Reference on EC 2.4.1.223 - glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kitagawa, H.; Egusa, N.; Tamura, J.I.; Kusche-Gullberg, M.; Lindahl, U.; Sugahara, K.
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha-1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate
J. Biol. Chem.
276
4834-4838
2001
Caenorhabditis elegans
Kim, B.T.; Kitagawa, H.; Tamura, J.I.; Saito, T.; Kusche-Gullberg, M.; Lindahl, U.; Sugahara, K.
Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha-1,4-N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/heparin biosynthesis
Proc. Natl. Acad. Sci. USA
98
7176-7181
2001
Homo sapiens
Kim, B.T.; Kitagawa, H.; Tamura, J.I.; Kusche-Gullberg, M.; Lindahl, U.; Sugahara, K.
Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: Chain initiation and elongation
J. Biol. Chem.
277
13659-13665
2002
Drosophila melanogaster (Q9XZ08)
Han, C.; Belenkaya, T.Y.; Khodoun, M.; Tauchi, M.; Lin, X.; Lin, X.
Distinct and collaborative roles of Drosophila EXT family proteins in morphopgen signalling and gradient formation
Development
131
1563-1575
2005
Drosophila melanogaster
Kitagawa, H.; Shimakawa, H.; Sugahara, K.
The tumor suppressor EXT-like gene EXTL2 encodes an alpha1,4N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glucosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate
J. Biol. Chem.
274
13933-13937
1999
Homo sapiens
Kim, B.T.; Kitagawa, H.; Tanaka, J.; Tamura, J.I.; Sugahara, K.
In vitro heparan sulfate polymerization: crucial roles of core protein moieties of primer substrates in addition to the EXT1-EXT2 interaction
J. Biol. Chem.
278
41618-41623
2003
Homo sapiens
Herr, P.; Korniychuk, G.; Yamamoto, Y.; Grubisic, K.; Oelgeschlaeger, M.
Regulation of TGF-beta signalling by N-acetylgalactosaminyltransferase-like 1
Development
135
1813-1822
2008
Xenopus laevis (Q6PA81)
Awad, W.; Kjellstroem, S.; Svensson Birkedal, G.; Mani, K.; Logan, D.T.
Structural and biophysical characterization of human EXTL3 domain organization, glycosylation, and solution structure
Biochemistry
57
1166-1177
2018
Homo sapiens (O43909)
Nadanaka, S.; Kitagawa, H.
Exostosin-like 2 regulates FGF2 signaling by controlling the endocytosis of FGF2
Biochim. Biophys. Acta Gen. Subj.
1862
791-799
2018
Mus musculus (Q9ES89), Mus musculus
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