Reference on EC 2.3.1.5 - arylamine N-acetyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Glowinski, I.B.; Weber, W.W.; Fysh, J.M.; Vaught, J.B.; King, C.M.
Evidence that arylhydroxamic acid N,O-acyltransferase and the genetically polymorphic N-acetyltransferase are properties of the same enzyme in rabbit liver
J. Biol. Chem.
255
7883-7890
1980
Oryctolagus cuniculus
Fajardo, N.; Abreu, P.; Alonso, R.
Determination of kinetic properties of serotonin-N-acetyltransferase in bovine pineal gland using HPLC with fluorimetric detection
J. Pineal Res.
13
80-84
1992
Bos taurus
Grant, D.M.; Blum, M.; Beer, M.; Meyer, U.A.
Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes
Mol. Pharmacol.
39
184-191
1991
Homo sapiens
Ohtomi, M.; Tomoyuki, I.; Deguchi, T.
Arylamine N-acetyltransferase from the chicken kidney: characterization of the enzyme and localization of the mRNA by in situ hybridization
Biomed. Res.
11
263-267
1990
Gallus gallus
-
Watson, A.P.; Wang, P.D.; Sim, E.
Arylamine N-acetyltransferase from fast (C57BL6) and slow (A/J) N-acetylating strains of mice
Biochem. Pharmacol.
39
647-654
1990
Mus musculus
Morton, D.J.
Effect of various cations on the activity of pineal gland N-acetyltransferase (EC 2.3.1.5) and hydroxyindole-O-methyl transferase (EC 2.1.1.4) in vitro
J. Pineal Res.
4
161-167
1987
Rattus norvegicus
Rougraff, P.M.; Paxton, R.
Purification and partial characterization of checken liver acetyl coenzymeA:arylamine N-acetyltransferase
Comp. Biochem. Physiol. B
86
601-606
1987
Gallus gallus, Columba sp., Oryctolagus cuniculus
Jendryczko, A.; Drozdz, M.
Effects of some complexing agents on acetyl-CoA:arylamine N-acetyltransferase
Rev. Roum. Biochim.
22
201-203
1985
Mesocricetus auratus
-
Gollamudi, R.; Rackley, R.J.; Autian, J.
A new substrate for the measurement of N-acetyltransferase activity
Enzyme
30
155-161
1983
Oryctolagus cuniculus, Homo sapiens, Mus musculus, no activity in Canis familiaris, Rattus norvegicus
Paul, R.C.; Ratledge, C.
Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes
Biochim. Biophys. Acta
320
9-15
1973
Klebsiella aerogenes, Klebsiella aerogenes N5-36
Barenholz, Y.; Edelman, I.; Gatt, S.
Amine:acetyl CoenzymeA acetyltransferase from the soluble fraction of Hansenula ciferri: isolation and properties
Biochim. Biophys. Acta
358
262-274
1974
Wickerhamomyces ciferrii
-
Andres, H.H.; Kolb, H.J.; Weiss, L.
Purification and physical-chemical properties of acetyl-CoA:arylamine N-acetyltransferase from pigeon liver
Biochim. Biophys. Acta
746
182-192
1983
Columba sp.
Andres, H.H.; Kolb, H.J.; Schreiber, R.J.; Weiss, L.
Characterization of the active site, substrate specificity and kinetic properties of acetyl-CoA:arylamine N-acetyltransferase from pigeon liver
Biochim. Biophys. Acta
746
193-201
1983
Anas sp., Columba sp., Meleagris gallopavo, Oncorhynchus mykiss
Hasmann, M.J.; Seidl, P.H.; Engelhardt, G.; Schleifer, K.H.
Acetyl-coenzyme A: arylamine N-acetyltransferases in microorganisms: screening and isolation of an enzyme from Bacillus cereus
Arch. Microbiol.
146
275-279
1986
Bacillus cereus, Cordyceps militaris
Yu, P.H.; Boulton, A.A.
N-Acylation of tyramines: purification and characterization of an arylamine N-acetyltransferase from rat brain and liver
Can. J. Biochem.
57
1204-1209
1979
Rattus norvegicus, Rattus norvegicus Wistar
Weber, W.W.
N-Acetyltransferase (mammalian liver)
Methods Enzymol.
17B
805-811
1971
Oryctolagus cuniculus, Homo sapiens, Platyrrhini, Rattus norvegicus
-
Mannens, G.; Siegers, G.; Claeys, A.
Assay for acetyl-CoA:arylamine N-acetyltransferase by high-performance liquid chromatography applied to serotonin N-acetylation
Biochim. Biophys. Acta
1037
1-6
1990
Columba sp.
Morrissey, J.J.; Edwards, S.B.; Lovenberg, W.
Comparison of rat pineal gland and rat liver serotonin-N-acetyltransferase
Biochem. Biophys. Res. Commun.
77
118-123
1977
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Schulte, E.H.; Schloot, W.; Goedde, H.W.
Purification of human liver serotonin/isoniazid N-acetyltransferase by preparative polyacrylamide gel elctrophoresis and determination of molecular weight
Z. Naturforsch. C
29c
661-666
1974
Homo sapiens
-
Weber, W.W.; King, C.M.
N-Acetyltransferase and arylhydroxamic acid acyltransferase
Methods Enzymol.
77
272-280
1981
no activity in Canis familiaris, Oryctolagus cuniculus
Ohtomi, M.; Sasaki, M.; Deguchi, T.
Two arylamine N-acetyltransferases from chicken pineal gland as identified by cDNA cloning
Eur. J. Biochem.
185
253-261
1989
Gallus gallus
Andres, H.H.; Klem, A.J.; Schopfer, L.M.; Harrison, J.K.; Weber, W.W.
On the active site of liver acetyl-CoA. Arylamine N-acetyltransferase from rapid acetylator rabbits (III/J)
J. Biol. Chem.
263
7521-7527
1988
Columba sp., Oryctolagus cuniculus
Deguchi, T.; Sakamoto, Y.; Sasaki, Y.; Uyemura, K.
Arylamine N-acetyltransferase from chicken liver. I. Monoclonal antibodies, immunoaffinity purification, and amino acid sequences
J. Biol. Chem.
263
7528-7533
1988
Gallus gallus
Ohsako, S.; Ohtomi, M.; Sakamoto, Y.; Uyemura, K.; Deguchi, T.
Arylamine N-acetyltransferase from chicken liver II. Cloning of cDNA and expression in Chinese hamster ovary cells
J. Biol. Chem.
263
7534-7538
1988
Gallus gallus
Dupret, J.M.; Grant, D.M.
Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2
J. Biol. Chem.
267
7381-7385
1992
Homo sapiens
Grant, D.M.; Lottspeich, F.; Meyer, U.A.
Evidence for two closely related isozymes of arylamine N-acetyltransferase in human liver
FEBS Lett.
244
203-207
1989
Homo sapiens
Hein, D.W.
