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Reference on EC 2.3.2.13 - protein-glutamine gamma-glutamyltransferase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Folk, J.E.; Cole, P.W.
Mechanism of action of guinea pig liver transglutaminase. I. Purification and properties of the enzyme: identification of a functional cysteine essential for activity
J. Biol. Chem.
241
5518-5525
1966
Cavia porcellus, Cavia porcellus Hartley
Manually annotated by BRENDA team
Takahashi, N.; Takahashi, Y.; Putnam, F.W.
Primary structure of blood coagulation factor XIIIa (fibrinoligase, transglutaminase) from human placenta
Proc. Natl. Acad. Sci. USA
83
8019-8023
1986
Homo sapiens
Manually annotated by BRENDA team
Delcros, J.G.; Roch, A.M.; Quash, G.
The competitive inhibition of tissue transglutaminase by alpha-difluoromethylornithine
FEBS Lett.
171
221-226
1984
Cavia porcellus
Manually annotated by BRENDA team
Brookhart, P.P.; McMahon, P.L.; Takahashi, M.
Purification of guinea pig liver transglutaminase using a phenylalanine-sepharose 4B affinity column
Anal. Biochem.
128
202-205
1983
Cavia porcellus
Manually annotated by BRENDA team
Lee, K.N.; Birckbichler, P.J.; Patterson, M.K.
GTP hydrolysis by guinea pig liver transglutaminase
Biochem. Biophys. Res. Commun.
162
1370-1375
1989
Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
Ando, Y.; Imamura, S.; Yamagata, Y.; Kikuchi, T.; Murachi, T.; Kannagi, R.
High-performance liquid chromatographic assay of transglutaminase and its application to the purification of human erythrocyte transglutaminase and platelet factor XIII
J. Biochem.
101
1331-1337
1987
Homo sapiens
Manually annotated by BRENDA team
Signorini, M.; Bortolotti, F.; Poltronieri, L.; Bergamini, C.M.
Human erythrocyte transglutaminase: purification and preliminary characterisation
Biol. Chem. Hoppe-Seyler
369
275-281
1988
Homo sapiens
Manually annotated by BRENDA team
Puzkin, E.G.; Raghuraman, V.
Catalytic properties of a calmodulin-regulated transglutaminase from human platelet and chicken gizzard
J. Biol. Chem.
260
16012-16020
1985
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Parameswaran, K.N.; Velasco, P.T.; Wilson, J.; Lorand, L.
Labeling of epsilon-lysine crosslinking sites in proteins with peptide substrates of factor XIIIa and transglutaminase
Proc. Natl. Acad. Sci. USA
87
8472-8475
1990
Oryctolagus cuniculus, Homo sapiens
Manually annotated by BRENDA team
Jensen, P.H.; Lorand, L.; Ebbesen, P.; Gliemann, J.
Type-2 plasminogen-activator inhibitor is a substrate for trophoblast transglutaminase and factor XIIIa. Transglutaminase-catalyzed cross-linking to cellular and extracellular structures
Eur. J. Biochem.
214
141-146
1993
Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
Achyuthan, K.E.; Mary, A.; Greenberg, C.S.
Tb(III)-ion-binding-induced conformational changes in platelet factor XIII
Biochem. J.
257
331-338
1989
Homo sapiens
Manually annotated by BRENDA team
Greenberg, C.S.; Birckbichler, P.J.; Rice, R.H.
Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues
FASEB J.
5
3071-3077
1991
Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Dadabay, C.Y.; Pike, L.J.
Purification and characterization of a cytosolic transglutaminase from a cultured human tumour-cell line
Biochem. J.
264
679-685
1989
Homo sapiens
Manually annotated by BRENDA team
Bergamini, C.M.; Signorini, M.; Poltronieri, L.
Inhibition of erythrocyte transglutaminase by GTP
Biochim. Biophys. Acta
916
149-151
1987
Homo sapiens
Manually annotated by BRENDA team
Folk, J.E.; Chung, S.I.
Transglutaminases
Methods Enzymol.
113
358-375
1985
Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
Folk, J.E.
The trimethylacetyl-transglutaminase complex
Methods Enzymol.
87
36-42
1982
Cavia porcellus
Manually annotated by BRENDA team
Ichinose, A.; Bottenus, R.E.; Davie, E.W.
Structure of transglutaminases
J. Biol. Chem.
265
13411-13414
1990
Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
Kawashima, S.
Inhibition of rat liver transglutaminase by nucleotides
Experientia
47
709-712
1991
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Wong, W.S.D.; Batt, C.; Kinsella, J.E.
Purification and characterization of rat liver transglutaminase
Int. J. Biochem.
22
53-59
1990
Rattus norvegicus
Manually annotated by BRENDA team
Nakayama, J.; Osaki, M.; Nagae, S.; Asahi, M.; Urabe, H.
Properties of partially purified mouse epidermal transglutaminase
J. Dermatol.
13
448-455
1986
Mus musculus, Mus musculus BALB/c
Manually annotated by BRENDA team
Negi, M.; Colbert, M.C.; Goldsmith, L.A.
High-molecular-weight human epidermal transglutaminase
J. Invest. Dermatol.
85
75-78
1985
Homo sapiens
Manually annotated by BRENDA team
Korner, G.; Schneider, D.E.; Purdon, M.A.; Bjornsson, T.D.
Bovine aortic endothelial cell transglutaminase. Enzyme characterization and regulation of activity
Biochem. J.
262
633-641
1989
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Coussons, P.J.; Price, N.C.; Kelly, S.M.; Fothergill-Gilmore, L.A.
The modification of bovine beta-caesin using transglutaminae purified from guinea pig liver
Biochem. Soc. Trans.
20
48S
1991
Cavia porcellus
Manually annotated by BRENDA team
Coussons, P.J.; Price, N.C.; Kelly, S.M.; Smith, B.; Sawyer, L.
Transglutaminase catalyses the modification of glutamine side chains in the C-terminal region of bovine beta-lactoglobulin
Biochem. J.
283
803-806
1992
Cavia porcellus
Manually annotated by BRENDA team
Berbers, G.A.M.; Bentlage, H.C.M.; Brans, A.M.M.; Bloemendal, H.; de Jong, W.W.
beta-Crystallin: endogenous substrate of lens transglutaminase. Characterization of the acyl-donor site in the beta Bp chain
Eur. J. Biochem.
135
315-320
1983
Bos taurus
Manually annotated by BRENDA team
Cocuzzi, E.T.; Chung, S.I.
Cellular transglutaminase. Lung matrix-associated transglutaminase: characterization and activation with sulfhydryls
J. Biol. Chem.
261
8122-8127
1986
Cricetulus griseus, Rattus norvegicus
Manually annotated by BRENDA team
Chang, S.K.; Chung, S.I.
Cellular transglutaminase. The particulate-associated transglutaminase from chondrosarcoma and liver: partial purification and characterization
J. Biol. Chem.
261
8112-8121
1986
Cavia porcellus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Slife, C.W.; Morris, G.S.; Snedeker, S.W.
Solubilization and properties of the liver plasma membrane transglutaminase
Arch. Biochem. Biophys.
257
39-47
1987
Rattus norvegicus, Rattus norvegicus Sasco
Manually annotated by BRENDA team
Seitz, J.; Keppler, C.; Huntemann, S.; Rausch, U.; Aumuller, G.
Purification and molecular characterization of a secretory transglutaminase from coagulating gland of the rat
Biochim. Biophys. Acta
1078
139-146
1991
Rattus norvegicus
Manually annotated by BRENDA team
Ikura, K.; Sakurai, H.; Okumura, K.; Sasaki, R.; Chiba, H.
One-step purification of guinea pig liver transglutaminase using a monoclonal-antibody immunoadsorbent
Agric. Biol. Chem.
49
3527-3531
1985
Cavia porcellus
-
Manually annotated by BRENDA team
Porta, R.; De Santis, A.; Esposito, C.; Draetta, G.F.; Di Donato, A.; Illiano, G.
Inhibition of adenylate cyclase by transglutaminase-catalyzed reactions in pigeon erythrocyte ghosts
Biochem. Biophys. Res. Commun.
138
596-603
1986
Columba livia
Manually annotated by BRENDA team
Lichti, U.; Ben, T.; Yuspan, S.H.
Retinoic acid-induced transglutaminase in mouse epidermal cells is distinct from epidermal transglutaminase
J. Biol. Chem.
260
1422-1426
1985
Mus musculus, Mus musculus BALB/c
Manually annotated by BRENDA team
Martinet, N.; Kim, H.C.; Girard, J.E.; Nigra, D.H.; Strong, D.H.; Chung, S.I.; Folk, J.E.
Epidermal and hair follicle transglutaminases. Partial characterization of soluble enzymes in newborn mouse skin
J. Biol. Chem.
263
4236-4241
1988
Mus musculus, Mus musculus CF57
Manually annotated by BRENDA team
Tokunaga, F.; Yamada, M.; Miyata, T.; Ding, Y.L.; Hiranaga-Kawabata, M.; Muta, T.; Iwanaga, S.
Limulus hemocyte transglutaminase. Its purification and characterization, and identification of the intracellular substrates
J. Biol. Chem.
268
252-261
1993
Tachypleus tridentatus
Manually annotated by BRENDA team
Icekson, I.; Apelbaum, A.
Evidence for transglutaminase activity in plant tissue
Plant Physiol.
84
972-974
1987
Pisum sativum
Manually annotated by BRENDA team
Ikura, K.; Tsuchiya, Y.; Sasaki, R.; Chiba, H.
Expression of guinea-pig liver transglutaminase cDNA in Escherichia coli. Amino-terminal N alpha-acetyl group is not essential for catalytic function of transglutaminase
Eur. J. Biochem.
187
705-711
1990
Cavia porcellus
Manually annotated by BRENDA team
Ando, H.; Adachi, M.; Umeda, K.; Matsuura, A.; Nonaka, M.; Uchio, K.; Tanaka, H.; Motoki, M.
Purification and characteristics of a novel transglutaminase derived from microorganisms
Agric. Biol. Chem.
53
2613-2617
1989
Cavia porcellus, Streptomyces sp.
-
Manually annotated by BRENDA team
Klein, J.D.; Guzman, E.; Kuehn, G.D.
Purification and partial characterization of transglutaminase from Physarum polycephalum
J. Bacteriol.
174
2599-2605
1992
Physarum polycephalum
Manually annotated by BRENDA team
Folk, J.E.; Chung, S.I.
Molecular and catalytic properties of transglutaminases
Adv. Enzymol. Relat. Areas Mol. Biol.
38
109-191
1973
Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
McCormack, S.A.; Wang, J.Y.; Viar, M.J.; Tague, L.; Davies, P.J.A.; Johnson, L.R.
