
Plasma lecithin: cholesterol acyltransferase in copper-deficient rats.
[Relationship between the activity of lecithin cholesterol acyltransferase, hyperlipoproteinemia type and the indicators of the system of hemostasis in chronic ischemic heart disease]
Neoplasms
Acinar cell carcinoma of rat pancreas: regulation of cholesterol esterification.
Alterations in plasma lipoproteins and heparin-releasable lipase activities in mice bearing the GRSL ascites tumor.
Alterations of cholesteryl ester metabolism characteristic for cancer.
Approach to the patient with extremely low HDL-cholesterol.
Corn silk extract improves cholesterol metabolism in C57BL/6J mouse fed high-fat diets.
Effect of selenium on lipids and some lipid metabolising enzymes in DMBA induced mammary tumor rats.
Efficacy of oral rosuvastatin intervention on HDL and its associated proteins in men with type 2 diabetes mellitus.
Higher Cardiovascular Risk in Common Variable Immunodeficiency and X-Linked Agammaglobulinaemia Patients.
Lipid composition and de novo cholesterogenesis in normal and neoplastic rat mammary tissues.
Lipopolysaccharide and tumor necrosis factor cause a fall in plasma concentration of lecithin: cholesterol acyltransferase in cynomolgus monkeys.
Preliminary assessment of differential expression of candidate genes associated with atherosclerosis.
Tumor targeting effects of a novel modified paclitaxel-loaded discoidal mimic high density lipoproteins.
Nephritis, Hereditary
An aid to the diagnosis of genetic disorders underlying adult-onset renal failure: a literature review.
Nephrotic Syndrome
A 33-year-old man with nephrotic syndrome and lecithin-cholesterol acyltransferase (LCAT) deficiency. Description of two new mutations in the LCAT gene.
A case of congenital nephrotic syndrome associated with partial deficiency of lecithin cholesterol acyltransferase (LCAT) and hypothyroidism.
Abnormal acyltransferase activities and accelerated cholesteryl ester transfer in patients with nephrotic syndrome.
Abnormal lipoprotein and apolipoprotein pattern in lipoprotein glomerulopathy.
Acquired lecithin-cholesterol acyltransferase deficiency in nephrotic syndrome.
Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome.
Immune-mediated acquired lecithin-cholesterol acyltransferase deficiency: A case report and literature review.
Lecithin cholesterol acyltransferase deficiency: ultrastructural examination of sequential renal biopsies.
Serum apolipoproteins A and B, lecithin: cholesterol acyl transferase activities and urinary cholesterol levels in nephrotic syndrome patients before and during steroid treatment.
The role of lipids in nephrosclerosis and glomerulosclerosis.
[Glomerular lipidosis].
[Lipoproteins, apolipoproteins, lipoprotein lipase, hepatic triglyceride lipase and lecithin cholesterol acyltransferase in patients with nephrotic syndrome]
Niemann-Pick Diseases
Structure and function of lamellar bodies, lipid-protein complexes involved in storage and secretion of cellular lipids.
Non-alcoholic Fatty Liver Disease
Plasma lecithin:cholesterol acyltransferase and phospholipid transfer protein activity independently associate with nonalcoholic fatty liver disease.
Obesity
Lecithin cholesterol acyltransferase (LCAT) null mice are protected from diet-induced obesity and insulin resistance in a gender specific manner through multiple pathways.
Lecithin:Cholesterol Acyltransferase (LCAT) Deficiency Promotes Differentiation of Satellite Cells to Brown Adipocytes in a Cholesterol-dependent Manner.
Lecithin:cholesterol acyltransferase activity, plasma and lipoprotein lipids and obesity in men and women.
Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice.
Osteoporosis, Postmenopausal
Reduction of lecithin-cholesterol acyltransferase, apolipoprotein D and the Lp(a) lipoprotein with the anabolic steroid stanozolol.
Overweight
Obesity Affects HDL Metabolism, Composition and Subclass Distribution.
Pancreatitis
Lecithin-cholesterol acyltransferase deficiency presenting with acute pancreatitis: effect of infusion of normal plasma on triglyceride-rich lipoproteins.
peptidyl-glutamate 4-carboxylase deficiency
Studies on inborn errors of metabolism in Norway.
Peripheral Nervous System Diseases
Familial lecithin: cholesterol acyltransferase deficiency complicated with unconjugated hyperbilirubinemia and peripheral neuropathy. The first reported cases in the Far East.