Acetylator genotype and arylamine-induced carcinogenesis
Biochim. Biophys. Acta
948
37-66
1988
Oryctolagus cuniculus, Homo sapiens, Mesocricetus auratus, Mus musculus, no activity in Canis familiaris, Salmonella enterica subsp. enterica serovar Typhimurium
Zaher, H.; Lindblad, W.J.; Jiang, W.; Doll, M.A.; Hein, D.W.; Svensson, C.K.
Acetyl CoA: arylamine N-acetyltransferase activity in rat hepatocytes cultured on different extracellular matrixes
Toxicol. in Vitro
11
271-283
1997
Rattus norvegicus
Sticha, K.R.; Sieg, C.A.; Bergstrom, C.P.; Hanna, P.E.; Wagner, C.R.
Overexpression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein
Protein Expr. Purif.
10
141-153
1997
Mesocricetus auratus
Bergstrom, C.P.; Wagner, C.R.; Ann, D.K.; Hanna, P.E.
Hamster monomorphic arylamine N-acetyltransferase: expression in Escherichia coli and purification
Protein Expr. Purif.
6
45-55
1995
Mesocricetus auratus
Upton, A.M.; Mushtaq, A.; Victor, T.C.; Sampson, S.L.; Sandy, J.; Smith, D.M.; Van Helden, P.V.; Sim, E.
Arylamine N-acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism
Mol. Microbiol.
42
309-317
2001
Mycobacterium tuberculosis, Mycobacterium tuberculosis variant bovis
Hickman, D.; Palamanda, J.R.; Unadkat, J.D.; Sim, E.
Enzyme kinetic properties of human recombinant arylamine N-acetyltransferase 2 allotypic variants expressed in Escherichia coli
Biochem. Pharmacol.
50
697-703
1995
Homo sapiens
Sticha, K.R.K.; Bergstrom, C.P.; Wagner, C.R.; Hanna, P.E.
Characterization of hamster recombinant monomorphic and polymorphic arylamine N-acetyltransferases. Bioactivation and mechanism-based inactivation studies with N-hydroxy-2-acetylaminofluorene
Biochem. Pharmacol.
56
47-59
1998
Mesocricetus auratus
Butcher, N.J.; Ilett, K.F.; Minchin, R.F.
Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-Aminobenzoic acid
Biochem. Pharmacol.
60
1829-1836
2000
Homo sapiens
Guray, T.; Guvenc, T.
Sheep tissue acetyl coenzyme A-dependent arylamine N-acetyltransferases
Comp. Biochem. Physiol. C
118C
305-310
1997
Ovis ammon
-
Tsou, M.F.; Chung, J.G.; Wu, L.T.; Cheng, K.S.; Hung, C.F.
Characterization of arylamine N-acetyltransferase in Enterobacter aerogenes
Microbios
94
133-143
1998
Klebsiella aerogenes
Chen, G.W.; Hung, C.F.; Chang, S.H.; Lin, J.G.; Chung, J.G.
Purification and characterization of an arylamine N-acetyltransferase from Lactobacillus acidophilus
Microbios
98
159-174
1999
Lactobacillus acidophilus
Chung, J.G.
Purification and characterization of an arylamine N-acetyltransferase in the nematode Enterobius vermicularis
Microbios
98
15-25
1999
Enterobius vermicularis
Fang, S.H.; Chung, J.G.; Chang, W.C.; Chang, S.S.
Evidence for arylamine N-acetyltransferase activity in the fungi Candida albicans
Toxicol. Lett.
92
109-116
1997
Candida albicans
Chung, J.G.; Wang, H.H.; Tsou, M.F.; Hsieh, S.E.; Lo, H.H.; Yen, Y.S.; Chang, S.S.; Wu, L.T.; Lee, J.H.; Hung, C.F.
Evidence for arylamine N-acetyltransferase activity in the bacterium Helicobacter pylori
Toxicol. Lett.
91
63-71
1997
Helicobacter pylori
Chung, J.G.; Kuo, H.M.; Lin, T.H.; Ho, C.C.; Lee, J.H.; Lai, J.M.; Levy, G.N.; Weber, W.W.
Evidence for arylamine N-acetyltransferase in the nematode Anisakis simplex
Cancer Lett.
106
1-8
1996
Anisakis simplex
Hsieh, S.E.; Lo, H.H.; Chung, J.G.
The characteristics of arylamine N-acetyltransferase in Pseudomonas aeruginosa
Curr. Microbiol.
36
353-360
1998
Pseudomonas aeruginosa
Chang, F.C.; Chung, J.G.
Evidence for arylamine N-acetyltransferase activity in the Escherichia coli
Curr. Microbiol.
36
125-130
1998
Escherichia coli
Yeh, C.C.; Hung, C.F.; Wang, W.L.; Chung, J.G.
Kinetics of acetyl coenzyme A: arylamine N-acetyltransferase from rapid and slow acetylator human benign prostatic hyperplasia tissues
Urol. Res.
29
311-316
2001
Homo sapiens
Mushtaq, A.; Payton, M.; Sim, E.
The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity
J. Biol. Chem.
277
12175-12181
2002
Salmonella enterica subsp. enterica serovar Typhimurium
Goodfellow, G.H.; Dupret, J.M.; Grant, D.M.
Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2
Biochem. J.
348
159-166
2000
Homo sapiens
-
Whitaker, D.P.; Goosey, M.W.
Purification and properties of the enzyme arylamine N-acetyltransferase from the housefly Musca domestica
Biochem. J.
295
149-154
1993
Musca domestica
-
Chung, J.G.; Chen, G.W.; Yeh, H.N.; Hung, C.F.; Huang, D.S.
Kinetics of acetyl coenzyme A:arylamine N-acetyltransferase from the human umbilical cord
Res. Commun. Pharmacol. Toxicol.
2
193-204
1997
Homo sapiens
-
Palamanda, J.R.; Hickman, D.; Ward, A.; Sim, E.; Romkes-Sparks, M.; Unadkat, J.D.
Dapsone acetylation by human liver arylamine N-acetyltransferases and interaction with antiopportunistic infection drugs
Drug Metab. Dispos.
23
473-477
1995
Homo sapiens
Rodriguez-Cabello, J.C.; Agapito, M.T.; Garcia-Herrero, I.; Recio, J.M.
Effects of EGTA and calmodulin, neutral thiol proteinases and protein kinase C inhibitors on loss of chicken pineal serotonin N-acetyltransferase activity
J. Comp. Physiol. B
159
583-588
1989
Gallus gallus
Namboodiri, M.A.A.; Brownstein, M.J.; Weller, J.L.; Voisin, P.; Klein, D.C.
Multiple forms of arylalkylamine N-acetyltransferases in the rat pineal gland: purification of one molecular form
J. Pineal Res.
4
235-246
1987
Oryctolagus cuniculus, Rattus norvegicus
Sekine, A.; Saito, S.; Iida, A.; Mitsunobu, Y.; Higuchi, S.; Harigae, S.; Nakamura, Y.
Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2, AANAT, ARD1, and L1CAM in the Japanese population
Hum. Genet.
46
314-319
2001
Saccharomyces cerevisiae, Homo sapiens
Holton, S.J.; Dairou, J.; Sandy, J.; Rodrigues-Lima, F.; Dupret, J.M.; Noble, M.E.M.; Sim, E.
Structure of Mesorhizobium loti arylamine N-acetyltransferase 1
Acta Crystallogr. Sect. F
61
14-16
2005
Mesorhizobium loti
Dairou, J.; Atmane, N.; Dupret, J.M.; Rodrigues-Lima, F.
Reversible inhibition of the human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 by S-nitrosothiols
Biochem. Biophys. Res. Commun.
307
1059-1065
2003
Homo sapiens
Westwood, I.M.; Holton, S.J.; Rodrigues-Lima, F.; Dupret, J.M.; Bhakta, S.; Noble, M.E.; Sim, E.
Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase
Biochem. J.
385
605-612
2005
Pseudomonas aeruginosa
Kawamura, A.; Graham, J.; Mushtaq, A.; Tsiftsoglou, S.A.; Vath, G.M.; Hanna, P.E.; Wagner, C.R.; Sim, E.
Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening
Biochem. Pharmacol.
69
347-359
2005
Mesocricetus auratus
Wang, H.; Vath, G.M.; Gleason, K.J.; Hanna, P.E.; Wagner, C.R.
Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies
Biochemistry
43
8234-8246
2004
Mesocricetus auratus
Delgoda, R.; Lian, L.Y.; Sandy, J.; Sim, E.
NMR investigation of the catalytic mechanism of arylamine N-acetyltransferase from Salmonella typhimurium
Biochim. Biophys. Acta
1620
8-14
2003
Salmonella enterica subsp. enterica serovar Typhimurium
Brooke, E.W.; Davies, S.G.; Mulvaney, A.W.; Pompeo, F.; Sim, E.; Vickers, R.J.
An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases
Bioorg. Med. Chem.
11
1227-1234
2003
Salmonella enterica subsp. enterica serovar Typhimurium, Mycolicibacterium smegmatis (O86309)
Winter, H.R.; Unadkat, J.D.
Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism
Drug Metab. Dispos.
33
969-976
2005
Homo sapiens
Atmane, N.; Dairou, J.; Paul, A.; Dupret, J.M.; Rodrigues-Lima, F.
Redox regulation of the human xenobiotic metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1). Reversible inactivation by hydrogen peroxide
J. Biol. Chem.
278
35086-35092
2003
Homo sapiens
Dairou, J.; Atmane, N.; Rodrigues-Lima, F.; Dupret, J.M.
Peroxynitrite irreversibly inactivates the human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) in human breast cancer cells: a cellular and mechanistic study
J. Biol. Chem.
279
7708-7714
2004
Homo sapiens
Bhakta, S.; Besra, G.S.; Upton, A.M.; Parish, T.; Sholto-Douglas-Vernon, C.; Gibson, K.J.; Knutton, S.; Gordon, S.; daSilva, R.P.; Anderton, M.C.; Sim, E.
Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target
J. Exp. Med.
199
1191-1199
2004
Mycobacterium tuberculosis variant bovis
Rodrigues-Lima, F.; Cooper, R.N.; Goudeau, B.; Atmane, N.; Chamagne, A.M.; Butler-Browne, G.; Sim, E.; Vicart, P.; Dupret, J.M.
Skeletal muscles express the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase
J. Histochem. Cytochem.
51
789-796
2003
Homo sapiens
Wakefield, L.; Cornish, V.; Broackes-Carter, F.; Sim, E.
Arylamine N-acetyltransferase 2 expression in the developing heart
J. Histochem. Cytochem.
53
583-592
2005
Mus musculus
Hui, C.S.; Kuo, H.M.; Yu, C.S.; Li, T.M.
Evidence for arylamine N-acetyltransferase activity in Klebsiella pneumoniae
J. Microbiol. Immunol. Infect.
37
208-215
2004
Klebsiella pneumoniae
Summerscales, J.E.; Josephy, P.D.
Human acetyl CoA:arylamine N-acetyltransferase variants generated by random mutagenesis
Mol. Pharmacol.
65
220-226
2004
Homo sapiens
Wang, H.; Vath, G.M.; Kawamura, A.; Bates, C.A.; Sim, E.; Hanna, P.E.; Wagner, C.R.
Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1
Protein J.
24
65-77
2005
Homo sapiens
Lo, H.H.; Chung, J.G.
The effects of plant phenolics, caffeic acid, chlorogenic acid and ferulic acid on arylamine N-acetyltransferase activities in human gastrointestinal microflora
Anticancer Res.
19
133-139
1999
Citrobacter koseri, Escherichia coli, Klebsiella aerogenes, Klebsiella pneumoniae, Pseudomonas aeruginosa
Lo, H.H.; Hsieh, S.E.; Tsai, K.J.; Chung, J.G.
The effects of ellagic acid on arylamine N-acetyltransferase activity in the bacterium Pseudomonas aeruginosa
Drug Chem. Toxicol.
22
555-562
1999
Pseudomonas aeruginosa
Delomenie, C.; Fouix, S.; Longuemaux, S.; Brahimi, N.; Bizet, C.; Picard, B.; Denamur, E.; Dupret, J.M.
Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid
J. Bacteriol.
183
3417-3427
2001
Aeromonas hydrophila, Achromobacter xylosoxidans, Bacteroides sp., Citrobacter amalonaticus, Citrobacter freundii, Citrobacter koseri, Escherichia coli, Helicobacter pylori, Klebsiella oxytoca, Klebsiella pneumoniae subsp. ozaenae, Klebsiella pneumoniae, Morganella morganii, Pasteurella multocida, Plesiomonas shigelloides, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens, Shigella flexneri, Citrobacter farmeri, Klebsiella pneumoniae subsp. rhinoscleromatis, Providencia alcalifaciens, Vibrio cholerae serotype O1, Homo sapiens (P11245), Homo sapiens (P18440), Homo sapiens, Escherichia coli 54.8, Aeromonas hydrophila 76.14, Klebsiella pneumoniae subsp. rhinoscleromatis 52.210, Citrobacter amalonaticus 82.89, Citrobacter freundii 57.32, Bacteroides sp. 100, Escherichia coli K-12 MG1655, Providencia alcalifaciens 82.90, Klebsiella pneumoniae subsp. ozaenae 52.211, Klebsiella pneumoniae 82.91, Helicobacter pylori 43579, Pseudomonas aeruginosa 100720, Plesiomonas shigelloides 63.5, Morganella morganii A.231, Pasteurella multocida 103286, Klebsiella oxytoca 103434, Shigella flexneri 82.48, Citrobacter koseri 82.94, Citrobacter farmeri 104553, Serratia marcescens 103235, Proteus vulgaris 58.60, Achromobacter xylosoxidans 71.32, Vibrio cholerae serotype O1 54.315
Rodrigues-Lima, F.; Dupret, J.M.