Polyamines influence transglutaminase activity and cell migration in two cell lines
Am. J. Physiol.
267
C706-C714
1994
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Singh, U.S.; Erickson, J.W.; Cerione, R.A.
Identification and biochemical characterization of an 80 kilodalton GTP-binding/transglutaminase from rabbit liver nuclei
Biochemistry
34
15863-15871
1995
Oryctolagus cuniculus
Manually annotated by BRENDA team
Kang, H.; Cho, Y.D.
Purification and properties of transglutaminase from soybean (Glycine max) leaves
Biochem. Biophys. Res. Commun.
223
288-292
1996
Glycine max
Manually annotated by BRENDA team
Hettasch, J.M.; Peoples, K.A.; Greenberg, C.S.
Analysis of factor XIII substrate specificity using recombinant human factor XIII and tissue transglutaminase chimeras
J. Biol. Chem.
272
25149-25156
1997
Homo sapiens
Manually annotated by BRENDA team
Kumazawa, Y.; Ohtsuka, T.; Ninomiya, D.; Seguro, K.
Purification and calcium dependence of transglutaminases from sheep hair follicles
Biosci. Biotechnol. Biochem.
61
1086-1090
1997
Ovis aries
Manually annotated by BRENDA team
Pasternack, R.; Laurent, H.P.; Ruth, T.; Kaiser, A.; Schon, N.; Fuchsbauer, H.L.
A fluorescent substrate of transglutaminase for detection and characterization of glutamine acceptor compounds
Anal. Biochem.
249
54-60
1997
Cavia porcellus, Streptomyces mobaraensis
Manually annotated by BRENDA team
Mottahedeh, J.; Marsh, R.
Characterization of 101-kDa transglutaminase from Physarum polycephalum and identification of LAV1-2 as substrate
J. Biol. Chem.
273
29888-29895
1998
Physarum polycephalum
Manually annotated by BRENDA team
Kwak, S.J.; Kim, S.Y.; Kim, Y.S.; Song, K.Y.; Kim, I.G.; Park, S.C.
Isolation and characterization of brain-specific transglutaminases from rat
Exp. Mol. Med.
30
177-185
1998
Rattus norvegicus
Manually annotated by BRENDA team
Murthy, S.N.P.; Velasco, P.T.; Lorand, L.
Properties of purified lens transglutaminase and regulation of its transamidase/crosslinking activity by GTP
Exp. Eye Res.
67
273-281
1998
Cavia porcellus, Oryctolagus cuniculus, Homo sapiens
Manually annotated by BRENDA team
Madi, A.; Punyiczki, M.; di Rao, M.; Piacentini, M.; Fesus, L.
Biochemical characterization and localization of transglutaminase in wild-type and cell-death mutants of the nematode Caenorhabditis elegans
Eur. J. Biochem.
253
583-590
1998
Caenorhabditis elegans
Manually annotated by BRENDA team
Zhang, J.; Guttmann, R.P.; Johnson, G.V.W.
Tissue transglutaminase is an in situ substrate of calpain: regulation of activity
J. Neurochem.
71
240-247
1998
Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
Hitomi, K.; Yamagiwa, Y.; Ikura, K.; Yamanishi, K.; Maki, M.
Characterization of human recombinant transglutaminase 1 purified from baculovirus-infected insect cells
Biosci. Biotechnol. Biochem.
64
2128-2137
2000
Homo sapiens
Manually annotated by BRENDA team
Ohtsuka, T.; Sawa, A.; Kawabata, R.; Nio, N.; Motoki, M.
Substrate specificities of microbial transglutaminase for primary amines
J. Agric. Food Chem.
48
6230-6233
2000
Cavia porcellus, Streptomyces mobaraensis
Manually annotated by BRENDA team
Sato, H.; Yamada, N.; Shimba, N.; Takahara, Y.
Unique substrate specificities of two adjacent glutamine residues in EAQQIVM for transglutaminase: identification and characterization of the reaction products by electrospray ionization tandem mass spectrometry
Anal. Biochem.
281
68-76
2000
Cavia porcellus
Manually annotated by BRENDA team
Nozawa, H.; Cho, S.Y.; Seki, N.
Purification and characterization of transglutaminase from squid gill
Fish. Sci.
67
912-919
2001
Loligo sp.
-
Manually annotated by BRENDA team
Nozawa, H.; Seki, N.
Purification of transglutaminase from scallop striated adductor muscle and NaCl-induced inactivation
Fish. Sci.
67
493-499
2001
Mizuhopecten yessoensis
-
Manually annotated by BRENDA team
Candi, E.; Oddi, S.; Terrinoni, A.; Paradisi, A.; Ranalli, M.; Finazzi-Agro, A.; Melino, G.
Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro
J. Biol. Chem.
276
35014-35023
2001
Homo sapiens
Manually annotated by BRENDA team
Ruse, M.; Lambert, A.; Robinson, N.; Ryan, D.; Shon, K.J.; Eckert, R.L.
S100A7, S100A10, and S100A11 are transglutaminase substrates
Biochemistry
40
3167-3173
2001
Homo sapiens
Manually annotated by BRENDA team
Ikura, K.; Kokubu, T.; Natsuka, S.; Ichikawa, A.; Adachi, M.; Nishihara, K.; Yanagi, H.; Utsumi, S.
Co-overexpression of folding modulators improves the solubility of the recombinant guinea pig liver transglutaminase expressed in Escherichia coli
Prep. Biochem. Biotechnol.
32
189-205
2002
Cavia porcellus
Manually annotated by BRENDA team
Griffin, M.; Casadio, R.; Bergamini, C.M.
Transglutaminases: Nature's biological glues
Biochem. J.
368
377-396
2002
Mammalia, Rattus norvegicus, Homo sapiens (P21980)
Manually annotated by BRENDA team
Wada, F.; Nakamura, A.; Masutani, T.; Ikura, K.; Maki, M.; Hitomi, K.
Identification of mammalian-type transglutaminase in Physarum polycephalum. Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity
Eur. J. Biochem.
269
3451-3460
2002
Physarum polycephalum
Manually annotated by BRENDA team
Ahvazi, B.; Kim, H.C.; Kee, S.H.; Nemes, Z.; Steinert, P.M.
Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for activation
EMBO J.
21
2055-2067
2002
Homo sapiens (Q08188), Homo sapiens
Manually annotated by BRENDA team
Villalonga, R.; Fernandez, M.; Fragoso, A.; Cao, R.; Di Pierro, P.; Mariniello, L.; Porta, R.
Transglutaminase-catalyzed synthesis of trypsin-cyclodextrin conjugates: Kinetics and stability properties
Biotechnol. Bioeng.
81
732-737
2003
Streptomyces sp.
Manually annotated by BRENDA team
Mariniello, L.; DiPierro, P.; Esposito, C.; Sorrentino, a.; Masi, P.; Porta, R.
Preparation and mechanical properties of edible pectin-soy flour films obtained in the absence or presence of transglutaminase
J. Biotechnol.
102
191-198
2003
Streptomyces sp.
Manually annotated by BRENDA team
Roth, E.B.; Sjoberg, K.; Stenberg, P.
Biochemical and immuno-pathological aspects of tissue transglutaminase in coeliac disease
Autoimmunity
36
221-226
2003
Cavia porcellus
Manually annotated by BRENDA team
Jeitner, T.M.; Delikatny, E.J.; Ahlqvist, J.; Capper, H.; Cooper, A.J.
Mechanism for the inhibition of transglutaminase 2 by cystamine
Biochem. Pharmacol.
69
961-970
2005
Cavia porcellus
Manually annotated by BRENDA team
Case, A.; Stein, R.L.
Kinetic analysis of the action of tissue transglutaminase on peptide and protein substrates
Biochemistry
42
9466-9481
2003
Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
de Barros Soares, L.H.; Assmann, F.; Zachia Ayub, M.A.
Purification and properties of a transglutaminase produced by a Bacillus circulans strain isolated from the Amazon environment
Biotechnol. Appl. Biochem.
37
295-299
2003
Niallia circulans
Manually annotated by BRENDA team
Nozawa, H.; Mori, T.; Kimura, M.; Seki, N.
Characterization of a transglutaminase from scallop hemocyte and identification of its intracellular substrates
Comp. Biochem. Physiol. B
140
395-402
2005
Patinopecten sp.
Manually annotated by BRENDA team
Huang, C.C.; Sritunyalucksana, K.; Soderhall, K.; Song, Y.L.
Molecular cloning and characterization of tiger shrimp (Penaeus monodon) transglutaminase
Dev. Comp. Immunol.
28
279-294
2004
Penaeus monodon
Manually annotated by BRENDA team
Jeon, J.H.; Lee, H.J.; Jang, G.Y.; Kim, C.W.; Shim, D.M.; Cho, S.Y.; Yeo, E.J.; Park, S.C.; Kim, I.G.
Different inhibition characteristics of intracellular transglutaminase activity by cystamine and cysteamine
Exp. Mol. Med.
36
576-581
2004
Homo sapiens
Manually annotated by BRENDA team
D'Argenio, G.; Calvani, M.; Della Valle, N.; Cosenza, V.; Di Matteo, G.; Giorgio, P.; Margarucci, S.; Petillo, O.; Jori, F.P.; Galderisi, U.; Peluso, G.
Differential expression of multiple transglutaminases in human colon: Impaired keratinocyte transglutaminase expression in ulcerative colitis
Gut
54
496-502
2005
Homo sapiens
Manually annotated by BRENDA team
Wu, Y.W.; Lai, W.F.; Tsai, Y.H.
Characterization of purified rat testicular transglutaminase and age-dependent changes of the enzyme activities
Int. J. Biochem. Cell Biol.
37
386-396
2005
Rattus norvegicus
Manually annotated by BRENDA team
Sorrentino, A.; Schillberg, S.; Fischer, R.; Rao, R.; Porta, R.; Mariniello, L.
Recombinant human tissue transglutaminase produced into tobacco suspension cell cultures is active and recognizes autoantibodies in the serum of celiac patients
Int. J. Biochem. Cell Biol.
37
842-851
2005
Homo sapiens
Manually annotated by BRENDA team
Autio, K.; Kruus, K.; Knaapila, A.; Gerber, N.; Flander, L.; Buchert, J.
Kinetics of transglutaminase-induced cross-linking of wheat proteins in dough
J. Agric. Food Chem.
53
1039-1045
2005
Streptomyces mobaraensis
Manually annotated by BRENDA team
Wada, F.; Ogawa, A.; Hanai, Y.; Nakamura, A.; Maki, M.; Hitomi, K.
Analyses of expression and localization of two mammalian-type transglutaminases in Physarum polycephalum, an acellular slime mold
J. Biochem.
136
665-672
2004
Physarum polycephalum
Manually annotated by BRENDA team
Ahvazi, B.; Boeshans, K.M.; Idler, W.; Baxa, U.; Steinert, P.M.