Peritonitis
Changes in the blood lipid-transporting system in rats over the first day of experimental peritonitis.
phosphatidylcholine-sterol o-acyltransferase deficiency
A case of acquired lecithin:cholesterol acyltransferase deficiency with sarcoidosis that remitted spontaneously.
A case of familial lecithin-cholesterol acyltransferase deficiency on hemodialysis for over 20 years.
A new case of familial LCAT deficiency.
A novel homozygous mutation causing lecithin-cholesterol acyltransferase deficiency in a proband of Romanian origin with a record of extreme gestational hyperlipidemia.
A review on lecithin:cholesterol acyltransferase deficiency.
A study of the small spherical high density lipoproteins of patients afflicted with familial lecithin: cholesterol acyltransferase deficiency.
A study of the structure of the gene for lecithin: cholesterol acyltransferase in four unrelated individuals with familial lecithin: cholesterol acyltransferase deficiency.
Abnormal lipoprotein appearing in plasma of patients who received a ten percent soybean oil emulsion infusion.
Abnormal plasma lipoproteins and lecithin-cholesterol acyltransferase deficiency in alcoholic liver disease.
Abnormalities in lipoproteins of d < 1.006 g/ml in familial lecithin:cholesterol acyltransferase deficiency.
Abnormalities in plasma lipoprotein in familial partial lecithin:cholesterol acyltransferase deficiency.
Acquired lecithin-cholesterol acyltransferase deficiency in nephrotic syndrome.
Acquired lecithin:cholesterol acyltransferase deficiency as a major factor in lowering plasma HDL levels in chronic kidney disease.
Activation of lipoprotein lipase by lipoprotein fractions of human serum.
Administration of the High-Density Lipoprotein Mimetic CER-001 for Inherited Lecithin-Cholesterol Acyltransferase Deficiency.
Amino acid composition of serum high density lipoprotein in patients with familial lecithin:cholesterol acyltransferase deficiency.
An aid to the diagnosis of genetic disorders underlying adult-onset renal failure: a literature review.
An unusual case of nephrotic syndrome.
ApoA-II expression in CETP transgenic mice increases VLDL production and impairs VLDL clearance.
Apolipoprotein AIMilano. Partial lecithin:cholesterol acyltransferase deficiency due to low levels of a functional enzyme.
Apolipoprotein and lipid distribution between vesicles and HDL-like particles formed during lipolysis of human very low density lipoproteins by perfused rat heart.
Apolipoproteins and lipoprotein families in familial lecithin: cholesterol acyltransferase deficiency.
Approach to the patient with extremely low HDL-cholesterol.
Cardiac surgery for a patient with familial lecithin: cholesterol acyltransferase deficiency.
Case Report: Management of Corneal Clouding from Lecithin: Cholesterol Acyltransferase Deficiency.
Causes of dysregulation of lipid metabolism in chronic renal failure.
Changes in lipoprotein profile and urinary albumin excretion in familial LCAT deficiency with lipid lowering therapy.
Characterization of apolipoprotein E-rich high density lipoproteins in familial lecithin:cholesterol acyltransferase deficiency.
Characterization of guinea pig plasma lipoproteins: the appearance of new lipoproteins in response to dietary cholesterol.
Characterization of subspecies of apolipoprotein A-I-containing lipoprotein in homozygotes for familial lecithin:cholesterol acyltransferase deficiency.
Characterization of subspecies of lipoprotein containing apolipoprotein A-I in heterozygotes for familial lecithin:cholesterol acyltransferase deficiency.
Cholesteryl ester storage disease with secondary lecithin cholesterol acyl transferase deficiency.
Clinical variant of Tangier disease in Japan: mutation of the ABCA1 gene in hypoalphalipoproteinemia with corneal lipidosis.
Clinical, biochemical, and genetic features in familial disorders of high density lipoprotein deficiency.
Co-existence of classic familial lecithin-cholesterol acyl transferase deficiency and fish eye disease in the same family.
Combined liver-kidney transplantation for rare diseases.
Concentrations of electrophoretic and size subclasses of apolipoprotein A-I-containing particles in human peripheral lymph.
Controversy over the atherogenicity of lipoprotein-X.
Corneal Clouding in a Young Woman With Low HDL Cholesterol.
Corticosteroid treatment of kidney disease in a patient with familial lecithin-cholesterol acyltransferase deficiency.
Decreased sodium influx and abnormal red cell membrane lipids in a patient with familial plasma lecithin: cholesterol acyltransferase deficiency.
