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Disease on EC 2.3.3.8 - ATP citrate synthase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Adenosine triphosphate citrate lyase mediates hypocitraturia in rats.
Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia.
Adenocarcinoma
ATP citrate lyase expression is associated with advanced stage and prognosis in gastric adenocarcinoma.
Alzheimer Disease
Coenzyme A-acetylating enzymes in Alzheimer's disease: possible cholinergic 'compartment' of pyruvate dehydrogenase.
Ataxia Telangiectasia
Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.
Atherosclerosis
ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: An updated review.
Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.
New Era of Lipid-Lowering Drugs.
Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr(-/-) Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid.
Targeting angiopoietin-like 3 in atherosclerosis: From bench to bedside.
atp citrate synthase deficiency
ATP-citrate lyase deficiency in the mouse.
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques.
Brain Diseases
[NADP malate dehydrogenase, acetyl-CoA synthetase and ATP citrate lyase in experimental cyanide encephalopathy]
Breast Neoplasms
ATP citrate lyase is increased in human breast cancer, depletion of which promotes apoptosis.
Cyclin E associates with the lipogenic enzyme ATP-citrate lyase to enable malignant growth of breast cancer cells.
Hydroxycitric acid potentiates the cytotoxic effect of tamoxifen in MCF-7 breast cancer cells through inhibition of ATP citrate lyase.
Lipogenetic and glycolytic enzyme activities in carcinoma and nonmalignant diseases of the human breast.
MiR-22 down-regulates the proto-oncogene ATP citrate lyase to inhibit the growth and metastasis of breast cancer.
mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer.
Carcinogenesis
A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results.
Activation of ATP citrate lyase by mTOR signal induces disturbed lipid metabolism in hepatitis B virus pre-S2 mutant tumorigenesis.
Carcinoma
Overexpression of ATP citrate lyase in renal cell carcinoma tissues and its effect on the human renal carcinoma cells in vitro.
Carcinoma, Hepatocellular
ATP citrate lyase inhibitor triggers endoplasmic reticulum stress to induce hepatocellular carcinoma cell apoptosis via p-eIF2?/ATF4/CHOP axis.
ATP-citrate lyase regulates stemness and metastasis in hepatocellular carcinoma via the Wnt/?-catenin signaling pathway.
GTP, a nonsubstrate of ATP citrate lyase, is a phosphodonor for the enzyme histidine autophosphorylation.
Carcinoma, Non-Small-Cell Lung
ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.
Prognostic impact of the combination of glucose transporter 1 and ATP citrate lyase in node-negative patients with non-small lung cancer.
Prognostic Value of Malic Enzyme and ATP-Citrate Lyase in Non-Small Cell Lung Cancer of the Young and the Elderly.
Spermidine reduces cancer-related mortality in humans.
Carcinoma, Ovarian Epithelial
Prognostic and therapeutic implications of increased ATP citrate lyase expression in human epithelial ovarian cancer.
Carcinoma, Renal Cell
Overexpression of ATP citrate lyase in renal cell carcinoma tissues and its effect on the human renal carcinoma cells in vitro.
Ubiquitination of PPAR-gamma by pVHL inhibits ACLY expression and lipid metabolism, is implicated in tumor progression.
Cardiovascular Diseases
Bempedoic acid for high-risk patients with CVD as adjunct lipid-lowering therapy: A cost-effectiveness analysis.
Mendelian Randomization Study of ACLY and Cardiovascular Disease.
Colonic Neoplasms
ACLY facilitates colon cancer cell metastasis by CTNNB1.
Biological Behavior and Lipid Metabolism of Colon Cancer Cells are Regulated by a Combination of Sterol Regulatory Element-Binding Protein 1 and ATP Citrate Lyase.
Colorectal Neoplasms
ATP citrate lyase mediates resistance of colorectal cancer cells to SN38.
Biological Behavior and Lipid Metabolism of Colon Cancer Cells are Regulated by a Combination of Sterol Regulatory Element-Binding Protein 1 and ATP Citrate Lyase.
Functional polymorphisms of ATP citrate lyase gene predicts clinical outcome of patients with advanced colorectal cancer.
Diabetes Mellitus
The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus.
Diabetes Mellitus, Type 2
Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells.
Dyslipidemias
Adenosine triphosphate citrate lyase: Emerging target in the treatment of dyslipidemia.
ATP-citrate lyase: genetics, molecular biology and therapeutic target for dyslipidemia.
Fatty Liver
Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.
Some lipogenic enzyme activities in rat livers in which an excessive fat accumulation occurred due to feeding low-level amino acid mixture diets.
Glioblastoma
Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+-NFAT signaling.
Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas.
Glioma
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation.
Hepatitis B
Activation of ATP citrate lyase by mTOR signal induces disturbed lipid metabolism in hepatitis B virus pre-S2 mutant tumorigenesis.
Hypercholesterolemia
Bempedoic acid, an inhibitor of ATP citrate lyase for the treatment of hypercholesterolemia: early indications and potential.
Lipid lowering with bempedoic acid added to a proprotein convertase subtilisin/kexin type 9 inhibitor therapy: A randomized, controlled trial.