Roles of calcium ions in the activation and activity of the transglutaminase 3 enzyme
J. Biol. Chem.
278
23834-23841
2003
Homo sapiens (Q08188)
Manually annotated by BRENDA team
Shin, D.M.; Jeon, J.H.; Kim, C.W.; Cho, S.Y.; Kwon, J.C.; Lee, H.J.; Choi, K.H.; Park, S.C.; Kim, I.G.
Cell Type-specific activation of intracellular transglutaminase 2 by oxidative stress or ultraviolet irradiation: implications of transglutaminase 2 in age-related cataractogenesis
J. Biol. Chem.
279
15032-15039
2004
Homo sapiens
Manually annotated by BRENDA team
Zanetti, L.; Ristoratore, F.; Bertoni, A.; Cariello, L.
Characterization of sea urchin transglutaminase, a protein regulated by guanine/adenine nucleotides
J. Biol. Chem.
279
49289-49297
2004
Paracentrotus lividus (Q8T316), Paracentrotus lividus
Manually annotated by BRENDA team
Rodolfo, C.; Mormone, E.; Matarrese, P.; Ciccosanti, F.; Farrace, M.G.; Garofano, E.; Piredda, L.; Fimia, G.M.; Malorni, W.; Piacentini, M.
Tissue transglutaminase is a multifunctional BH3-only protein
J. Biol. Chem.
279
54783-54792
2004
Homo sapiens
Manually annotated by BRENDA team
Ahvazi, B.; Boeshans, K.M.; Idler, W.; Baxa, U.; Steinert, P.M.; Rastinejad, F.
Structural basis for the coordinated regulation of transglutaminase 3 by guanine nucleotides and calcium/magnesium
J. Biol. Chem.
279
7180-7192
2004
Homo sapiens
Manually annotated by BRENDA team
Stephens, P.; Grenard, P.; Aeschlimann, P.; Langley, M.; Blain, E.; Errington, R.; Kipling, D.; Thomas, D.; Aeschlimann, D.
Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses
J. Cell Sci.
117
3389-3403
2004
Homo sapiens
Manually annotated by BRENDA team
Lu, S.Y.; Zhou, N.D.; Tian, Y.P.; Li, H.Z.; Chen, J.
Purification and properties of transglutaminase from Streptoverticillium mobaraense
J. Food Biochem.
27
109-125
2003
Streptomyces mobaraensis
Manually annotated by BRENDA team
Pfleiderer, C.; Mainusch, M.; Weber, J.; Hils, M.; Fuchsbauer, H.L.
Inhibition of bacterial transglutaminase by its heat-treated pro-enzyme
Microbiol. Res.
160
265-271
2005
Streptomyces mobaraensis
Manually annotated by BRENDA team
Della Mea, M.; Di Sandro, A.; Dondini, L.; Del Duca, S.; Vantini, F.; Bergamini, C.; Bassi, R.; Serafini-Fracassini, D.
A Zea mays 39-kDa thylakoid transglutaminase catalyzes the modification by polyamines of light-harvesting complex II in a light-dependent way
Planta
219
754-764
2004
Zea mays
Manually annotated by BRENDA team
Gillet, S.M.F.G.; Chica, R.A.; Keillor, J.W.; Pelletier, J.N.
Expression and rapid purification of highly active hexahistidine-tagged guinea pig liver transglutaminase
Protein Expr. Purif.
33
256-264
2004
Cavia porcellus
Manually annotated by BRENDA team
Chica, R.A.; Gagnon, P.; Keillor, J.W.; Pelletier, J.N.
Tissue transglutaminase acylation: proposed role of conserved active site Tyr and Trp residues revealed by molecular modeling of peptide substrate binding
Protein Sci.
13
979-991
2004
Pagrus major
Manually annotated by BRENDA team
Case, A.; Stein, R.L.
Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor
Biochemistry
46
1106-1115
2007
Homo sapiens
Manually annotated by BRENDA team
Yeh, M.; Kao, L.; Huang, C.; Tsai, I.
Biochemical characterization and cloning of transglutaminases responsible for hemolymph clotting in Penaeus monodon and Marsupenaeus japonicus
Biochim. Biophys. Acta
1764
1167-1178
2006
Penaeus japonicus (Q0GYS4), Penaeus japonicus, Penaeus monodon (Q6YNC7), Penaeus monodon
Manually annotated by BRENDA team
Cleary, D.B.; Maurer, M.C.
Characterizing the specificity of activated Factor XIII for glutamine-containing substrate peptides
Biochim. Biophys. Acta
1764
1207-1217
2006
Homo sapiens
Manually annotated by BRENDA team
Pardin, C.; Gillet, S.M.; Keillor, J.W.
Synthesis and evaluation of peptidic irreversible inhibitors of tissue transglutaminase
Bioorg. Med. Chem.
14
8379-8385
2006
Cavia porcellus
Manually annotated by BRENDA team
Marrano, C.; de Macedo, P.; Gagnon, P.; Lapierre, D.; Gravel, C.; Keillor, J.W.
Synthesis and evaluation of novel dipeptide-bound 1,2,4-thiadiazoles as irreversible inhibitors of guinea pig liver transglutaminase
Bioorg. Med. Chem.
9
3231-3241
2001
Cavia porcellus
Manually annotated by BRENDA team
Duval, E.; Case, A.; Stein, R.L.; Cuny, G.D.
Structure-activity relationship study of novel tissue transglutaminase inhibitors
Bioorg. Med. Chem. Lett.
15
1885-1889
2005
Homo sapiens
Manually annotated by BRENDA team
Lin, S.J.; Hsieh, Y.F.; Wang, P.M.; Chu, W.S.
Efficient purification of transglutaminase from recombinant Streptomyces platensis at various scales
Biotechnol. Lett.
29
111-115
2007
Streptomyces platensis
Manually annotated by BRENDA team
Carvajal-Vallejos, P.K.; Campos, A.; Fuentes-Prior, P.; Villalobos, E.; Almeida, A.M.; Barbera, E.; Torne, J.M.; Santos, M.
Purification and in vitro refolding of maize chloroplast transglutaminase over-expressed in Escherichia coli
Biotechnol. Lett.
29
1255-1262
2007
Zea mays
Manually annotated by BRENDA team
Choi, K.; Siegel, M.; Piper, J.L.; Yuan, L.; Cho, E.; Strnad, P.; Omary, B.; Rich, K.M.; Khosla, C.
Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2
Chem. Biol.
12
469-475
2005
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Biagi, F.; Campanella, J.; Laforenza, U.; Gastaldi, G.; Tritto, S.; Grazioli, M.; Villanacci, V.; Corazza, G.R.
Transglutaminase 2 in the enterocytes is coeliac specific and gluten dependent
Dig. Liver Dis.
38
652-658
2006
Homo sapiens
Manually annotated by BRENDA team
Brobey, R.K.; Soong, L.
Leishmania species: evidence for transglutaminase activity and its role in parasite proliferation
Exp. Parasitol.
114
94-102
2006
Leishmania amazonensis
Manually annotated by BRENDA team
Wada, F.; Hasegawa, H.; Nakamura, A.; Sugimura, Y.; Kawai, Y.; Sasaki, N.; Shibata, H.; Maki, M.; Hitomi, K.
Identification of substrates for transglutaminase in Physarum polycephalum, an acellular slime mold, upon cellular mechanical damage
FEBS J.
274
2766-2777
2007
Physarum polycephalum
Manually annotated by BRENDA team
Worratao, A.; Yongsawatdigul, J.
Purification and characterization of transglutaminase from tropical tilapia (Oreochromis niloticus)
Food Chem.
93
651-658
2005
Oreochromis niloticus
Manually annotated by BRENDA team
Uma, V.; Geetha, M.; Murugan, V.; Kaliraj, P.
Isolation and characterization of recombinant Brugian parasitic transglutaminase
Indian J. Biotechnol.
5
317-326
2006
Brugia malayi
-
Manually annotated by BRENDA team
Sugimura, Y.; Hosono, M.; Wada, F.; Yoshimura, T.; Maki, M.; Hitomi, K.
Screening for the preferred substrate sequence of transglutaminase using a phage-displayed peptide library: identification of peptide substrates for TGASE 2 and Factor XIIIA
J. Biol. Chem.
281
17699-17706
2006
Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
Wakshlag, J.J.; McNeill, C.J.; Antonyak, M.A.; Boehm, J.E.; Fuji, R.; Balkman, C.E.; Zgola, M.; Cerione, R.A.; Page, R.L.
Expression and activity of transglutaminase II in spontaneous tumours of dogs and cats
J. Comp. Pathol.
134
202-210
2006
Canis lupus familiaris, Felis catus
Manually annotated by BRENDA team
Janiak, A.; Zemskov, E.A.; Belkin, A.M.
Cell surface transglutaminase promotes RhoA activation via integrin clustering and suppression of the Src-p190RhoGAP signaling pathway
Mol. Biol. Cell
17
1606-1619
2006
Homo sapiens
Manually annotated by BRENDA team
Yuan, L.; Siegel, M.; Choi, K.; Khosla, C.; Miller, C.R.; Jackson, E.N.; Piwnica-Worms, D.; Rich, K.M.
Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy
Oncogene
26
2563-2573
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Robinson, N.J.; Glazier, J.D.; Greenwood, S.L.; Baker, P.N.; Aplin, J.D.
Tissue transglutaminase expression and activity in placenta
Placenta
27
148-157
2005
Homo sapiens
Manually annotated by BRENDA team
Liu, X.Q.; Yang, X.Q.; Xie, F.H.; Song, L.Y.; Zhang, G.Q.; Qian, S.J.
On-column refolding and purification of transglutaminase from Streptomyces fradiae expressed as inclusion bodies in Escherichia coli
Protein Expr. Purif.
51
179-186
2007
Streptomyces fradiae, Streptomyces fradiae (Q0GYU0)
Manually annotated by BRENDA team
Shweke, N.; Boulos, N.; Jouanneau, C.; Vandermeersch, S.; Melino, G.; Dussaule, J.C.; Chatziantoniou, C.; Ronco, P.; Boffa, J.J.
Tissue transglutaminase contributes to interstitial renal fibrosis by favoring accumulation of fibrillar collagen through TGF-beta activation and cell infiltration
Am. J. Pathol.
173
631-642
2008
Mus musculus
Manually annotated by BRENDA team
Eckert, R.L.; Sturniolo, M.T.; Jans, R.; Kraft, C.A.; Jiang, H.; Rorke, E.A.
TIG3: a regulator of type I transglutaminase activity in epidermis
Amino Acids
36
739-746
2009
Homo sapiens
Manually annotated by BRENDA team
Griffin, M.; Mongeot, A.; Collighan, R.; Saint, R.E.; Jones, R.A.; Coutts, I.G.; Rathbone, D.L.