Defective enzyme causes lecithin-cholesterol acyltransferase deficiency in a Japanese kindred.
Demonstration of intact intracellular cholesterol esterification and normal low-density lipoprotein pathway in fibroblasts from a patient with lecithin:cholesterol acyltransferase deficiency.
Detection of erythrocyte membrane structural abnormalities in lecithin: cholesterol acyltransferase deficiency using a spin label approach.
Determination of apolipoprotein A and its constitutive A-I and A-II polypeptides by separate electroimmunoassays.
Differential diagnosis of Schnyder corneal dystrophy.
Differential phenotypic expression by three mutant alleles in familial lecithin:cholesterol acyltransferase deficiency.
Discrepancies between lipoprotein(a) concentrations in icteric sera measured by immunonephelometry and electroimmunodiffusion.
Effect of early enteral feeding on apolipoprotein AI levels and high-density lipoprotein heterogeneity in preterm infants.
Effects of plasma infusion on plasma lipids, apoproteins and plasma enzyme activities in familial lecithin: cholesterol acyltransferase deficiency.
Endocrine Dysfunctions in Patients with Inherited Metabolic Diseases.
Enzymic esterification of cholesterol in rat intestinal mucosa catalyzed by acyl-CoA: cholesterol acyltransferase.
Erythrocyte membrane alterations in lecithin:cholesterol acyltransferase deficiency.
Evidence for impaired cellular cholesterol removal mediated by apo A-I containing lipoproteins in patients with familial lecithin: cholesterol acyltransferase deficiency.
Familial hypoalphalipoproteinemias.
Familial Lecithin Cholesterol Acyl Transferase Deficiency with Chronic Kidney Disease.
Familial lecithin-cholesterol acyltransferase deficiency in a Japanese family: evidence for functionally defective enzyme in homozygotes and obligate heterozygotes.
Familial lecithin-cholesterol acyltransferase deficiency in four Norwegian Families. Evidence for low levels of a functionally defective enzyme.
Familial lecithin-cholesterol acyltransferase deficiency.
Familial lecithin-cholesterol acyltransferase deficiency: biochemical characteristics and molecular analysis of a new LCAT mutation in a Polish family.
Familial lecithin: cholesterol acyltransferase deficiency complicated with unconjugated hyperbilirubinemia and peripheral neuropathy. The first reported cases in the Far East.
Familial lecithin: cholesterol acyltransferase deficiency. Study of two new patients and their close relatives.
Familial lecithin:cholesterol acyltransferase deficiency - a new metabolic disease with renal involvement.
Familial Lecithin:cholesterol acyltransferase deficiency with renal failure in two siblings. First case report from India.
Familial lecithin:cholesterol acyltransferase deficiency. Biochemistry of the cornea.
Familial lecithin:cholesterol acyltransferase deficiency. Further studies on plasma lipoproteins and plasma postheparin lipase activity of a patient with normal renal function.
Familial lecithin:cholesterol acyltransferase deficiency. Report of a fourth family from northwestern Norway.
Familial lecithin:cholesterol acyltransferase deficiency. Report of a third Norwegian family with two afflicted members.
Familial lecithin:cholesterol acyltransferase deficiency. Studies on lipid composition and morphology of tissues.
Familial lecithin:cholesterol acyltransferase deficiency. Ultrastructural studies on lipid deposition and tissue reactions.
Familial lecithin:cholesterol acyltransferase deficiency: First-in-human treatment with enzyme replacement.
Familial lecithin:cholesterol acyltransferase deficiency: further resolution of lipoprotein particle heterogeneity in the low density interval.
Familial lecithin:cholesterol acyltransferase deficiency: molecular analysis of a compound heterozygote: LCAT (Arg147 --> Trp) and LCAT (Tyr171 --> Stop).
Familial plasma lecithin: cholesterol acyltransferase deficiency.
Familial plasma lecithin: cholesterol acyltransferase deficiency. A new family with partial LCAT activity.
Familial plasma lecithin: cholesterol acyltransferase deficiency. A study of the platelets.
Familial splenomegaly: macrophage hypercatabolism of lipoproteins associated with apolipoprotein E mutation [apolipoprotein E (delta149 Leu)].
Free cholesterol deposition in the cornea of human apolipoprotein A-II transgenic mice with functional lecithin: cholesterol acyltransferase deficiency.
Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II.
Gene therapy for dyslipidemia: clinical prospects.
Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease.
Glomerular mesangiolipidosis in Alagille syndrome (arteriohepatic dysplasia).
HDL and type 2 diabetes: the chicken or the egg?
Hereditary lecithin cholesterol acyltransferase deficiency. Report of a new family with two afflicted sisters.
Hereditary lecithin-cholesterol acyltransferase deficiency and Bloom syndrome in the same individual.
Hereditary lecithin-cholesterol acyltransferase deficiency. Case report of a German patient.
Hereditary lecithin-cholesterol acyltransferase deficiency. Report of 2 new cases and review of the literature.
Hereditary plasma lecithin-cholesterol acyl transferase deficiency: a heterozygous variant with erythrocyte membrane abnormalities.
Heterogeneity of nascent high density lipoproteins secreted by the hepatoma-derived cell line, Hep G2.
Histiocytic and Nonhistiocytic Glomerular Lesions: Foam Cells and Their Mimickers.
Histopathology of corneal changes in lecithin-cholesterol acyltransferase deficiency.
Human lecithin:cholesterol acyltransferase deficiency: in vivo kinetics of low-density lipoprotein and lipoprotein-X.
Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance.
Hypocomplementemic type II membranoproliferative glomerulonephritis in a male patient with familial lecithin-cholesterol acyltransferase deficiency due to two different allelic mutations.
Identification of lipoprotein families in familial lecithin: cholesterol acyltransferase deficiency.
Identification of the abnormal cholestatic lipoprotein (LP-X) in familial lecithin:Cholesterol acyltransferase deficiency.
Immune-mediated acquired lecithin-cholesterol acyltransferase deficiency: A case report and literature review.
In vitro effects of lecithin:cholesterol acyltransferase on apolipoprotein distribution in familial lecithin:cholesterol acyltransferase deficiency.
In Vivo Imaging of the Cornea in a Patient with Lecithin-Cholesterol Acyltransferase Deficiency.
In vivo imaging of the cornea in a patient with lecithin-cholesterol acyltransferase deficiency.
Isolated low HDL-cholesterol as an important risk factor for coronary heart disease.
Lecithin cholesterol acyl transferase deficiency. Light and electron microscopic finding from two corneas.
Lecithin cholesterol acyl transferase deficiency: molecular analysis of a mutated allele.
Lecithin cholesterol acyltransferase deficiency protects from diet-induced insulin resistance and obesity--novel insights from mouse models.
Lecithin cholesterol acyltransferase deficiency: ultrastructural examination of sequential renal biopsies.
Lecithin-cholesterol acyltransferase deficiency presenting with acute pancreatitis: effect of infusion of normal plasma on triglyceride-rich lipoproteins.
Lecithin-cholesterol acyltransferase deficiency: first report of case in a United States citizen.
Lecithin: cholesterol acyltransferase deficiency: identification of two defective alleles in fibroblast cDNA.
Lecithin:Cholesterol Acyltransferase Activation by Sulfhydryl-Reactive Small Molecules: Role of Cysteine-31.
Lecithin:cholesterol acyltransferase deficiency and cell membrane lipids and function in human liver disease.
Lecithin:cholesterol acyltransferase deficiency associated with hepatic schistosomiasis mansoni.
Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice.
Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice.
Lecithin:cholesterol acyltransferase deficiency.
Lecithin:cholesterol acyltransferase deficiency: identification of a causative gene mutation and a co-inherited protein polymorphism.
Lipid and lipoprotein abnormalities in liver disease: the possible role of lecithin: cholesterol acyltransferase deficiency.
Lipoprotein abnormalities in galactosamine hepatitis: a model of experimental lecithin:cholesterol acyltransferase deficiency.
Lipoprotein and lecithin: cholesterol acyltransferase changes in galactosamine-induced rat liver injury.
Lipoprotein subfractions highly associated with renal damage in familial lecithin:cholesterol acyltransferase deficiency.
Long-term follow-up of a patient with lecithin cholesterol acyltransferase deficiency syndrome after kidney transplantation.
Low density lipoprotein-activated lysolecithin acylation by human plasma lecithin-cholesterol acyltransferase. Identity of lysolecithin acyltransferase and lecithin-cholesterol acyltransferase.
Lp8 is potentially associated with partial lecithin:cholesterol acyltransferase deficiency in a patient with primary biliary cirrhosis.
Management of lipoprotein X and its complications in a patient with primary sclerosing cholangitis.
Marked atherosclerosis in a patient with familiar lecithin: cholesterol acyltransferase deficiency associated with end-stage renal disease and diabetes mellitus.
Marked HDL deficiency and premature coronary heart disease.
