Disease on EC 2.4.2.28 - S-methyl-5'-thioadenosine phosphorylase
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Adenocarcinoma of Lung
MTAP-deficiency could predict better treatment response in advanced lung adenocarcinoma patients initially treated with pemetrexed-platinum chemotherapy and bevacizumab.
Adenoma
[Expression of methylthioadenosine phosphorylase (MTAP) gene and demethylation of its promoter in human colorectal cancer.]
Adenomatous Polyposis Coli
Transition state analogue of MTAP extends lifespan of APCMin/+ mice.
Astrocytoma
Expression of Methylthioadenosine Phosphorylase (MTAP) in Pilocytic Astrocytomas.
Astrocytoma
Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2A homozygous deletion in the assessment of adult-type infiltrating astrocytoma.
Biliary Tract Neoplasms
Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers.
Breast Neoplasms
Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line.
Carcinoma
5'-deoxy-5'-methylthioadenosine phosphorylase--II. Role of the enzyme in the metabolism and antineoplastic action of adenine-substituted analogs of 5'-deoxy-5'-methylthioadenosine.
Carcinoma
Codeletion of the genes for p16INK4, methylthioadenosine phosphorylase, interferon-alpha1, interferon-beta1, and other 9p21 markers in human malignant cell lines.
Carcinoma
Expression and localisation of methylthioadenosine phosphorylase (MTAP) in oral squamous cell carcinoma and their significance in epithelial-to-mesenchymal transition.
Carcinoma
Gene deletion chemoselectivity: codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the alpha- and beta-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy.
Carcinoma
Immunohistochemical diagnosis of methylthioadenosine phosphorylase (MTAP) deficiency in non-small cell lung carcinoma.
Carcinoma
Loss of Methylthioadenosine Phosphorylase by Immunohistochemistry Is Common in Pulmonary Sarcomatoid Carcinoma and Sarcomatoid Mesothelioma.
Carcinoma
Methylthioadenosine phosphorylase expression in cutaneous squamous cell carcinoma.
Carcinoma
Methylthioadenosine phosphorylase inactivation depends on gene deletion in laryngeal squamous cell carcinoma.
Carcinoma
Strong expression of methylthioadenosine phosphorylase (MTAP) in human colon carcinoma cells is regulated by TCF1/[beta]-catenin.
Carcinoma, Hepatocellular
Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA).
Carcinoma, Hepatocellular
Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC).
Carcinoma, Non-Small-Cell Lung
Immunohistochemical diagnosis of methylthioadenosine phosphorylase (MTAP) deficiency in non-small cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
[Expression and clinical significance of methylthioadenosine phosphorylase gene in patients with non-small cell lung cancer]
Carcinoma, Squamous Cell
Methylthioadenosine phosphorylase expression in cutaneous squamous cell carcinoma.
Chondrosarcoma
Methylthioadenosine phosphorylase gene deletions are frequently detected by fluorescence in situ hybridization in conventional chondrosarcomas.
Chordoma
Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma.
Colorectal Neoplasms
[Expression of methylthioadenosine phosphorylase (MTAP) gene and demethylation of its promoter in human colorectal cancer.]
Coronary Artery Disease
Association between rs10118757(A/G) in methylthioadenosine phosphorylase gene and coronary artery disease in Chinese Hans.
Fanconi Anemia
Epigenetic regulation of Fanconi anemia genes implicates PRMT5 blockage as a strategy for tumor chemosensitization.
Glioblastoma
Epigenetic regulation of Fanconi anemia genes implicates PRMT5 blockage as a strategy for tumor chemosensitization.
Glioblastoma
Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine.
Glioblastoma
MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.
Glioma
Codeletion of the genes for p16INK4, methylthioadenosine phosphorylase, interferon-alpha1, interferon-beta1, and other 9p21 markers in human malignant cell lines.
Glioma
Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers.
Glioma
Loss of 5'-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness.
Glioma
Molecular genetic analysis of chromosome 9p in methylthioadenosine phosphorylase deficient glioma cell lines.
Glioma
Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2A homozygous deletion in the assessment of adult-type infiltrating astrocytoma.
Head and Neck Neoplasms
A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers.
Hematologic Neoplasms
Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: Current strategies.
Keratosis
Losses of 3p14 and 9p21 as shown by fluorescence in situ hybridization are early events in tumorigenesis of oral squamous cell carcinoma and already occur in simple keratosis.
Leukemia
5'-deoxy-5'-methylthioadenosine phosphorylase deficiency in leukemia: genetics and biochemical aspects.
Leukemia
5'-Deoxy-5'-methylthioadenosine phosphorylase--III. Role of the enzyme in the metabolism and action of 5'-halogenated adenosine analogs.
Leukemia
5'-deoxy-5'-methylthioadenosine phosphorylase--V. Acycloadenosine derivatives as inhibitors of the enzyme.
Leukemia
A polymorphic region defined by pCN2 (the 3' nontranslated region of N-ras) maps to chromosome 9cen-p12.
Leukemia
Chemotherapy targeting methylthioadenosine phosphorylase (MTAP) deficiency in adult T cell leukemia (ATL).
Leukemia
Codeletion of the genes for p16INK4, methylthioadenosine phosphorylase, interferon-alpha1, interferon-beta1, and other 9p21 markers in human malignant cell lines.
Leukemia
Conversion of 5'-deoxy-5'-methylthioadenosine and 5'-deoxy-5'-methylthioinosine to methionine in cultured human leukemic cells.
Leukemia
Methylthioadenosine phosphorylase deficiency in acute leukemia: pathologic, cytogenetic, and clinical features.
Leukemia
Synthesis and antiproliferative effects of novel 5'-fluorinated analogues of 5'-deoxy-5'-(methylthio)adenosine.
Leukemia
Targeting 5'-deoxy-5'-(methylthio)adenosine phosphorylase by 5'-haloalkyl analogues of 5'-deoxy-5'-(methylthio)adenosine.
Leukemia, Lymphoid
Comparison of the biological effects of four irreversible inhibitors of ornithine decarboxylase in two murine lymphocytic leukemia cell lines.
Leukemia, Lymphoid
Methylthioadenosine phosphorylase and purine nucleoside phosphorylase in B-chronic lymphocytic leukemia.
Leukemia, T-Cell
5'-deoxy-5'-methylthioadenosine phosphorylase--II. Role of the enzyme in the metabolism and antineoplastic action of adenine-substituted analogs of 5'-deoxy-5'-methylthioadenosine.
Leukemia, T-Cell
Chemotherapy targeting methylthioadenosine phosphorylase (MTAP) deficiency in adult T cell leukemia (ATL).
Leukemia, T-Cell
Conversion of 5'-deoxy-5'-methylthioadenosine and 5'-deoxy-5'-methylthioinosine to methionine in cultured human leukemic cells.
Leukemia-Lymphoma, Adult T-Cell
The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia.
Leukoplakia, Oral
Losses of 3p14 and 9p21 as shown by fluorescence in situ hybridization are early events in tumorigenesis of oral squamous cell carcinoma and already occur in simple keratosis.
Liver Cirrhosis
Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma.
Liver Diseases
Expression and function of methylthioadenosine phosphorylase in chronic liver disease.
Lung Neoplasms
Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.
Lung Neoplasms
Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC).
Lung Neoplasms
Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells.
Lung Neoplasms
Methylthioadenosine phosphorylase deficiency in human non-small cell lung cancers.
Lung Neoplasms
[Expression and clinical significance of methylthioadenosine phosphorylase gene in patients with non-small cell lung cancer]
Lymphoma
A polymorphic region defined by pCN2 (the 3' nontranslated region of N-ras) maps to chromosome 9cen-p12.
Lymphoma
Heterogeneity of the toxic mechanisms of methylthioadenosine in methylthioadenosine phosphorylase deficient murine lymphoma cells.
Lymphoma
Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy.
Lymphoma
Methylthioadenosine phosphorylase gene is silenced by promoter hypermethylation in human lymphoma cell line DHL-9: another mechanism of enzyme deficiency.
Lymphoma
Modulation of adenine nucleoside excretion and incorporation in adenosine deaminase deficient human lymphoma cells.
Lymphoma, Mantle-Cell
Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy.
Lymphoma, T-Cell
Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma.