Synthesis of potent water-soluble tissue transglutaminase inhibitors
Bioorg. Med. Chem. Lett.
18
5559-5562
2008
Homo sapiens
Manually annotated by BRENDA team
Juranic, Z.; Radic, J.; Konic-Ristic, A.; Jelic, S.; Mihaljevic, B.; Stankovic, I.; Matkovic, S.; Besu, I.; Gavrilovic, D.
Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma
BMC Immunol.
9
22
2008
Homo sapiens
Manually annotated by BRENDA team
Harrison, C.A.; Layton, C.M.; Hau, Z.; Bullock, A.J.; Johnson, T.S.; MacNeil, S.
Transglutaminase inhibitors induce hyperproliferation and parakeratosis in tissue-engineered skin
Br. J. Dermatol.
156
247-257
2007
Homo sapiens
Manually annotated by BRENDA team
Kim, D.S.; Park, K.S.; Jeong, K.C.; Lee, B.I.; Lee, C.H.; Kim, S.Y.
Glucosamine is an effective chemo-sensitizer via transglutaminase 2 inhibition
Cancer Lett.
273
243-249
2008
Homo sapiens
Manually annotated by BRENDA team
Ohtake, Y.; Maruko, A.; Ohishi, N.; Kawaguchi, M.; Satoh, T.; Ohkubo, Y.
Effect of retinoic acid on transglutaminase and ornithine decarboxylase activities during liver regeneration
Cell Biochem. Funct.
26
359-365
2008
Rattus norvegicus
Manually annotated by BRENDA team
Kawai, Y.; Wada, F.; Sugimura, Y.; Maki, M.; Hitomi, K.
Transglutaminase 2 activity promotes membrane resealing after mechanical damage in the lung cancer cell line A549
Cell Biol. Int.
32
928-934
2008
Homo sapiens
Manually annotated by BRENDA team
Lai, T.S.; Liu, Y.; Tucker, T.; Daniel, K.R.; Sane, D.C.; Toone, E.; Burke, J.R.; Strittmatter, W.J.; Greenberg, C.S.
Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries
Chem. Biol.
15
969-978
2008
Homo sapiens
Manually annotated by BRENDA team
Verma, A.; Guha, S.; Wang, H.; Fok, J.Y.; Koul, D.; Abbruzzese, J.; Mehta, K.
Tissue transglutaminase regulates focal adhesion kinase/AKT activation by modulating PTEN expression in pancreatic cancer cells
Clin. Cancer Res.
14
1997-2005
2008
Homo sapiens
Manually annotated by BRENDA team
Nahrendorf, M.; Aikawa, E.; Figueiredo, J.L.; Stangenberg, L.; van den Borne, S.W.; Blankesteijn, W.M.; Sosnovik, D.E.; Jaffer, F.A.; Tung, C.H.; Weissleder, R.
Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction
Eur. Heart J.
29
445-454
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Hsu, T.C.; Huang, C.Y.; Chiang, S.Y.; Lai, W.X.; Tsai, C.H.; Tzang, B.S.
Transglutaminase inhibitor cystamine alleviates the abnormality in liver from NZB/W F1 mice
Eur. J. Pharmacol.
579
382-389
2008
Mus musculus
Manually annotated by BRENDA team
Hsu, T.C.; Chiang, S.Y.; Huang, C.Y.; Tsay, G.J.; Yang, C.W.; Huang, C.N.; Tzang, B.S.
Beneficial effects of treatment with transglutaminase inhibitor cystamine on macrophage response in NZB/W F1 mice
Exp. Biol. Med. (Maywood)
232
195-203
2007
Mus musculus
Manually annotated by BRENDA team
Alford, S.C.; Bazowski, J.; Lorimer, H.; Elowe, S.; Howard, P.L.
Tissue transglutaminase clusters soluble A-type ephrins into functionally active high molecular weight oligomers
Exp. Cell Res.
313
4170-4179
2007
Mus musculus
Manually annotated by BRENDA team
Boros, S.; Wilmarth, P.A.; Kamps, B.; de Jong, W.W.; Bloemendal, H.; Lampi, K.; Boelens, W.C.
Tissue transglutaminase catalyzes the deamidation of glutamines in lens betaB(2)- and betaB(3)-crystallins
Exp. Eye Res.
86
383-393
2008
Sus scrofa
Manually annotated by BRENDA team
Shin, D.M.; Jeon, J.H.; Kim, C.W.; Cho, S.Y.; Lee, H.J.; Jang, G.Y.; Jeong, E.M.; Lee, D.S.; Kang, J.H.; Melino, G.; Park, S.C.; Kim, I.G.
TGFbeta mediates activation of transglutaminase 2 in response to oxidative stress that leads to protein aggregation
FASEB J.
22
2498-2507
2008
Homo sapiens
Manually annotated by BRENDA team
Faverman, L.; Mikhaylova, L.; Malmquist, J.; Nurminskaya, M.
Extracellular transglutaminase 2 activates beta-catenin signaling in calcifying vascular smooth muscle cells
FEBS Lett.
582
1552-1557
2008
Mus musculus
Manually annotated by BRENDA team
Schmidt, S.; Adolf, F.; Fuchsbauer, H.L.
The transglutaminase activating metalloprotease inhibitor from Streptomyces mobaraensis is a glutamine and lysine donor substrate of the intrinsic transglutaminase
FEBS Lett.
582
3132-3138
2008
Streptomyces mobaraensis, Streptomyces mobaraensis 40847
Manually annotated by BRENDA team
Cui, L.; Du, G.; Zhang, D.; Liu, H.; Chen, J.
Purification and characterization of transglutaminase from a newly isolated Streptomyces hygroscopicus
Food Chem.
105
612-618
2007
Streptomyces hygroscopicus, Streptomyces hygroscopicus WSH03-13
Manually annotated by BRENDA team
Tovar-Vidales, T.; Roque, R.; Clark, A.F.; Wordinger, R.J.
Tissue transglutaminase expression and activity in normal and glaucomatous human trabecular meshwork cells and tissues
Invest. Ophthalmol. Vis. Sci.
49
622-628
2008
Homo sapiens
Manually annotated by BRENDA team
Cabrera-Chavez, F.; Rouzaud-Sandez, O.; Sotelo-Cruz, N.; Calderon de la Barca, A.M.
Transglutaminase treatment of wheat and maize prolamins of bread increases the serum IgA reactivity of celiac disease patients
J. Agric. Food Chem.
56
1387-1391
2008
Homo sapiens
Manually annotated by BRENDA team
Zhang, D.; Wang, M.; Du, G.; Zhao, Q.; Wu, J.; Chen, J.
Surfactant protein of the Streptomyces subtilisin inhibitor family inhibits transglutaminase activation in Streptomyces hygroscopicus
J. Agric. Food Chem.
56
3403-3408
2008
Streptomyces hygroscopicus
Manually annotated by BRENDA team
Hartley, D.M.; Zhao, C.; Speier, A.C.; Woodard, G.A.; Li, S.; Li, Z.; Walz, T.
Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation
J. Biol. Chem.
283
16790-16800
2008
Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
Hemung, B.; Yongsawatdigul, J.
Partial purification and characterization of transglutaminase from threadfin bream (Nemipterus sp.) liver
J. Food Biochem.
32
182-200
2008
Nemipterus sp.
Manually annotated by BRENDA team
Maiuri, L.; Luciani, A.; Giardino, I.; Raia, V.; Villella, V.R.; DApolito, M.; Pettoello-Mantovani, M.; Guido, S.; Ciacci, C.; Cimmino, M.; Cexus, O.N.; Londei, M.; Quaratino, S.
Tissue transglutaminase activation modulates inflammation in cystic fibrosis via PPARgamma down-regulation
J. Immunol.
180
7697-7705
2008
Homo sapiens
Manually annotated by BRENDA team
Campisi, A.; Bramanti, V.; Caccamo, D.; Li Volti, G.; Cannavo, G.; Curro, M.; Raciti, G.; Galvano, F.; Amenta, F.; Vanella, A.; Ientile, R.; Avola, R.
Effect of growth factors and steroids on transglutaminase activity and expression in primary astroglial cell cultures
J. Neurosci. Res.
86
1297-1305
2008
Rattus norvegicus
Manually annotated by BRENDA team
Gupta, M.; Greenberg, C.S.; Eckman, D.M.; Sane, D.C.
Arterial vimentin is a transglutaminase substrate: a link between vasomotor activity and remodeling?
J. Vasc. Res.
44
339-344
2007
Homo sapiens
Manually annotated by BRENDA team
Akar, U.; Ozpolat, B.; Mehta, K.; Fok, J.; Kondo, Y.; Lopez-Berestein, G.
Tissue transglutaminase inhibits autophagy in pancreatic cancer cells
Mol. Cancer Res.
5
241-249
2007
Homo sapiens
Manually annotated by BRENDA team
Siegel, M.; Khosla, C.
Transglutaminase 2 inhibitors and their therapeutic role in disease states
Pharmacol. Ther.
115
232-245
2007
Cavia porcellus, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Pinto-Marijuan, M.; de Agazio, M.; Zacchini, M.; Santos, M.A.; Torne, J.M.; Fleck, I.
Response of transglutaminase activity and bound putrescine to changes in light intensity under natural or controlled conditions in Quercus ilex leaves
Physiol. Plant.
131
159-169
2007
Quercus ilex
Manually annotated by BRENDA team
del Duca, S.; Betti, L.; Trebbi, G.; Serafini-Fracassini, D.; Torrigiani, P.
Transglutaminase activity changes during the hypersensitive reaction, a typical defense response of tobacco NN plants to TMV
Physiol. Plant.
131
241-250
2007
Nicotiana tabacum
Manually annotated by BRENDA team
Della Mea, M.; De Filippis, F.; Genovesi, V.; Serafini Fracassini, D.; Del Duca, S.
The acropetal wave of developmental cell death of tobacco corolla is preceded by activation of transglutaminase in different cell compartments
Plant Physiol.
144
1211-1222
2007
Nicotiana tabacum
Manually annotated by BRENDA team
Pinkas, D.M.; Strop, P.; Brunger, A.T.; Khosla, C.
Transglutaminase 2 undergoes a large conformational change upon activation
PLoS Biol.
5
e327
2007
Homo sapiens (P21980), Homo sapiens
Manually annotated by BRENDA team
Siegel, M.; Strnad, P.; Watts, R.E.; Choi, K.; Jabri, B.; Omary, M.B.; Khosla, C.
Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury
PLoS ONE
3
e1861
2008
Mus musculus
Manually annotated by BRENDA team
Placido, D.; Fernandes, C.G.; Isidro, A.; Carrondo, M.A.; Henriques, A.O.; Archer, M.