Markedly accelerated catabolism of apolipoprotein A-II (ApoA-II) and high density lipoproteins containing ApoA-II in classic lecithin: cholesterol acyltransferase deficiency and fish-eye disease.
Molecular diagnosis of lecithin: cholesterol acyltransferase deficiency in a presymptomatic proband.
Molecular pathways in the transformation of model discoidal lipoprotein complexes induced by lecithin:cholesterol acyltransferase.
Molecular species of phosphatidylcholine in familial lecithin-cholesterol acyltransferase deficiency: effect of enzyme supplementation.
Nephropathy of familial lecithin-cholesterol acyltransferase deficiency: report of a case.
New in-vivo techniques for measuring lipoprotein metabolism.
Novel Missense LCAT Gene Mutation Associated with an Atypical Phenotype of Familial LCAT Deficiency in Two Portuguese Brothers.
Novel missense variants in LCAT and APOB genes in an Italian kindred with familial lecithin:cholesterol acyltransferase deficiency and hypobetalipoproteinemia.
Ocular manifestations in familial lecithin: cholesterol acyltransferase deficiency.
Ophthalmic observations in lecithin cholesterol acyltransferase deficiency.
Plasma beta-2-microglobulin and urinary albumin: creatinine ratio in lecithin: cholesterol acyltransferase deficiency.
Plasma lecithin-cholesterol acyltransferase deficiency in a child with terminal pulmonary hyaline membrane disease.
Plasma lipoprotein abnormalities in heterozygotes for familial lecithin:cholesterol acyltransferase deficiency.
Plasma lipoprotein alterations and morphologic changes with lipid deposition in the kidney of patients with hepatorenal syndrome.
Plasma lipoprotein metabolism in familial lecithin:cholesterol acyltransferase deficiency.
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency. Further studies of very low and low density lipoprotein abnormalities.
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: effects of dietary manipulation.
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: effects of incubation with lecithin: cholesterol acyltransferase in vitro.
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: lipid composition and reactivity in vitro.
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: physical and chemical studies of low and high density lipoproteins.
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: structure of low and high density lipoproteins as revealed by elctron microscopy.
Plasma lipoproteins in patients with familial plasma lecithin: cholesterol acyltransferase deficiency: apolipoprotein composition of isolated fractions.
Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency.
Possible association between an abnormal low density lipoprotein and nephropathy in lecithin: cholesterol acyltransferase deficiency.
Possible induction of renal dysfunction in patients with lecithin:cholesterol acyltransferase deficiency by oxidized phosphatidylcholine in glomeruli.
Postabsorptive retinyl palmitate removal is retarded in lecithin-cholesterol acyltransferase deficiency.
Prebeta-migrating high density lipoprotein: quantitation in normal and hyperlipidemic plasma by solid phase radioimmunoassay following electrophoretic transfer.
Prematurity and lecithin-cholesterol acyltransferase deficiency in newborn infants.
Presence of (alpha)-1-lipoprotein in patients with familial plasma lecithin: cholesterol acyltransferase deficiency.
Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouse.
Promotion of sterol efflux and net transport by apolipoprotein E in lecithin:cholesterol acyltransferase deficiency.
Quantitative studies of lipoprotein-X in familial lecithin: cholesterol acyltransferase deficiency and during cholesterol esterification.
Rapid electrophoretic separation of pre-beta-migrating high density lipoproteins using automated PhastSystem: application to analysis of lecithin:cholesterol acyltransferase-deficient plasma.
Rapid normalization of severe hypercholesterolemia mediated by lipoprotein X after liver transplantation in a patient with cholestasis - a case report.
Recognizing familial lecithin cholesterol acyltransferase deficiency at the slit lamp.
Recurrence of lecithin cholesterol acyltransferase deficiency after kidney transplantation.
Recurrent glomerulopathy in a renal allograft due to lecithin cholesterol acyltransferase deficiency.
Renal failure in familial lecithin-cholesterol acyltransferase deficiency.
Renal failure in familial lecithin: cholesterol acyltransferase deficiency.
Renal lesions in familial lecithin-cholesterol acyltransferase deficiency. Ultrastructural heterogeneity of glomerular changes.
Renal lipidosis associated with arteriohepatic dysplasia (Alagille's syndrome).
Sea-blue histiocytes in familial lecithin: cholesterol acyltransferase deficiency.
Self-adaptive modification of red-cell membrane lipids in lecithin: cholesterol acyltransferase deficiency. Lipid analysis and spin labeling.
