Information on EC 2.3.2.19 - ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase

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The expected taxonomic range for this enzyme is: Bacillus circulans

EC NUMBER
COMMENTARY hide
2.3.2.19
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RECOMMENDED NAME
GeneOntology No.
ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + ribostamycin = gamma-L-glutamyl-butirosin B + BtrI acyl-carrier protein
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
butirosin biosynthesis
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Neomycin, kanamycin and gentamicin biosynthesis
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase
The enzyme attaches the side chain of the aminoglycoside antibiotics of the butirosin family. The side chain confers resistance against several aminoglycoside-modifying enzymes.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-(gamma-L-glutamylamino)-(S)-2-hydroxylbutanoyl -[BtrI acyl-carrier protein] + neomycin
gamma-L-glutamyl-neomycin + BtrI acyl-carrier protein
show the reaction diagram
4-(gamma-L-glutamylamino)-(S)-2-hydroxylbutanoyl-[BtrI acyl-carrier protein] + paromomycin
gamma-L-glutamyl-paromomycin + BtrI acyl-carrier protein
show the reaction diagram
4-(gamma-L-glutamylamino)-(S)-2-hydroxylbutanoyl-[BtrI acyl-carrier protein] + ribostamycin
gamma-L-glutamyl-butirosin B + BtrI acyl-carrier protein
show the reaction diagram
additional information
?
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
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