Auto-induction and purification of a Bacillus subtilis transglutaminase (Tgl) and its preliminary crystallographic characterization
Protein Expr. Purif.
59
1-8
2008
Bacillus subtilis
Manually annotated by BRENDA team
Chen, C.S.; Wu, C.H.; Lai, Y.C.; Lee, W.S.; Chen, H.M.; Chen, R.J.; Chen, L.C.; Ho, Y.S.; Wang, Y.J.
NF-kappaB-activated tissue transglutaminase is involved in ethanol-induced hepatic injury and the possible role of propolis in preventing fibrogenesis
Toxicology
246
148-157
2008
Homo sapiens
Manually annotated by BRENDA team
Qiu, J.F.; Zhang, Z.Q.; Chen, W.; Wu, Z.Y.
Cystamine ameliorates liver fibrosis induced by carbon tetrachloride via inhibition of tissue transglutaminase
World J. Gastroenterol.
13
4328-4332
2007
Rattus norvegicus
Manually annotated by BRENDA team
Ponnusamy, M.; Pang, M.; Annamaraju, P.K.; Zhang, Z.; Gong, R.; Chin, Y.E.; Zhuang, S.
Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways
Am. J. Physiol. Renal Physiol.
297
F1361-F1370
2009
Mus musculus
Manually annotated by BRENDA team
Del Duca, S.; Cai, G.; Di Sandro, A.; Serafini-Fracassini, D.
Compatible and self-incompatible pollination in Pyrus communis displays different polyamine levels and transglutaminase activity
Amino Acids
38
659-667
2009
Pyrus communis
Manually annotated by BRENDA team
Di Pierro, P.; Mariniello, L.; Sorrentino, A.; Villalonga, R.; Chico, B.; Porta, R.
Putrescine-polysaccharide conjugates as transglutaminase substrates and their possible use in producing crosslinked films
Amino Acids
38
669-675
2010
Streptomyces mobaraensis
Manually annotated by BRENDA team
Hitomi, K.; Kitamura, M.; Alea, M.P.; Ceylan, I.; Thomas, V.; El Alaoui, S.
A specific colorimetric assay for measuring transglutaminase 1 and factor XIII activities
Anal. Biochem.
394
281-283
2009
Homo sapiens
Manually annotated by BRENDA team
Sugimura, Y.; Yokoyama, K.; Nio, N.; Maki, M.; Hitomi, K.
Identification of preferred substrate sequences of microbial transglutaminase from Streptomyces mobaraensis using a phage-displayed peptide library
Arch. Biochem. Biophys.
477
379-383
2008
Streptomyces mobaraensis
Manually annotated by BRENDA team
Pardin, C.; Roy, I.; Chica, R.A.; Bonneil, E.; Thibault, P.; Lubell, W.D.; Pelletier, J.N.; Keillor, J.W.
Photolabeling of tissue transglutaminase reveals the binding mode of potent cinnamoyl inhibitors
Biochemistry
48
3346-3353
2009
Cavia porcellus
Manually annotated by BRENDA team
Ozaki, S.; Ebisui, E.; Hamada, K.; Goto, J.; Suzuki, A.Z.; Terauchi, A.; Mikoshiba, K.
Potent transglutaminase inhibitors, aryl beta-aminoethyl ketones
Bioorg. Med. Chem. Lett.
20
1141-1144
2010
Cavia porcellus
Manually annotated by BRENDA team
Yang, H.L.; Pan, L.; Lin, Y.
Purification and on-column activation of a recombinant histidine-tagged pro-transglutaminase after soluble expression in Escherichia coli
Biosci. Biotechnol. Biochem.
73
2531-2534
2009
Streptomyces mobaraensis
Manually annotated by BRENDA team
Lin, X.; Soederhaell, K.; Soederhaell, I.
Transglutaminase activity in the hematopoietic tissue of a crustacean, Pacifastacus leniusculus, importance in hemocyte homeostasis
BMC Immunol.
9
58
2008
Pacifastacus leniusculus (Q964D3), Pacifastacus leniusculus
Manually annotated by BRENDA team
Pardin, C.; Roy, I.; Lubell, W.D.; Keillor, J.W.
Reversible and competitive cinnamoyl triazole inhibitors of tissue transglutaminase
Chem. Biol. Drug Des.
72
189-196
2008
Cavia cutleri (P08587)
Manually annotated by BRENDA team
Kiraly, R.; Csosz, E.; Kurtan, T.; Antus, S.; Szigeti, K.; Simon-Vecsei, Z.; Korponay-Szabo, I.R.; Keresztessy, Z.; Fesues, L.
Functional significance of five noncanonical Ca2+-binding sites of human transglutaminase 2 characterized by site-directed mutagenesis
FEBS J.
276
7083-7096
2009
Homo sapiens
Manually annotated by BRENDA team
Hodrea, J.; Demeny, M.A.; Majai, G.; Sarang, Z.; Korponay-Szabo, I.R.; Fesues, L.
Transglutaminase 2 is expressed and active on the surface of human monocyte-derived dendritic cells and macrophages
Immunol. Lett.
130
74-81
2010
Homo sapiens (P21980), Homo sapiens
Manually annotated by BRENDA team
Clare, D.A.; Gharst, G.; Maleki, S.J.; Sanders, T.H.
Effects of transglutaminase catalysis on the functional and immunoglobulin binding properties of peanut flour dispersions containing casein
J. Agric. Food Chem.
56
10913-10921
2008
Streptomyces mobaraensis
Manually annotated by BRENDA team
Agyare, K.K.; Damodaran, S.
pH-stability and thermal properties of microbial transglutaminase-treated whey protein isolate
J. Agric. Food Chem.
58
1946-1953
2010
Streptomyces mobaraensis
Manually annotated by BRENDA team
Satpathy, M.; Shao, M.; Emerson, R.; Donner, D.B.; Matei, D.
Tissue transglutaminase regulates matrix metalloproteinase-2 in ovarian cancer by modulating cAMP-response element-binding protein activity
J. Biol. Chem.
284
15390-15399
2009
Homo sapiens
Manually annotated by BRENDA team
Zhang, Z.; Xing, J.; Ma, L.; Gong, R.; Chin, Y.E.; Zhuang, S.
Transglutaminase-1 regulates renal epithelial cell proliferation through activation of Stat-3
J. Biol. Chem.
284
3345-3353
2009
Mus musculus (Q9JLF6)
Manually annotated by BRENDA team
Yi, S.J.; Groffen, J.; Heisterkamp, N.
Transglutaminase 2 regulates the GTPase-activating activity of Bcr
J. Biol. Chem.
284
35645-35651
2009
Homo sapiens
Manually annotated by BRENDA team
Zeugolis, D.I.; Panengad, P.P.; Yew, E.S.; Sheppard, C.; Phan, T.T.; Raghunath, M.
An in situ and in vitro investigation for the transglutaminase potential in tissue engineering
J. Biomed. Mater. Res. A
92
1310-1320
2010
Homo sapiens
Manually annotated by BRENDA team
Plagmann, I.; Chalaris, A.; Kruglov, A.A.; Nedospasov, S.; Rosenstiel, P.; Rose-John, S.; Scheller, J.
Transglutaminase-catalyzed covalent multimerization of Camelidae anti-human TNF single domain antibodies improves neutralizing activity
J. Biotechnol.
142
170-178
2009
Streptomyces mobaraensis
Manually annotated by BRENDA team
Tseng, H.C.; Lin, H.J.; Sudhakar Gandhi, P.S.; Wang, C.Y.; Chen, Y.H.
Purification and identification of transglutaminase from mouse coagulating gland and its cross-linking activity among seminal vesicle secretion proteins
J. Chromatogr. B
876
198-202
2008
Mus musculus (Q8BZH1), Mus musculus
Manually annotated by BRENDA team
Pietroni, V.; Di Giorgi, S.; Paradisi, A.; Ahvazi, B.; Candi, E.; Melino, G.
Inactive and highly active, proteolytically processed transglutaminase-5 in epithelial cells
J. Invest. Dermatol.
128
2760-2766
2008
Homo sapiens
Manually annotated by BRENDA team
Csosz, E.; Bagossi, P.; Nagy, Z.; Dosztanyi, Z.; Simon, I.; Fesus, L.
Substrate preference of transglutaminase 2 revealed by logistic regression analysis and intrinsic disorder examination
J. Mol. Biol.
383
390-402
2008
Homo sapiens
Manually annotated by BRENDA team
Pardin, C.; Pelletier, J.N.; Lubell, W.D.; Keillor, J.W.
Cinnamoyl inhibitors of tissue transglutaminase
J. Org. Chem.
73
5766-5775
2008
Cavia porcellus
Manually annotated by BRENDA team
Jang, G.Y.; Jeon, J.H.; Cho, S.Y.; Shin, D.M.; Kim, C.W.; Jeong, E.M.; Bae, H.C.; Kim, T.W.; Lee, S.H.; Choi, Y.; Lee, D.S.; Park, S.C.; Kim, I.G.
Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cells
Oncogene
29
356-367
2010
Homo sapiens
Manually annotated by BRENDA team
Kamiya, N.; Abe, H.; Goto, M.; Tsuji, Y.; Jikuya, H.
Fluorescent substrates for covalent protein labeling catalyzed by microbial transglutaminase
Org. Biomol. Chem.
7
3407-3412
2009
Streptomyces mobaraensis (P81453)
Manually annotated by BRENDA team
Tagami, U.; Shimba, N.; Nakamura, M.; Yokoyama, K.; Suzuki, E.; Hirokawa, T.
Substrate specificity of microbial transglutaminase as revealed by three-dimensional docking simulation and mutagenesis
Protein Eng. Des. Sel.
22
747-752
2009
Streptomyces mobaraensis (P81453)
Manually annotated by BRENDA team
Lai, T.S.; Davies, C.; Greenberg, C.S.
Human tissue transglutaminase is inhibited by pharmacologic and chemical acetylation
Protein Sci.
19
229-235
2010
Homo sapiens (P21980), Homo sapiens
Manually annotated by BRENDA team
Sobieszczuk-Nowicka, E.; Krzeslowska, M.; Legocka, J.
Transglutaminases and their substrates in kinetin-stimulated etioplast-to-chloroplast transformation in cucumber cotyledons
Protoplasma
233
187-194
2008
Cucumis sativus
Manually annotated by BRENDA team
Watanabe, K.; Tsunoda, K.; Itoh, M.; Fukui, M.; Mori, H.; Hitomi, K.
Transglutaminase 2 and Factor XIII catalyze distinct substrates in differentiating osteoblastic cell line: utility of highly reactive substrate peptides
Amino Acids
44
209-214
2013
Mus musculus
Manually annotated by BRENDA team
Facchiano, F.; DArcangelo, D.; Lentini, A.; Rossi, S.; Senatore, C.; Pannellini, T.; Tabolacci, C.; Facchiano, A.M.; Facchiano, A.; Beninati, S.
