Reference on EC 2.3.3.5 - 2-methylcitrate synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Uchiyama, H.; Ando, M.; Toyonaka, Y.; Tabuchi, T.
Subcellular localization of the methylcitric-acid-cycle enzymes in propionate metabolism of Yarrowia lipolytica
Eur. J. Biochem.
125
523-527
1982
Yarrowia lipolytica
Miyakoshi, S.; Uchiyama, H.; Someya, T.; Satoh, T.; Tabuchi, T.
Distribution of the methylcitric acid cycle and beta-oxidation pathway for propionate catabolism in fungi
Agric. Biol. Chem.
51
2381-2387
1987
Aspergillus niger, Saccharomyces cerevisiae, Diutina catenulata, Cutaneotrichosporon curvatum, Debaryomyces hansenii, Starmerella gropengiesseri, Vanrija humicola, Kluyveromyces marxianus, Yarrowia lipolytica, Starmerella magnoliae, Wickerhamiella pararugosa, Wickerhamomyces anomalus, Metschnikowia pulcherrima, Citeromyces matritensis, Cryptococcus neoformans, Schwanniomyces polymorphus, Saccharomycopsis fibuligera, Ogataea angusta, Cyberlindnera saturnus, Lipomyces starkeyi, Mucor rouxianus, Neurospora crassa, no activity in Candida rugosa, Priceomyces haplophilus, Pseudomonas aeruginosa, Rhizopus microsporus var. chinensis, Torulaspora delbrueckii, Ustilago crus-galli, Ustilago utriculosa, Rhizopus microsporus var. chinensis IAM 6003, Saccharomyces cerevisiae SANK 50182, Ustilago utriculosa F-B-5, Cyberlindnera saturnus IAM 4094, Ustilago crus-galli F-B-6
-
Karlsson, E.N.; Abou-Hachem, M.; Holst, O.; Danson, M.J.; Hough, D.W.
Rhodothermus marinus: a thermophilic bacterium producing dimeric and hexameric citrate synthase isoenzymes
Extremophiles
6
51-56
2002
Escherichia coli, Pseudomonas aeruginosa, Rhodothermus marinus
Brock, M.; Fischer, R.; Linder, D.; Buckel, W.
Methylcitrate synthase from Aspergillus nidulans: implications for propionate as an antifungal agent
Mol. Microbiol.
35
961-973
2000
Aspergillus nidulans
Tabuchi, T.; Uchiyama, H.
Methylcitrate condensing and methylisocitrate cleaving enzymes; evidence for the pathway of oxidation of propionyl-CoA to pyruvate via C7-tricarboxylic acids
Agric. Biol. Chem.
39
2035-2042
1975
Yarrowia lipolytica
-
Uchiyama, H.; Tabuchi, T.
Properties of methylcitrate synthase from Candida lipolytica
Agric. Biol. Chem.
40
1411-1418
1976
Yarrowia lipolytica, Escherichia coli
-
Watson, D.; Lindel, D.L.; Fall, R.
Pseudomonas aeruginosa contains an inducible methylcitrate synthase
Curr. Microbiol.
8
17-21
1983
Yarrowia lipolytica, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas citronellolis, Pseudomonas aeruginosa PAO
-
Pronk, J.T.; van der Linden-Beuman, A.; Verduyn, C.; Scheffers, W.A.; van Dijken, J.P.
Propionate metabolism in Saccharomyces cerevisiae: implications for the metabolon hypothesis
Microbiology
140
717-722
1994
Saccharomyces cerevisiae, Yarrowia lipolytica, Saccharomyces cerevisiae CBS 8066
-
Textor, S.; Wendisch, V.F.; De Graaf, A.A.; Mueller, U.; Linder, M.I.; Linder, D.; Buckel, W.
Propionate oxidation in Escherichia coli: evidence for operation of a methylcitrate cycle in bacteria
Arch. Microbiol.
168
428-436
1997
Saccharomyces cerevisiae, Yarrowia lipolytica, Escherichia coli, Escherichia coli (P31660), Salmonella enterica, Salmonella enterica (Q56063)
Gerike, U.; Hough, D.W.; Russell, N.J.; Dyall-Smith, M.L.; Danson, M.J.