3D Model of human arylamine N-acetyltransferase 2: structural basis of the slow acetylator phenotype of the R64Q variant and analysis of the active-site loop
Biochem. Biophys. Res. Commun.
291
116-123
2002
Homo sapiens (P11245), Homo sapiens
Wang, H.; Liu, L.; Hanna, P.E.; Wagner, C.R.
Catalytic mechanism of hamster arylamine N-acetyltransferase 2
Biochemistry
44
11295-11306
2005
Mesocricetus auratus (P50293)
Madikane, V.E.; Bhakta, S.; Russell, A.J.; Campbell, W.E.; Claridge, T.D.; Elisha, B.G.; Davies, S.G.; Smith, P.; Sim, E.
Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris
Bioorg. Med. Chem.
15
3579-3586
2007
Mycobacterium tuberculosis, Mycobacterium tuberculosis variant bovis, Mycolicibacterium smegmatis, Mycobacterium tuberculosis H37Rv
Westwood, I.M.; Sim, E.
Kinetic characterization of arylamine N-acetyltransferase from Pseudomonas aeruginosa
BMC Biochem.
8
3
2007
Pseudomonas aeruginosa
Butcher, N.J.; Tetlow, N.L.; Cheung, C.; Broadhurst, G.M.; Minchin, R.F.
Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells
Cancer Res.
67
85-92
2007
Homo sapiens, Homo sapiens (P18440)
Wu, L.T.; Tsou, M.F.; Ho, C.C.; Chuang, J.Y.; Kuo, H.M.; Chung, J.G.
Berberine inhibits arylamine N-acetyltransferase activity and gene expression in Salmonella typhi
Curr. Microbiol.
51
255-261
2005
Salmonella enterica subsp. enterica serovar Typhimurium
Walraven, J.M.; Trent, J.O.; Hein, D.W.
Computational and eperimental aalyses of mammalian arylamine N-acetyltransferase structure and function
Drug Metab. Dispos.
35
1001-1007
2007
Homo sapiens, Homo sapiens (P11245), Homo sapiens (P18440)
Lee, Y.; Wu, T.
Effects of 5-methoxypsoralen (5-MOP) on arylamine N-acetyltransferase activity in the stomach and colon of rats and human stomach and colon tumor cell lines
In Vivo
19
1061-1070
2005
Homo sapiens, Rattus norvegicus
Minchin, R.F.; Hanna, P.E.; Dupret, J.M.; Wagner, C.R.; Rodrigues-Lima, F.; Butcher, N.J.
Molecules in focus. Arylamine N-acetyltransferase I
Int. J. Biochem. Cell Biol.
39
1999-2005
2007
Homo sapiens, Homo sapiens (P18440)
Suzuki, H.; Ohnishi, Y.; Horinouchi, S.
Arylamine N-acetyltransferase responsible for acetylation of 2-aminophenols in Streptomyces griseus
J. Bacteriol.
189
2155-2159
2007
Streptomyces griseus (A2V7M5), Streptomyces griseus, Streptomyces griseus IFO 13350 (A2V7M5)
Liu, F.; Zhang, N.; Zhou, X.; Hanna, P.E.; Wagner, C.R.; Koepp, D.M.; Walters, K.J.
Arylamine N-acetyltransferase aggregation and constitutive ubiquitylation
J. Mol. Biol.
361
482-492
2006
Homo sapiens (P11245), Homo sapiens (P18440), Homo sapiens, Mesocricetus auratus (P50292), Mesocricetus auratus (P50293)
Zhang, N.; Liu, L.; Liu, F.; Wagner, C.R.; Hanna, P.E.; Walters, K.J.
NMR-based model reveals the structural determinants of mammalian arylamine N-acetyltransferase substrate specificity
J. Mol. Biol.
363
188-200
2006
Homo sapiens (P11245), Homo sapiens (P18440), Homo sapiens, Mesocricetus auratus (P50293)
Walraven, J.M.; Doll, M.A.; Hein, D.W.
Identification and characterization of functional rat arylamine N-acetyltransferase 3: comparisons with rat arylamine N-acetyltransferases 1 and 2
J. Pharmacol. Exp. Ther.
319
369-375
2006
Rattus norvegicus (Q80SX3)
Loehle, J.A.; Cornish, V.; Wakefield, L.; Doll, M.A.; Neale, J.R.; Zang, Y.; Sim, E.; Hein, D.W.
N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice
J. Pharmacol. Exp. Ther.
319
724-728
2006
Mus musculus (P50294), Mus musculus (P50295)
Savulescu, M.R.; Mushtaq, A.; Josephy, P.D.
Screening and characterizing human NAT2 variants
Methods Enzymol.
400
192-215
2005
Homo sapiens (P11245), Homo sapiens
Dupret, J.M.; Dairou, J.; Atmane, N.; Rodrigues-Lima, F.
Inactivation of human arylamine N-acetyltransferase 1 by hydrogen peroxide and peroxynitrite
Methods Enzymol.
400
215-229
2005
Homo sapiens (P11245), Homo sapiens (P18440), Homo sapiens
Anderton, M.C.; Bhakta, S.; Besra, G.S.; Jeavons, P.; Eltis, L.D.; Sim, E.
Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG
Mol. Microbiol.
59
181-192
2006
Mycobacterium tuberculosis variant bovis
Geylan-Su, Y.S.; Isgoer, B.; Coban, T.; Kapucuoglu, N.; Aydintug, S.; Iscan, M.; Iscan, M.; Gueray, T.
Comparison of NAT1, NAT2 and GSTT2-2 activities in normal and neoplastic human breast tissues
Neoplasma
53
73-78
2006
Homo sapiens (P11245), Homo sapiens (P18440)
Barker, D.F.; Husain, A.; Neale, J.R.; Martini, B.D.; Zhang, X.; Doll, M.A.; States, J.C.; Hein, D.W.
Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1
Pharmacogenet. Genomics
16
515-525
2006
Homo sapiens
Kukongviriyapan, V.; Phromsopha, N.; Tassaneeyakul, W.; Kukongviriyapan, U.; Sripa, B.; Hahnvajanawong, V.; Bhudhisawasdi, V.
Inhibitory effects of polyphenolic compounds on human arylamine N-acetyltransferase 1 and 2
Xenobiotica
36
15-28
2006
Homo sapiens (P11245), Homo sapiens (P18440), Homo sapiens
Wenzel, C.Q.; Daniels, C.; Keates, R.A.; Brewer, D.; Lam, J.S.
Evidence that WbpD is an N-acetyltransferase belonging to the hexapeptide acyltransferase superfamily and an important protein for O-antigen biosynthesis in Pseudomonas aeruginosa PAO1
Mol. Microbiol.
57
1288-1303
2005
Pseudomonas aeruginosa
Pluvinage, B.; de la Sierra-Gallay, I.L.; Martins, M.; Ragunathan, N.; Dupret, J.M.; Rodrigues-Lima, F.