Lymphoma, T-Cell, Cutaneous
Independent Loss of Methylthioadenosine Phosphorylase (MTAP) in Primary Cutaneous T-Cell Lymphoma.
Melanoma
Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma.
Melanoma
Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma.
Melanoma
Distinct deletions of chromosome 9p associated with melanoma versus glioma, lung cancer, and leukemia.
Melanoma
Methylthioadenosine phosphorylase represents a predictive marker for response to adjuvant interferon therapy in patients with malignant melanoma.
Melanoma
Nucleotide-metabolism and chromosome alterations in human-malignant melanoma xenografts.
Melanoma
Polymorphisms in nevus-associated genes MTAP, PLA2G6, and IRF4 and the risk of invasive cutaneous melanoma.
Melanoma
Significantly decreased methylthioadenosine phosphorylase expression in malignant melanoma.
Melanoma
The metabolite 5'-methylthioadenosine signals through the adenosine receptor A2B in melanoma.
Melanoma
Tissue microarray analysis of methylthioadenosine phosphorylase protein expression in melanocytic skin tumors.
Mesothelioma
c-MET immunohistochemistry for differentiating malignant mesothelioma from benign mesothelial proliferations.
Mesothelioma
CD146 immunohistochemical staining for the separation of benign from malignant mesothelial proliferations.
Mesothelioma
Correlation of methylthioadenosine phosphorylase (MTAP) protein expression with MTAP and CDKN2A copy number in malignant pleural mesothelioma.
Mesothelioma
Genomic-based ancillary assays offer improved diagnostic yield of effusion cytology with potential challenges in malignant pleural mesothelioma.
Mesothelioma
Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas.
Mesothelioma
Loss of Methylthioadenosine Phosphorylase by Immunohistochemistry Is Common in Pulmonary Sarcomatoid Carcinoma and Sarcomatoid Mesothelioma.
Mesothelioma
The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas.
Mesothelioma
The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity.
Mesothelioma
Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression.
Mesothelioma, Malignant
c-MET immunohistochemistry for differentiating malignant mesothelioma from benign mesothelial proliferations.
Mesothelioma, Malignant
Correlation of methylthioadenosine phosphorylase (MTAP) protein expression with MTAP and CDKN2A copy number in malignant pleural mesothelioma.
Mesothelioma, Malignant
Genomic-based ancillary assays offer improved diagnostic yield of effusion cytology with potential challenges in malignant pleural mesothelioma.
Mesothelioma, Malignant
Malignant mesothelioma in situ diagnosed by methylthioadenosine phosphorylase loss and homozygous deletion of CDKN2A: a case report.
Mesothelioma, Malignant
The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas.
Mesothelioma, Malignant
Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression.
Mesothelioma, Malignant
Usefulness of methylthioadenosine phosphorylase and BRCA-associated protein 1 immunohistochemistry in the diagnosis of malignant mesothelioma in effusion cytology specimens.
Mesothelioma, Malignant
Utility of Methylthioadenosine Phosphorylase Compared With BAP1 Immunohistochemistry, and CDKN2A and NF2 Fluorescence In Situ Hybridization in Separating Reactive Mesothelial Proliferations From Epithelioid Malignant Mesotheliomas.
Myocardial Infarction
Association between rs10118757(A/G) in methylthioadenosine phosphorylase gene and coronary artery disease in Chinese Hans.
Myocardial Infarction
MTAP and CDKN2B genes are associated with myocardial infarction in Chinese Hans.
Myocardial Infarction
[Association between methylthioadenosine phosphorylase gene single nucleotide polymorphisms and myocardial infarction in Chinese Han ethnicity.]
Nasopharyngeal Carcinoma
Characterization and Prognostic Significance of Methylthioadenosine Phosphorylase Deficiency in Nasopharyngeal Carcinoma.
Neoplasm Metastasis
Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.
Neoplasm Metastasis
Methylthioadenosine phosphorylase represents a predictive marker for response to adjuvant interferon therapy in patients with malignant melanoma.
Neoplasms
5'-Deoxy-5'-methylthioadenosine phosphorylase and p16INK4 deficiency in multiple tumor cell lines.
