Information on EC 2.4.1.B49 - 8-demethyl-tetracenomycin-C rhamnosyltransferase

Word Map on EC 2.4.1.B49
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Streptomyces olivaceus

EC NUMBER
COMMENTARY hide
2.4.1.B49
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
8-demethyl-tetracenomycin-C rhamnosyltransferase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dTDP-L-rhamnose + 8-demethyl-tetracenomycin C = dTDP + 8-demethyl-8-alpha-L-rhamnosyl tetracenomycin C
show the reaction diagram
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
dTDP-L-rhamnose:8-demethyl-tetracenomycin-C 8-O-rhamnosyltransferase
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
glycosyltransferase gene is present in cosmid 16F4
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
the enzyme is involved in the biosynthesis of the antitumor drug elloramycin
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dTDP-L-rhamnose + 8-demethyltetracenomycin C
dTDP + 8-demethyl-8-alpha-L-rhamnosyl tetracenomycin C
show the reaction diagram
dTDP-L-rhamnose + 8-demethyltetracenomycin C
dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C
show the reaction diagram
additional information
?
-
-
broad deoxysugar recognition pattern. The enzyme is able to transfer different L- and D-deoxysugars to 8-demethyl-tetracenomycin C
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dTDP-L-rhamnose + 8-demethyltetracenomycin C
dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C
show the reaction diagram
-
the enzyme is involved in the biosynthesis of the antitumor drug elloramycin
-
-
?
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L309A
-
mutation increases the efficiency of L-olivose to 8-demethyltetracenomycin C
L309I
-
mutation increases the efficiency of L-rhamnose to 8-demethyltetracenomycin C
L309M
-
mutation increases the efficiency of D-boivinose to 8-demethyltetracenomycin C
L309V
-
mutation increases the efficiency of L-olivose to 8-demethyltetracenomycin C
L309Y
-
mutation increases the efficiency of L-olivose to 8-demethyltetracenomycin C
N312Q
-
mutation increases the efficiency of L-olivose to 8-demethyltetracenomycin C
N312S
-
mutation increases the efficiency of L-olivose to 8-demethyltetracenomycin C
N312T
-
mutation increases the efficiency of L-olivose to 8-demethyltetracenomycin C
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis