Information on EC 2.4.1.23 - sphingosine beta-galactosyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.4.1.23
-
RECOMMENDED NAME
GeneOntology No.
sphingosine beta-galactosyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-galactose + sphingosine = UDP + psychosine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Sphingolipid metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-galactose:sphingosine 1-beta-galactosyltransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9032-90-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
normal and twitcher mice
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDPgalactose + D-1,3,4-trihydroxy-2-aminooctadecane
?
show the reaction diagram
-
weak activity
-
-
?
UDPgalactose + DL-1-hydroxy-2-amino-octadecane
?
show the reaction diagram
UDPgalactose + DL-erythro-1,3-dihydroxy-2-amino-4-cis-octadecene
?
show the reaction diagram
UDPgalactose + DL-erythro-1,3-dihydroxy-2-amino-4-heptadecyne
?
show the reaction diagram
-
weak activity
-
-
?
UDPgalactose + DL-erythro-trans-sphingosine
UDP + psychosine
show the reaction diagram
UDPgalactose + DL-threo-1,3-dihydroxy-2-amino-4-cis-octadecene
?
show the reaction diagram
-
weak activity
-
-
?
UDPgalactose + DL-threo-1,3-dihydroxy-2-amino-4-octadecyne
?
show the reaction diagram
UDPgalactose + DL-threo-1,3-dihydroxy-2-amino-4-trans-heptadecene
?
show the reaction diagram
-
weak activity
-
-
?
UDPgalactose + DL-threo-1,3-dihydroxy-2-amino-4-trans-nonadecene
?
show the reaction diagram
-
weak activity
-
-
?
UDPgalactose + DL-threo-1,3-dihydroxy-2-amino-4-trans-octadecene
?
show the reaction diagram
-
weak activity
-
-
?
UDPgalactose + DL-threo-1,3-dihydroxy-2-aminooctadecane
?
show the reaction diagram
-
weak activity
-
-
?
UDPgalactose + N-acetyl-DL-threo-trans-sphingosine
UDP + N-acetylpsychosine
show the reaction diagram
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
2-8 mM, stimulation
Mn2+
-
2-3 mM, slight stimulation
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Tween-20
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.25
UDPgalactose
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
activity in central nervous tissue increases with age, maximal activity at 25 postnatal days
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 9
-
70% of maximal activity at pH 7, 85% of maximal activity at pH 9.0
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
highest activity together with spinal cord
Manually annotated by BRENDA team
-
highest activity together with brainstem
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
lyophilized powder is indefinitely stable in the deep-frozen
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial