Information on EC 2.4.1.216 - trehalose 6-phosphate phosphorylase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
2.4.1.216
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RECOMMENDED NAME
GeneOntology No.
trehalose 6-phosphate phosphorylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
alpha,alpha-trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate
show the reaction diagram
The enzyme from Lactococcus lactis is specific for trehalose 6-phosphate. Differs from EC 2.4.1.64, alpha,alpha-trehalose phosphorylase, in that trehalose in not a substrate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycosyl group transfer
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-
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phospho group transfer
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-
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Phosphorylation
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
trehalose degradation III
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SYSTEMATIC NAME
IUBMB Comments
alpha,alpha-trehalose 6-phosphate:phosphate beta-D-glucosyltransferase
The enzyme from Lactococcus lactis is specific for trehalose 6-phosphate. Differs from EC 2.4.1.64, alpha,alpha-trehalose phosphorylase, in that trehalose is not a substrate.
CAS REGISTRY NUMBER
COMMENTARY hide
403512-51-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
collected from the upper Chesapeake Bay, China
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-
Manually annotated by BRENDA team
strain 496
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Manually annotated by BRENDA team
strain 496
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-
Manually annotated by BRENDA team
high activity
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-
Manually annotated by BRENDA team
Lactobacillus casei ssp. casei
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-
-
Manually annotated by BRENDA team
Lactobacillus delbrueckii ssp. delbrueckii
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-
-
Manually annotated by BRENDA team
CAA77100
SwissProt
Manually annotated by BRENDA team
and strain derivatives, overview, gene trePP
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Manually annotated by BRENDA team
Leuconostoc mesenteroides ssp. dextranicum
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-
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Manually annotated by BRENDA team
Leuconostoc weissella
high activity
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-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
alpha,alpha-trehalose 6-phosphate + phosphate
D-glucose 6-phosphate + beta-D-glucose 1-phosphate
show the reaction diagram
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-
-
-
?
trehalose 6-phosphate + phosphate
glucose 6-phosphate + beta-D-glucose 1-phosphate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha,alpha-trehalose 6-phosphate + phosphate
D-glucose 6-phosphate + beta-D-glucose 1-phosphate
show the reaction diagram
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-
-
-
?
trehalose 6-phosphate + phosphate
glucose 6-phosphate + beta-D-glucose 1-phosphate
show the reaction diagram
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.9
beta-D-glucose 1-phosphate
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4
glucose 6-phosphate
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6
Trehalose 6-phosphate
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.8
Leuconostoc weissella
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
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assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
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assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
94000
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, sequence comparison, quantitative RT-PCR enzyme expression analysis
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overexpression in Escherichia coli and Lactococcus lactis
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information