Tissue transglutaminase activity protects from cutaneous melanoma metastatic dissemination: an in vivo study
Amino Acids
44
53-61
2013
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Kwon, M.H.; Jung, S.H.; Kim, Y.M.; Ha, K.S.
Simultaneous activity assay of two transglutaminase isozymes, blood coagulation factor XIII and transglutaminase 2, by use of fibrinogen arrays
Anal. Chem.
83
8718-8724
2011
Cavia porcellus
Manually annotated by BRENDA team
Yokoyama, K.; Utsumi, H.; Nakamura, T.; Ogaya, D.; Shimba, N.; Suzuki, E.; Taguchi, S.
Screening for improved activity of a transglutaminase from Streptomyces mobaraensis created by a novel rational mutagenesis and random mutagenesis
Appl. Microbiol. Biotechnol.
87
2087-2096
2010
Streptomyces mobaraensis, Streptomyces mobaraensis s-8112
Manually annotated by BRENDA team
Di Sandro, A.; Del Duca, S.; Verderio, E.; Hargreaves, A.J.; Scarpellini, A.; Cai, G.; Cresti, M.; Faleri, C.; Iorio, R.A.; Hirose, S.; Furutani, Y.; Coutts, I.G.; Griffin, M.; Bonner, P.L.; Serafini-Fracassini, D.
An extracellular transglutaminase is required for apple pollen tube growth
Biochem. J.
429
261-271
2010
Malus domestica
Manually annotated by BRENDA team
Spolaore, B.; Raboni, S.; Ramos Molina, A.; Satwekar, A.; Damiano, N.; Fontana, A.
Local unfolding is required for the site-specific protein modification by transglutaminase
Biochemistry
51
8679-8689
2012
Streptomyces mobaraensis
Manually annotated by BRENDA team
Kloeck, C.; Jin, X.; Choi, K.; Khosla, C.; Madrid, P.B.; Spencer, A.; Raimundo, B.C.; Boardman, P.; Lanza, G.; Griffin, J.H.
Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2
Bioorg. Med. Chem. Lett.
21
2692-2696
2011
Homo sapiens
Manually annotated by BRENDA team
Carvajal, P.; Gibert, J.; Campos, N.; Lopera, O.; Barbera, E.; Torne, J.M.; Santos, M.
Activity of maize transglutaminase overexpressed in Escherichia coli inclusion bodies: an alternative to protein refolding
Biotechnol. Prog.
27
232-240
2011
Zea mays
Manually annotated by BRENDA team
Wang, Y.; Ande, S.R.; Mishra, S.
Phosphorylation of transglutaminase 2 (TG2) at serine-216 plays a role in TG2 mediated activation of nuclear factor-kappa B and in the downregulation of PTEN
BMC Cancer
12
277
2012
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Boros, S.; Xi, Q.; Dimke, H.; van der Kemp, A.W.; Tudpor, K.; Verkaart, S.; Lee, K.P.; Bindels, R.J.; Hoenderop, J.G.
Tissue transglutaminase inhibits the TRPV5-dependent calcium transport in an N-glycosylation-dependent manner
Cell. Mol. Life Sci.
69
981-992
2012
Mus musculus
Manually annotated by BRENDA team
Stamnaes, J.; Pinkas, D.M.; Fleckenstein, B.; Khosla, C.; Sollid, L.M.
Redox regulation of transglutaminase 2 activity
J. Biol. Chem.
285
25402-25409
2010
Homo sapiens
Manually annotated by BRENDA team
Yang, M.T.; Chang, C.H.; Wang, J.M.; Wu, T.K.; Wang, Y.K.; Chang, C.Y.; Li, T.T.
Crystal structure and inhibition studies of transglutaminase from Streptomyces mobaraense
J. Biol. Chem.
286
7301-7307
2011
Streptomyces mobaraensis
Manually annotated by BRENDA team
Wang, Z.; Collighan, R.J.; Pytel, K.; Rathbone, D.L.; Li, X.; Griffin, M.
Characterization of heparin-binding site of tissue transglutaminase: its importance in cell surface targeting, matrix deposition, and cell signaling
J. Biol. Chem.
287
13063-13083
2012
Cavia porcellus (Q7M0F8)
Manually annotated by BRENDA team
Zhang, L.; Zhang, L.; Yi, H.; Du, M.; Ma, C.; Han, X.; Feng, Z.; Jiao, Y.; Zhang, Y.
Enzymatic characterization of transglutaminase from Streptomyces mobaraensis DSM 40587 in high salt and effect of enzymatic cross-linking of yak milk proteins on functional properties of stirred yogurt
J. Dairy Sci.
95
3559-3568
2012
Streptomyces mobaraensis, Streptomyces mobaraensis DSM 40587
Manually annotated by BRENDA team
Prime, M.E.; Andersen, O.A.; Barker, J.J.; Brooks, M.A.; Cheng, R.K.; Toogood-Johnson, I.; Courtney, S.M.; Brookfield, F.A.; Yarnold, C.J.; Marston, R.W.; Johnson, P.D.; Johnsen, S.F.; Palfrey, J.J.; Vaidya, D.; Erfan, S.; Ichihara, O.; Felicetti, B.; Palan, S.; Pedret-Dunn, A.; Schaertl, S.; Sternberger, I.
Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntingtons disease
J. Med. Chem.
55
1021-1046
2012
Homo sapiens (P21980), Homo sapiens
Manually annotated by BRENDA team
Salter, N.W.; Ande, S.R.; Nguyen, H.K.; Nyomba, B.L.; Mishra, S.
Functional characterization of naturally occurring transglutaminase 2 mutants implicated in early-onset type 2 diabetes
J. Mol. Endocrinol.
48
203-216
2012
Mus musculus
Manually annotated by BRENDA team
Campos, A.; Carvajal-Vallejos, P.K.; Villalobos, E.; Franco, C.F.; Almeida, A.M.; Coelho, A.V.; Torne, J.M.; Santos, M.
Characterisation of Zea mays L. plastidial transglutaminase: interactions with thylakoid membrane proteins
Plant Biol.
12
708-716
2010
Zea mays
Manually annotated by BRENDA team
Dafik, L.; Albertelli, M.; Stamnaes, J.; Sollid, L.M.; Khosla, C.
Activation and inhibition of transglutaminase 2 in mice
PLoS ONE
7
e30642
2012
Mus musculus
Manually annotated by BRENDA team
Roy, I.; Smith, O.; Clouthier, C.M.; Keillor, J.W.
Expression, purification and kinetic characterisation of human tissue transglutaminase
Protein Expr. Purif.
87
41-46
2013
Homo sapiens (P21980), Homo sapiens
Manually annotated by BRENDA team
Du, K.; Liu, Z.; Cui, W.; Zhou, L.; Liu, Y.; Du, G.; Chen, J.; Zhou, Z.
pH-dependent activation of Streptomyces hygroscopicus transglutaminase mediated by intein
Appl. Environ. Microbiol.
80
723-729
2014
Streptomyces hygroscopicus, Streptomyces hygroscopicus WSH03-13
Manually annotated by BRENDA team
Gundersen, M.T.; Keillor, J.W.; Pelletier, J.N.
Microbial transglutaminase displays broad acyl-acceptor substrate specificity
Appl. Microbiol. Biotechnol.
98
219-230
2014
Streptomyces mobaraensis
Manually annotated by BRENDA team
Kanchan, K.; Erguelen, E.; Kiraly, R.; Simon-Vecsei, Z.; Fuxreiter, M.; Fesues, L.
Identification of a specific one amino acid change in recombinant human transglutaminase 2 that regulates its activity and calcium sensitivity
Biochem. J.
455
261-272
2013
Homo sapiens (P21980), Homo sapiens
Manually annotated by BRENDA team
Fernandes, C.G.; Placido, D.; Lousa, D.; Brito, J.A.; Isidro, A.; Soares, C.M.; Pohl, J.; Carrondo, M.A.; Archer, M.; Henriques, A.O.
Structural and functional characterization of an ancient bacterial transglutaminase sheds light on the minimal requirements for protein cross-linking
Biochemistry
54
5723-5734
2015
Bacillus subtilis
Manually annotated by BRENDA team
Arockiaraj, J.; Gnanam, A.J.; Palanisamy, R.; Kumaresan, V.; Bhatt, P.; Thirumalai, M.K.; Roy, A.; Pasupuleti, M.; Kasi, M.; Sathyamoorthi, A.; Arasu, A.
A prawn transglutaminase: molecular characterization and biochemical properties
Biochimie
95
2354-2364
2013
Macrobrachium rosenbergii (A0A024GWU1), Macrobrachium rosenbergii
Manually annotated by BRENDA team
Liu, S.; Wan, D.; Wang, M.; Madzak, C.; Du, G.; Chen, J.
Overproduction of pro-transglutaminase from Streptomyces hygroscopicus in Yarrowia lipolytica and its biochemical characterization
BMC Biotechnol.
15
75
2015
Streptomyces hygroscopicus (D9J009), Streptomyces hygroscopicus, Streptomyces hygroscopicus WSH03-13 (D9J009)
Manually annotated by BRENDA team
Salis, B.; Spinetti, G.; Scaramuzza, S.; Bossi, M.; Saccani Jotti, G.; Tonon, G.; Crobu, D.; Schrepfer, R.
High-level expression of a recombinant active microbial transglutaminase in Escherichia coli
BMC Biotechnol.
15
84
2015
Streptomyces mobaraensis (Q2VI01), Streptomyces mobaraensis
Manually annotated by BRENDA team
Piacentini, M.; DEletto, M.; Farrace, M.G.; Rodolfo, C.; Del Nonno, F.; Ippolito, G.; Falasca, L.
Characterization of distinct sub-cellular location of transglutaminase type II: changes in intracellular distribution in physiological and pathological states
Cell Tissue Res.
358
793-805
2014
Homo sapiens
Manually annotated by BRENDA team
Badarau, E.; Wang, Z.; Rathbone, D.L.; Costanzi, A.; Thibault, T.; Murdoch, C.E.; El Alaoui, S.; Bartkeviciute, M.; Griffin, M.
Development of potent and selective tissue transglutaminase inhibitors: their effect on TG2 function and application in pathological conditions
Chem. Biol.
22
1347-1361
2015
Homo sapiens
Manually annotated by BRENDA team
Karashima, T.; Furumura, M.; Ishii, N.; Ohyama, B.; Saruta, H.; Natsuaki, Y.; Nakama, T.; Ohata, C.; Tsuruta, D.; Hitomi, K.; Hashimoto, T.