Citrate synthase and 2-methylcitrate synthase: structural, functional and evolutionary relationships
Microbiology
144
929-935
1998
Arthrobacter sp., Escherichia coli, Escherichia coli JM109, no activity in Sus scrofa, Pyrococcus furiosus, Saccharomyces cerevisiae, Salmonella enterica, Thermoplasma acidophilum, Yarrowia lipolytica
-
Braemer, C.O.; Steinbuechel, A.
The methylcitric acid pathway in Ralstonia eutropha: new genes identified involved in propionate metabolism
Microbiology
147
2203-2214
2001
Aspergillus nidulans, Cupriavidus metallidurans, Escherichia coli, Neisseria meningitidis, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas putida KT 2240, Salmonella enterica, Vibrio cholerae serotype O1
Braemer, C.O.; Silva, L.F.; Gomez, J.G.C.; Priefert, H.; Steinbuechel, A.
Identification of the 2-methylcitrate pathway involved in the catabolism of propionate in the polyhydroxyalkanoate-producing strain Burkholderia sacchari IPT101T and analysis of a mutant accumulating a copolyester with higher 3-hydroxyvalerate content
Appl. Environ. Microbiol.
68
271-279
2002
Aspergillus nidulans, Burkholderia cepacia, Paraburkholderia sacchari, Escherichia coli, Escherichia coli (Q8X694), Salmonella enterica, Salmonella enterica (Q56063), Neisseria meningitidis, Pseudomonas aeruginosa, Pseudomonas aeruginosa (Q9I5E3), Pseudomonas putida, Pseudomonas fluorescens, Shewanella putrefaciens, Pseudomonas syringae, Pyrococcus furiosus, Cupriavidus metallidurans, Cupriavidus metallidurans (Q937N9), Vibrio cholerae serotype O1, Vibrio cholerae (Q9KSC1), Legionella pneumophila (Q9XBT3), Pseudomonas putida contig10768, Paraburkholderia sacchari IPT101, Pseudomonas syringae contig5376, Shewanella putrefaciens contig93, Pseudomonas putida KT 2240, Burkholderia cepacia contig261, Pseudomonas fluorescens contig267, Escherichia coli O157:H17, Escherichia coli O157:H17 (Q8X694)
Brock, M.; Maerker, C.; Schuetz, A.; Voelker, U.; Buckel, W.
Oxidation of propionate to pyruvate in Escherichia coli: Involvement of methylcitrate dehydratase and aconitase
Eur. J. Biochem.
269
6184-6194
2002
Yarrowia lipolytica, Escherichia coli, Escherichia coli (P31660), Salmonella enterica, Cupriavidus metallidurans
Claes, W.A.; Puehler, A.; Kalinowski, J.
Identification of two prpDBC gene clusters in Corynebacterium glutamicum and their involvement in propionate degradation via the 2-methylcitrate cycle
J. Bacteriol.
184
2728-2739
2002
Aspergillus nidulans, Corynebacterium glutamicum, Corynebacterium glutamicum (Q8NSH7), Corynebacterium glutamicum (Q8NSL1), Paraburkholderia sacchari, Yarrowia lipolytica, Escherichia coli, Escherichia coli (P31660), Pseudomonas aeruginosa, Cupriavidus metallidurans, Cupriavidus metallidurans (Q937N9), Salmonella enterica (Q56063), Salmonella enterica
Maerker, C.; Rohde, M.; Brakhage, A.A.; Brock, M.
Methylcitrate synthase from Aspergillus fumigatus. Propionyl-CoA affects polyketide synthesis, growth and morphology of conidia
FEBS J.
272
3615-3630
2005
Aspergillus fumigatus (Q50I20), Aspergillus fumigatus
Ewering, C.; Braemer, C.O.; Bruland, N.; Bethke, A.; Steinbuechel, A.
Occurrence and expression of tricarboxylate synthases in Ralstonia eutropha
Appl. Microbiol. Biotechnol.