Crystallization and preliminary X-ray characterization of arylamine N-acetyltransferase C (BanatC) from Bacillus anthracis
Acta Crystallogr. Sect. F
63
862-864
2007
Bacillus anthracis
Pluvinage, B.; Li de la Sierra-Gallay, I.; Martins, M.; Ragunathan, N.; Dupret, J.; Rodrigues-Lima, F.
Crystallization and preliminary x-ray characterization of arylamine N-acetyltransferase C (BanatC) from Bacillus anthracis
Acta Crystallogr. Sect. F
F63
862-864
2007
Bacillus anthracis
Atmane, N.; Dairou, J.; Flatters, D.; Martins, M.; Pluvinage, B.; Derreumaux, P.; Dupret, J.M.; Rodrigues-Lima, F.
The conserved glycine/alanine residue of the active-site loop containing the putative acetylCoA-binding motif is essential for the overall structural integrity of Mesorhizobium loti arylamine N-acetyltransferase 1
Biochem. Biophys. Res. Commun.
361
256-262
2007
Mesorhizobium loti
Kawamura, A.; Westwood, I.; Wakefield, L.; Long, H.; Zhang, N.; Walters, K.; Redfield, C.; Sim, E.
Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1
Biochem. Pharmacol.
75
1550-1560
2008
Mus musculus
Pluvinage, B.; Dairou, J.; Possot, O.M.; Martins, M.; Fouet, A.; Dupret, J.M.; Rodrigues-Lima, F.
Cloning and molecular characterization of three arylamine N-acetyltransferase genes from Bacillus anthracis: identification of unusual enzymatic properties and their contribution to sulfamethoxazole resistance
Biochemistry
46
7069-7078
2007
Bacillus anthracis (A0A0F7R932), Bacillus anthracis (Q81PT0), Bacillus anthracis (Q81R98), Bacillus anthracis
Sikora, A.L.; Frankel, B.A.; Blanchard, J.S.
Kinetic and chemical mechanism of arylamine N-acetyltransferase from Mycobacterium tuberculosis
Biochemistry
47
10781-10789
2008
Mycobacterium tuberculosis
Wakefield, L.; Cornish, V.; Long, H.; Kawamura, A.; Zhang, X.; Hein, D.W.; Sim, E.
Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system
Biomarkers
13
106-118
2008
Mus musculus
Liu, L.; Von Vett, A.; Zhang, N.; Walters, K.J.; Wagner, C.R.; Hanna, P.E.
Arylamine N-acetyltransferases: characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2
Chem. Res. Toxicol.
20
1300-1308
2007
Homo sapiens
Liu, L.; Wagner, C.R.; Hanna, P.E.
Human Arylamine N-Acetyltransferase 1: In Vitro and Intracellular Inactivation by Nitrosoarene Metabolites of Toxic and Carcinogenic Arylamines
Chem. Res. Toxicol.
21
2005-2016
2008
Homo sapiens
Grant, D.M.
Structures of human arylamine N-acetyltransferases
Curr. Drug Metab.
9
465-470
2008
Homo sapiens, Mesocricetus auratus
Sim, E.; Sandy, J.; Evangelopoulos, D.; Fullam, E.; Bhakta, S.; Westwood, I.; Krylova, A.; Lack, N.; Noble, M.
Arylamine N-acetyltransferases in mycobacteria
Curr. Drug Metab.
9
510-519
2008
Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium tuberculosis variant bovis, Mycobacterium marinum, Rhodococcus, Mycolicibacterium vanbaalenii, Mycobacterium ulcerans, Mycobacterium sp. MCS, Mycobacterium sp. KMS, Mycobacterium sp. JLS, Mycolicibacterium gilvum, Mycobacterium tuberculosis variant bovis BCG, Mycolicibacterium smegmatis (O86309), Mycolicibacterium smegmatis, Homo sapiens (P11245), Homo sapiens, Mycobacterium ulcerans Agy99, Mycolicibacterium vanbaalenii PYR-1, Mycolicibacterium gilvum PYR-GCK, Rhodococcus RHA1
Makarova, S.I.
Human N-acetyltransferases and drug-induced hepatotoxicity
Curr. Drug Metab.
9
538-545
2008
Homo sapiens
Sim, E.; Walters, K.; Boukouvala, S.
Arylamine N-acetyltransferases: from structure to function
Drug Metab. Rev.
40
479-510
2008
Homo sapiens (P11245)
Kubota, R.; Ohno, M.; Hasunuma, T.; Iijima, H.; Azuma, J.
Dose-escalation study of isoniazid in healthy volunteers with the rapid acetylator genotype of arylamine N-acetyltransferase 2
Eur. J. Clin. Pharmacol.
63
927-933
2007
Homo sapiens
Possuelo, L.G.; Castelan, J.A.; de Brito, T.C.; Ribeiro, A.W.; Cafrune, P.I.; Picon, P.D.; Santos, A.R.; Teixeira, R.L.; Gregianini, T.S.; Hutz, M.H.; Rossetti, M.L.; Zaha, A.
Association of slow N-acetyltransferase 2 profile and anti-TB drug-induced hepatotoxicity in patients from Southern Brazil
Eur. J. Clin. Pharmacol.
64
673-681
2008
Homo sapiens (P11245)
Sim, E.; Westwood, I.; Fullam, E.
Arylamine N-acetyltransferases
Expert. Opin. Drug Metab. Toxicol.
3
169-184
2007
Canis lupus familiaris, Homo sapiens, Mesocricetus auratus, Mus musculus, Mycobacterium tuberculosis variant bovis, Mus spretus
Wakefield, L.; Robinson, J.; Long, H.; Ibbitt, J.C.; Cooke, S.; Hurst, H.C.; Sim, E.
Arylamine N-acetyltransferase 1 expression in breast cancer cell lines: a potential marker in estrogen receptor-positive tumors
Genes Chromosomes Cancer
47
118-126
2008
Homo sapiens
Wu, H.; Dombrovsky, L.; Tempel, W.; Martin, F.; Loppnau, P.; Goodfellow, G.H.; Grant, D.M.; Plotnikov, A.N.
Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases
J. Biol. Chem.
282
30189-30197
2007
Homo sapiens
Mulyono, R.; Takenaka, S.; Sasano, Y.; Murakami, S.; Aoki, K.
Bacillus cereus strain 10-L-2 produces two arylamine N-acetyltransferases that transform 4-phenylenediamine into 4-aminoacetanilide
J. Biosci. Bioeng.
103
147-154
2007
Bacillus cereus, Bacillus cereus 10-L-2
Yuliwulandari, R.; Sachrowardi, Q.; Nishida, N.; Takasu, M.; Batubara, L.; Susmiarsih, T.P.; Rochani, J.T.; Wikaningrum, R.; Miyashita, R.; Miyagawa, T.; Sofro, A.S.; Tokunaga, K.