Spin label studies of erythrocytes with abnormal lipid composition: comparison of red cells in a hereditary hemolytic syndrome and lecithin: cholesterol acyltransferase deficiency.
Splanchnic production of discoidal plasma high-density lipoprotein in man.
Splenomegaly with sea-blue histiocytosis, dyslipidemia, and nephropathy in a patient with lecithin-cholesterol acyltransferase deficiency: a clinicopathologic correlation.
Structural studies on serum lipoproteins in homozygotes and heterozygotes for the lecithin:cholesterol acyltransferase deficiency gene.
Studies on inborn errors of metabolism in Norway.
Studies on the pre-alpha-lipoprotein in patients with familial lecithin: cholesterol acyltransferase deficiency.
Studies on the protein moiety of serum high density lipoprotein from patients with familial lecithin: cholesterol acyltransferase deficiency.
Study of the components of reverse cholesterol transport in lecithin:cholesterol acyltransferase deficiency.
Substrate specificity of lecithin:cholesterol acyltransferase. Esterification of desmosterol, b-sitosterol, and cholecalciferol in human plasma.
Successful renal transplantation in a patient with familial lecithin:cholesterol acyltransferase deficiency.
The basic apolipoprotein A-I in the patients with familial lecithin:cholesterol acyltransferase deficiency.
The characterization of lipoproteins in the high density fraction obtained from patients with familial lecithin:cholesterol acyltransferase deficiency and their interaction with cultured human fibroblasts.
The effect of plasma transfusion on the plasma cholesterol esters in patients with familial plasma lecithin: cholesterol acyltransferase deficiency.
The genetic defect of the original Norwegian lecithin:cholesterol acyltransferase deficiency families.
The influence of plasma from patients with familial plasma lecithin: cholesterol acyltransferase deficiency on the lipid pattern of erythrocytes.
The lipemia in familial plasma lecithin: cholesterol acyltransferase deficiency.
The molecular basis of lecithin:cholesterol acyltransferase deficiency syndromes: a comprehensive study of molecular and biochemical findings in 13 unrelated Italian families.
The role of lecithin:cholesterol acyltransferase deficiency in the apoprotein metabolism of alcoholic hepatitis.
The ultrastructure of plasma lipoproteins in lecithin:cholesterol acyltransferase deficiency.
Transmission of two novel mutations in a pedigree with familial lecithin:cholesterol acyltransferase deficiency: structure-function relationships and studies in a compound heterozygous proband.
Two different allelic mutations in a Finnish family with lecithin:cholesterol acyltransferase deficiency.
Two novel mutations of lecithin:cholesterol acyltransferase (LCAT) gene and the influence of APOE genotypes on clinical manifestations.
Ultrastructural aspects of familial lecithin-cholesterol acyltransferase deficiency.
Undetectable high-density lipoprotein cholesterol in acute malaria.
Unusual lipid composition of erythrocytes from the insectivorous bat Molossus molossus.
Unusual renal biopsy findings in a patient with familial lecithin:cholesterol acyltransferase deficiency.
[A case of familial lecithin: cholesterol acyltransferase deficiency]
[Case of familial lecithin: cholesterol acyltransferase deficiency]
[Characteristics of red cell membrane disorders in the Japanese population]
[Clinical features of lecithin-cholesterol acyltransferase deficiency]
[Congenital lecithin-cholesterol acyltransferase deficiency. Description of a new case]
[Decreased sodium influx in leaky red cell membranes in familial lecithin-cholesterol acyltransferase deficiency]
[Familial alpha lipoprotein deficiency. Tangier disease, familial hypoalphalipoproteinemia and familial deficiency of lecithin cholesterol acyltransferase deficiency]
[Familial lecithin cholesterol acyltransferase deficiencies]
[Familial lecithin cholesterol acyltransferase deficiency]
[Familial lecithin-cholesterol acyltransferase deficiency]
[Glomerular lipidosis].
[Lecithin-cholesterol acyltransferase deficiency and fish eye disease]
[Metabolic disorders and corneal changes (author's transl)]
Pneumonia
Decreased apolipoprotein C-III concentration in the high-density lipoprotein fraction from calves inoculated with Pasteurella haemolytica and bovine herpes virus-1.
Reduction in serum lecithin:cholesterol acyltransferase activity in natural cases of pneumonia in calves.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Lecithin cholesterol acyltransferase activity in acute lymphoblastic leukemia.
Proteinuria
Abnormal lipoprotein and apolipoprotein pattern in lipoprotein glomerulopathy.
Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome.
An unusual presentation of LCAT deficiency as nephrotic syndrome with normal serum HDL-C level.
Characterization of a new LCAT mutation causing familial LCAT deficiency (FLD) and the role of APOE as a modifier gene of the FLD phenotype.
Corticosteroid treatment of kidney disease in a patient with familial lecithin-cholesterol acyltransferase deficiency.
Familial lecithin-cholesterol acyltransferase (LCAT) deficiency; a differential of proteinuria.
Lecithin-cholesterol acyltransferase (LCAT) deficiency without mutations in the coding sequence: a case report and literature review.
Marked HDL deficiency and premature coronary heart disease.
Paradoxical fall in proteinuria during pregnancy in an LCAT-deficient patient-A case report.
Point mutation (C to T) of the LCAT gene resulting in A140C substitution.
Sex dimorphism in serum lecithin: cholesterol acyltransferase and lipoprotein lipase activities in adult sickle cell anaemia patients with proteinuria.
Therapeutic management of a new case of LCAT deficiency with a multifactorial long-term approach based on high doses of angiotensin II receptor blockers (ARBs).
Two different allelic mutations in the lecithin:cholesterol acyltransferase (LCAT) gene resulting in classic LCAT deficiency: LCAT (tyr83-->stop) and LCAT (tyr156-->asn).
Two novel mutations of lecithin:cholesterol acyltransferase (LCAT) gene and the influence of APOE genotypes on clinical manifestations.
[Corneal opacity as the leading symptom of hereditary lecithin-cholesterol acyltransferase (LCAT) deficiency. Case report and a review of the literature]
Psoriasis
Biological anti-psoriatic therapy profoundly affects high-density lipoprotein function.
Renal Insufficiency
A novel frameshift mutation of the lecithin:cholesterol acyltransferase (LCAT) gene associated with renal failure in familial LCAT deficiency.
A novel in vivo lecithin-cholesterol acyltransferase (LCAT)-deficient mouse expressing predominantly LpX is associated with spontaneous glomerulopathy.
Atorvastatin Improves Hepatic Lipid Metabolism and Protects Renal Damage in Adenine-Induced Chronic Kidney Disease in Sprague-Dawley Rats.
Characterization of a new LCAT mutation causing familial LCAT deficiency (FLD) and the role of APOE as a modifier gene of the FLD phenotype.
Familial Lecithin:cholesterol acyltransferase deficiency with renal failure in two siblings. First case report from India.
Lipoprotein subfractions highly associated with renal damage in familial lecithin:cholesterol acyltransferase deficiency.
Marked HDL deficiency and premature coronary heart disease.
Molecular defect in familial lecithin:cholesterol acyltransferase (LCAT) deficiency: a single nucleotide insertion in LCAT gene causes a complete deficient type of the disease.
Renal failure in familial lecithin-cholesterol acyltransferase deficiency.
Renal failure in familial lecithin: cholesterol acyltransferase deficiency.
Renal Insufficiency, Chronic
Acquired lecithin:cholesterol acyltransferase deficiency as a major factor in lowering plasma HDL levels in chronic kidney disease.
Combined liver-kidney transplantation for rare diseases.
Familial Lecithin Cholesterol Acyl Transferase Deficiency with Chronic Kidney Disease.
Low Plasma Lecithin: Cholesterol Acyltransferase (LCAT) Concentration Predicts Chronic Kidney Disease.
Novel Missense LCAT Gene Mutation Associated with an Atypical Phenotype of Familial LCAT Deficiency in Two Portuguese Brothers.
[Causes and risks of hyperlipidemia during dialysis and after renal transplantation]
Sarcoidosis
A case of acquired lecithin:cholesterol acyltransferase deficiency with sarcoidosis that remitted spontaneously.
Schistosomiasis
[Plasma lecithin-cholesterol acyltransferase activity (LCAT) in late schistosomiasis and chronic liver disease]
Schistosomiasis mansoni
Alterations in the fatty acyl composition of plasma cholesteryl esters in Brazilian patients with hepatosplenic schistosomiasis mansoni.
Effect of experimental schistosomiasis mansoni on plasma and erythrocyte lipids and on plasma lecithin: cholesterol acyltransferase in the mouse.
Lecithin:cholesterol acyltransferase deficiency associated with hepatic schistosomiasis mansoni.
Sea-Blue Histiocyte Syndrome
Splenomegaly with sea-blue histiocytosis, dyslipidemia, and nephropathy in a patient with lecithin-cholesterol acyltransferase deficiency: a clinicopathologic correlation.