Neoplasms
5'-deoxy-5'-methylthioadenosine phosphorylase--V. Acycloadenosine derivatives as inhibitors of the enzyme.
Neoplasms
5-Iodoribose 1-phosphate, an analog of ribose 1-phosphate. Enzymatic synthesis and kinetic studies with enzymes of purine, pyrimidine, and sugar phosphate metabolism.
Neoplasms
A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer.
Neoplasms
A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer.
Neoplasms
Analysis of tumor suppressor gene on human chromosome 9 in mouse x human somatic cell hybrids.
Neoplasms
Characterization and Prognostic Significance of Methylthioadenosine Phosphorylase Deficiency in Nasopharyngeal Carcinoma.
Neoplasms
Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma.
Neoplasms
Chemical genetic screening for compounds that preferentially inhibit growth of methylthioadenosine phosphorylase (MTAP)-deficient Saccharomyces cerevisiae.
Neoplasms
Codeletion of the genes for p16INK4, methylthioadenosine phosphorylase, interferon-alpha1, interferon-beta1, and other 9p21 markers in human malignant cell lines.
Neoplasms
Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: evidence of homozygous deletion in esophageal noninvasive precursor lesions and therapeutic implications.
Neoplasms
Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21.
Neoplasms
Defects in methylthioadenosine phosphorylase are associated with but not responsible for methionine-dependent tumor cell growth.
Neoplasms
Deficiency of 5'-deoxy-5'-methylthioadenosine phosphorylase activity in malignancy. Absence of the protein in human enzyme-deficient cell lines.
Neoplasms
Detection of methylthioadenosine phosphorylase (MTAP) and p16 gene deletion in T cell acute lymphoblastic leukemia by real-time quantitative PCR assay.
Neoplasms
Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
Neoplasms
Distinct deletions of chromosome 9p associated with melanoma versus glioma, lung cancer, and leukemia.
Neoplasms
Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA).
Neoplasms
Downregulation of methylthioadenosin phosphorylase by homozygous deletion in gastric carcinoma.
Neoplasms
EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine.
Neoplasms
Enzyme deficiency and tumor suppressor genes: absence of 5'-deoxy-5'-methylthioadenosine phosphorylase in human tumors.
Neoplasms
Epigenetic regulation of Fanconi anemia genes implicates PRMT5 blockage as a strategy for tumor chemosensitization.
Neoplasms
Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function.
Neoplasms
Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma.
Neoplasms
Frequent deletion in the methylthioadenosine phosphorylase gene in T-cell acute lymphoblastic leukemia: strategies for enzyme-targeted therapy.
Neoplasms
Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers.
Neoplasms
Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in Mice.
Neoplasms
Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.
Neoplasms
Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas.
Neoplasms
Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC).
Neoplasms
Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers.
Neoplasms
Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers.
Neoplasms
Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine.
Neoplasms
Identification of gene expression profiles predicting tumor cell response to L-alanosine.
Neoplasms
Increased sensitivity to thiopurines in methylthioadenosine phosphorylase-deleted cancers.
Neoplasms
Independent Loss of Methylthioadenosine Phosphorylase (MTAP) in Primary Cutaneous T-Cell Lymphoma.
Neoplasms
Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy.
Neoplasms
Leishmania infantum 5'-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target.
Neoplasms
Loss of 5'-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness.
Neoplasms
Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer.
Neoplasms
Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors.
Neoplasms
Losses of 3p14 and 9p21 as shown by fluorescence in situ hybridization are early events in tumorigenesis of oral squamous cell carcinoma and already occur in simple keratosis.
Neoplasms
MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage.
Neoplasms
Methionine and Kynurenine Activate Oncogenic Kinases in Glioblastoma, and Methionine Deprivation Compromises Proliferation.
Neoplasms
Methods to Study the Role of Methionine-Restricted Diet and Methioninase in Cancer Growth Control.
Neoplasms
Methylthioadenosine nucleoside phosphorylase deficiency in methylthio-dependent cancer cells.
Neoplasms
Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells.
Neoplasms
Methylthioadenosine phosphorylase expression in cutaneous squamous cell carcinoma.
Neoplasms
Methylthioadenosine phosphorylase gene is silenced by promoter hypermethylation in human lymphoma cell line DHL-9: another mechanism of enzyme deficiency.
