Reference on EC 2.4.1.174 - glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rohrmann, K.; Niemann, R.; Buddecke, E.
Two N-acetylgalactosaminyltransferases are involved in the biosynthesis of chondroitin sulfate
Eur. J. Biochem.
148
463-469
1985
Bos taurus
Gotoh, M.; Sato, T.; Akashima, T.; Iwasaki, H.; Kameyama, A.; Mochizuki, H.; Yada, T.; Inaba, N.; Zhang, Y.; Kikuchi, N.; Kwon, Y.D.; Togayachi, A.; Kudo, T.; Nishihara, S.; Watanabe, H.; Kimata, K.; Narimatsu, H.
Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis
J. Biol. Chem.
277
38189-38196
2002
Homo sapiens (Q8TDX6)
Uyama, T.; Kitagawa, H.; Tamura, J.I.; Sugahara, K.
Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase. The key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate
J. Biol. Chem.
277
8841-8846
2002
Homo sapiens (Q8TDX6)
Uyama, T.; Kitagawa, H.; Tanaka, J.; Tamura, J.i.; Ogawa, T.; Sugahara, K.
Molecular cloning and expression of a second chondroitin N-acetylgalactosaminyltransferase involved in the initiation and elongation of chondroitin/dermatan sulfate
J. Biol. Chem.
278
3072-3078
2003
Homo sapiens (Q8N6G5), Homo sapiens (Q8TDX6)
Sakai, K.; Kimata, K.; Sato, T.; Gotoh, M.; Narimatsu, H.; Shinomiya, K.; Watanabe, H.
Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage
J. Biol. Chem.
282
4152-4161
2007
Homo sapiens, Mus musculus
Watanabe, Y.; Takeuchi, K.; Higa Onaga, S.; Sato, M.; Tsujita, M.; Abe, M.; Natsume, R.; Li, M.; Furuichi, T.; Saeki, M.; Izumikawa, T.; Hasegawa, A.; Yokoyama, M.; Ikegawa, S.; Sakimura, K.; Amizuka, N.; Kitagawa, H.; Igarashi, M.
Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development
Biochem. J.
432
47-55
2010
Mus musculus, Mus musculus C57BL/6N
Izumikawa, T.; Koike, T.; Kitagawa, H.
Chondroitin 4-O-sulfotransferase-2 regulates the number of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1
Biochem. J.
441
697-705
2012
Mus musculus
Wilson, D.G.; Phamluong, K.; Lin, W.Y.; Barck, K.; Carano, R.A.; Diehl, L.; Peterson, A.S.; Martin, F.; Solloway, M.J.
Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning
Dev. Biol.
363
413-425
2012
Mus musculus
Gulberti, S.; Jacquinet, J.C.; Chabel, M.; Ramalanjaona, N.; Magdalou, J.; Netter, P.; Coughtrie, M.W.; Ouzzine, M.; Fournel-Gigleux, S.
Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) involved in chondroitin sulfate initiation: impact of sulfation on activity and specificity
Glycobiology
22
561-571
2012
Homo sapiens
Sato, T.; Kudo, T.; Ikehara, Y.; Ogawa, H.; Hirano, T.; Kiyohara, K.; Hagiwara, K.; Togayachi, A.; Ema, M.; Takahashi, S.; Kimata, K.; Watanabe, H.; Narimatsu, H.
Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism
J. Biol. Chem.
286
5803-5812
2011
Mus musculus, Mus musculus C57/BL6J
Saigoh, K.; Izumikawa, T.; Koike, T.; Shimizu, J.; Kitagawa, H.; Kusunoki, S.
Chondroitin beta-1,4-N-acetylgalactosaminyltransferase-1 missense mutations are associated with neuropathies
J. Hum. Genet.
56
143-146
2011
Homo sapiens (Q8TDX6), Homo sapiens
Ogawa, H.; Hatano, S.; Sugiura, N.; Nagai, N.; Sato, T.; Shimizu, K.; Kimata, K.; Narimatsu, H.; Watanabe, H.
Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development
PLoS ONE
7
e43806
2012
Mus musculus
Filipek-Gorniok, B.; Holmborn, K.; Haitina, T.; Habicher, J.; Oliveira, M.B.; Hellgren, C.; Eriksson, I.; Kjellen, L.; Kreuger, J.; Ledin, J.
Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development
Dev. Dyn.
242
964-975
2013
Danio rerio (A8E7C8), Danio rerio (E7F6G2)
Zheng, J.; Wu, C.; Ma, W.; Zhang, Y.; Hou, T.; Xu, H.; Wu, S.; Yao, X.; Guo, X.
Abnormal expression of chondroitin sulphate N-acetylgalactosaminyltransferase 1 and Hapln-1 in cartilage with Kashin-Beck disease and primary osteoarthritis
Int. Orthop.
37
2051-2059
2013
Homo sapiens (Q8TDX6)
Izumikawa, T.; Sato, B.; Mikami, T.; Tamura, J.; Igarashi, M.; Kitagawa, H.