Measurement of bempedoic acid and its keto metabolite in human plasma and urine using solid phase extraction and electrospray LC-MS/MS.
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis.
Hyperglycemia
Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.
Effects of high sucrose diet on insulin-like effects of vanadate in diabetic rats.
Hyperinsulinism
Chronic hyperinsulinemia in the fetal rhesus monkey: effects of physiologic hyperinsulinemia on fetal substrates, hormones, and hepatic enzymes.
Chronic hyperinsulinemia in the fetal rhesus monkey: effects on hepatic enzymes active in lipogenesis and carbohydrate metabolism.
Hyperlipidemias
Docking study of novel antihyperlipidemic thieno[2,3-d]pyrimidine; LM-1554, with some molecular targets related to hyperlipidemia - an investigation into its mechanism of action.
Forrestiacids?A and?B, Pentaterpene Inhibitors of ACL and Lipogenesis: Extending the Limits of Computational NMR Methods in the Structure Assignment of Complex Natural Products.
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis.
Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders.
Hypokalemia
Adenosine triphosphate citrate lyase mediates hypocitraturia in rats.
Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia.
Hypothyroidism
A tissue-specific increase in lipogenesis in rat brown adipose tissue in hypothyroidism.
Insulin Resistance
Changes in lipid synthesis in rat adipose tissue during development.
Pyruvate dehydrogenase and ATP citrate (pro-3S)-lyase activities in adipose tissue and liver of the young lean and the older obese rat.
Insulinoma
Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells.
Leukemia
Enzyme activities of NADPH-forming metabolic pathways in normal and leukemic leukocytes.
Leukemia, Myeloid, Acute
Enzyme activities of NADPH-forming metabolic pathways in normal and leukemic leukocytes.
Liver Diseases
ATP Citrate Lyase and LncRNA NONMMUT010685 Play Crucial Role in Nonalcoholic Fatty Liver Disease Based on Analysis of Microarray Data.
Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease.
In Steatotic Cells, ATP-Citrate Lyase mRNA Is Efficiently Translated through a Cap-Independent Mechanism, Contributing to the Stimulation of De Novo Lipogenesis.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Diseases, Alcoholic
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Neoplasms
Aberrant lipid metabolism as a therapeutic target in liver cancer.
Lung Neoplasms
ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-actiated protein kinase (MAPK) and phosphatidylinositol-3- kinase (PI3K)/AKT pathways.
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Prognostic impact of the combination of glucose transporter 1 and ATP citrate lyase in node-negative patients with non-small lung cancer.
Prognostic Value of Malic Enzyme and ATP-Citrate Lyase in Non-Small Cell Lung Cancer of the Young and the Elderly.
Spermidine reduces cancer-related mortality in humans.
Melanoma
ATP-citrate lyase epigenetically potentiates oxidative phosphorylation to promote melanoma growth and adaptive resistance to MAPK inhibition.
Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea.
Identification of potential diagnostic and prognostic biomarkers for prostate cancer.
Myocardial Infarction
Weighted gene co?expression network analysis in identification of key genes and networks for ischemic?reperfusion remodeling myocardium.
Nasopharyngeal Carcinoma
ER resident protein 44 promotes malignant phenotype in nasopharyngeal carcinoma through the interaction with ATP citrate lyase.
Neoplasm Metastasis
ATP-citrate lyase regulates stemness and metastasis in hepatocellular carcinoma via the Wnt/?-catenin signaling pathway.
Clinical-translational approaches to the Nm23-H1 metastasis suppressor.
IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R.
MiR-22 down-regulates the proto-oncogene ATP citrate lyase to inhibit the growth and metastasis of breast cancer.
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Neoplasms
A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results.
Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis.
Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth.
ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via ?-ketoglutarate.
ACLY is the novel signaling target of PIP2/PIP3 and Lyn in acute myeloid leukemia.
Adding a combination of hydroxycitrate and lipoic acid (METABLOC™) to chemotherapy improves effectiveness against tumor development: experimental results and case report.
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation.
ATP Citrate Lyase (ACLY): A Promising Target for Cancer Prevention and Treatment.
ATP citrate lyase inhibition can suppress tumor cell growth.
ATP citrate lyase inhibitor triggers endoplasmic reticulum stress to induce hepatocellular carcinoma cell apoptosis via p-eIF2?/ATF4/CHOP axis.
ATP Citrate Lyase Inhibitors as Novel Cancer Therapeutic Agents.
ATP citrate lyase is increased in human breast cancer, depletion of which promotes apoptosis.
ATP citrate lyase knockdown impacts cancer stem cells in vitro.
ATP citrate lyase: A central metabolic enzyme in cancer.
ATP-citrate lyase epigenetically potentiates oxidative phosphorylation to promote melanoma growth and adaptive resistance to MAPK inhibition.
ATP-citrate lyase regulates stemness and metastasis in hepatocellular carcinoma via the Wnt/?-catenin signaling pathway.
ATP-Citrate Lyase: A Key Player in Cancer Metabolism.
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.
Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression.
Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells.
