Reference on EC 2.3.2.26 - HECT-type E3 ubiquitin transferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nuber, U.; Scheffner, M.
Identification of determinants in E2 ubiquitin-conjugating enzymes required for hect E3 ubiquitin-protein ligase interaction
J. Biol. Chem.
274
7576-7582
1999
Saccharomyces cerevisiae (P39940), Saccharomyces cerevisiae, Homo sapiens (Q05086), Homo sapiens, Saccharomyces cerevisiae ATCC 204508 (P39940)
Yu, J.; Lan, J.; Zhu, Y.; Li, X.; Lai, X.; Xue, Y.; Jin, C.; Huang, H.
The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara
Biochem. Biophys. Res. Commun.
367
805-812
2008
Homo sapiens (Q5T447)
Park, Y.; Yoon, S.K.; Yoon, J.B.
TRIP12 functions as an E3 ubiquitin ligase of APP-BP1
Biochem. Biophys. Res. Commun.
374
294-298
2008
Homo sapiens (Q14669)
Xia, Z.; Webster, A.; Du, F.; Piatkov, K.; Ghislain, M.; Varshavsky, A.
Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway
J. Biol. Chem.
283
24011-24028
2008
Saccharomyces cerevisiae (P19812), Saccharomyces cerevisiae ATCC 204508 (P19812)
Li, Y.; Ozaki, T.; Kikuchi, H.; Yamamoto, H.; Ohira, M.; Nakagawara, A.
A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner
Oncogene
27
3700-3709
2008
Homo sapiens (Q76N89)
Chen, A.; Gao, B.; Zhang, J.; McEwen, T.; Ye, S.Q.; Zhang, D.; Fang, D.
The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination
Mol. Cell. Biol.
29
5348-5356
2009
Homo sapiens (O00308)
Lu, K.; Li, P.; Zhang, M.; Xing, G.; Li, X.; Zhou, W.; Bartlam, M.; Zhang, L.; Rao, Z.; He, F.
Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection
J. Biol. Chem.
286
16861-16870
2011
Homo sapiens (Q9HCE7)
Lin, D.Y.; Diao, J.; Zhou, D.; Chen, J.
Biochemical and structural studies of a HECT-like ubiquitin ligase from Escherichia coli O157:H7
J. Biol. Chem.
286
441-449
2011
Escherichia coli (A0A0H3JDV8)
Maspero, E.; Mari, S.; Valentini, E.; Musacchio, A.; Fish, A.; Pasqualato, S.; Polo S.
Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation
EMBO Rep.
12
342-349
2011
Homo sapiens (P46934)
Kamadurai, H.B.; Qiu, Y.; Deng, A.; Harrison, J.S.; Macdonald, C.; Actis, M.; Rodrigues, P.; Miller, D.J.; Souphron, J.; Lewis, S.M.; Kurinov, I.; Fujii, N.; Hammel, M.; Piper, R.; Kuhlman, B.; Schulman, B.A.
Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3
eLife
2
e00828
2013
Saccharomyces cerevisiae (P39940), Saccharomyces cerevisiae ATCC 204508 (P39940)
Hu, G.; Wang, X.; Saunders, D.; Henderson, M.; Russell, A.; Herring, B.; Zhou, J.
Modulation of myocardin function by the ubiquitin E3 ligase UBR5
J. Biol. Chem.
286
11800-11809
2011
Mus musculus (Q80TP3)
Zanier, K.; Charbonnier, S.; Baltzinger, M.; Nomine, Y.; Altschuh, D.; Trave, G.
Kinetic analysis of the interactions of human papillomavirus E6 oncoproteins with the ubiquitin ligase E6AP using surface plasmon resonance
J. Mol. Biol.
349
401-412
2005
Homo sapiens (Q05086)
Lin, Q.; Wang, J.; Childress, C.; Sudol, M.; Carey, D.; Yang, W.
HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK
Mol. Cell. Biol.
30
1541-1554
2010
Homo sapiens (P46934)
Maspero, E.; Valentini, E.; Mari, S.; Cecatiello, V.; Soffientini, P.; Pasqualato, S.; Polo, S.
Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming
Nat. Struct. Mol. Biol.
20
696-701
2013
Homo sapiens (P46934), Homo sapiens
Miao, Y.; Zentgraf, U.
A HECT E3 ubiquitin ligase negatively regulates Arabidopsis leaf senescence through degradation of the transcription factor WRKY53
Plant J.
63
179-188
2010
Arabidopsis thaliana (Q9SU29)
Li, Y.; Kong, Y.; Zhou, Z.; Chen, H.; Wang, Z.; Hsieh, Y.C.; Zhao, D.; Zhi, X.; Huang, J.; Zhang, J.; Li, H.; Chen, C.
The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8
Cell Death Dis.
4
e935
2013
Homo sapiens (Q5T447)
Rossi, M.; Rotblat, B.; Ansell, K.; Amelio, I.; Caraglia, M.; Misso, G.; Bernassola, F.; Cavasotto, C.; Knight, R.; Ciechanover, A.; Melino, G.