71
80-89
2006
Cupriavidus necator (Q2Z1A8), Cupriavidus necator, Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 (Q2Z1A8)
Ewering, C.; Heuser, F.; Benoelken, J.K.; Braemer, C.O.; Steinbuechel, A.
Metabolic engineering of strains of Ralstonia eutropha and Pseudomonas putida for biotechnological production of 2-methylcitric acid
Metab. Eng.
8
587-602
2006
Cupriavidus necator, Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
Ibrahim-Granet, O.; Dubourdeau, M.; Latgé, J.; Ave, P.; Huerre, M.; Brakhage, A.; Brock, M.
Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis
Cell. Microbiol.
10
134-148
2008
Aspergillus fumigatus
Rocco, C.J.; Escalante-Semerena, J.C.
In Salmonella enterica, 2-methylcitrate blocks gluconeogenesis
J. Bacteriol.
192
771-778
2010
Salmonella enterica, Salmonella enterica JE2170
Domin, N.; Wilson, D.; Brock, M.
Methylcitrate cycle activation during adaptation of Fusarium solani and Fusarium verticillioides to propionyl-CoA-generating carbon sources
Microbiology
155
3903-3912
2009
Fusarium verticillioides, Fusarium solani
Fleck, C.B.; Brock, M.
Characterization of an acyl-CoA: carboxylate CoA-transferase from Aspergillus nidulans involved in propionyl-CoA detoxification
Mol. Microbiol.
68
642-656
2008
Aspergillus nidulans
Chittori, S.; Savithri, H.S.; Murthy, M.R.
Crystal structure of Salmonella typhimurium 2-methylcitrate synthase: Insights on domain movement and substrate specificity
J. Struct. Biol.
174
58-68
2011
Salmonella enterica subsp. enterica serovar Typhimurium (Q56063), Salmonella enterica subsp. enterica serovar Typhimurium
Eniyan, K.; Bajpai, U.
Cloning, expression, purification and bioinformatic analysis of 2-methylcitrate synthase from Mycobacterium tuberculosis
Asian Pac. J. Trop. Med.
8
19-23
2015
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Kobayashi, K.; Hattori, T.; Honda, Y.; Kirimura, K.
Gene identification and functional analysis of methylcitrate synthase in citric acid-producing Aspergillus niger WU-2223L
Biosci. Biotechnol. Biochem.
77
1492-1498
2013
Aspergillus niger, Aspergillus niger WU-2223L
Reddick, J.J.; Sirkisoon, S.; Dahal, R.A.; Hardesty, G.; Hage, N.E.; Booth, W.T.; Quattlebaum, A.L.; Mills, S.N.; Meadows, V.G.; Adams, S.L.H.; Doyle, J.S.; Kiel, B.E.
First biochemical characterization of a methylcitric acid cycle from Bacillus subtilis strain 168
Biochemistry
56
5698-5711
2017
Bacillus subtilis (P45858), Bacillus subtilis 168 (P45858)
Digianantonio, K.M.; Korolev, M.; Hecht, M.H.
A non-natural protein rescues cells deleted for a key enzyme in central metabolism
ACS Synth. Biol.
6
694-700
2017
Escherichia coli (P31660), Escherichia coli
Schlachter, C.R.; Klapper, V.; Radford, T.; Chruszcz, M.
Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase
Biol. Chem.
400
1567-1581
2019
Aspergillus fumigatus (Q50I20), Aspergillus fumigatus
Liu, W.B.; Liu, X.X.; Shen, M.J.; She, G.L.; Ye, B.C.
The nitrogen regulator GlnR directly controls transcription of the prpDBC operon involved in methylcitrate cycle in Mycobacterium smegmatis
J. Bacteriol.
201
e00099-19
2019
Mycolicibacterium smegmatis
Zhang, Y.; Zhou, X.; Wang, X.; Wang, L.; Xia, M.; Luo, J.; Shen, Y.; Wang, M.
Improving phytosterol biotransformation at low nitrogen levels by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum
Microb. Cell Fact.
19
13
2020
Mycolicibacterium neoaurum
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