Neoplasms
Methylthioadenosine phosphorylase inactivation depends on gene deletion in laryngeal squamous cell carcinoma.
Neoplasms
Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites.
Neoplasms
Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line.
Neoplasms
Molecular cloning of the human methylthioadenosine phosphorylase processed pseudogene and localization to 3q28.
Neoplasms
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.
Neoplasms
MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis.
Neoplasms
Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target.
Neoplasms
Ocular Expression and Distribution of Products of the POAG-Associated Chromosome 9p21 Gene Region.
Neoplasms
Presence of methylthioadenosine phosphorylase (MTAP) in hematopoietic stem/progenitor cells: its therapeutic implication for MTAP (-) malignancies.
Neoplasms
PRMT5 silencing selectively affects MTAP-deleted mesothelioma: In vitro evidence of a novel promising approach.
Neoplasms
Purification and characterization of recombinant human 5'-methylthioadenosine phosphorylase: definite identification of coding cDNA.
Neoplasms
Quantification of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry in cultured tumor cells and liver biopsies.
Neoplasms
Quantitative analysis of 5'-deoxy-5'-methylthioadenosine in melanoma cells by liquid chromatography-stable isotope ratio tandem mass spectrometry.
Neoplasms
Selective killing of human malignant cell lines deficient in methylthioadenosine phosphorylase, a purine metabolic enzyme.
Neoplasms
Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy.
Neoplasms
Selective PRMT5 Inhibitors Suppress Human CD8+ T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA.
Neoplasms
SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth.
Neoplasms
Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine.
Neoplasms
Status of methylthioadenosine phosphorylase and its impact on cellular response to L-alanosine and methylmercaptopurine riboside in human soft tissue sarcoma cells.
Neoplasms
Strong expression of methylthioadenosine phosphorylase (MTAP) in human colon carcinoma cells is regulated by TCF1/[beta]-catenin.
Neoplasms
Studies on the regulation of ornithine decarboxylase in yeast: effect of deletion in the MEU1 gene.
Neoplasms
Suppressive effects of tumor cell-derived 5'-deoxy-5'-methylthioadenosine on human T cells.
Neoplasms
Synergistic inhibition of polyamine synthesis and growth by difluoromethylornithine plus methylthioadenosine in methylthioadenosine phosphorylase-deficient murine lymphoma cells.
Neoplasms
Targeting 5'-deoxy-5'-(methylthio)adenosine phosphorylase by 5'-haloalkyl analogues of 5'-deoxy-5'-(methylthio)adenosine.
Neoplasms
Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: Current strategies.
Neoplasms
The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia.
Neoplasms
Tissue microarray analysis of methylthioadenosine phosphorylase protein expression in melanocytic skin tumors.
Neoplasms
Use of alanosine as a methylthioadenosine phosphorylase-selective therapy for T-cell acute lymphoblastic leukemia in vitro.
Neoplasms
Usefulness of methylthioadenosine phosphorylase and BRCA-associated protein 1 immunohistochemistry in the diagnosis of malignant mesothelioma in effusion cytology specimens.
Neoplasms
Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2A homozygous deletion in the assessment of adult-type infiltrating astrocytoma.
Neoplasms
[Expression of methylthioadenosine phosphorylase (MTAP) gene and demethylation of its promoter in human colorectal cancer.]
Nevus
Methylthioadenosine phosphorylase represents a predictive marker for response to adjuvant interferon therapy in patients with malignant melanoma.
Nevus, Pigmented
Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma.
Osteosarcoma
Methylthioadenosine phosphorylase deficiency in Japanese osteosarcoma patients.
Pancreatic Neoplasms
Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer.
Pancreatic Neoplasms
MTAP deficiency-induced metabolic reprogramming creates a vulnerability to co-targeting de novo purine synthesis and glycolysis in pancreatic cancer.
Pancreatitis
Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine ?-synthase.