High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy
Cell Death Dis.
5
e935
2014
Homo sapiens (Q96J02)
-
Wang, R.; Kaul, Z.; Ambardekar, C.; Yamamoto, T.G.; Kavdia, K.; Kodali, K.; High, A.A.; Kitagawa, R.
HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans
Development
140
2149-2159
2013
Caenorhabditis elegans
Krsmanovic, T.; Koelling, R.
The HECT E3 ubiquitin ligase Rsp5 is important for ubiquitin homeostasis in yeast
FEBS Lett.
577
215-219
2004
Saccharomyces cerevisiae (P39940), Saccharomyces cerevisiae
Nie, J.; Liu, L.; Wu, M.; Xing, G.; He, S.; Yin, Y.; Tian, C.; He, F.; Zhang, L.
HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation
FEBS Lett.
584
3005-3012
2010
Homo sapiens (Q9HCE7)
Angers, A.; Ramjaun, A.R.; McPherson, P.S.
The HECT domain ligase Itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system
J. Biol. Chem.
279
11471-11479
2004
Homo sapiens (Q96J02)
Park, Y.; Yoon, S.K.; Yoon, J.B.
The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway
J. Biol. Chem.
284
1540-1549
2009
Homo sapiens (Q14669), Homo sapiens
Edwin, F.; Anderson, K.; Patel, T.B.
HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2
J. Biol. Chem.
285
255-264
2010
Homo sapiens (P46934)
Tran, H.; Bustos, D.; Yeh, R.; Rubinfeld, B.; Lam, C.; Shriver, S.; Zilberleyb, I.; Lee, M.W.; Phu, L.; Sarkar, A.A.; Zohn, I.E.; Wertz, I.E.; Kirkpatrick, D.S.; Polakis, P.
HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction
J. Biol. Chem.
288
3753-3767
2013
Homo sapiens
Ding, Y.; Zhang, Y.; Xu, C.; Tao, Q.H.; Chen, Y.G.
HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation
J. Biol. Chem.
288
8289-8298
2013
Homo sapiens (Q96PU5)
Osmundson, E.C.; Ray, D.; Moore, F.E.; Gao, Q.; Thomsen, G.H.; Kiyokawa, H.
The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint
J. Cell Biol.
183
267-277
2008
Homo sapiens
Verdecia, M.A.; Joazeiro, C.A.; Wells, N.J.; Ferrer, J.L.; Bowman, M.E.; Hunter, T.; Noel, J.P.
Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase
Mol. Cell
11
249-259
2003
Homo sapiens (Q9H0M0)
Downes, B.P.; Stupar, R.M.; Gingerich, D.J.; Vierstra, R.D.
The HECT ubiquitin-protein ligase (UPL) family in Arabidopsis: UPL3 has a specific role in trichome development
Plant J.
35
729-742
2003
Arabidopsis thaliana (Q6WWW4)
Aerne, B.L.; Gailite, I.; Sims, D.; Tapon, N.
Hippo stabilises its adaptor Salvador by antagonising the HECT ubiquitin ligase Herc4
PLoS ONE
10
e0131113
2015
Drosophila melanogaster, Drosophila melanogaster S2
ZeRuth, G.T.; Williams, J.G.; Cole, Y.C.; Jetten, A.M.
HECT E3 ubiquitin ligase Itch functions as a novel negative regulator of Gli-Similar 3 (Glis3) transcriptional activity
PLoS ONE
10
e0131303
2015
Rattus norvegicus
Jiang, J.; Zheng, J.; She, Y.; Jia, Z.
Expression and purification of human WWP2 HECT domain in Escherichia coli
Protein Expr. Purif.
110
95-101
2015
Homo sapiens (O00308)
Rodriguez, M.S.; Gwizdek, C.; Haguenauer-Tsapis, R.; Dargemont, C.
The HECT ubiquitin ligase Rsp5p is required for proper nuclear export of mRNA in Saccharomyces cerevisiae
Traffic
4
566-575
2003
Saccharomyces cerevisiae
Gong, W.; Zhang, X.; Zhang, W.; Li, J.; Li, Z.
Structure of the HECT domain of human WWP2
Acta Crystallogr. Sect. F
71
1251-1257
2015
Homo sapiens (O00308), Homo sapiens
Otaki, Y.; Takahashi, H.; Watanabe, T.; Funayama, A.; Netsu, S.; Honda, Y.; Narumi, T.; Kadowaki, S.; Hasegawa, H.; Honda, S.; Arimoto, T.; Shishido, T.; Miyamoto, T.; Kamata, H.; Nakajima, O.; Kubota, I.
HECT-type ubiquitin E3 ligase ITCH interacts with thioredoxin-interacting protein and ameliorates reactive oxygen species-induced cardiotoxicity
J. Am. Heart Assoc.
5
e002485
2016
Mus musculus, Rattus norvegicus
An, C.I.; Ganio, E.; Hagiwara, N.
Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells
Skeletal Muscle
3
11
2013
Mus musculus, Homo sapiens (Q14669)
Dong, S.; Liu, J.; Li, L.; Wang, H.; Ma, H.; Zhao, Y.; Zhao, J.