Polymorphisms of promoter and coding regions of the arylamine N-acetyltransferase 2 (NAT2) gene in the Indonesian population: proposal for a new nomenclature
J. Hum. Genet.
53
201-209
2008
Homo sapiens
Fullam, E.; Westwood, I.M.; Anderton, M.C.; Lowe, E.D.; Sim, E.; Noble, M.E.
Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase
J. Mol. Biol.
375
178-191
2008
Mycobacterium marinum
Martins, M.; Pluvinage, B.; de la Sierra-Gallay, I.L.; Barbault, F.; Dairou, J.; Dupret, J.M.; Rodrigues-Lima, F.
Functional and structural characterization of the arylamine N-acetyltransferase from the opportunistic pathogen Nocardia farcinica
J. Mol. Biol.
383
549-560
2008
Nocardia farcinica, Nocardia farcinica (Q5YYQ3)
Roemer, H.C.; Weistenhofer, W.; Lohlein, D.; Geller, F.; Blomeke, B.; Golka, K.
N-acetyltransferase 1 in colon and rectal cancer cases from an industrialized area
J. Toxicol. Environ. Health Part A
71
902-905
2008
Homo sapiens
Lichter, J.; Heckelen, A.; Fischer, K.; Blomeke, B.
Expression of N-acetyltransferase in monocyte-derived dendritic cells
J. Toxicol. Environ. Health Part A
71
960-964
2008
Homo sapiens
Fukino, K.; Sasaki, Y.; Hirai, S.; Nakamura, T.; Hashimoto, M.; Yamagishi, F.; Ueno, K.
Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients
J. Toxicol. Sci.
33
187-195
2008
Homo sapiens
Wakefield, L.; Long, H.; Lack, N.; Sim, E.
Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene
Mamm. Genome
18
270-276
2007
Mus musculus
Ragunathan, N.; Dairou, J.; Pluvinage, B.; Martins, M.; Petit, E.; Janel, N.; Dupret, J.M.; Rodrigues-Lima, F.
Identification of the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 as a new target of cisplatin in breast cancer cells: molecular and cellular mechanisms of inhibition
Mol. Pharmacol.
73
1761-1768
2008
Homo sapiens, Mus musculus
Teixeira, R.L.; Miranda, A.B.; Pacheco, A.G.; Lopes, M.Q.; Fonseca-Costa, J.; Rabahi, M.F.; Melo, H.M.; Kritski, A.L.; Mello, F.C.; Suffys, P.N.; Santos, A.R.
Genetic profile of the arylamine N-acetyltransferase 2 coding gene among individuals from two different regions of Brazil
Mutat. Res.
624
31-40
2007
Homo sapiens
Oda, Y.; Watanabe, T.; Terao, Y.; Nukaya, H.; Wakabayashi, K.
Genotoxic activation of 2-phenylbenzotriazole-type compounds by human cytochrome P4501A1 and N-acetyltransferase expressed in Salmonella typhimurium umu strains
Mutat. Res.
654
52-57
2008
Homo sapiens
Kim, S.J.; Kang, H.S.; Chang, H.L.; Jung, Y.C.; Sim, H.B.; Lee, K.S.; Ro, J.; Lee, E.S.
Promoter hypomethylation of the N-acetyltransferase 1 gene in breast cancer
Oncol. Rep.
19
663-668
2008
Homo sapiens
Fakis, G.; Boukouvala, S.; Kawamura, A.; Kennedy, S.
Description of a novel polymorphic gene encoding for arylamine N-acetyltransferase in the rhesus macaque (Macaca mulatta), a model animal for endometriosis
Pharmacogenet. Genomics
17
181-188
2007
Macaca mulatta, Macaca mulatta (Q7YRG5)
Hein, D.W.; Boukouvala, S.; Grant, D.M.; Minchin, R.F.; Sim, E.
Changes in consensus arylamine N-acetyltransferase gene nomenclature
Pharmacogenet. Genomics
18
367-368
2008
Gallus gallus, Oryctolagus cuniculus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus
Buranrat, B.; Prawan, A.; Sripa, B.; Kukongviriyapan, V.
Inflammatory cytokines suppress arylamine N-acetyltransferase 1 in cholangiocarcinoma cells
World J. Gastroenterol.
13
6219-6225
2007
Homo sapiens
So, M.; Hvastkovs, E.G.; Bajrami, B.; Schenkman, J.B.; Rusling, J.F.
Electrochemical genotoxicity screening for arylamines bioactivated by N-acetyltransferase
Anal. Chem.
80
1192-1200
2008
Columba livia
Takubo, K.; Tsuchiya, H.; Kurimasa, A.; Arnesen, T.; Ryoke, K.; Shiota, G.
Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil
Anticancer Drugs
20
668-675
2009
Homo sapiens
Erickson, R.P.; McQueen, C.A.; Chau, B.; Gokhale, V.; Uchiyama, M.; Toyoda, A.; Ejima, F.; Maho, N.; Sakaki, Y.; Gondo, Y.
An N-ethyl-N-nitrosourea-induced mutation in N-acetyltransferase 1 in mice
Biochem. Biophys. Res. Commun.
370
285-288
2008
Mus musculus
Zhang, N.; Walters, K.J.
Insights into how protein dynamics affects arylamine N-acetyltransferase catalysis
Biochem. Biophys. Res. Commun.
385
395-401
2009
Mesocricetus auratus
Tiang, J.M.; Butcher, N.J.; Minchin, R.F.
Small molecule inhibition of arylamine N-Acetyltransferase Type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells
Biochem. Biophys. Res. Commun.
393
95-100
2010
Homo sapiens
Russell, A.J.; Westwood, I.M.; Crawford, M.H.; Robinson, J.; Kawamura, A.; Redfield, C.; Laurieri, N.; Lowe, E.D.; Davies, S.G.; Sim, E.
Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2
Bioorg. Med. Chem.
17
905-918
2009
Homo sapiens
Mitchell, D.J.; Minchin, R.F.
E. coli nitroreductase/CB1954 gene-directed enzyme prodrug therapy: role of arylamine N-acetlytransferase 2
Cancer Gene Ther.
15
758-764
2008
Homo sapiens
Guilhen, A.C.; Bufalo, N.E.; Morari, E.C.; Leite, J.L.; Assumpcao, L.V.; Tincani, A.J.; Ward, L.S.
Role of the N-acetyltransferase 2 detoxification system in thyroid cancer susceptibility
Clin. Cancer Res.
15
406-412
2009
Homo sapiens
Walraven, J.M.; Trent, J.O.; Hein, D.W.
Structure-function analyses of single nucleotide polymorphisms in human N-acetyltransferase 1
Drug Metab. Rev.
40
169-184
2008
Homo sapiens (P11245)
Zhou, X.; Zhang, N.; Liu, L.; Walters, K.J.; Hanna, P.E.; Wagner, C.R.
Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190
FEBS J.