Pleural Effusion
Fluorescence in situ hybridization detection of chromosome 22 monosomy in pleural effusion cytology for the diagnosis of mesothelioma.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Deficiency of methylthioadenosine phosphorylase in human leukemic cells in vivo.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Detection of methylthioadenosine phosphorylase (MTAP) and p16 gene deletion in T cell acute lymphoblastic leukemia by real-time quantitative PCR assay.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Frequent deletion in the methylthioadenosine phosphorylase gene in T-cell acute lymphoblastic leukemia: strategies for enzyme-targeted therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Methylthioadenosine phosphorylase as target for chemoselective treatment of T-cell acute lymphoblastic leukemic cells.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Use of alanosine as a methylthioadenosine phosphorylase-selective therapy for T-cell acute lymphoblastic leukemia in vitro.
Prostatic Neoplasms
Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target.
Prostatic Neoplasms
Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy.
Prostatic Neoplasms
The essential role of methylthioadenosine phosphorylase in prostate cancer.
Protein Deficiency
Characterization and Prognostic Significance of Methylthioadenosine Phosphorylase Deficiency in Nasopharyngeal Carcinoma.
Protein Deficiency
Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance.
Retinoblastoma
Lymphoblastic leukemia with lymphomatous features associated with abnormalities of the short arm of chromosome 9.
s-methyl-5'-thioadenosine phosphorylase deficiency
5'-Deoxy-5'-methylthioadenosine phosphorylase and p16INK4 deficiency in multiple tumor cell lines.
s-methyl-5'-thioadenosine phosphorylase deficiency
5'-deoxy-5'-methylthioadenosine phosphorylase deficiency in leukemia: genetics and biochemical aspects.
s-methyl-5'-thioadenosine phosphorylase deficiency
5'-Methylthioadenosine phosphorylase deficiency in malignant cells: recessive expression of the defective phenotype in intraspecies (mouse X mouse) hybrids.
s-methyl-5'-thioadenosine phosphorylase deficiency
Characterization and Prognostic Significance of Methylthioadenosine Phosphorylase Deficiency in Nasopharyngeal Carcinoma.
s-methyl-5'-thioadenosine phosphorylase deficiency
Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance.
s-methyl-5'-thioadenosine phosphorylase deficiency
Methylthioadenosine nucleoside phosphorylase deficiency in methylthio-dependent cancer cells.
s-methyl-5'-thioadenosine phosphorylase deficiency
Methylthioadenosine phosphorylase deficiency in acute leukemia: pathologic, cytogenetic, and clinical features.
s-methyl-5'-thioadenosine phosphorylase deficiency
Methylthioadenosine phosphorylase deficiency in human leukemias and solid tumors.
s-methyl-5'-thioadenosine phosphorylase deficiency
Methylthioadenosine phosphorylase deficiency in human non-small cell lung cancers.
s-methyl-5'-thioadenosine phosphorylase deficiency
Methylthioadenosine phosphorylase deficiency in Japanese osteosarcoma patients.
s-methyl-5'-thioadenosine phosphorylase deficiency
The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas.
Sarcoma
Status of methylthioadenosine phosphorylase and its impact on cellular response to L-alanosine and methylmercaptopurine riboside in human soft tissue sarcoma cells.
Sarcoma 180
5'-deoxy-5'-methylthioadenosine phosphorylase--V. Acycloadenosine derivatives as inhibitors of the enzyme.
Sarcoma 180
5-Iodoribose 1-phosphate, an analog of ribose 1-phosphate. Enzymatic synthesis and kinetic studies with enzymes of purine, pyrimidine, and sugar phosphate metabolism.
Sarcoma 180
Substrate specificities of 5'-deoxy-5'-methylthioadenosine phosphorylase from Trypanosoma brucei brucei and mammalian cells.
Squamous Cell Carcinoma of Head and Neck
Expression and localisation of methylthioadenosine phosphorylase (MTAP) in oral squamous cell carcinoma and their significance in epithelial-to-mesenchymal transition.
Squamous Cell Carcinoma of Head and Neck
Methylthioadenosine phosphorylase inactivation depends on gene deletion in laryngeal squamous cell carcinoma.
Trypanosomiasis
Leishmania infantum 5'-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target.
Trypanosomiasis, Bovine
In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides.
Tuberculosis
Identification of Rv0535 as methylthioadenosine phosphorylase from Mycobacterium tuberculosis.
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