The HECT ubiquitin E3 ligase Smurf2 degrades my-opioid receptor 1 in the ubiquitin-proteasome system in lung epithelial cells
Am. J. Physiol. Cell Physiol.
316
C632-C640
2019
Mus musculus (A2A5Z6)
Singh, S.; Sivaraman, J.
Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity
Biochem. J.
477
905-923
2020
Homo sapiens (Q15386)
Xu, Y.; Anderson, D.; Ye, Y.
The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation
Cell Discov.
2
16040
2016
Homo sapiens (Q7Z6Z7)
Byrne, R.; Mund, T.; Licchesi, J.
Activity-based probes for HECT E3 ubiquitin ligases
ChemBioChem
18
1415-1427
2017
Chlorocebus aethiops, Homo sapiens (Q15386)
Liu, Y.; HuangFu, W.; Huang, H.; Wu, W.; Chen, Y.; Yen, Y.; Huang, H.; Nien, C.; Lai, M.; Pan, S.; Liou, J.
1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma
Eur. J. Med. Chem.
140
84-91
2017
Homo sapiens (Q96J02)
Nakatsukasa, K.; Sone, M.; Alemayehu, D.; Okumura, F.; Kamura, T.
The HECT-type ubiquitin ligase Tom1 contributes to the turnover of Spo12, a component of the FEAR network, in G2/M phase
FEBS Lett.
592
1716-1724
2018
Saccharomyces cerevisiae (Q03280)
Safdar, K.; Gu, A.; Xu, X.; Au, A.; Taylor, J.; Flibotte, S.; Moerman, D.G.; Maine, E.M.
UBR-5, a conserved HECT-type E3 ubiquitin ligase, negatively regulates notch-type signaling in Caenorhabditis elegans
G3 (Bethesda)
6
2125-2134
2016
Caenorhabditis elegans (G5EDT9), Caenorhabditis elegans
Zhu, B.; Das, S.; Mitra, S.; Farris, T.; McBride, J.
Ehrlichia chaffeensis TRP120 moonlights as a HECT E3 ligase involved in selfand host ubiquitination to influence protein interactions and stability for intracellular survival
Infect. Immun.
85
e00290
2017
Ehrlichia chaffeensis, Homo sapiens (Q96PU5)
Braganza, A.; Li, J.; Zeng, X.; Yates, N.; Dey, N.; Andrews, J.; Clark, J.; Zamani, L.; Wang, X.; St Croix, C.; OSullivan, R.; Garcia-Exposito, L.; Brodsky, J.; Sobol, R.
UBE3B is a calmodulin-regulated, mitochondrion-associated E3 ubiquitin ligase
J. Biol. Chem.
292
2470-2484
2017
Homo sapiens (Q7Z3V4), Homo sapiens
Todaro, D.R.; Augustus-Wallace, A.C.; Klein, J.M.; Haas, A.L.
Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly
J. Biol. Chem.
293
18192-18206
2018
Homo sapiens
Mund, T.; Pelham, H.
Substrate clustering potently regulates the activity of WW-HECT domain-containing ubiquitin ligases
J. Biol. Chem.
293
5200-5209
2018
Homo sapiens (O00308)
Singh, S.; Ng, J.; Nayak, D.; Sivaraman, J.
Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activities in vitro
J. Biol. Chem.
294
19934-19949
2019
Homo sapiens (O15033)
Lin, Q.; Dai, Q.; Meng, H.; Sun, A.; Wei, J.; Peng, K.; Childress, C.; Chen, M.; Shao, G.; Yang, W.
The HECT E3 ubiquitin ligase NEDD4interacts with and ubiquitylates SQSTM1 for inclusion body autophagy
J. Cell Sci.
130
3839-3850
2017
Homo sapiens (P46934)
Pergolizzi, B.; Bracco, E.; Bozzaro, S.
A new HECT ubiquitin ligase regulating chemotaxis and development in Dictyostelium discoideum
J. Cell Sci.
130
551-562
2017
Dictyostelium discoideum (Q54L33)
Jaeckl, M.; Stollmaier, C.; Strohaeker, T.; Hyz, K.; Maspero, E.; Polo, S.; Wiesner, S.
beta-Sheet augmentation is a conserved mechanism of priming HECT E3 ligases for ubiquitiniquitin ligation
J. Mol. Biol.
430
3218-3233
2018
Homo sapiens (Q7Z6Z7), Homo sapiens (Q9HAU4)
Zhang, W.; Wu, K.; Sartori, M.; Kamadurai, H.; Ordureau, A.; Jiang, C.; Mercredi, P.; Murchie, R.; Hu, J.; Persaud, A.; Mukherjee, M.; Li, N.; Doye, A.; Walker, J.; Sheng, Y.; Hao, Z.; Li, Y.; Brown, K.; Lemichez, E.; Chen, J.; Tong, Y.; Harper, J.; Moffat, J.
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes
Mol. Cell.
62
121-136
2016
Homo sapiens
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