Sepsis
Alteration of Lysophosphatidylcholine-Related Metabolic Parameters in the Plasma of Mice with Experimental Sepsis.
Alterations in lipoprotein homeostasis during human experimental endotoxemia and clinical sepsis.
Lipid metabolism in critical illness.
Sleep Deprivation
[Sleep deprivation effect on lecithin-cholesterol acyltransferase basal activity and on plasma levels of triglycerides and cholesterol (author's transl)]
Starvation
Effects of starvation and plasma exchange on lecithin: cholesterol acyltransferase activity and cholesterol efflux in cholesterol-fed pigs.
sterol o-acyltransferase deficiency
[Familial alpha lipoprotein deficiency. Tangier disease, familial hypoalphalipoproteinemia and familial deficiency of lecithin cholesterol acyltransferase deficiency]
Tangier Disease
Apoprotein A-I and lecithin: cholesterol acyltransferase in a patient with Tangier disease.
Approach to the patient with extremely low HDL-cholesterol.
Cholesterol esterification by lecithin-cholesterol acyltransferase in A-I-free plasma.
Cholesteryl ester transfer activity in plasma of patients with familial high-density lipoprotein deficiency.
Clinical variant of Tangier disease in Japan: mutation of the ABCA1 gene in hypoalphalipoproteinemia with corneal lipidosis.
Corneal changes in the dislipoproteinaemias.
Different substrate specificities of plasma lecithin: cholesterol acyl transferase in fish eye disease and Tangier disease.
Differential diagnosis of Schnyder corneal dystrophy.
Familial hypoalphalipoproteinemias.
Familial splenomegaly: macrophage hypercatabolism of lipoproteins associated with apolipoprotein E mutation [apolipoprotein E (delta149 Leu)].
Generation of pre-beta 1-HDL and conversion into alpha-HDL. Evidence for disturbed HDL conversion in Tangier disease.
HDL Genetic Defects.
Isolated low HDL-cholesterol as an important risk factor for coronary heart disease.
Lecithin:cholesterol acyltransferase in familial HDL deficiency (Tangier disease).
Reverse cholesterol transport in plasma of patients with different forms of familial HDL deficiency.
The role of high density lipoproteins in lecithin:cholesterol acyltransferase activity: perspectives from Tangier disease.
Undetectable high-density lipoprotein cholesterol in acute malaria.
[Familial alpha lipoprotein deficiency. Tangier disease, familial hypoalphalipoproteinemia and familial deficiency of lecithin cholesterol acyltransferase deficiency]
[Familial hypoalphalipoproteinemia. Vergani's disease]
[Inborn errors of high-density lipoprotein metabolism].
Thrombotic Microangiopathies
Histiocytic and Nonhistiocytic Glomerular Lesions: Foam Cells and Their Mimickers.
triacylglycerol lipase deficiency
Alpha-lecithin:cholesterol acyltransferase deficiency. Lack of both phospholipase A2 and acyltransferase activities characteristic of high density lipoprotein lecithin:cholesterol acyltransferase in fish eye disease.
Apolipoprotein AIMilano. Partial lecithin:cholesterol acyltransferase deficiency due to low levels of a functional enzyme.
Causes of dysregulation of lipid metabolism in chronic renal failure.
Lipoprotein abnormalities associated with lipopolysaccharide-induced lecithin: cholesterol acyltransferase and lipase deficiency.
[Familial alpha lipoprotein deficiency. Tangier disease, familial hypoalphalipoproteinemia and familial deficiency of lecithin cholesterol acyltransferase deficiency]
Uremia
Lecithin-cholesterol acyltransferase (LCAT) activity in chronic uremia.
Vascular Diseases
Lecithin: cholesterol acyltransferase (LCAT) deficiency and risk of vascular disease: 25 year follow-up.
Vitamin E Deficiency
Depression of lecithin-cholesterol acyltransferase esterification in vitamin E-deficient monkeys.
Studies of serum lecithin-cholesterol acyl transferase activity in rat: effect of vitamin E deficiency, oxidized dietary fat, or intravenous administration of ozonides or hydroperoxides.
Wolman Disease
[Metabolic disorders and corneal changes (author's transl)]
Xanthomatosis, Cerebrotendinous
Increased concentrations of cholestanol and apolipoprotein B in the cerebrospinal fluid of patients with cerebrotendinous xanthomatosis. Effect of chenodeoxycholic acid.