Information on EC 2.4.1.70 - poly(ribitol-phosphate) N-acetylglucosaminyltransferase

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The expected taxonomic range for this enzyme is: Staphylococcus aureus

EC NUMBER
COMMENTARY hide
2.4.1.70
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RECOMMENDED NAME
GeneOntology No.
poly(ribitol-phosphate) N-acetylglucosaminyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + poly(ribitol phosphate) = UDP + (N-acetyl-alpha-D-glucosaminyl)poly(ribitol phosphate)
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)
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SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase
Involved in the synthesis of teichoic acids.
CAS REGISTRY NUMBER
COMMENTARY hide
37277-71-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strains H or Duncan: primarily N-acetyl-beta-glucosamine transfer, strain 3528: N-acetyl-alpha-glucosamine transfer, strain Copenhagen: both transferases
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-glucose + poly(ribitol phosphate)
UDP + glucosyl-poly(ribitol phosphate)
show the reaction diagram
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10% of activity with UDP-N-acetyl-D-glucosamine
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?
UDP-N-acetyl-D-glucosamine + poly(ribitol phosphate)
UDP + N-acetyl-D-glucosaminyl-poly(ribitol phosphate)
show the reaction diagram
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D-alanyl-N-acetyl-alpha-galactosamine poly(ribitol phosphate) is a less efficient acceptor, poor donor substrate is UDPglucose, no activity with teichoic acid, D-ribitol 5-phosphate or partial alkali hydrolysates of teichoic acid or N-acetyl-galactosamine polyribitol phosphate, UDP-N-acetyl-galactosamine, N-acetyl-galactosamine and N-acetyl-galactosamine phosphate
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ir
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-D-glucosamine + poly(ribitol phosphate)
UDP + N-acetyl-D-glucosaminyl-poly(ribitol phosphate)
show the reaction diagram
-
D-alanyl-N-acetyl-alpha-galactosamine poly(ribitol phosphate) is a less efficient acceptor, poor donor substrate is UDPglucose, no activity with teichoic acid, D-ribitol 5-phosphate or partial alkali hydrolysates of teichoic acid or N-acetyl-galactosamine polyribitol phosphate, UDP-N-acetyl-galactosamine, N-acetyl-galactosamine and N-acetyl-galactosamine phosphate
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ir
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ca2+
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slight activation
Co2+
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slight activation
Mg2+
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8 mM, required for activity
Mn2+
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slight activation
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.06
poly(ribitol phosphate)
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0.7
UDP-N-acetylglucosamine
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
frozen, N-acetyl-alpha-D-glucosamine transferase, not N-acetyl-beta-D-glucosamine transferase, a few months
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