Distinct protein expression and activity of transglutaminases found in different epidermal tumors
Exp. Dermatol.
23
433-435
2014
Homo sapiens
Manually annotated by BRENDA team
Fukui, M.; Kuramoto, K.; Yamasaki, R.; Shimizu, Y.; Itoh, M.; Kawamoto, T.; Hitomi, K.
Identification of a highly reactive substrate peptide for transglutaminase 6 and its use in detecting transglutaminase activity in the skin epidermis
FEBS J.
280
1420-1429
2013
Mus musculus
Manually annotated by BRENDA team
Curro, M.; Gangemi, C.; Gugliandolo, A.; Risitano, R.; Ferlazzo, N.; Ientile, R.; Caccamo, D.
Transglutaminase 2 is involved in homocysteine-induced activation of human THP-1 monocytes
Free Radic. Res.
49
299-308
2015
Homo sapiens
Manually annotated by BRENDA team
Le, B.V.; Nguyen, J.B.; Logarajah, S.; Wang, B.; Marcus, J.; Williams, H.P.; Catteruccia, F.; Baxter, R.H.
Characterization of Anopheles gambiae transglutaminase 3 (AgTG3) and its native substrate plugin
J. Biol. Chem.
288
4844-4853
2013
Anopheles gambiae
Manually annotated by BRENDA team
Boroughs, L.K.; Antonyak, M.A.; Cerione, R.A.
A novel mechanism by which tissue transglutaminase activates signaling events that promote cell survival
J. Biol. Chem.
289
10115-10125
2014
Mus musculus
Manually annotated by BRENDA team
Yu, J.; Pian, Y.; Ge, J.; Guo, J.; Zheng, Y.; Jiang, H.; Hao, H.; Yuan, Y.; Jiang, Y.; Yang, M.
Functional and structural characterization of the antiphagocytic properties of a novel transglutaminase from Streptococcus suis
J. Biol. Chem.
290
19081-19092
2015
Streptococcus suis (A5JSJ3), Streptococcus suis
Manually annotated by BRENDA team
Kloeck, C.; Herrera, Z.; Albertelli, M.; Khosla, C.
Discovery of potent and specific dihydroisoxazole inhibitors of human transglutaminase 2
J. Med. Chem.
57
9042-9064
2014
Homo sapiens
Manually annotated by BRENDA team
Li, H.; Zhang, L.; Cui, Y.; Luo, X.; Xue, C.; Wang, S.; Jiao, Y.; Zhang, S.; Liu, W.; Fan, R.; Du, M.; Yi, H.; Han, X.
Characterization of recombinant Zea mays transglutaminase expressed in Pichia pastoris and its impact on full and non-fat yoghurts
J. Sci. Food Agric.
94
1225-1230
2014
Zea mays
Manually annotated by BRENDA team
Kikuta, A.; Furukawa, E.; Ogawa, R.; Suganuma, N.; Saitoh, M.; Nishimaki, T.; Katsumura, T.; Oota, H.; Kawamoto, T.; Tatsukawa, H.; Hashimoto, H.; Hitomi, K.
biochemical characterization of medaka (Oryzias latipes) transglutaminases, OlTGK1 and OlTGK2, as orthologues of human keratinocyte-type transglutaminase
PLoS ONE
10
e0144194
2015
Oryzias latipes (A0A0S3Q197), Oryzias latipes (A0A0S3Q1B1), Oryzias latipes
Manually annotated by BRENDA team
Fang, J.Y.; Tan, S.J.; Yang, Z.; Tayag, C.; Han, B.
Tumor bioengineering using a transglutaminase crosslinked hydrogel
PLoS ONE
9
e105616
2014
Homo sapiens
Manually annotated by BRENDA team
Christensen, B.; Zachariae, E.D.; Scavenius, C.; Thybo, M.; Callesen, M.M.; Kloverpris, S.; Oxvig, C.; Enghild, J.J.; Sorensen, E.S.
Identification of transglutaminase reactive residues in human osteopontin and their role in polymerization
PLoS ONE
9
e113650
2014
Cavia porcellus
Manually annotated by BRENDA team
Rickert, M.; Strop, P.; Lui, V.; Melton-Witt, J.; Farias, S.E.; Foletti, D.; Shelton, D.; Pons, J.; Rajpal, A.
Production of soluble and active microbial transglutaminase in Escherichia coli for site-specific antibody drug conjugation
Protein Sci.
25
442-455
2016
Streptomyces mobaraensis
Manually annotated by BRENDA team
Wilhelmus, M.M.; de Jager, M.; Smit, A.B.; van der Loo, R.J.; Drukarch, B.
Catalytically active tissue transglutaminase colocalises with Abeta pathology in Alzheimers disease mouse models
Sci. Rep.
6
20569
2016
Mus musculus
Manually annotated by BRENDA team
Ivashkin, E.; Melnikova, V.; Kurtova, A.; Brun, N.R.; Obukhova, A.; Khabarova, M.Y.; Yakusheff, A.; Adameyko, I.; Gribble, K.E.; Voronezhskaya, E.E.
Transglutaminase activity determines nuclear localization of serotonin immunoreactivity in the early embryos of invertebrates and vertebrates
ACS Chem. Neurosci.
10
3888-3899
2019
Mesocentrotus nudus, Scaphechinus mirabilis, Paracentrotus lividus (Q8T316)
Manually annotated by BRENDA team
Ohtake, K.; Mukai, T.; Iraha, F.; Takahashi, M.; Haruna, K.I.; Date, M.; Yokoyama, K.; Sakamoto, K.
Engineering an automaturing transglutaminase with enhanced thermostability by genetic code expansion with two codon reassignments
ACS Synth. Biol.
7
2170-2176
2018
Streptomyces mobaraensis (P81453), Streptomyces mobaraensis
Manually annotated by BRENDA team
Boehme, B.; Moritz, B.; Wendler, J.; Hertel, T.C.; Ihling, C.; Brandt, W.; Pietzsch, M.
Enzymatic activity and thermoresistance of improved microbial transglutaminase variants
Amino Acids
52
313-326
2020
Streptomyces mobaraensis (P81453), Streptomyces mobaraensis
Manually annotated by BRENDA team
Yu, C.M.; Zhou, H.; Zhang, W.F.; Yang, H.M.; Tang, J.B.
Site-specific, covalent immobilization of BirA by microbial transglutaminase A reusable biocatalyst for invitro biotinylation
Anal. Biochem.
511
10-12
2016
Streptomyces mobaraensis (P81453)
Manually annotated by BRENDA team
Zhuang, R.; Khosla, C.
Substrates, inhibitors, and probes of mammalian transglutaminase 2
Anal. Biochem.
591
113560
2020
Homo sapiens (P21980), Homo sapiens
Manually annotated by BRENDA team
Razavian, S.; Kashfi, A.; Khoshraftar, Z.
Purification of bovine liver transglutaminase by gel filtration
Appl. Biol. Chem.
63
6
2020
Bos taurus
-
Manually annotated by BRENDA team
Chan, S.K.; Lim, T.S.
Bioengineering of microbial transglutaminase for biomedical applications
Appl. Microbiol. Biotechnol.
103
2973-2984
2019
Streptomyces mobaraensis (P81453)
Manually annotated by BRENDA team
Wells, E.A.; Anderson, M.A.; Zeczycki, T.N.
15(V/K) kinetic isotope effect and steady-state kinetic analysis for the transglutaminase 2 catalyzed deamidation and transamidation reactions
Arch. Biochem. Biophys.
643
57-61
2018
Homo sapiens (P21980)
Manually annotated by BRENDA team
Yamane, M.; Sugimura, K.; Kawasaki, H.; Tatsukawa, H.; Hitomi, K.
Analysis on transglutaminase 1 and its substrates using specific substrate peptide in cultured keratinocytes
Biochem. Biophys. Res. Commun.
478
343-348
2016
Homo sapiens (P22735)
Manually annotated by BRENDA team
Liu, Y.; Huang, L.; Shan, M.; Sang, J.; Li, Y.; Jia, L.; Wang, N.; Wang, S.; Shao, S.; Liu, F.; Lu, F.
Enhancing the activity and thermostability of Streptomyces mobaraensis transglutaminase by directed evolution and molecular dynamics simulation
Biochem. Eng. J.
151
107333
2019
Streptomyces mobaraensis (P81453)
-
Manually annotated by BRENDA team
Erguelen, E.; Becsi, B.; Csomos, I.; Fesues, L.; Kanchan, K.
Identification of DNAJA1 as a novel interacting partner and a substrate of human transglutaminase 2
Biochem. J.
473
3889-3901
2016
Homo sapiens (P21980), Homo sapiens
Manually annotated by BRENDA team
Spolaore, B.; Raboni, S.; Satwekar, A.A.; Grigoletto, A.; Mero, A.; Montagner, I.M.; Rosato, A.; Pasut, G.; Fontana, A.
Site-specific transglutaminase-mediated conjugation of interferon alpha-2b at glutamine or lysine residues
Bioconjug. Chem.
27
2695-2706
2016
Streptomyces mobaraensis (P81453)
Manually annotated by BRENDA team
Spidel, J.L.; Vaessen, B.; Albone, E.F.; Cheng, X.; Verdi, A.; Kline, J.B.
Site-specific conjugation to native and engineered lysines in human immunoglobulins by microbial transglutaminase
Bioconjug. Chem.
28
2471-2484
2017
Streptomyces mobaraensis (P81453)
Manually annotated by BRENDA team
Deweid, L.; Avrutina, O.; Kolmar, H.
Microbial transglutaminase for biotechnological and biomedical engineering
Biol. Chem.
400
257-274
2019
Bacillus subtilis (P40746), Streptomyces mobaraensis (P81453), Streptomyces mobaraensis, Kutzneria albida (W5WHY8), Bacillus subtilis 168 (P40746), Kutzneria albida DSM 43870 (W5WHY8)
Manually annotated by BRENDA team
Takada, Y.; Watanabe, Y.; Okuya, K.; Tatsukawa, H.; Hashimoto, H.; Hitomi, K.
Biochemical characterization of the medaka (Oryzias latipes) orthologue for mammalian tissue-type transglutaminase (TG2)
Biosci. Biotechnol. Biochem.
81
469-474
2017
Oryzias latipes (A0A0S3Q161), Oryzias latipes
Manually annotated by BRENDA team
Mu, D.; Lu, J.; Shu, C.; Li, H.; Li, X.; Cai, J.; Luo, S.; Yang, P.; Jiang, S.; Zheng, Z.
Improvement of the activity and thermostability of microbial transglutaminase by multiple-site mutagenesis
Biosci. Biotechnol. Biochem.
82
106-109
2018
Streptomyces mobaraensis (P81453), Streptomyces mobaraensis
Manually annotated by BRENDA team
Tokai, S.; Uraji, M.; Hatanaka, T.
Molecular insights into the mechanism of substrate recognition of Streptomyces transglutaminases
Biosci. Biotechnol. Biochem.
84
575-582
2020
Streptomyces mobaraensis (P81453), Streptomyces mobaraensis, Streptomyces cinnamoneus (Q8GR90), Streptomyces cinnamoneus, Streptomyces cinnamoneus NBRC 13864 (Q8GR90), Streptomyces mobaraensis NBRC 13819 (P81453)
Manually annotated by BRENDA team
Liu, S.; Wang, M.; Du, G.; Chen, J.
Improving the active expression of transglutaminase in Streptomyces lividans by promoter engineering and codon optimization
BMC Biotechnol.
16
75
2016
Streptomyces hygroscopicus (P81453), Streptomyces hygroscopicus, Streptomyces hygroscopicus WSH03-13 (P81453)
Manually annotated by BRENDA team
Javitt, G.; Ben-Barak-Zelas, Z.; Jerabek-Willemsen, M.; Fishman, A.
Constitutive expression of active microbial transglutaminase in Escherichia coli and comparative characterization to a known variant
BMC Biotechnol.
17
23
2017
Streptomyces mobaraensis (P81453)
Manually annotated by BRENDA team
Schulze-Krebs, A.; Canneva, F.; Schnepf, R.; Dobner, J.; Dieterich, W.; Von Hoersten, S.
In situ enzymatic activity of transglutaminase isoforms on brain tissue sections of rodents A new approach to monitor differences in post-translational protein modifications during neurodegeneration
Brain Res.
1631
22-33
2016
Rattus norvegicus (F1M4T7), Mus musculus (P21981), Mus musculus (Q8BM11), Rattus norvegicus Sprague-Dawley (F1M4T7), Mus musculus C57BL/6J (P21981), Mus musculus C57BL/6J (Q8BM11)
Manually annotated by BRENDA team
Wodtke, R.; Schramm, G.; Pietzsch, J.; Pietsch, M.; Loeser, R.
Synthesis and kinetic characterisation of water-soluble fluorogenic acyl donors for transglutaminase 2
ChemBioChem
17
1263-1281
2016
Cavia porcellus (H0VXN6)
Manually annotated by BRENDA team
Pina Dore, M.; Pes, G.M.; Errigo, A.; Manca, A.; Realdi, G.
Tissue transglutaminase activity in human gastric mucosa according to Helicobacter pylori infection
Exp. Biol. Med. (Maywood)
243
1161-1164
2018
Homo sapiens (P21980), Homo sapiens
Manually annotated by BRENDA team
Lorand, L.; Iismaa, S.E.
Transglutaminase diseases from biochemistry to the bedside
FASEB J.
33
3-12
2019
Homo sapiens (O43548), Homo sapiens (O95932), Homo sapiens (P16452), Homo sapiens (P21980), Homo sapiens (P22735), Homo sapiens (P49221), Homo sapiens (Q08188), Homo sapiens (Q96PF1), Homo sapiens, Mus musculus (P21981), Mus musculus (Q9JLF6)
Manually annotated by BRENDA team
Alvarez, R.G.; Karki, P.; Langleite, I.E.; Bakksjo, R.J.; Eichacker, L.A.; Furnes, C.
Characterisation of a novel cold-adapted calcium-activated transglutaminase implications for medicine and food processing
FEBS Open Bio
10
495-506
2020
Gadus morhua (V9I378), Gadus morhua
Manually annotated by BRENDA team
Sirikharin, R.; Soederhaell, I.; Soederhaell, K.
Characterization of a cold-active transglutaminase from a crayfish, Pacifastacus leniusculus
Fish Shellfish Immunol.
80
546-549
2018
Cavia porcellus (A0A286XL02), Cavia porcellus, Pacifastacus leniusculus (Q964D3), Pacifastacus leniusculus
Manually annotated by BRENDA team
Zhang, Y.; He, S.; Simpson, B.K.
A cold active transglutaminase from Antarctic krill (Euphausia superba) purification, characterization and application in the modification of cold-set gelatin gel
Food Chem.
232
155-162
2017
Euphausia superba
Manually annotated by BRENDA team
Li, H.; Cui, Y.; Zhang, L.; Zhang, L.; Liu, H.; Yu, J.
Optimization of recombinant Zea mays transglutaminase production and its influence on the functional properties of yogurt
Food Sci. Biotechnol.
26
723-730
2017
Zea mays
Manually annotated by BRENDA team
Ioannidis, N.E.; Malliarakis, D.; Torne, J.M.; Santos, M.; Kotzabasis, K.
The over-expression of the plastidial transglutaminase from maize in Arabidopsis increases the activation threshold of photoprotection
Front. Plant Sci.
7
635
2016
Zea mays (Q6KF70), Zea mays
Manually annotated by BRENDA team
Alavi, F.; Emam-Djomeh, Z.; Salami, M.; Mohammadian, M.
Effect of microbial transglutaminase on the mechanical properties and microstructure of acid-induced gels and emulsion gels produced from thermal denatured egg white proteins
Int. J. Biol. Macromol.
153
523-532
2020
Streptomyces mobaraensis (P81453)
Manually annotated by BRENDA team
Steffen, W.; Ko, F.C.; Patel, J.; Lyamichev, V.; Albert, T.J.; Benz, J.; Rudolph, M.G.; Bergmann, F.; Streidl, T.; Kratzsch, P.; Boenitz-Dulat, M.; Oelschlaegel, T.; Schraeml, M.
Discovery of a microbial transglutaminase enabling highly site-specific labeling of proteins
J. Biol. Chem.
292
15622-15635
2017
Kutzneria albida (W5WHY8), Kutzneria albida, Kutzneria albida DSM 43870 (W5WHY8)
Manually annotated by BRENDA team
Wan, W.; He, D.; Xue, Z.; Zhang, Z.
Specific mutation of transglutaminase gene from Streptomyces hygroscopicus H197 and characterization of microbial transglutaminase
J. Biosci.
42
537-546
2017
Streptomyces hygroscopicus (A0A291LTQ0), Streptomyces hygroscopicus H197 (A0A291LTQ0)
Manually annotated by BRENDA team
Zhang, L.; Rao, W.; Muhayimana, S.; Zhang, X.; Xu, J.; Xiao, C.; Huang, Q.
Purification and biochemical characterization of a novel transglutaminase from Mythimna separata larvae (Noctuidae, Lepidoptera)
J. Biotechnol.
265
1-7
2018
Mythimna separata
Manually annotated by BRENDA team
Sun, H.; Kaartinen, M.T.
Transglutaminase activity regulates differentiation, migration and fusion of osteoclasts via affecting actin dynamics
J. Cell. Physiol.
233
7497-7513
2018
Mus musculus (P21981), Mus musculus (Q8BH61), Mus musculus (Q9JLF6)
Manually annotated by BRENDA team
Fotschki, J.; Wroblewska, B.; Fotschki, B.; Kalicki, B.; Rigby, N.; Mackie, A.
Microbial transglutaminase alters the immunogenic potential and cross-reactivity of horse and cow milk proteins
J. Dairy Sci.
103
2153-2166
2020
Streptomyces mobaraensis (P81453)
Manually annotated by BRENDA team
Akbar, A.; McNeil, N.M.R.; Albert, M.R.; Ta, V.; Adhikary, G.; Bourgeois, K.; Eckert, R.L.; Keillor, J.W.
Structure-activity relationships of potent, targeted covalent inhibitors that abolish both the transamidation and GTP binding activities of human tissue transglutaminase
J. Med. Chem.
60
7910-7927
2017
Homo sapiens
Manually annotated by BRENDA team
Wodtke, R.; Hauser, C.; Ruiz-Gomez, G.; Jaeckel, E.; Bauer, D.; Lohse, M.; Wong, A.; Pufe, J.; Ludwig, F.A.; Fischer, S.; Hauser, S.; Greif, D.; Pisabarro, M.T.; Pietzsch, J.; Pietsch, M.; Loeser, R.
Nepsilon-acryloyllysine piperazides as irreversible inhibitors of transglutaminase 2 synthesis, structure-activity relationships, and pharmacokinetic profiling
J. Med. Chem.
61
4528-4560
2018
Cavia porcellus (H0VXN6), Homo sapiens (O95932), Homo sapiens (P00488), Homo sapiens (P21980), Homo sapiens (P22735), Homo sapiens (Q08188), Mus musculus (P21981)
Manually annotated by BRENDA team
St-Jacques, A.; Rachel, N.; Curry, D.; Gillet, S.; Clouthier, C.; Keillor, J.; Pelletier, J.; Chica, R.
Specificity of transglutaminase-catalyzed peptide synthesis
J. Mol. Catal. B
123
53-61
2016
Cavia porcellus (H0VXN6)
-
Manually annotated by BRENDA team
Jin, M.; Huang, J.; Pei, Z.; Huang, J.; Gao, H.; Chang, Z.
Purification and characterization of a high-salt-resistant microbial transglutaminase from Streptomyces mobaraensis
J. Mol. Catal. B
133
6-11
2016
Streptomyces mobaraensis (P81453), Streptomyces mobaraensis TX (P81453)
-
Manually annotated by BRENDA team
Li, H.; Zhang, T.; Li, J.; Li, H.; Xu, Y.; Yu, J.
Expression of Zea mays transglutaminase in Pichia pastoris under different promoters and its impact on properties of acidified milk protein concentrate gel
J. Sci. Food Agric.
99
4518-4523
2019
Zea mays
Manually annotated by BRENDA team
Katt, W.P.; Antonyak, M.A.; Cerione, R.A.
Opening up about tissue transglutaminase when conformation matters more than enzymatic activity
Med One
3
e180011
2018
Homo sapiens (P21980)
Manually annotated by BRENDA team
Long, H.; Ma, K.; Xiao, Z.; Ren, X.; Yang, G.
Preparation and characteristics of gelatin sponges crosslinked by microbial transglutaminase
PeerJ
5
e3665
2017
Streptomyces mobaraensis (P81453)
Manually annotated by BRENDA team
Ha, H.J.; Kwon, S.; Jeong, E.M.; Kim, C.M.; Lee, K.B.; Kim, I.G.; Park, H.H.
Structure of natural variant transglutaminase 2 reveals molecular basis of gaining stability and higher activity
PLoS ONE
13
e0204707
2018
Homo sapiens (P21980), Homo sapiens
Manually annotated by BRENDA team
Rachel, N.M.; Quaglia, D.; Levesque, E.; Charette, A.B.; Pelletier, J.N.
Engineered, highly reactive substrates of microbial transglutaminase enable protein labeling within various secondary structure elements
Protein Sci.
26
2268-2279
2017
Streptomyces mobaraensis (P81453)
Manually annotated by BRENDA team