Information on EC 2.3.1.62 - 2-acylglycerophosphocholine O-acyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)

The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.3.1.62
-
RECOMMENDED NAME
GeneOntology No.
2-acylglycerophosphocholine O-acyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine = CoA + phosphatidylcholine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Glycerophospholipid metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
64295-73-4
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
male Wistar strain
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
NT-1
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
show the reaction diagram
arachidonoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-arachidonoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
arachidonoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-arachidonoyl-2-palmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
gamma-linolenoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-gamma-linolenoyl-2-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
linoleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-linoleoyl-2-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
linoleoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-linoleoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
linoleoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-linoleoyl-2-palmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
myristoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-myristoyl-2-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
oleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
oleoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
oleoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
palmitoleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoleoyl-2-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
palmitoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
show the reaction diagram
palmitoyl-CoA + 2-linolenoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-linolenoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 2-linoleoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 2-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
show the reaction diagram
palmitoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
palmitoyl-CoA + 2-stearoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine
show the reaction diagram
stearoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
stearoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
show the reaction diagram
stearoyl-CoA + 2-linolenoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-linolenoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
stearoyl-CoA + 2-linoleoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
stearoyl-CoA + 2-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
stearoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-palmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
stearoyl-CoA + 2-stearoyl-sn-glycero-3-phosphocholine
CoA + 1,2-distearoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
enhanced activity by 75%
additional information
-
Ca2+ does not affect activity
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,5'-dithiobis-(2-nitrobenzoic acid)
-
0.5 mM 76% activity
dithiothreitol
-
0.5 mM 47% activity
N-ethylmaleimide
p-chloromercuribenzoate
-
above 2.0 mM
palmitoyl-CoA
stearoyl-CoA
-
above 0.064 mM
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
bovine serum albumin
-
fatty acid deficient, 2 mg per ml
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
specific activities of microsomal preparations from cells grown at different temperatures
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-70°C, membrane preparation, at least 2 months
-