276
6928-6941
2009
Mesocricetus auratus
Erickson, R.; Cao, W.; Acuna, D.; Strnatka, D.; Hunter, R.; Chau, B.; Wakefield, L.; Sim, E.; Mcqueen, C.
Confirmation of the role of N-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts
Mol. Reprod. Dev.
75
1071-1076
2008
Homo sapiens, Mus musculus
Fullam, E.; Kawamura, A.; Wilkinson, H.; Abuhammad, A.; Westwood, I.; Sim, E.
Comparison of the arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis
Protein J.
28
281-293
2009
Mycobacterium tuberculosis, Mycobacterium marinum
Dairou, J.; Petit, E.; Ragunathan, N.; Baeza-Squiban, A.; Marano, F.; Dupret, J.M.; Rodrigues-Lima, F.
Arylamine N-acetyltransferase activity in bronchial epithelial cells and its inhibition by cellular oxidants
Toxicol. Appl. Pharmacol.
236
366-371
2009
Homo sapiens, Mus musculus
Rawal, J.; Jones, R.; Payne, A.; Gardner, I.
Strategies to prevent N-acetyltransferase-mediated metabolism in a series of piperazine-containing pyrazalopyrimidine compounds
Xenobiotica
38
1219-1239
2008
Homo sapiens, Rattus norvegicus
Laurieri, N.; Dairou, J.; Egleton, J.E.; Stanley, L.A.; Russell, A.J.; Dupret, J.M.; Sim, E.; Rodrigues-Lima, F.
From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2
PLoS ONE
9
e96370
2014
Homo sapiens, Mus musculus
Abuhammad, A.; Lowe, E.D.; McDonough, M.A.; Shaw Stewart, P.D.; Kolek, S.A.; Sim, E.; Garman, E.F.
Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity
Acta Crystallogr. Sect. D
69
1433-1446
2013
Mycobacterium tuberculosis (P9WJI5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WJI5)
Cocaign, A.; Kubiak, X.; Xu, X.; Garnier, G.; Li de la Sierra-Gallay, I.; Chi-Bui, L.; Dairou, J.; Busi, F.; Abuhammad, A.; Haouz, A.; Dupret, J.M.; Herrmann, J.L.; Rodrigues-Lima, F.
Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition
Acta Crystallogr. Sect. D
70
3066-3079
2014
Mycobacteroides abscessus, Mycobacteroides abscessus CIP 104536T
Xu, X.; Li de la Sierra-Gallay, I.; Kubiak, X.; Duval, R.; Chaffotte, A.F.; Dupret, J.M.; Haouz, A.; Rodrigues-Lima, F.
Insight into cofactor recognition in arylamine N-acetyltransferase enzymes: structure of Mesorhizobium loti arylamine N-acetyltransferase in complex with coenzyme A
Acta Crystallogr. Sect. D
71
266-273
2015
Mesorhizobium loti (Q98D42), Mesorhizobium loti
Stepp, M.W.; Mamaliga, G.; Doll, M.A.; States, J.C.; Hein, D.W.
Folate-dependent hydrolysis of acetyl-coenzyme A by recombinant human and rodent arylamine N-acetyltransferases
Biochem. Biophys. Rep.
3
45-50
2015
Homo sapiens
Minchin, R.F.; Butcher, N.J.
The role of lysine(100) in the binding of acetylcoenzyme A to human arylamine N-acetyltransferase 1: implications for other acetyltransferases
Biochem. Pharmacol.
94
195-202
2015
Homo sapiens
Egleton, J.E.; Thinnes, C.C.; Seden, P.T.; Laurieri, N.; Lee, S.P.; Hadavizadeh, K.S.; Measures, A.R.; Jones, A.M.; Thompson, S.; Varney, A.; Wynne, G.M.; Ryan, A.; Sim, E.; Russell, A.J.
Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1
Bioorg. Med. Chem.
22
3030-3054
2014
Homo sapiens
Endo, Y.; Yamashita, H.; Takahashi, S.; Sato, S.; Yoshimoto, N.; Asano, T.; Hato, Y.; Dong, Y.; Fujii, Y.; Toyama, T.
Immunohistochemical determination of the miR-1290 target arylamine N-acetyltransferase 1 (NAT1) as a prognostic biomarker in breast cancer
BMC Cancer
14
990
2015
Homo sapiens
Laurieri, N.; Kawamura, A.; Westwood, I.M.; Varney, A.; Morris, E.; Russell, A.J.; Stanley, L.A.; Sim, E.
Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding
BMC Pharmacol. Toxicol.
15
68
2014
Homo sapiens (P11245), Homo sapiens
Sim, E.; Abuhammad, A.; Ryan, A.
Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery
Br. J. Pharmacol.
171
2705-2725
2014
Homo sapiens
Deng, Z.J.; Butcher, N.J.; Mortimer, G.M.; Jia, Z.; Monteiro, M.J.; Martin, D.J.; Minchin, R.F.
Interaction of human arylamine N-acetyltransferase 1 with different nanomaterials
Drug Metab. Dispos.
42
377-383
2014
Homo sapiens
Kubiak, X.; Dairou, J.; Dupret, J.M.; Rodrigues-Lima, F.
Crystal structure of arylamine N-acetyltransferases: insights into the mechanisms of action and substrate selectivity
Expert. Opin. Drug Metab. Toxicol.
9
349-362
2013
Mycobacterium marinum (B2HIZ6), Mycolicibacterium smegmatis (O86309), Homo sapiens (P11245), Homo sapiens (P18440), Salmonella enterica subsp. enterica serovar Typhimurium (Q00267), Bacillus cereus (Q81AS3), Bacillus anthracis (Q81R98), Mesorhizobium loti (Q98D42)
Kubiak, X.; Li de la Sierra-Gallay, I.; Chaffotte, A.F.; Pluvinage, B.; Weber, P.; Haouz, A.; Dupret, J.M.; Rodrigues-Lima, F.
Structural and biochemical characterization of an active arylamine N-acetyltransferase possessing a non-canonical Cys-His-Glu catalytic triad
J. Biol. Chem.
288
22493-22505
2013
Bacillus cereus
Duval, R.; Xu, X.; Bui, L.C.; Mathieu, C.; Petit, E.; Cariou, K.; Dodd, R.H.; Dupret, J.M.; Rodrigues-Lima, F.
Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens
Oncotarget
7
8688-8699
2016
Homo sapiens
Laurieri, N.; Egleton, J.E.; Varney, A.; Thinnes, C.C.; Quevedo, C.E.; Seden, P.T.; Thompson, S.; Rodrigues-Lima, F.; Dairou, J.; Dupret, J.M.; Russell, A.J.; Sim, E.
A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1
PLoS ONE
8
e70600
2013
Homo sapiens, Mus musculus
Gorain, B.; Chakraborty, S.; Pal, M.M.; Sarkar, R.; Samanta, S.K.; Karmakar, S.; Sen, T.