GlcUAbeta1-3Galbeta1-3Galbeta1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1
J. Biol. Chem.
290
5438-5448
2015
Mus musculus (Q8BJQ9), Mus musculus (Q8C1F4), Mus musculus C57BL/6 (Q8BJQ9), Mus musculus C57BL/6 (Q8C1F4)
Takeuchi, K.; Yoshioka, N.; Higa Onaga, S.; Watanabe, Y.; Miyata, S.; Wada, Y.; Kudo, C.; Okada, M.; Ohko, K.; Oda, K.; Sato, T.; Yokoyama, M.; Matsushita, N.; Nakamura, M.; Okano, H.; Sakimura, K.; Kawano, H.; Kitagawa, H.; Igarashi, M.
Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury
Nat. Commun.
4
2740
2013
Mus musculus (Q8BJQ9)
Saigoh, K.; Yoshimura, S.; Izumikawa, T.; Miyata, S.; Tabara, Y.; Matsushita, T.; Miki, T.; Miyamoto, K.; Hirano, M.; Kitagawa, H.; Kira, J.I.; Kusunoki, S.
Chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism: association with progression of multiple sclerosis
Neurosci. Res.
108
55-59
2016
Homo sapiens (Q8TDX6)
Zhang, L.; Ren, X.; Chen, Y.; Gao, Y.; Wang, N.; Lu, Z.; Gao, L.; Qin, L.; Wang, Y.; Gao, H.; Li, K.; Jiang, L.; Cui, H.; Liu, C.; Zhang, Y.; Qi, X.; Wang, X.
Chondroitin sulfate N-acetylgalactosaminyltransferase-2 contributes to the replication of infectious bursal disease virus via interaction with the capsid protein VP2
Viruses
7
1474-1491
2015
Gallus gallus (E1C2T4), Gallus gallus
Vodopiutz, J.; Mizumoto, S.; Lausch, E.; Rossi, A.; Unger, S.; Janocha, N.; Costantini, R.; Seidl, R.; Greber-Platzer, S.; Yamada, S.; Mueller, T.; Jilma, B.; Ganger, R.; Superti-Furga, A.; Ikegawa, S.; Sugahara, K.; Janecke, A.R.
Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) deficiency results in a mild skeletal dysplasia and joint laxity
Hum. Mutat.
38
34-38
2017
Homo sapiens (Q8TDX6), Homo sapiens
Ji, X.Y.; Chen, J.H.; Zheng, G.H.; Huang, M.H.; Zhang, L.; Yi, H.; Jin, J.; Jiang, J.D.; Peng, Z.G.; Li, Z.R.
Design and synthesis of cajanine analogues against hepatitis C virus through down-regulating host chondroitin sulfate N-acetylgalactosaminyltransferase 1
J. Med. Chem.
59
10268-10284
2016
Homo sapiens (Q8TDX6)
Yoshioka, N.; Miyata, S.; Tamada, A.; Watanabe, Y.; Kawasaki, A.; Kitagawa, H.; Takao, K.; Miyakawa, T.; Takeuchi, K.; Igarashi, M.
Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis
Mol. Brain
10
47
2017
Mus musculus (Q8BJQ9)
Clausen, T.M.; Pereira, M.A.; Al Nakouzi, N.; Oo, H.Z.; Agerbaek, M.O.; Lee, S.; Oerum-Madsen, M.S.; Kristensen, A.R.; El-Naggar, A.; Grandgenett, P.M.; Grem, J.L.; Hollingsworth, M.A.; Holst, P.J.; Theander, T.; Sorensen, P.H.; Daugaard, M.; Salanti, A.
Oncofetal chondroitin sulfate glycosaminoglycans are key players in integrin signaling and tumor cell motility
Mol. Cancer Res.
14
1288-1299
2016
Mus musculus (Q8BJQ9), Mus musculus, Homo sapiens (Q8TDX6), Homo sapiens, Mus musculus C57BL/6 (Q8BJQ9)
Igarashi, M.; Takeuchi, K.; Sugiyama, S.
Roles of CSGalNAcT1, a key enzyme in regulation of CS synthesis, in neuronal regeneration and plasticity
Neurochem. Int.
119
77-83
2018
Mus musculus (Q8BJQ9), Mus musculus (Q8C1F4), Homo sapiens (Q8N6G5), Homo sapiens (Q8TDX6)
Shimbo, M.; Suzuki, R.; Fuseya, S.; Sato, T.; Kiyohara, K.; Hagiwara, K.; Okada, R.; Wakui, H.; Tsunakawa, Y.; Watanabe, H.; Kimata, K.; Narimatsu, H.; Kudo, T.; Takahashi, S.
Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2
PLoS ONE
12
e0190333
2017
Mus musculus (Q8BJQ9), Mus musculus (Q8C1F4), Mus musculus C57BL/6 (Q8BJQ9), Mus musculus C57BL/6 (Q8C1F4)
Sakai, D.; Nakai, T.; Hiraishi, S.; Nakamura, Y.; Ando, K.; Naiki, M.; Watanabe, M.
Upregulation of glycosaminoglycan synthesis by neurotropin in nucleus pulposus cells via stimulation of chondroitin sulfate N-acetylgalactosaminyltransferase 1 a new approach to attenuation of intervertebral disc degeneration
PLoS ONE
13
e0202640
2018
Homo sapiens (Q8TDX6), Homo sapiens
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