Decreased Warburg effect induced by ATP citrate lyase suppression inhibits tumor growth in pancreatic cancer.
Differentiation of human tumors from nonmalignant tissue by natural-abundance 13C NMR spectroscopy.
Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells.
Functional polymorphisms of ATP citrate lyase gene predicts clinical outcome of patients with advanced colorectal cancer.
Human adipocyte differentiation and composition of disease-relevant lipids are regulated by miR-221-3p.
Hydroxycitrate causes altered pyruvate metabolism by tumorigenic cells.
Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth.
Increased lipogenesis in cancer cells: new players, novel targets.
Inhibition of ATP Citrate Lyase Induces an Anticancer Effect via Reactive Oxygen Species: AMPK as a Predictive Biomarker for Therapeutic Impact.
Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells.
Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer.
Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4.
Leelamine is a Novel Lipogenesis Inhibitor in Prostate Cancer Cells In Vitro and In Vivo.
Liver fat content and lipid metabolism in dairy cows during early lactation and during a mid-lactation feed restriction.
Mendelian Randomization Study of ACLY and Cardiovascular Disease.
miR-133b acts as a tumor suppressor and negatively regulates ATP citrate lyase via PPAR? in gastric cancer.
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Myeloid-Specific Acly Deletion Alters Macrophage Phenotype In Vitro and In Vivo without Affecting Tumor Growth.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Pharmacological induction of mesenchymal-epithelial transition via inhibition of H2S biosynthesis and consequent suppression of ACLY activity in colon cancer cells.
Polyamine regulating protein antizyme binds to ATP citrate lyase to accelerate acetyl-CoA production in cancer cells.
Prognostic and therapeutic implications of increased ATP citrate lyase expression in human epithelial ovarian cancer.
Prognostic Value of Malic Enzyme and ATP-Citrate Lyase in Non-Small Cell Lung Cancer of the Young and the Elderly.
Resveratrol prevents hepatic steatosis and endoplasmic reticulum stress and regulates the expression of genes involved in lipid metabolism, insulin resistance, and inflammation in rats.
Retraction note to: decreased Warburg effect induced by ATP citrate lyase suppression inhibits tumor growth in pancreatic cancer.
Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer.
Systematic integration of molecular profiles identifies miR-22 as a regulator of lipid and folate metabolism in breast cancer cells.
Targeting ACLY Attenuates Tumor Growth and Acquired Cisplatin Resistance in Ovarian Cancer by Inhibiting the PI3K-AKT Pathway and Activating the AMPK-ROS Pathway.
Targeting Mitochondrial Citrate Transport in Breast Cancer Cell Lines.
The metabolic advantage of tumor cells.
The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis.
Weighted gene co?expression network analysis in identification of key genes and networks for ischemic?reperfusion remodeling myocardium.
Neuroblastoma
The enzymes of acetyl-CoA metabolism in differentiating cholinergic (s-20) and noncholinergic (NIE-115) neuroblastoma cells.
Non-alcoholic Fatty Liver Disease
ATP Citrate Lyase and LncRNA NONMMUT010685 Play Crucial Role in Nonalcoholic Fatty Liver Disease Based on Analysis of Microarray Data.
Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Obesity
Changes in hepatic lipogenic enzyme activities in voles and mice treated with monosodium aspartate.
Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial.
The impact of hydroxycitric acid on the lipid metabolism profile under experimental insulin resistance syndrome of Syrian hamsters.
Osteosarcoma
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Ovarian Neoplasms
Regulation of protein metabolism in cancer.
Targeting ACLY Attenuates Tumor Growth and Acquired Cisplatin Resistance in Ovarian Cancer by Inhibiting the PI3K-AKT Pathway and Activating the AMPK-ROS Pathway.
Overweight
ATP-citrate lyase is an epigenetic regulator to promote obesity-related kidney injury.
Lipogenic gene expression in abdominal adipose and liver tissues of diet-induced overweight cats.
Pancreatic Neoplasms
Decreased Warburg effect induced by ATP citrate lyase suppression inhibits tumor growth in pancreatic cancer.
Retraction note to: decreased Warburg effect induced by ATP citrate lyase suppression inhibits tumor growth in pancreatic cancer.
Prostatic Neoplasms
Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling.
Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth.
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism.
Retraction: Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling.
Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.
Sepsis
Serum proteome-wide identified ATP citrate lyase as a novel informative diagnostic and prognostic biomarker in pediatric sepsis: A pilot study.
Starvation
Age-dependent hepatic lipogenic enzyme activities in starved-refed rats.
Engineering cytoplasmic acetyl-CoA synthesis decouples lipid production from nitrogen starvation in the oleaginous yeast Rhodosporidium azoricum.
Stomach Neoplasms
miR-133b acts as a tumor suppressor and negatively regulates ATP citrate lyase via PPAR? in gastric cancer.
Uterine Cervical Neoplasms
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Vitamin B 6 Deficiency
Effects of vitamin B6 deficiency on liver, kidney, and adipose tissue enzymes associated with carbohydrate and lipid metabolism, and on glucose uptake by rat epididymal adipose tissue.