Arylamine N-acetyl transferase (NAT) in the blue secretion of Telescopium telescopium: xenobiotic metabolizing enzyme as a biomarker for detection of environmental pollution
SpringerPlus
3
666
2014
Telescopium telescopium
Kleinpenning, F.; Eising, S.; Berkenbosch, T.; Garzero, V.; Schaart, J.M.; Bonger, K.M.
Subcellular protein labeling by a spatially restricted arylamine N-acetyltransferase
ACS Chem. Biol.
13
1932-1937
2018
Homo sapiens (P18440)
Doll, M.A.; Salazar-Gonzalez, R.A.; Bodduluri, S.; Hein, D.W.
Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes
Acta Pharm. Sin. B
7
517-522
2017
Homo sapiens (P11245), Homo sapiens
Turijan-Espinoza, E.; Salazar-Gonzalez, R.A.; Uresti-Rivera, E.E.; Hernandez-Hernandez, G.E.; Ortega-Juarez, M.; Milan, R.; Portales-Perez, D.
A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity
Acta Pharm. Sin. B
8
188-199
2018
Homo sapiens (P11245), Homo sapiens (P18440)
Salazar-Gonzalez, R.A.; Turijan-Espinoza, E.; Hein, D.W.; Nino-Moreno, P.C.; Romano-Moreno, S.; Milan-Segovia, R.C.; Portales-Perez, D.P.
Arylamine N-acetyltransferase 1 in situ N-acetylation on CD3+ peripheral blood mononuclear cells correlate with NATb mRNA and NAT1 haplotype
Arch. Toxicol.
92
661-668
2018
Homo sapiens (P18440), Homo sapiens
Witham, K.L.; Minchin, R.F.; Butcher, N.J.
Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway
Biochem. Pharmacol.
125
93-100
2017
Homo sapiens (P18440), Homo sapiens
Minchin, R.F.; Rosengren, K.J.; Burow, R.; Butcher, N.J.
Allosteric regulation of arylamine N-acetyltransferase 1 by adenosine triphosphate
Biochem. Pharmacol.
158
153-160
2018
Homo sapiens (P18440)
Wang, T.; Marei, H.E.
Landscape of NAT2 polymorphisms among breast cancer
Biomed. Pharmacother.
77
191-196
2016
Homo sapiens
Kubiak, X.; Duval, R.; Pluvinage, B.; Chaffotte, A.F.; Dupret, J.M.; Rodrigues-Lima, F.
Xenobiotic-metabolizing enzymes in Bacillus anthracis molecular and functional analysis of a truncated arylamine N-acetyltransferase isozyme
Br. J. Pharmacol.
174
2174-2182
2017
Bacillus anthracis (A0A0J1HNH1), Bacillus anthracis
Li, P.; Butcher, N.J.; Minchin, R.F.
Effect arylamine N-acetyltransferase 1 on morphology, adhesion, migration, and invasion of MDA-MB-231 cells role of matrix metalloproteinases and integrin alphaV
Cell Adh. Migr.
14
1-11
2020
Homo sapiens
Uno, Y.; Murayama, N.; Yamazaki, H.
Molecular and functional characterization of N-acetyltransferases NAT1 and NAT2 in cynomolgus macaque
Chem. Res. Toxicol.
31
1269-1276
2018
Macaca fascicularis (A0A4Y1K7T4), Macaca fascicularis (A0A4Y1K7V2)
Wang, L.; Minchin, R.F.; Essebier, P.J.; Butcher, N.J.
Loss of human arylamine N-acetyltransferase I regulates mitochondrial function by inhibition of the pyruvate dehydrogenase complex
Int. J. Biochem. Cell Biol.
110
84-90
2019
Homo sapiens (P18440), Homo sapiens
Cloete, R.; Akurugu, W.A.; Werely, C.J.; van Helden, P.D.; Christoffels, A.
Structural and functional effects of nucleotide variation on the human TB drug metabolizing enzyme arylamine N-acetyltransferase 1
J. Mol. Graph. Model.
75
330-339
2017
Homo sapiens (P18440), Homo sapiens
Stepp, M.W.; Doll, M.A.; Carlisle, S.M.; States, J.C.; Hein, D.W.
Genetic and small molecule inhibition of arylamine N-acetyltransferase 1 reduces anchorage-independent growth in human breast cancer cell line MDA-MB-231
Mol. Carcinog.
57
549-558
2018
Homo sapiens (P18440), Homo sapiens
Xu, X.; Mathieu, C.; Berthelet, J.; Duval, R.; Bui, L.C.; Busi, F.; Dupret, J.M.; Rodrigues-Lima, F.
Human arylamine N-acetyltransferase 1 is inhibited by the dithiocarbamate pesticide thiram
Mol. Pharmacol.
92
358-365
2017
Homo sapiens (P18440), Homo sapiens
Li, P.; Butcher, N.J.; Minchin, R.F.
Arylamine N-acetyltransferase 1 regulates expression of matrix metalloproteinase 9 in breast cancer cells role of hypoxia-inducible factor 1-alpha
Mol. Pharmacol.
96
573-579
2019
Homo sapiens (P18440), Homo sapiens
Gao, S.; Tan, H.; Lang, L.; Bai, J.; Ji, Y.
The effect of alpha-solanine on the activity, gene expression, and kinetics of arylamine N-acetyltransferase in HepG2 cells
Oncol. Rep.
39
2427-2435
2018
Homo sapiens (P11245)
Wang, L.; Minchin, R.F.; Butcher, N.J.
Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation Role in the regulation of p53 stability
PLoS ONE
13
e0193560
2018
Homo sapiens (P18440), Homo sapiens
Boukouvala, S.; Chasapopoulou, Z.; Giannouri, D.; Kontomina, E.; Marinakis, N.; Rizou, S.V.; Stefani, I.; Tsirka, T.; Veyssiere, C.; Zaliou, S.; Sabbagh, A.; Crouau-Roy, B.; Fakis, G.
Population variability of rhesus macaque (Macaca mulatta) NAT1 gene for arylamine N-acetyltransferase 1 Functional effects and comparison with human
Sci. Rep.
9
10937
2019
Macaca mulatta (F6Q3X1), Macaca mulatta
Hein, D.W.; Zhang, X.; Doll, M.A.
Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4-methylene bis (2-chloroaniline) biotransformation
Toxicol. Lett.
283
100-105
2018
Homo sapiens (P11245), Homo sapiens
Garefalaki, V.; Kontomina, E.; Ioannidis, C.; Savvidou, O.; Vagena-Pantoula, C.; Papavergi, M.G.; Olbasalis, I.; Patriarcheas, D.; Fylaktakidou, K.C.; Felfoeldi, T.; Marialigeti, K.; Fakis, G.; Boukouvala, S.
The actinobacterium Tsukamurella paurometabola has a functionally divergent arylamine N-acetyltransferase (NAT) homolog
World J. Microbiol. Biotechnol.
35
174
2019
Tsukamurella paurometabola (D5UNC2), Tsukamurella paurometabola, Tsukamurella paurometabola DSM 20162 (D5UNC2)
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